The effects of palmitate on hepatic insulin resistance are mediated by NADPH oxidase 3-derived reactive oxygen species through JNK and p38 MAPK pathways

Journal of Biological Chemistry

Volumn 285, Issue 39, 2010, Pages 29965-29973

  Gao, Dan ^a,b   Nong, Shanwei ^b   Huang, Xiuqing ^b   Lu, Yonggang ^a,b   Zhao, Hongye ^a,b   Lin, Yajun ^b   Man, Yong ^b   Wang, Shu ^b   Yang, Jiefu ^b   Li, Jian ^a,b  

^a GRADUATE SCHOOL OF PEKING UNION MEDICAL COLLEGE   (China)

^b Ministry of Health   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACIDS; OXYGEN;

DB/DB MOUSE; ELEVATED PLASMA; FREE FATTY ACID; GLUCONEOGENESIS; HEPATIC INSULIN RESISTANCE; HEPATOCYTES; HEPG2 CELLS; INSULIN RESISTANCE; MOLECULAR MECHANISM; NADPH OXIDASE; P38 MAPK; REACTIVE OXYGEN SPECIES; UP-REGULATION;

INSULIN;

FATTY ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 3; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; GLYCOGEN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; NOX3 PROTEIN, HUMAN; NOX3 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; GLUCONEOGENESIS; GLYCOGEN ANALYSIS; HUMAN; HUMAN CELL; INSULIN RESISTANCE; LIPID STORAGE; LIVER; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEPG2 CELL LINE; METABOLISM; OBESITY; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOGEN; HEP G2 CELLS; HEPATOCYTES; HUMANS; INSULIN RESISTANCE; LIVER; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; NADPH OXIDASE; OBESITY; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PALMITIC ACID; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77956921023     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.128694     Document Type: Article

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