An unSIRTain role in longevity

Nature Medicine

Volumn 17, Issue 11, 2011, Pages 1350-1351

  De Cabo, Rafael ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SIRTUIN 1; SIRTUIN 2;

AGING; ANIMAL; ARTICLE; ENERGY METABOLISM; GENETICS; HUMAN; LONGEVITY; METABOLISM; PHYSIOLOGY;

AGING; ANIMALS; ENERGY METABOLISM; HUMANS; LONGEVITY; SIRTUIN 1; SIRTUIN 2;

EID: 84856041363     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1111-1350     Document Type: Article

References (13)

1. Tissenbaum, H. A.& Guarente, L.Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.Nature 410, 227–230 (2001).
2. Rogina, B. & Helfand, S.Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. USA 101, 15998–16003 (2004).
3. Burnett, C. et al. Absence of effects of Sir2 overexpression on lifespan in C.elegans and Drosophila.Nature 477, 482–485 (2011).
4. Viswanathan, M. & Guarente, L.Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes.Nature 477, E1–E2 (2011).
5. Taguchi, A., Wartschow, L.M.& White, M.F.Brain IRS2 signaling coordinates life span and nutrient homeostasis.Science 317, 369–372 (2007).
6. Blüher, M., Kahn, B.B.& Kahn, C.R.Extended longevity in mice lacking the insulin receptor in adipose tissue.Science 299, 572–574 (2003).
7. Bauer, J. H.et al. dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D.melanogaster.Aging (Albany NY) 1, 38–48 (2009).
8. Satoh A, Stein L, Imai S. The role of mammalian sirtuins in the regulation of metabolism, aging and longevity.Handb.Exp.Pharmacol.206, 125–162 (2011).
9. Kaeberlein, M., McVey, M.& Guarente, L.The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.Genes Dev.13, 2570–2580 (1999).
10. Canto, C. & Auwerx, J.Don’t write sirtuins off.Nature 477, 411 (2011).
11. Berdichevsky, A., Viswanathan, M., Horvitz, H.R.& Guarente, L.C.elegans SIR-2.1 interacts with 14–3-3 proteins to activate DAF-16 and extend life span.Cell 125, 1165–1177 (2006).
12. Viswanathan, M., Kim, S.K., Berdichevsky, A.& Guarente, L.A role for SIR-2.1 regulation of ER stress response genes in determining C.elegans life span.Dev.Cell 9, 605–615 (2005).
13. Rizki, G. et al. The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.PLoS Genet.7, e1002235 (2011).