PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3

Nature Medicine

Volumn 10, Issue 5, 2004, Pages 530-534

  Koo, Seung Hoi ^a   Satoh, Hiroaki ^b   Herzig, Stephan ^a   Lee, Chih Hao ^a   Hedrick, Susan ^a   Kulkarni, Rohit ^c   Evans, Ronald M ^a   Olefsky, Jerrold ^b   Montminy, Marc ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; HEPATOCYTE NUCLEAR FACTOR 4; HORMONE RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; RNA; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ARTICLE; GLUCONEOGENESIS; GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; VIRUS RECOMBINANT;

ANIMALS; BASE SEQUENCE; CELL CYCLE PROTEINS; DIABETES MELLITUS, TYPE 2; DNA; HUMANS; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

ADENOVIRIDAE; ANIMALIA; MAMMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 2442701392     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1044     Document Type: Article

References (28)

1. Saltiel, A. & Kahn, C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806 (2001).
2. Hribal, M., Oriente, F. & Accili, D. Mouse models of insulin resistance. Am. J. Physiol. Endocrinol. Metab. 282, E977-E981 (2002).
3. Yoon, J. et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413, 131-138 (2001).
4. Herzig, S. et al. CREB regulates hepatic gluconeogenesis via the co-activator PGC-1. Nature 413, 179-183 (2001).
5. Rhee, J. et al. Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): requirement for hepatocyte nuclear factor 4α in gluconeogenesis. Proc. Natl. Acad. Sci. USA 100, 4012-4017 (2003).
6. Du, K., Herzig, S., Kulkarni, R.N. & Montminy, M. TRB-3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300, 1574-1577 (2003).
7. Saltiel, A.R. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104, 517-529 (2001).
8. Hanson, R.W. & Reshef, L. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu. Rev. Biochem. 66, 581-611 (1997).
9. Imai, E., Miner, J.N., Mitchell, J.A., Yamamoto, K.R. & Granner, D.K. Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J. Biol. Chem. 268, 5353-5356 (1993).
10. Kliewer, S., Xu, H., Lambert, M. & Willson, T. Peroxisome proliferator-activated receptors: from genes to physiology. Recent Prog. Horm. Res. 56, 239-263 (2001).
11. Wu, Z. et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98, 115-124 (1999).
12. Brazil, D.P. & Hemmings, B.A. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem. Sci. 26, 657-664 (2001).
13. Cho, H. et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB β). Science 292, 1728-1731 (2001).
14. Klingenspor, M., Xu, P., Cohen, R., Welch, C. & Reue, K. Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics. J. Biol. Chem. 274, 23078-23084 (1999).
15. Brown, P.J. et al. Identification of a subtype selective human PPARα agonist through parallel-array synthesis. Bioorg. Med. Chem. Lett. 11, 1225-1227 (2001).
16. Michael, M.D. et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell 6, 87-97 (2000).
17. Kliewer, S. et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA 91, 7355-7359 (1994).
18. Kersten, S. et al. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J. Clin. Invest. 103, 1489-1498 (1999).
19. Leone, T.C., Weinheimer, C.J. & Kelly, D.P. A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: the PPARα-null mouse as a model of fatty acid oxidation disorders. Proc. Natl. Acad. Sci. USA 96, 7473-7478 (1999).
20. Bernal-Mizrachi, C. et al. Dexamethasone induction of hypertension and diabetes is PPAR-α dependent in LDL receptor-null mice. Nat. Med. 9, 1069-1075 (2003).
21. Tordjman, K. et al. PPARα deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. J. Clin. Invest. 107, 1025-1034 (2001).
22. Dresner, A. et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J. Clin. Invest. 103, 253-259 (1999).
23. Shimomura, I. et al. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol. Cell 6, 77-86 (2000).
24. Kruszynska, Y. et al. Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. J. Clin. Endocrinol. Metab. 87, 226-234 (2002).
25. Peterfy, M., Phan, J., Xu, P. & Reue, K. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat. Genet. 27, 121-124 (2001).
26. Koo, S.H. & Towle, H. Glucose regulation of mouse S(14) gene expression in hepatocytes. Involvement of a novel transcription factor complex. J. Biol. Chem. 275, 5200-5207 (2000).
27. Hevener, A.L. et al. Muscle-specific Pparg deletion causes insulin resistance. Nat. Med. 9, 1491-1497 (2003).
28. Hevener, A.L., Reichart, D., Janez, A. & Olefsky, J. Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male Wistar rats. Diabetes 50, 2316-2322 (2001).