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Volumn 44, Issue 6, 2011, Pages 851-863

The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD +

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BETA ADRENERGIC RECEPTOR; CLENBUTEROL; CYCLIC AMP; NICOTINAMIDE ADENINE DINUCLEOTIDE; SERINE; SIRTUIN 1;

EID: 84255198350     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2011.12.005     Document Type: Article
Times cited : (275)

References (44)
  • 3
    • 33749853607 scopus 로고    scopus 로고
    • A probability-based approach for high-throughput protein phosphorylation analysis and site localization
    • Beausoleil S.A., Villén J., Gerber S.A., Rush J., Gygi S.P. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat. Biotechnol. 2006, 24:1285-1292.
    • (2006) Nat. Biotechnol. , vol.24 , pp. 1285-1292
    • Beausoleil, S.A.1    Villén, J.2    Gerber, S.A.3    Rush, J.4    Gygi, S.P.5
  • 5
    • 77953257025 scopus 로고    scopus 로고
    • Aging and disease: connections to sirtuins
    • Donmez G., Guarente L. Aging and disease: connections to sirtuins. Aging Cell 2010, 9:285-290.
    • (2010) Aging Cell , vol.9 , pp. 285-290
    • Donmez, G.1    Guarente, L.2
  • 6
    • 77955046461 scopus 로고    scopus 로고
    • SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
    • Donmez G., Wang D., Cohen D.E., Guarente L. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 2010, 142:320-332.
    • (2010) Cell , vol.142 , pp. 320-332
    • Donmez, G.1    Wang, D.2    Cohen, D.E.3    Guarente, L.4
  • 7
    • 33644660537 scopus 로고    scopus 로고
    • PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
    • Finck B.N., Kelly D.P. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J. Clin. Invest. 2006, 116:615-622.
    • (2006) J. Clin. Invest. , vol.116 , pp. 615-622
    • Finck, B.N.1    Kelly, D.P.2
  • 8
    • 43049121395 scopus 로고    scopus 로고
    • Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
    • Fulco M., Cen Y., Zhao P., Hoffman E.P., McBurney M.W., Sauve A.A., Sartorelli V. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev. Cell 2008, 14:661-673.
    • (2008) Dev. Cell , vol.14 , pp. 661-673
    • Fulco, M.1    Cen, Y.2    Zhao, P.3    Hoffman, E.P.4    McBurney, M.W.5    Sauve, A.A.6    Sartorelli, V.7
  • 10
    • 77951225449 scopus 로고    scopus 로고
    • DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
    • Guo X., Williams J.G., Schug T.T., Li X. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J. Biol. Chem. 2010, 285:13223-13232.
    • (2010) J. Biol. Chem. , vol.285 , pp. 13223-13232
    • Guo, X.1    Williams, J.G.2    Schug, T.T.3    Li, X.4
  • 11
    • 78649482634 scopus 로고    scopus 로고
    • SIRT1: recent lessons from mouse models
    • Herranz D., Serrano M. SIRT1: recent lessons from mouse models. Nat. Rev. Cancer 2010, 10:819-823.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 819-823
    • Herranz, D.1    Serrano, M.2
  • 12
    • 33745534953 scopus 로고    scopus 로고
    • Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide
    • Hoff K.G., Avalos J.L., Sens K., Wolberger C. Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide. Structure 2006, 14:1231-1240.
    • (2006) Structure , vol.14 , pp. 1231-1240
    • Hoff, K.G.1    Avalos, J.L.2    Sens, K.3    Wolberger, C.4
  • 13
    • 48249099388 scopus 로고    scopus 로고
    • Adopting new orphans into the family of metabolic regulators
    • Hummasti S., Tontonoz P. Adopting new orphans into the family of metabolic regulators. Mol. Endocrinol. 2008, 22:1743-1753.
    • (2008) Mol. Endocrinol. , vol.22 , pp. 1743-1753
    • Hummasti, S.1    Tontonoz, P.2
  • 14
    • 4744371376 scopus 로고    scopus 로고
    • Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle
    • Huss J.M., Torra I.P., Staels B., Giguère V., Kelly D.P. Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol. Cell. Biol. 2004, 24:9079-9091.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 9079-9091
    • Huss, J.M.1    Torra, I.P.2    Staels, B.3    Giguère, V.4    Kelly, D.P.5
  • 15
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • Imai S., Armstrong C.M., Kaeberlein M., Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000, 403:795-800.
    • (2000) Nature , vol.403 , pp. 795-800
    • Imai, S.1    Armstrong, C.M.2    Kaeberlein, M.3    Guarente, L.4
  • 17
    • 0033214237 scopus 로고    scopus 로고
    • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • Kaeberlein M., McVey M., Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 1999, 13:2570-2580.
    • (1999) Genes Dev. , vol.13 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 18
    • 69949138641 scopus 로고    scopus 로고
    • CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
    • Kang H., Jung J.-W., Kim M.K., Chung J.H. CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS ONE 2009, 4:e6611. 10.1371/journal.pone.0006611.
    • (2009) PLoS ONE , vol.4
    • Kang, H.1    Jung, J.-W.2    Kim, M.K.3    Chung, J.H.4
  • 19
    • 43049138812 scopus 로고    scopus 로고
    • Orphan nuclear receptor NOR-1 enhances 3',5'-cyclic adenosine 5'-monophosphate-dependent uncoupling protein-1 gene transcription
    • Kumar N., Liu D., Wang H., Robidoux J., Collins S. Orphan nuclear receptor NOR-1 enhances 3',5'-cyclic adenosine 5'-monophosphate-dependent uncoupling protein-1 gene transcription. Mol. Endocrinol. 2008, 22:1057-1064.
    • (2008) Mol. Endocrinol. , vol.22 , pp. 1057-1064
    • Kumar, N.1    Liu, D.2    Wang, H.3    Robidoux, J.4    Collins, S.5
  • 21
    • 0035913911 scopus 로고    scopus 로고
    • Negative control of p53 by Sir2alpha promotes cell survival under stress
    • Luo J., Nikolaev A.Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 2001, 107:137-148.
    • (2001) Cell , vol.107 , pp. 137-148
    • Luo, J.1    Nikolaev, A.Y.2    Imai, S.3    Chen, D.4    Su, F.5    Shiloh, A.6    Guarente, L.7    Gu, W.8
  • 22
    • 16844384829 scopus 로고    scopus 로고
    • Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway
    • Maxwell M.A., Cleasby M.E., Harding A., Stark A., Cooney G.J., Muscat G.E.O. Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway. J. Biol. Chem. 2005, 280:12573-12584.
    • (2005) J. Biol. Chem. , vol.280 , pp. 12573-12584
    • Maxwell, M.A.1    Cleasby, M.E.2    Harding, A.3    Stark, A.4    Cooney, G.J.5    Muscat, G.E.O.6
  • 23
    • 34347237611 scopus 로고    scopus 로고
    • An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation
    • Miura S., Kawanaka K., Kai Y., Tamura M., Goto M., Shiuchi T., Minokoshi Y., Ezaki O. An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation. Endocrinology 2007, 148:3441-3448.
    • (2007) Endocrinology , vol.148 , pp. 3441-3448
    • Miura, S.1    Kawanaka, K.2    Kai, Y.3    Tamura, M.4    Goto, M.5    Shiuchi, T.6    Minokoshi, Y.7    Ezaki, O.8
  • 26
    • 77950237717 scopus 로고    scopus 로고
    • The changed metabolic world with human brown adipose tissue: therapeutic visions
    • Nedergaard J., Cannon B. The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab. 2010, 11:268-272.
    • (2010) Cell Metab. , vol.11 , pp. 268-272
    • Nedergaard, J.1    Cannon, B.2
  • 27
    • 10844236451 scopus 로고    scopus 로고
    • Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
    • Nemoto S., Fergusson M.M., Finkel T. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 2004, 306:2105-2108.
    • (2004) Science , vol.306 , pp. 2105-2108
    • Nemoto, S.1    Fergusson, M.M.2    Finkel, T.3
  • 29
    • 44249088564 scopus 로고    scopus 로고
    • The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle
    • Pearen M.A., Myers S.A., Raichur S., Ryall J.G., Lynch G.S., Muscat G.E.O. The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle. Endocrinology 2008, 149:2853-2865.
    • (2008) Endocrinology , vol.149 , pp. 2853-2865
    • Pearen, M.A.1    Myers, S.A.2    Raichur, S.3    Ryall, J.G.4    Lynch, G.S.5    Muscat, G.E.O.6
  • 31
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P., Wu Z., Park C.W., Graves R., Wright M., Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998, 92:829-839.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 32
    • 10944270187 scopus 로고    scopus 로고
    • The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
    • Revollo J.R., Grimm A.A., Imai S. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J. Biol. Chem. 2004, 279:50754-50763.
    • (2004) J. Biol. Chem. , vol.279 , pp. 50754-50763
    • Revollo, J.R.1    Grimm, A.A.2    Imai, S.3
  • 33
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    • Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005, 434:113-118.
    • (2005) Nature , vol.434 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4    Spiegelman, B.M.5    Puigserver, P.6
  • 35
    • 38649123072 scopus 로고    scopus 로고
    • Conserved metabolic regulatory functions of sirtuins
    • Schwer B., Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell Metab. 2008, 7:104-112.
    • (2008) Cell Metab. , vol.7 , pp. 104-112
    • Schwer, B.1    Verdin, E.2
  • 36
    • 69249206539 scopus 로고    scopus 로고
    • A continuous microplate assay for sirtuins and nicotinamide-producing enzymes
    • Smith B.C., Hallows W.C., Denu J.M. A continuous microplate assay for sirtuins and nicotinamide-producing enzymes. Anal. Biochem. 2009, 394:101-109.
    • (2009) Anal. Biochem. , vol.394 , pp. 101-109
    • Smith, B.C.1    Hallows, W.C.2    Denu, J.M.3
  • 37
    • 77953169046 scopus 로고    scopus 로고
    • Cellular bioenergetics as a target for obesity therapy
    • Tseng Y.-H., Cypess A.M., Kahn C.R. Cellular bioenergetics as a target for obesity therapy. Nat. Rev. Drug Discov. 2010, 9:465-482.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 465-482
    • Tseng, Y.-H.1    Cypess, A.M.2    Kahn, C.R.3
  • 38
    • 33646124709 scopus 로고    scopus 로고
    • Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation
    • Uldry M., Yang W., St-Pierre J., Lin J., Seale P., Spiegelman B.M. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab. 2006, 3:333-341.
    • (2006) Cell Metab. , vol.3 , pp. 333-341
    • Uldry, M.1    Yang, W.2    St-Pierre, J.3    Lin, J.4    Seale, P.5    Spiegelman, B.M.6
  • 41
    • 80053134340 scopus 로고    scopus 로고
    • Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
    • Viswanathan M., Guarente L. Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature 2011, 477:E1-E2.
    • (2011) Nature , vol.477
    • Viswanathan, M.1    Guarente, L.2
  • 42
    • 27644585190 scopus 로고    scopus 로고
    • A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span
    • Viswanathan M., Kim S.K., Berdichevsky A., Guarente L. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell 2005, 9:605-615.
    • (2005) Dev. Cell , vol.9 , pp. 605-615
    • Viswanathan, M.1    Kim, S.K.2    Berdichevsky, A.3    Guarente, L.4
  • 43
    • 28544438180 scopus 로고    scopus 로고
    • PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism
    • Wende A.R., Huss J.M., Schaeffer P.J., Giguère V., Kelly D.P. PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol. Cell. Biol. 2005, 25:10684-10694.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 10684-10694
    • Wende, A.R.1    Huss, J.M.2    Schaeffer, P.J.3    Giguère, V.4    Kelly, D.P.5
  • 44
    • 34250897968 scopus 로고    scopus 로고
    • SIRT1 regulates the function of the Nijmegen breakage syndrome protein
    • Yuan Z., Zhang X., Sengupta N., Lane W.S., Seto E. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol. Cell 2007, 27:149-162.
    • (2007) Mol. Cell , vol.27 , pp. 149-162
    • Yuan, Z.1    Zhang, X.2    Sengupta, N.3    Lane, W.S.4    Seto, E.5


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