Vascular endothelial growth factor blockade prevents the beneficial effects of β-blocker therapy on cardiac function, angiogenesis, and remodeling in heart failure

Circulation: Heart Failure

Volumn 6, Issue 6, 2013, Pages 1259-1267

  Rengo, Giuseppe ^a,b,d   Cannavo, Alessandro ^b,d   Liccardo, Daniela ^b   Zincarelli, Carmela ^a   De Lucia, Claudio ^b   Pagano, Gennaro ^b   Komici, Klara ^b   Parisi, Valentina ^b   Scala, Oriana ^c   Agresta, Alessia ^c   Rapacciuolo, Antonio ^c   Filardi, Pasquale Perrone ^c   Ferrara, Nicola ^a,b   Koch, Walter J ^d   Trimarco, Bruno ^c   Femminella, Grazia Daniela ^b   Leosco, Dario ^b,d  

^a IRCCS   (Italy)

^b Department of Translational Medical Sciences ^*  (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenergic 1 receptor antagonists; Angiogenesis; Heart failure; Vascular endothelial growth factor A

Indexed keywords

ADENOVIRUS VECTOR; BISOPROLOL; BRAIN NATRIURETIC PEPTIDE; COLLAGEN TYPE 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G2A; MESSENGER RNA; PLACEBO; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 2; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CAPILLARY FLOW; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ECHOCARDIOGRAPHY; ENZYME ACTIVATION; GENE EXPRESSION; HEART FAILURE; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART MUSCLE PERFUSION; HEART RATE; HEART SIZE; HEART VENTRICLE REMODELING; HEART WEIGHT; HISTOPATHOLOGY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TREATMENT DURATION; ADRENERGIC Β-1 RECEPTOR ANTAGONISTS; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; HEART MUSCLE; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TREATMENT OUTCOME; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS;

ADRENERGIC Β-1 RECEPTOR ANTAGONISTS; ANGIOGENESIS; HEART FAILURE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ANIMALS; BISOPROLOL; CORONARY CIRCULATION; DISEASE MODELS, ANIMAL; HEART FAILURE; MALE; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VENTRICULAR REMODELING;

EID: 84889683167     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.113.000329     Document Type: Article

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