Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice

Diabetologia

Volumn 55, Issue 10, 2012, Pages 2769-2778

  Henstridge, D C ^a   Bruce, C R ^a,b   Pang, C P ^a   Lancaster, G I ^a   Allen, T L ^a   Estevez, E ^a   Gardner, T ^a   Weir, J M ^a   Meikle, P J ^a   Lam, K S L ^c   Xu, A ^c   Fujii, N ^d   Goodyear, L J ^e   Febbraio, M A ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d TOKYO METROPOLITAN UNIVERSITY   (Japan)

^e JOSLIN DIABETES CENTER   (United States)

Author keywords

Inflammation; Insulin resistance; JNK; Obesity; Serine threonine kinases; Skeletal muscle

Indexed keywords

HYBRID PROTEIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN KINASE B; SERINE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; THREONINE; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; GENE; GENE OVEREXPRESSION; GLUCOSE METABOLISM; INSULIN RESISTANCE; JNK GENE; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PLASMID; PRIORITY JOURNAL; SKELETAL MUSCLE; TIBIALIS ANTERIOR MUSCLE; TISSUE SPECIFICITY; WILD TYPE;

ANIMALS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; MUSCLE, SKELETAL; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84866129230     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2652-8     Document Type: Article

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