-
2
-
-
0034751858
-
Serine phosphorylation of insulin receptor substrate-1: A novel target for the reversal of insulin resistance
-
Sykiotis GP, Papavassiliou AG. Serine phosphorylation of insulin receptor substrate-1: a novel target for the reversal of insulin resistance. Mol Endocrinol 2001; 15: 1864-9.
-
(2001)
Mol Endocrinol
, vol.15
, pp. 1864-1869
-
-
Sykiotis, G.P.1
Papavassiliou, A.G.2
-
4
-
-
70449724835
-
Cellular mechanisms of insulin resistance: Role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation
-
Tanti JF, Jager J. Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Curr Opin Pharmacol 2009; 9: 753-62.
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 753-762
-
-
Tanti, J.F.1
Jager, J.2
-
5
-
-
77956185248
-
CJun NH2-terminal kinase 1 (JNK1): Roles in metabolic regulation of insulin resistance
-
Sabio G, Davis RJ. cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends Biochem Sci 2010; 35: 490-6.
-
(2010)
Trends Biochem Sci
, vol.35
, pp. 490-496
-
-
Sabio, G.1
Davis, R.J.2
-
7
-
-
77951918926
-
Macrophages, inflammation, and insulin resistance
-
Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010; 72: 219-46.
-
(2010)
Annu Rev Physiol
, vol.72
, pp. 219-246
-
-
Olefsky, J.M.1
Glass, C.K.2
-
9
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NFkappaB
-
Cai D, Yuan M, Frantz DF, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NFkappaB. Nat Med 2005; 11: 183-90.
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
-
10
-
-
0030028606
-
The expression of TNF alpha by human muscle. Relationship to insulin resistance
-
Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA. The expression of TNF alpha by human muscle. Relationship to insulin resistance. J Clin Invest 1996; 97: 1111-6.
-
(1996)
J Clin Invest
, vol.97
, pp. 1111-1116
-
-
Saghizadeh, M.1
Ong, J.M.2
Garvey, W.T.3
Henry, R.R.4
Kern, P.A.5
-
11
-
-
0035979775
-
Reversal of obesity-and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
-
Yuan M, Konstantopoulos N, Lee J, et al. Reversal of obesity-and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001; 293: 1673-7.
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
-
12
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature 2002; 420: 333-6.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
-
13
-
-
34347369726
-
Hypoglycemic action of thiazolidinediones/ peroxisome proliferator-activated receptor gamma by inhibition of the c-Jun NH2-terminal kinase pathway
-
Diaz-Delfin J, Morales M, Caelles C. Hypoglycemic action of thiazolidinediones/ peroxisome proliferator-activated receptor gamma by inhibition of the c-Jun NH2-terminal kinase pathway. Diabetes 2007; 56: 1865-71.
-
(2007)
Diabetes
, vol.56
, pp. 1865-1871
-
-
Diaz-Delfin, J.1
Morales, M.2
Caelles, C.3
-
14
-
-
34547602916
-
Loss-offunction mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
-
Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, et al. Loss-offunction mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 2007; 56: 1986-98.
-
(2007)
Diabetes
, vol.56
, pp. 1986-1998
-
-
Tsukumo, D.M.1
Carvalho-Filho, M.A.2
Carvalheira, J.B.3
-
15
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006; 116: 3015-25.
-
(2006)
J Clin Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
16
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007; 8: 519-29.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
17
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004; 306: 457-61.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
-
18
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U, Yilmaz E, Ozcan L, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006; 313: 1137-40.
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
-
19
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus
-
Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008; 29: 42-61.
-
(2008)
Endocr Rev
, vol.29
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
21
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
Urano F, Wang X, Bertolotti A, et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000; 287: 664-6.
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
Bertolotti, A.3
-
22
-
-
0142059951
-
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
-
Lee AH, Iwakoshi NN, Glimcher LH. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 2003; 23: 7448-59.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7448-7459
-
-
Lee, A.H.1
Iwakoshi, N.N.2
Glimcher, L.H.3
-
23
-
-
52749091008
-
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals
-
Boden G, Duan X, Homko C, et al. Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 2008; 57: 2438-44.
-
(2008)
Diabetes
, vol.57
, pp. 2438-2444
-
-
Boden, G.1
Duan, X.2
Homko, C.3
-
24
-
-
62749178966
-
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss
-
Gregor MF, Yang L, Fabbrini E, et al. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 2009; 58: 693-700.
-
(2009)
Diabetes
, vol.58
, pp. 693-700
-
-
Gregor, M.F.1
Yang, L.2
Fabbrini, E.3
-
25
-
-
84878218164
-
Activation of PPARalpha ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress
-
Chan SM, Sun RQ, Zeng XY, et al. Activation of PPARalpha ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress. Diabetes 2013; 62: 2095-105.
-
(2013)
Diabetes
, vol.62
, pp. 2095-2105
-
-
Chan, S.M.1
Sun, R.Q.2
Zeng, X.Y.3
-
26
-
-
34447625413
-
Metabolic stress in insulin's target cells leads to ROS accumulation - a hypothetical common pathway causing insulin resistance
-
Eriksson JW. Metabolic stress in insulin's target cells leads to ROS accumulation - a hypothetical common pathway causing insulin resistance. FEBS Lett 2007; 581: 3734-42.
-
(2007)
FEBS Lett
, vol.581
, pp. 3734-3742
-
-
Eriksson, J.W.1
-
27
-
-
79551470306
-
Oxidative stress, insulin signaling, and diabetes
-
Rains JL, Jain SK. Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med 2011; 50: 567-75.
-
(2011)
Free Radic Biol Med
, vol.50
, pp. 567-575
-
-
Rains, J.L.1
Jain, S.K.2
-
28
-
-
33645860825
-
Reactive oxygen species have a causal role in multiple forms of insulin resistance
-
Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006; 440: 944-8.
-
(2006)
Nature
, vol.440
, pp. 944-948
-
-
Houstis, N.1
Rosen, E.D.2
Lander, E.S.3
-
29
-
-
28844461131
-
Proposed mechanisms for the induction of insulin resistance by oxidative stress
-
Bloch-Damti A, Bashan N. Proposed mechanisms for the induction of insulin resistance by oxidative stress. Antioxid Redox Signal 2005; 7: 1553-67.
-
(2005)
Antioxid Redox Signal
, vol.7
, pp. 1553-1567
-
-
Bloch-Damti, A.1
Bashan, N.2
-
30
-
-
22044443268
-
The molecular basis for oxidative stress-induced insulin resistance
-
Evans JL, Maddux BA, Goldfine ID. The molecular basis for oxidative stress-induced insulin resistance. Antioxid Redox Signal 2005; 7: 1040-52.
-
(2005)
Antioxid Redox Signal
, vol.7
, pp. 1040-1052
-
-
Evans, J.L.1
Maddux, B.A.2
Goldfine, I.D.3
-
31
-
-
34548488370
-
Oxidative stress and the JNK pathway in diabetes
-
Kaneto H, Matsuoka TA, Nakatani Y, Kawamori D, Matsuhisa M, Yamasaki Y. Oxidative stress and the JNK pathway in diabetes. Curr Diabetes Rev 2005; 1: 65-72.
-
(2005)
Curr Diabetes Rev
, vol.1
, pp. 65-72
-
-
Kaneto, H.1
Matsuoka, T.A.2
Nakatani, Y.3
Kawamori, D.4
Matsuhisa, M.5
Yamasaki, Y.6
-
32
-
-
27444445460
-
JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes
-
Nguyen MT, Satoh H, Favelyukis S, et al. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem 2005; 280: 35361-71.
-
(2005)
J Biol Chem
, vol.280
, pp. 35361-35371
-
-
Nguyen, M.T.1
Satoh, H.2
Favelyukis, S.3
-
33
-
-
33750823407
-
Saturated fatty acids inhibit induction of insulin gene transcription by JNKmediated phosphorylation of insulin-receptor substrates
-
Solinas G, Naugler W, Galimi F, Lee MS, Karin M. Saturated fatty acids inhibit induction of insulin gene transcription by JNKmediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci U S A 2006; 103: 16454-9.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 16454-16459
-
-
Solinas, G.1
Naugler, W.2
Galimi, F.3
Lee, M.S.4
Karin, M.5
-
34
-
-
67649304876
-
Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria
-
Nakamura S, Takamura T, Matsuzawa-Nagata N, et al. Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. J Biol Chem 2009; 284: 14809-18.
-
(2009)
J Biol Chem
, vol.284
, pp. 14809-14818
-
-
Nakamura, S.1
Takamura, T.2
Matsuzawa-Nagata, N.3
-
35
-
-
81055140936
-
Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes
-
Iwakami S, Misu H, Takeda T, et al. Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes. PLoS One 2011; 6: e27401.
-
(2011)
PLoS One
, vol.6
-
-
Iwakami, S.1
Misu, H.2
Takeda, T.3
-
36
-
-
7044230885
-
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
-
Kaneto H, Nakatani Y, Miyatsuka T, et al. Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat Med 2004; 10: 1128-32.
-
(2004)
Nat Med
, vol.10
, pp. 1128-1132
-
-
Kaneto, H.1
Nakatani, Y.2
Miyatsuka, T.3
-
37
-
-
8544244943
-
Modulation of the JNK pathway in liver affects insulin resistance status
-
Nakatani Y, Kaneto H, Kawamori D, et al. Modulation of the JNK pathway in liver affects insulin resistance status. J Biol Chem 2004; 279: 45803-9.
-
(2004)
J Biol Chem
, vol.279
, pp. 45803-45809
-
-
Nakatani, Y.1
Kaneto, H.2
Kawamori, D.3
-
38
-
-
34547942526
-
Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice
-
Yang R, Wilcox DM, Haasch DL, et al. Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice. J Biol Chem 2007; 282: 22765-74.
-
(2007)
J Biol Chem
, vol.282
, pp. 22765-22774
-
-
Yang, R.1
Wilcox, D.M.2
Haasch, D.L.3
-
39
-
-
43849104298
-
Antioxidants preserve redox balance and inhibit c-Jun-N-terminal kinase pathway while improving insulin signaling in fat-fed rats: Evidence for the role of oxidative stress on IRS-1 serine phosphorylation and insulin resistance
-
Vinayagamoorthi R, Bobby Z, Sridhar MG. Antioxidants preserve redox balance and inhibit c-Jun-N-terminal kinase pathway while improving insulin signaling in fat-fed rats: evidence for the role of oxidative stress on IRS-1 serine phosphorylation and insulin resistance. J Endocrinol 2008; 197: 287-96.
-
(2008)
J Endocrinol
, vol.197
, pp. 287-296
-
-
Vinayagamoorthi, R.1
Bobby, Z.2
Sridhar, M.G.3
-
40
-
-
84862846889
-
Glucose oxidase induces insulin resistance via influencing multiple targets in vitro and in vivo: The central role of oxidative stress
-
Wang X, Gu C, He W, et al. Glucose oxidase induces insulin resistance via influencing multiple targets in vitro and in vivo: The central role of oxidative stress. Biochimie 2012; 94: 1705-17.
-
(2012)
Biochimie
, vol.94
, pp. 1705-1717
-
-
Wang, X.1
Gu, C.2
He, W.3
-
41
-
-
11244320393
-
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
-
Essers MA, Weijzen S, de Vries-Smits AM, et al. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. Embo J 2004; 23: 4802-12.
-
(2004)
Embo J
, vol.23
, pp. 4802-4812
-
-
Essers, M.A.1
Weijzen, S.2
de Vries-Smits, A.M.3
-
42
-
-
50949102655
-
Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator- 1alpha in hepatic insulin resistance
-
Kumashiro N, Tamura Y, Uchida T, et al. Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator- 1alpha in hepatic insulin resistance. Diabetes 2008; 57: 2083-91.
-
(2008)
Diabetes
, vol.57
, pp. 2083-2091
-
-
Kumashiro, N.1
Tamura, Y.2
Uchida, T.3
-
43
-
-
79953210362
-
Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis
-
Fernandez-Marcos PJ, Auwerx J. Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr 2011; 93: 884S-90.
-
(2011)
Am J Clin Nutr
, vol.93
-
-
Fernandez-Marcos, P.J.1
Auwerx, J.2
-
44
-
-
0035855905
-
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
-
Herzig S, Long F, Jhala US, et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 2001; 413: 179-83.
-
(2001)
Nature
, vol.413
, pp. 179-183
-
-
Herzig, S.1
Long, F.2
Jhala, U.S.3
-
45
-
-
0035855858
-
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
-
Yoon JC, Puigserver P, Chen G, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 2001; 413: 131-8.
-
(2001)
Nature
, vol.413
, pp. 131-138
-
-
Yoon, J.C.1
Puigserver, P.2
Chen, G.3
-
46
-
-
2442701392
-
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3
-
Koo SH, Satoh H, Herzig S, et al. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med 2004; 10: 530-4.
-
(2004)
Nat Med
, vol.10
, pp. 530-534
-
-
Koo, S.H.1
Satoh, H.2
Herzig, S.3
-
47
-
-
77956921023
-
The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways
-
Gao D, Nong S, Huang X, et al. The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. J Biol Chem 2010; 285: 29965-73.
-
(2010)
J Biol Chem
, vol.285
, pp. 29965-29973
-
-
Gao, D.1
Nong, S.2
Huang, X.3
-
48
-
-
34547502060
-
Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes
-
Takamura T, Honda M, Sakai Y, et al. Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes. Biochem Biophys Res Commun 2007; 361: 379-84.
-
(2007)
Biochem Biophys Res Commun
, vol.361
, pp. 379-384
-
-
Takamura, T.1
Honda, M.2
Sakai, Y.3
-
49
-
-
12344305124
-
Mitochondrial dysfunction and type 2 diabetes
-
Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science 2005; 307: 384-7.
-
(2005)
Science
, vol.307
, pp. 384-387
-
-
Lowell, B.B.1
Shulman, G.I.2
-
50
-
-
0038025371
-
Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
-
Petersen KF, Befroy D, Dufour S, et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003; 300: 1140-2.
-
(2003)
Science
, vol.300
, pp. 1140-1142
-
-
Petersen, K.F.1
Befroy, D.2
Dufour, S.3
-
51
-
-
67349265189
-
Is skeletal muscle mitochondrial dysfunction a cause or an indirect consequence of insulin resistance in humans?
-
Dumas JF, Simard G, Flamment M, Ducluzeau PH, Ritz P. Is skeletal muscle mitochondrial dysfunction a cause or an indirect consequence of insulin resistance in humans? Diabetes Metab 2009; 35: 159-67.
-
(2009)
Diabetes Metab
, vol.35
, pp. 159-167
-
-
Dumas, J.F.1
Simard, G.2
Flamment, M.3
Ducluzeau, P.H.4
Ritz, P.5
-
52
-
-
0033668021
-
Lipid oxidation is reduced in obese human skeletal muscle
-
Kim JY, Hickner RC, Cortright RL, Dohm GL, Houmard JA. Lipid oxidation is reduced in obese human skeletal muscle. Am J Physiol Endocrinol Metab 2000; 279: E1039-44.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.279
-
-
Kim, J.Y.1
Hickner, R.C.2
Cortright, R.L.3
Dohm, G.L.4
Houmard, J.A.5
-
53
-
-
0036788293
-
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
-
Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002; 51: 2944-50.
-
(2002)
Diabetes
, vol.51
, pp. 2944-2950
-
-
Kelley, D.E.1
He, J.2
Menshikova, E.V.3
Ritov, V.B.4
-
54
-
-
12144275294
-
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
-
Ritov VB, Menshikova EV, He J, Ferrell RE, Goodpaster BH, Kelley DE. Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 2005; 54: 8-14.
-
(2005)
Diabetes
, vol.54
, pp. 8-14
-
-
Ritov, V.B.1
Menshikova, E.V.2
He, J.3
Ferrell, R.E.4
Goodpaster, B.H.5
Kelley, D.E.6
-
55
-
-
0038054341
-
PGC-1alpharesponsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
Mootha VK, Lindgren CM, Eriksson KF, et al. PGC-1alpharesponsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003; 34: 267-73.
-
(2003)
Nat Genet
, vol.34
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
Eriksson, K.F.3
-
56
-
-
0037477855
-
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
-
Patti ME, Butte AJ, Crunkhorn S, et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A 2003; 100: 8466-71.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8466-8471
-
-
Patti, M.E.1
Butte, A.J.2
Crunkhorn, S.3
-
57
-
-
34247637323
-
Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes
-
Misu H, Takamura T, Matsuzawa N, et al. Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes. Diabetologia 2007; 50: 268-77.
-
(2007)
Diabetologia
, vol.50
, pp. 268-277
-
-
Misu, H.1
Takamura, T.2
Matsuzawa, N.3
-
58
-
-
77953532427
-
The mitochondrial proteome: A dynamic functional program in tissues and disease states
-
Balaban RS. The mitochondrial proteome: a dynamic functional program in tissues and disease states. Environ Mol Mutagen 2010; 51: 352-9.
-
(2010)
Environ Mol Mutagen
, vol.51
, pp. 352-359
-
-
Balaban, R.S.1
-
59
-
-
33644749330
-
Activation of AMPactivated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells
-
Kukidome D, Nishikawa T, Sonoda K, et al. Activation of AMPactivated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells. Diabetes 2006; 55: 120-7.
-
(2006)
Diabetes
, vol.55
, pp. 120-127
-
-
Kukidome, D.1
Nishikawa, T.2
Sonoda, K.3
-
60
-
-
9444272216
-
Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms
-
Cleasby ME, Dzamko N, Hegarty BD, Cooney GJ, Kraegen EW, Ye JM. Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms. Diabetes 2004; 53: 3258-66.
-
(2004)
Diabetes
, vol.53
, pp. 3258-3266
-
-
Cleasby, M.E.1
Dzamko, N.2
Hegarty, B.D.3
Cooney, G.J.4
Kraegen, E.W.5
Ye, J.M.6
-
61
-
-
85047689659
-
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone
-
Wilson-Fritch L, Nicoloro S, Chouinard M, et al. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest 2004; 114: 1281-9.
-
(2004)
J Clin Invest
, vol.114
, pp. 1281-1289
-
-
Wilson-Fritch, L.1
Nicoloro, S.2
Chouinard, M.3
-
62
-
-
24144496019
-
Rosiglitazone improves myocardial glucose uptake in patients with type 2 diabetes and coronary artery disease: A 16-week randomized, doubleblind, placebo-controlled study
-
Lautamaki R, Airaksinen KE, Seppanen M, et al. Rosiglitazone improves myocardial glucose uptake in patients with type 2 diabetes and coronary artery disease: a 16-week randomized, doubleblind, placebo-controlled study. Diabetes 2005; 54: 2787-94.
-
(2005)
Diabetes
, vol.54
, pp. 2787-2794
-
-
Lautamaki, R.1
Airaksinen, K.E.2
Seppanen, M.3
-
63
-
-
17844385363
-
Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo
-
Bogacka I, Xie H, Bray GA, Smith SR. Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes 2005; 54: 1392-9.
-
(2005)
Diabetes
, vol.54
, pp. 1392-1399
-
-
Bogacka, I.1
Xie, H.2
Bray, G.A.3
Smith, S.R.4
-
64
-
-
0036300538
-
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
-
Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 2002; 51: 2005-11.
-
(2002)
Diabetes
, vol.51
, pp. 2005-2011
-
-
Itani, S.I.1
Ruderman, N.B.2
Schmieder, F.3
Boden, G.4
-
65
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)- associated phosphatidylinositol 3-kinase activity in muscle
-
Yu C, Chen Y, Cline GW, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)- associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 2002; 277: 50230-6.
-
(2002)
J Biol Chem
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
-
66
-
-
0034903710
-
Prevention of fat-induced insulin resistance by salicylate
-
Kim JK, Kim YJ, Fillmore JJ, et al. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 2001; 108: 437-46.
-
(2001)
J Clin Invest
, vol.108
, pp. 437-446
-
-
Kim, J.K.1
Kim, Y.J.2
Fillmore, J.J.3
-
67
-
-
78649660058
-
Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: Role of oxidative stress
-
Yuzefovych L, Wilson G, Rachek L. Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Am J Physiol Endocrinol Metab 2010; 299: E1096-105.
-
(2010)
Am J Physiol Endocrinol Metab
, vol.299
-
-
Yuzefovych, L.1
Wilson, G.2
Rachek, L.3
-
68
-
-
56949089426
-
Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: A molecular mechanism leading to hepatic insulin resistance
-
Lim JH, Lee HJ, Ho Jung M, Song J. Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance. Cell Signal 2009; 21: 169-77.
-
(2009)
Cell Signal
, vol.21
, pp. 169-177
-
-
Lim, J.H.1
Lee, H.J.2
Ho Jung, M.3
Song, J.4
-
69
-
-
78649704325
-
Autophagy and metabolism
-
Rabinowitz JD, White E. Autophagy and metabolism. Science 2010; 330: 1344-8.
-
(2010)
Science
, vol.330
, pp. 1344-1348
-
-
Rabinowitz, J.D.1
White, E.2
-
70
-
-
52749094770
-
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
-
Jung HS, Chung KW, Won Kim J, et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab 2008; 8: 318-24.
-
(2008)
Cell Metab
, vol.8
, pp. 318-324
-
-
Jung, H.S.1
Chung, K.W.2
Won Kim, J.3
-
71
-
-
52749093177
-
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
-
Ebato C, Uchida T, Arakawa M, et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab 2008; 8: 325-32.
-
(2008)
Cell Metab
, vol.8
, pp. 325-332
-
-
Ebato, C.1
Uchida, T.2
Arakawa, M.3
-
72
-
-
77957299576
-
Role of autophagy in beta-cell function and mass
-
Hur KY, Jung HS, Lee MS. Role of autophagy in beta-cell function and mass. Diabetes Obes Metab 2010; 12 Suppl 2: 20-6.
-
Diabetes Obes Metab 2010
, vol.12
, Issue.SUPPL. 2
, pp. 20-26
-
-
Hur, K.Y.1
Jung, H.S.2
Lee, M.S.3
-
73
-
-
77956400005
-
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
-
Yang L, Li P, Fu S, Calay ES, Hotamisligil GS. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab 2010; 11: 467-78.
-
(2010)
Cell Metab
, vol.11
, pp. 467-478
-
-
Yang, L.1
Li, P.2
Fu, S.3
Calay, E.S.4
Hotamisligil, G.S.5
-
74
-
-
71449091240
-
Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: Inhibition of FoxO1-dependent expression of key autophagy genes by insulin
-
Liu HY, Han J, Cao SY, et al. Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. J Biol Chem 2009; 284: 31484-92.
-
(2009)
J Biol Chem
, vol.284
, pp. 31484-31492
-
-
Liu, H.Y.1
Han, J.2
Cao, S.Y.3
-
75
-
-
84862309959
-
Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: Ameliorating effects of (-)-epigallocatechin-3-gallate
-
Yan J, Feng Z, Liu J, et al. Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: ameliorating effects of (-)-epigallocatechin-3-gallate. J Nutr Biochem 2012; 23: 716-24.
-
(2012)
J Nutr Biochem
, vol.23
, pp. 716-724
-
-
Yan, J.1
Feng, Z.2
Liu, J.3
-
76
-
-
77954251401
-
Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes
-
Ost A, Svensson K, Ruishalme I, et al. Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes. Mol Med 2010; 16: 235-46.
-
(2010)
Mol Med
, vol.16
, pp. 235-246
-
-
Ost, A.1
Svensson, K.2
Ruishalme, I.3
-
78
-
-
49549104494
-
Could glucose be a proaging factor?
-
Kassi E, Papavassiliou AG. Could glucose be a proaging factor? J Cell Mol Med 2008; 12: 1194-8.
-
(2008)
J Cell Mol Med
, vol.12
, pp. 1194-1198
-
-
Kassi, E.1
Papavassiliou, A.G.2
-
79
-
-
77958484950
-
Free fatty acids stimulate autophagy in pancreatic beta-cells via JNK pathway
-
Komiya K, Uchida T, Ueno T, et al. Free fatty acids stimulate autophagy in pancreatic beta-cells via JNK pathway. Biochem Biophys Res Commun 2010; 401: 561-7.
-
(2010)
Biochem Biophys Res Commun
, vol.401
, pp. 561-567
-
-
Komiya, K.1
Uchida, T.2
Ueno, T.3
-
80
-
-
33845459165
-
Autophagy is activated for cell survival after endoplasmic reticulum stress
-
Ogata M, Hino S, Saito A, et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 2006; 26: 9220-31.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 9220-9231
-
-
Ogata, M.1
Hino, S.2
Saito, A.3
-
81
-
-
63849308518
-
Endoplasmic reticulum stress-mediated autophagy/ apoptosis induced by capsaicin (8-methyl-N-vanillyl-6- nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells
-
Oh SH, Lim SC. Endoplasmic reticulum stress-mediated autophagy/ apoptosis induced by capsaicin (8-methyl-N-vanillyl-6- nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells. J Pharmacol Exp Ther 2009; 329: 112-22.
-
(2009)
J Pharmacol Exp Ther
, vol.329
, pp. 112-122
-
-
Oh, S.H.1
Lim, S.C.2
-
82
-
-
44949237240
-
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
-
Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 2008; 30: 678-88.
-
(2008)
Mol Cell
, vol.30
, pp. 678-688
-
-
Wei, Y.1
Pattingre, S.2
Sinha, S.3
Bassik, M.4
Levine, B.5
-
83
-
-
68349110789
-
JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy
-
Wu H, Wang MC, Bohmann D. JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy. Mech Dev 2009; 126: 624-37.
-
(2009)
Mech Dev
, vol.126
, pp. 624-637
-
-
Wu, H.1
Wang, M.C.2
Bohmann, D.3
-
84
-
-
36448940798
-
FoxO3 controls autophagy in skeletal muscle in vivo
-
Mammucari C, Milan G, Romanello V, et al. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 2007; 6: 458-71.
-
(2007)
Cell Metab
, vol.6
, pp. 458-471
-
-
Mammucari, C.1
Milan, G.2
Romanello, V.3
-
85
-
-
41449113346
-
Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor
-
Zhao J, Brault JJ, Schild A, Goldberg AL. Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor. Autophagy 2008; 4: 378-80.
-
(2008)
Autophagy
, vol.4
, pp. 378-380
-
-
Zhao, J.1
Brault, J.J.2
Schild, A.3
Goldberg, A.L.4
-
86
-
-
17044408768
-
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
-
Wang MC, Bohmann D, Jasper H. JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 2005; 121: 115-25.
-
(2005)
Cell
, vol.121
, pp. 115-125
-
-
Wang, M.C.1
Bohmann, D.2
Jasper, H.3
-
87
-
-
80052546811
-
Inflammation and cellular stress: A mechanistic link between immune-mediated and metabolically driven pathologies
-
Rath E, Haller D. Inflammation and cellular stress: a mechanistic link between immune-mediated and metabolically driven pathologies. Eur J Nutr 2011; 50: 219-33.
-
(2011)
Eur J Nutr
, vol.50
, pp. 219-233
-
-
Rath, E.1
Haller, D.2
-
88
-
-
0029915016
-
The oxidative inactivation of sarcoplasmic reticulum Ca(2+)-ATPase by peroxynitrite
-
Viner RI, Huhmer AF, Bigelow DJ, Schoneich C. The oxidative inactivation of sarcoplasmic reticulum Ca(2+)-ATPase by peroxynitrite. Free Radic Res 1996; 24: 243-59.
-
(1996)
Free Radic Res
, vol.24
, pp. 243-259
-
-
Viner, R.I.1
Huhmer, A.F.2
Bigelow, D.J.3
Schoneich, C.4
-
89
-
-
0033984036
-
Modulation of endoplasmic reticulum-bound cholesterol regulatory enzymes by iron/ascorbate-mediated lipid peroxidation
-
Brunet S, Thibault L, Lepage G, Seidman EG, Dube N, Levy E. Modulation of endoplasmic reticulum-bound cholesterol regulatory enzymes by iron/ascorbate-mediated lipid peroxidation. Free Radic Biol Med 2000; 28: 46-54.
-
(2000)
Free Radic Biol Med
, vol.28
, pp. 46-54
-
-
Brunet, S.1
Thibault, L.2
Lepage, G.3
Seidman, E.G.4
Dube, N.5
Levy, E.6
-
90
-
-
35848957485
-
Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword?
-
Malhotra JD, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal 2007; 9: 2277-93.
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 2277-2293
-
-
Malhotra, J.D.1
Kaufman, R.J.2
-
91
-
-
47949099916
-
From endoplasmic-reticulum stress to the inflammatory response
-
Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response. Nature 2008; 454: 455-62.
-
(2008)
Nature
, vol.454
, pp. 455-462
-
-
Zhang, K.1
Kaufman, R.J.2
-
92
-
-
84866129230
-
Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice
-
Henstridge DC, Bruce CR, Pang CP, et al. Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice. Diabetologia 2012; 55: 2769-78.
-
(2012)
Diabetologia
, vol.55
, pp. 2769-2778
-
-
Henstridge, D.C.1
Bruce, C.R.2
Pang, C.P.3
-
93
-
-
79960898591
-
Mitochondria and endoplasmic reticulum: Mitochondriaendoplasmic reticulum interplay in type 2 diabetes pathophysiology
-
Rieusset J. Mitochondria and endoplasmic reticulum: mitochondriaendoplasmic reticulum interplay in type 2 diabetes pathophysiology. Int J Biochem Cell Biol 2011; 43: 1257-62.
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 1257-1262
-
-
Rieusset, J.1
-
94
-
-
41949114990
-
Role of mitochondrial dysfunction in insulin resistance
-
Kim JA, Wei Y, Sowers JR. Role of mitochondrial dysfunction in insulin resistance. Circ Res 2008; 102: 401-14.
-
(2008)
Circ Res
, vol.102
, pp. 401-414
-
-
Kim, J.A.1
Wei, Y.2
Sowers, J.R.3
-
95
-
-
38849199866
-
Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice
-
Bonnard C, Durand A, Peyrol S, et al. Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest 2008; 118: 789-800.
-
(2008)
J Clin Invest
, vol.118
, pp. 789-800
-
-
Bonnard, C.1
Durand, A.2
Peyrol, S.3
-
96
-
-
0346340042
-
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction
-
Krauss S, Zhang CY, Scorrano L, et al. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest 2003; 112: 1831-42.
-
(2003)
J Clin Invest
, vol.112
, pp. 1831-1842
-
-
Krauss, S.1
Zhang, C.Y.2
Scorrano, L.3
-
97
-
-
0037984371
-
Visualizing superoxide production in normal and diabetic rat islets of Langerhans
-
Bindokas VP, Kuznetsov A, Sreenan S, Polonsky KS, Roe MW, Philipson LH. Visualizing superoxide production in normal and diabetic rat islets of Langerhans. J Biol Chem 2003; 278: 9796-801.
-
(2003)
J Biol Chem
, vol.278
, pp. 9796-9801
-
-
Bindokas, V.P.1
Kuznetsov, A.2
Sreenan, S.3
Polonsky, K.S.4
Roe, M.W.5
Philipson, L.H.6
-
98
-
-
0842306477
-
The biology of mitochondrial uncoupling proteins
-
Rousset S, Alves-Guerra MC, Mozo J, et al. The biology of mitochondrial uncoupling proteins. Diabetes 2004; 53 Suppl 1: S130-5.
-
Diabetes 2004
, vol.53
, Issue.SUPPL. 1
-
-
Rousset, S.1
Alves-Guerra, M.C.2
Mozo, J.3
-
100
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
-
Saitoh T, Fujita N, Jang MH, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008; 456: 264-8.
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
-
101
-
-
78650848689
-
The emerging role of autophagy in the pathophysiology of diabetes mellitus
-
Gonzalez CD, Lee MS, Marchetti P, et al. The emerging role of autophagy in the pathophysiology of diabetes mellitus. Autophagy 2011; 7: 2-11.
-
(2011)
Autophagy
, vol.7
, pp. 2-11
-
-
Gonzalez, C.D.1
Lee, M.S.2
Marchetti, P.3
-
102
-
-
72549095406
-
Regulation mechanisms and signaling pathways of autophagy
-
He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009; 43: 67-93.
-
(2009)
Annu Rev Genet
, vol.43
, pp. 67-93
-
-
He, C.1
Klionsky, D.J.2
-
103
-
-
27544487938
-
JNK: Bridging the insulin signaling and inflammatory pathway
-
Liu G, Rondinone CM. JNK: bridging the insulin signaling and inflammatory pathway. Curr Opin Investig Drugs 2005; 6: 979-87.
-
(2005)
Curr Opin Investig Drugs
, vol.6
, pp. 979-987
-
-
Liu, G.1
Rondinone, C.M.2
-
105
-
-
59149084125
-
Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes
-
Ijaz A, Tejada T, Catanuto P, et al. Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes. Kidney Int 2009; 75: 381-8.
-
(2009)
Kidney Int
, vol.75
, pp. 381-388
-
-
Ijaz, A.1
Tejada, T.2
Catanuto, P.3
-
106
-
-
55949100580
-
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site
-
Stebbins JL, De SK, Machleidt T, et al. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci U S A 2008; 105: 16809-13.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 16809-16813
-
-
Stebbins, J.L.1
De, S.K.2
Machleidt, T.3
-
107
-
-
57049105164
-
Pharmacological characterization of a small molecule inhibitor of c-Jun kinase
-
Cho H, Black SC, Looper D, et al. Pharmacological characterization of a small molecule inhibitor of c-Jun kinase. Am J Physiol Endocrinol Metab 2008; 295: E1142-51.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.295
-
-
Cho, H.1
Black, S.C.2
Looper, D.3
-
108
-
-
84875825054
-
The protective effect and underlying mechanism of metformin on neointima formation in fructoseinduced insulin resistant rats
-
Lu J, Ji J, Meng H, et al. The protective effect and underlying mechanism of metformin on neointima formation in fructoseinduced insulin resistant rats. Cardiovasc Diabetol 2013; 12: 58.
-
(2013)
Cardiovasc Diabetol
, vol.12
, pp. 58
-
-
Lu, J.1
Ji, J.2
Meng, H.3
-
109
-
-
84855765351
-
Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathway
-
Jung TW, Lee MW, Lee YJ, Kim SM. Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathway. Biochem Biophys Res Commun 2012; 417: 147-52.
-
(2012)
Biochem Biophys Res Commun
, vol.417
, pp. 147-152
-
-
Jung, T.W.1
Lee, M.W.2
Lee, Y.J.3
Kim, S.M.4
-
110
-
-
84882763389
-
Activation in Pancreatic beta-Cells Leads to Glucose Intolerance Caused by Insulin Resistance in Pancreas
-
Lanuza-Masdeu J, Arevalo MI, Vila C, Barbera A, Gomis R, Caelles C. In Vivo JNK Activation in Pancreatic beta-Cells Leads to Glucose Intolerance Caused by Insulin Resistance in Pancreas. Diabetes 2013; 62: 2308-17.
-
(2013)
Diabetes
, vol.62
, pp. 2308-2317
-
-
Lanuza-Masdeu, J.1
Arevalo, M.I.2
Vila, C.3
Barbera, A.4
Gomis, R.5
Caelles, C.6
In Vivo, J.N.K.7
-
111
-
-
80051863257
-
The Monascus metabolite monascin against TNF-alpha-induced insulin resistance via suppressing PPAR-gamma phosphorylation in C2C12 myotubes
-
Lee BH, Hsu WH, Liao TH, Pan TM. The Monascus metabolite monascin against TNF-alpha-induced insulin resistance via suppressing PPAR-gamma phosphorylation in C2C12 myotubes. Food Chem Toxicol 2011; 49: 2609-17.
-
(2011)
Food Chem Toxicol
, vol.49
, pp. 2609-2617
-
-
Lee, B.H.1
Hsu, W.H.2
Liao, T.H.3
Pan, T.M.4
-
112
-
-
80052517174
-
Glucagonlike peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis
-
Svegliati-Baroni G, Saccomanno S, Rychlicki C, et al. Glucagonlike peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis. Liver Int 2011; 31: 1285-97.
-
(2011)
Liver Int
, vol.31
, pp. 1285-1297
-
-
Svegliati-Baroni, G.1
Saccomanno, S.2
Rychlicki, C.3
-
113
-
-
84876403316
-
Cyclosporin A attenuates weight gain and improves glucose tolerance in diet-induced obese mice
-
Jiang M, Wang C, Meng Q, et al. Cyclosporin A attenuates weight gain and improves glucose tolerance in diet-induced obese mice. Mol Cell Endocrinol 2013; 370: 96-102.
-
(2013)
Mol Cell Endocrinol
, vol.370
, pp. 96-102
-
-
Jiang, M.1
Wang, C.2
Meng, Q.3
-
114
-
-
84858992662
-
Green tea catechins ameliorate adipose insulin resistance by improving oxidative stress
-
Yan J, Zhao Y, Suo S, Liu Y, Zhao B. Green tea catechins ameliorate adipose insulin resistance by improving oxidative stress. Free Radic Biol Med 2012; 52: 1648-57.
-
(2012)
Free Radic Biol Med
, vol.52
, pp. 1648-1657
-
-
Yan, J.1
Zhao, Y.2
Suo, S.3
Liu, Y.4
Zhao, B.5
-
115
-
-
84867102899
-
Epicatechin prevents TNFalpha-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes
-
Vazquez-Prieto MA, Bettaieb A, Haj FG, Fraga CG, Oteiza PI. (-)- Epicatechin prevents TNFalpha-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes. Arch Biochem Biophys 2012; 527: 113-8.
-
(2012)
Arch Biochem Biophys
, vol.527
, pp. 113-118
-
-
Vazquez-Prieto, M.A.1
Bettaieb, A.2
Haj, F.G.3
Fraga, C.G.4
Oteiza, P.I.5
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