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Volumn 7, Issue 1, 2011, Pages 2-11

The emerging role of autophagy in the pathophysiology of diabetes mellitus

Author keywords

Autoimmunity; Autophagy; Diabetes complications; Diabetes mellitus; Mitochondria dysfunction; Oxidative stress

Indexed keywords

BAFILOMYCIN A1; INSULIN; METFORMIN; RAPAMYCIN; REACTIVE OXYGEN METABOLITE;

EID: 78650848689     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.7.1.13044     Document Type: Review
Times cited : (261)

References (122)
  • 1
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 2
    • 34447132925 scopus 로고    scopus 로고
    • Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells
    • DOI 10.1158/0008-5472.CAN-06-4217
    • Kim EH, Sohn S, Kwon HJ, Kim SU, Kim MJ, Lee SJ, Choi KS. Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res 2007; 67:6314-24. (Pubitemid 47037514)
    • (2007) Cancer Research , vol.67 , Issue.13 , pp. 6314-6324
    • Eun, H.K.1    Sohn, S.2    Hyuk, J.K.3    Kim, S.U.4    Kim, M.-J.5    Lee, S.-J.6    Kyeong, S.C.7
  • 3
    • 34547624687 scopus 로고    scopus 로고
    • 3: A human scfv antibody against trail receptor 2 induces autophagic cell death in both trail-sensitive and trail-resistant cancer cells
    • Park KJ, Lee SH, Kim TI, Lee HW, Lee CH, Kim EH, et al. 3: A human scfv antibody against trail receptor 2 induces autophagic cell death in both trail-sensitive and trail-resistant cancer cells. Cancer Res 2008; 67:7317-34.
    • (2008) Cancer Res , vol.67 , pp. 7317-7334
    • Park, K.J.1    Lee, S.H.2    Kim, T.I.3    Lee, H.W.4    Lee, C.H.5    Kim, E.H.6
  • 4
    • 20144381544 scopus 로고    scopus 로고
    • Essential roles of atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death
    • Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, et al. Essential roles of atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 2007; 280:20722-9.
    • (2007) J Biol Chem , vol.280 , pp. 20722-20729
    • Pyo, J.O.1    Jang, M.H.2    Kwon, Y.K.3    Lee, H.J.4    Jun, J.I.5    Woo, H.N.6
  • 6
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C, Klionsky D. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009; 43:67-95.
    • (2009) Annu Rev Genet , vol.43 , pp. 67-95
    • He, C.1    Klionsky, D.2
  • 7
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • DOI 10.1038/nature06639, PII NATURE06639
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451:1069-75. (Pubitemid 351317450)
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 8
    • 68149139456 scopus 로고    scopus 로고
    • The autophagy effector Beclin 1: A novel BH3-only protein
    • Sinha S, Levine B. The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene 2008; 1:137-48.
    • (2008) Oncogene , vol.1 , pp. 137-148
    • Sinha, S.1    Levine, B.2
  • 10
    • 61649124031 scopus 로고    scopus 로고
    • The role of autophagy in pancreatic beta-cell and diabetes
    • Fujitani Y, Kawamori R, Watada H. The role of autophagy in pancreatic beta-cell and diabetes. Autophagy 2009; 5:280-2.
    • (2009) Autophagy , vol.5 , pp. 280-282
    • Fujitani, Y.1    Kawamori, R.2    Watada, H.3
  • 11
    • 61649085637 scopus 로고    scopus 로고
    • Macroautophagy in homeostasis of pancreatic β-cell
    • Jung HS, Lee MS. Macroautophagy in homeostasis of pancreatic β-cell. Autophagy 2009; 5:241-3.
    • (2009) Autophagy , vol.5 , pp. 241-243
    • Jung, H.S.1    Lee, M.S.2
  • 13
    • 33847404337 scopus 로고    scopus 로고
    • Autophagy Gene-Dependent Clearance of Apoptotic Cells during Embryonic Development
    • DOI 10.1016/j.cell.2006.12.044, PII S009286740700178X
    • Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, et al. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 2007; 128:931-46. (Pubitemid 46341412)
    • (2007) Cell , vol.128 , Issue.5 , pp. 931-946
    • Qu, X.1    Zou, Z.2    Sun, Q.3    Luby-Phelps, K.4    Cheng, P.5    Hogan, R.N.6    Gilpin, C.7    Levine, B.8
  • 14
    • 21044455137 scopus 로고    scopus 로고
    • Impairment of starvation induced and constitutive autophagy in atg7-deficient mice
    • Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, et al. Impairment of starvation induced and constitutive autophagy in atg7-deficient mice. J Cell Biol 2005; 169:425-34.
    • (2005) J Cell Biol , vol.169 , pp. 425-434
    • Komatsu, M.1    Waguri, S.2    Ueno, T.3    Iwata, J.4    Murata, S.5    Tanida, I.6
  • 15
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441:885-9.
    • (2006) Nature , vol.441 , pp. 885-889
    • Hara, T.1    Nakamura, K.2    Matsui, M.3    Yamamoto, A.4    Nakahara, Y.5    Suzuki-Migishima, R.6
  • 16
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441:880-4.
    • (2006) Nature , vol.441 , pp. 880-884
    • Komatsu, M.1    Waguri, S.2    Chiba, T.3    Murata, S.4    Iwata, J.5    Tanida, I.6
  • 17
    • 34249714158 scopus 로고    scopus 로고
    • The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
    • Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 2007; 13:619-24.
    • (2007) Nat Med , vol.13 , pp. 619-624
    • Nakai, A.1    Yamaguchi, O.2    Takeda, T.3    Higuchi, Y.4    Hikoso, S.5    Taniike, M.6
  • 18
    • 69349094578 scopus 로고    scopus 로고
    • Role and regulation of autophagy in cancer
    • Chen N, Karantza-Wadsworth V. Role and regulation of autophagy in cancer. Biochim Biophys Acta 2009; 1793:1516-23.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1516-1523
    • Chen, N.1    Karantza-Wadsworth, V.2
  • 19
    • 4344660368 scopus 로고    scopus 로고
    • The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases
    • DOI 10.1016/j.biocel.2004.05.007, PII S1357272504002006
    • Bergamini E, Cavallini G, Donati A, Gori Z. The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases. Int J Biochem Cell Biol 2004; 36:2392-404. (Pubitemid 39119754)
    • (2004) International Journal of Biochemistry and Cell Biology , vol.36 , Issue.12 , pp. 2392-2404
    • Bergamini, E.1    Cavallini, G.2    Donati, A.3    Gori, Z.4
  • 20
    • 67749084303 scopus 로고    scopus 로고
    • Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: The diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005)
    • Nathan DM, Zinman B, Cleary PA, Backlund JY, Genuth S, Miller R, Orchard TJ. Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005). Arch Intern Med 2009; 169:1307-16.
    • (2009) Arch Intern Med , vol.169 , pp. 1307-1316
    • Nathan, D.M.1    Zinman, B.2    Cleary, P.A.3    Backlund, J.Y.4    Genuth, S.5    Miller, R.6    Orchard, T.J.7
  • 21
    • 70449448530 scopus 로고    scopus 로고
    • th Annual World Congress on the Insulin Resistance Syndrome
    • th Annual World Congress on the Insulin Resistance Syndrome. Diabetes Care 2009; 32:127-33.
    • (2009) Diabetes Care , vol.32 , pp. 127-133
    • Bloomgarden, Z.T.1
  • 22
    • 38549110110 scopus 로고    scopus 로고
    • Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
    • Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, et al. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 2008; 27:433-46.
    • (2008) EMBO J , vol.27 , pp. 433-446
    • Twig, G.1    Elorza, A.2    Molina, A.J.3    Mohamed, H.4    Wikstrom, J.D.5    Walzer, G.6
  • 23
    • 62449110463 scopus 로고    scopus 로고
    • Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling
    • Tal MC, Sasai M, Lee HK, Yordy B, Shadel GS, Iwasaki A. Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci USA 2009; 106:2770-5.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2770-2775
    • Tal, M.C.1    Sasai, M.2    Lee, H.K.3    Yordy, B.4    Shadel, G.S.5    Iwasaki, A.6
  • 24
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006; 440:944-8.
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 25
    • 1642377274 scopus 로고    scopus 로고
    • Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
    • DOI 10.1056/NEJMoa031314
    • Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Eng J Med 2004; 350:664-71. (Pubitemid 38364625)
    • (2004) New England Journal of Medicine , vol.350 , Issue.7 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 26
    • 0028899789 scopus 로고
    • Phosphorylation of ribosomal protein s6 is inhibitory for autophagy in isolated rat hepatocytes
    • Blommaart EF, Luiken JJ, Blommaart PJ, van Woerkom GM, Meijer AJ. Phosphorylation of ribosomal protein s6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem 1995; 270:2320-6.
    • (1995) J Biol Chem , vol.270 , pp. 2320-2326
    • Blommaart, E.F.1    Luiken, J.J.2    Blommaart, P.J.3    Van Woerkom, G.M.4    Meijer, A.J.5
  • 27
    • 71449091240 scopus 로고    scopus 로고
    • Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: Inhibition of FoxO1-dependent expression of key autophagy genes by insulin
    • Liu HY, Han J, Cao SY, Hong T, Zhuo D, Shi J, et al. Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. J Biol Chem 2009; 284:31484-92.
    • (2009) J Biol Chem , vol.284 , pp. 31484-31492
    • Liu, H.Y.1    Han, J.2    Cao, S.Y.3    Hong, T.4    Zhuo, D.5    Shi, J.6
  • 28
  • 29
    • 0033540037 scopus 로고    scopus 로고
    • Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
    • Maechler P, Wollheim CB. Mitochondrial glutamate acts as a messenger in glucoseinduced insulin exocytosis. Nature 1999; 402:685-9. (Pubitemid 129516341)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 685-689
    • Maechler, P.1    Wollheim, C.B.2
  • 31
    • 34248581851 scopus 로고    scopus 로고
    • ER-phagy: Selective autophagy of the endoplasmic reticulum
    • Bernales S, Schuck S, Walter P. ER-phagy: Selective autophagy of the endoplasmic reticulum. Autophagy 2007; 3:285-7.
    • (2007) Autophagy , vol.3 , pp. 285-287
    • Bernales, S.1    Schuck, S.2    Walter, P.3
  • 33
    • 52749093177 scopus 로고    scopus 로고
    • Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
    • Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab 2008; 8:325-32.
    • (2008) Cell Metab , vol.8 , pp. 325-332
    • Ebato, C.1    Uchida, T.2    Arakawa, M.3    Komatsu, M.4    Ueno, T.5    Komiya, K.6
  • 34
    • 52749094770 scopus 로고    scopus 로고
    • Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
    • Jung HS, Chung KW, Won Kim J, Kim J, Komatsu M, Tanaka K, et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab 2008; 8:318-24.
    • (2008) Cell Metab , vol.8 , pp. 318-324
    • Jung, H.S.1    Chung, K.W.2    Won Kim, J.3    Kim, J.4    Komatsu, M.5    Tanaka, K.6
  • 35
    • 34548368589 scopus 로고    scopus 로고
    • Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine β-cells
    • Marsh BJ, Soden C, Alarcon C, Wicksteed BL, Yaekura K, Costin AJ, et al. Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine β-cells. Mol Endocrinol 2007; 21:2255-69.
    • (2007) Mol Endocrinol , vol.21 , pp. 2255-2269
    • Marsh, B.J.1    Soden, C.2    Alarcon, C.3    Wicksteed, B.L.4    Yaekura, K.5    Costin, A.J.6
  • 36
    • 58149463600 scopus 로고    scopus 로고
    • Protective role of autophagy in palmitate-induced INS-1 beta-cell death
    • Choi SE, Lee SM, Lee YJ, Li LJ, Lee SJ, Lee JH, et al. Protective role of autophagy in palmitate-induced INS-1 beta-cell death. Endocrinology 2009; 150:126-34.
    • (2009) Endocrinology , vol.150 , pp. 126-134
    • Choi, S.E.1    Lee, S.M.2    Lee, Y.J.3    Li, L.J.4    Lee, S.J.5    Lee, J.H.6
  • 38
    • 34047179973 scopus 로고    scopus 로고
    • Ubiquitinated protein aggregates form in pancreatic β-cells during diabetes-induced oxidative stress and are regulated by autophagy
    • Kaniuk NA, Kiraly M, Bates H, Vranic M, Volchuk A, Brumell JH. Ubiquitinated protein aggregates form in pancreatic β-cells during diabetes-induced oxidative stress and are regulated by autophagy. Diabetes 2007; 56:930-9.
    • (2007) Diabetes , vol.56 , pp. 930-939
    • Kaniuk, N.A.1    Kiraly, M.2    Bates, H.3    Vranic, M.4    Volchuk, A.5    Brumell, J.H.6
  • 39
    • 37149012111 scopus 로고    scopus 로고
    • Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide
    • Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler PC. Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. Am J Physiol 2007; 293:1656-62.
    • (2007) Am J Physiol , vol.293 , pp. 1656-1662
    • Huang, C.J.1    Haataja, L.2    Gurlo, T.3    Butler, A.E.4    Wu, X.5    Soeller, W.C.6    Butler, P.C.7
  • 40
    • 34250183177 scopus 로고    scopus 로고
    • HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
    • Pandey UB, Nie Z, Batlevi Y, McCary BA, Ritson GP, Nedelsky NB, et al. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 2007; 447:859-63.
    • (2007) Nature , vol.447 , pp. 859-863
    • Pandey, U.B.1    Nie, Z.2    Batlevi, Y.3    McCary, B.A.4    Ritson, G.P.5    Nedelsky, N.B.6
  • 41
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neudodegeneration in mice
    • Komatsu M, Waguri S, Chiba T, Murata S, Iwata JI, Tanida I, et al. Loss of autophagy in the central nervous system causes neudodegeneration in mice. Nature 2006; 441:880-4.
    • (2006) Nature , vol.441 , pp. 880-884
    • Komatsu, M.1    Waguri, S.2    Chiba, T.3    Murata, S.4    Iwata, J.I.5    Tanida, I.6
  • 42
    • 70349641034 scopus 로고    scopus 로고
    • Autophagy and the pancreatic beta-cell in human type 2 diabetes
    • Marchetti P, Masini M. Autophagy and the pancreatic beta-cell in human type 2 diabetes. Autophagy 2009; 5:1055-6.
    • (2009) Autophagy , vol.5 , pp. 1055-1056
    • Marchetti, P.1    Masini, M.2
  • 43
    • 56349138968 scopus 로고    scopus 로고
    • DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death
    • Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Mizushima N, Kimchi A. DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death Differ 2008; 15:1875-86.
    • (2008) Cell Death Differ , vol.15 , pp. 1875-1886
    • Gozuacik, D.1    Bialik, S.2    Raveh, T.3    Mitou, G.4    Shohat, G.5    Mizushima, N.6    Kimchi, A.7
  • 44
    • 14244256097 scopus 로고    scopus 로고
    • Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
    • DOI 10.1210/en.2004-0921
    • Khamzina L, Veilleux A, Bergeron S, Marette A. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance. Endocrinology 2005; 146:1473-81. (Pubitemid 40289337)
    • (2005) Endocrinology , vol.146 , Issue.3 , pp. 1473-1481
    • Khamzina, L.1    Veilleux, A.2    Bergeron, S.3    Marette, A.4
  • 45
    • 0032586826 scopus 로고    scopus 로고
    • Apoptosis of pancreatic B-cells detected in accelerated diabetes of NOD mice: No role of Fas-Fas ligand interaction in autoimmune diabetes
    • DOI 10.1002/(SICI)1521-4141(199902)29:02<455::AID-IMMU455>3.0.CO;2- A
    • Kim YH, Kim S, Kim KA, Yagita H, Kayagaki N, Kim KW, Lee MS. Apoptosis of pancreatic β-cells detected in accelerated diabetes of nod mice: No role of Fas- Fas ligand interaction in autoimmune diabetes. Eur J Immunol 1999; 29:455-65. (Pubitemid 29078506)
    • (1999) European Journal of Immunology , vol.29 , Issue.2 , pp. 455-465
    • Kim, Y.-H.1    Kim, S.2    Kim, K.-A.3    Yagita, H.4    Kayagaki, N.5    Kim, K.-W.6    Lee, M.-S.7
  • 46
    • 0035856952 scopus 로고    scopus 로고
    • β-cell death during progression to diabetes
    • Mathis D, Vence L, Benoist C. β-cell death during progression to diabetes. Nature 2001; 414:792-8.
    • (2001) Nature , vol.414 , pp. 792-798
    • Mathis, D.1    Vence, L.2    Benoist, C.3
  • 47
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation and tumorigenesis
    • Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation and tumorigenesis. Cancer Cell 2006; 10:51-64.
    • (2006) Cancer Cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3    Bray, K.4    Anderson, D.5    Chen, G.6
  • 48
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • DOI 10.1038/nrm2239, PII NRM2239
    • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: Crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007; 8:741-52. (Pubitemid 47312826)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 50
    • 33745845126 scopus 로고    scopus 로고
    • Autophagy contributes to caspase-independent macrophage cell death
    • Xu Y, Kim SO, Li Y, Han J. Autophagy contributes to caspase-independent macrophage cell death. J Biol Chem 2006; 281:19179-87.
    • (2006) J Biol Chem , vol.281 , pp. 19179-19187
    • Xu, Y.1    Kim, S.O.2    Li, Y.3    Han, J.4
  • 51
    • 56249090667 scopus 로고    scopus 로고
    • Loss of the autophagy protein atg16l1 enhances endotoxin-induced il-1β production
    • Saitoh T, Fujita N, Saitoh T, Fujita N, Jang MH, et al. Loss of the autophagy protein atg16l1 enhances endotoxin-induced il-1β production. Nature 2008; 456:264-9.
    • (2008) Nature , vol.456 , pp. 264-269
    • Saitoh, T.1    Fujita, N.2    Saitoh, T.3    Fujita, N.4    Jang, M.H.5
  • 52
    • 33947134377 scopus 로고    scopus 로고
    • Autophagy-dependent viral recognition by plasmacytoid dendritic cells
    • Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 2007; 315:1398-401.
    • (2007) Science , vol.315 , pp. 1398-1401
    • Lee, H.K.1    Lund, J.M.2    Ramanathan, B.3    Mizushima, N.4    Iwasaki, A.5
  • 53
    • 33846224369 scopus 로고    scopus 로고
    • Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes
    • Schmid D, Pypaert M, Munz C. Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity 2007; 26:79-92.
    • (2007) Immunity , vol.26 , pp. 79-92
    • Schmid, D.1    Pypaert, M.2    Munz, C.3
  • 54
    • 67349269904 scopus 로고    scopus 로고
    • Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection
    • English L, Chemali M, Duron J, Rondeau C, Laplante A, Gingras D, et al. Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nat Immunol 2009; 10:480-7.
    • (2009) Nat Immunol , vol.10 , pp. 480-487
    • English, L.1    Chemali, M.2    Duron, J.3    Rondeau, C.4    Laplante, A.5    Gingras, D.6
  • 55
    • 0027468997 scopus 로고
    • Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice
    • Christianson SW, Shultz LD, Leiter EH. Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Diabetes 1993; 42:44-55.
    • (1993) Diabetes , vol.42 , pp. 44-55
    • Christianson, S.W.1    Shultz, L.D.2    Leiter, E.H.3
  • 57
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008; 29:42-61.
    • (2008) Endocr Rev , vol.29 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 58
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
    • Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 2007; 26:1749-60.
    • (2007) EMBO J , vol.26 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 59
    • 0033011114 scopus 로고    scopus 로고
    • Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin
    • DOI 10.1038/6535
    • Burkart V, Wang ZQ, Radons J, Heller B, Herceg Z, Stingl L, et al. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. Nat Med 1999; 5:314-9. (Pubitemid 29124368)
    • (1999) Nature Medicine , vol.5 , Issue.3 , pp. 314-319
    • Burkart, V.1    Wang, Z.-Q.2    Radons, J.3    Heller, B.4    Herceg, Z.5    Stingl, L.6    Wagner, E.F.7    Kolb, H.8
  • 60
    • 58249098507 scopus 로고    scopus 로고
    • A novel function of poly(ADP-ribose)polymerase-1 in modulation of autophagy and necrosis under oxidative stress
    • Huang Q, Wu YT, Tan HL, Ong CN, Shen HM. A novel function of poly(ADP-ribose)polymerase-1 in modulation of autophagy and necrosis under oxidative stress. Cell Death Differ 2009; 16:264-77.
    • (2009) Cell Death Differ , vol.16 , pp. 264-277
    • Huang, Q.1    Wu, Y.T.2    Tan, H.L.3    Ong, C.N.4    Shen, H.M.5
  • 61
    • 35448932469 scopus 로고    scopus 로고
    • Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: A prophylactic and protective role
    • DOI 10.1016/j.ejphar.2007.09.002, PII S0014299907009764
    • Meghana K, Sanjeev G, Ramesh B. Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: a prophylactic and protective role. Eur J Pharmacol 2007; 577:183-91. (Pubitemid 47632529)
    • (2007) European Journal of Pharmacology , vol.577 , Issue.1-3 , pp. 183-191
    • Meghana, K.1    Sanjeev, G.2    Ramesh, B.3
  • 62
    • 0014606996 scopus 로고
    • Diabetogenic action of streptozotocin: Relationship of dose to metabolic response
    • Junod A, Lambert AE, Stauffacher W, Renold AE. Diabetogenic action of streptozotocin: relationship of dose to metabolic response. J Clin Invest 1969; 48:2129-39.
    • (1969) J Clin Invest , vol.48 , pp. 2129-2139
    • Junod, A.1    Lambert, A.E.2    Stauffacher, W.3    Renold, A.E.4
  • 63
    • 65649099390 scopus 로고    scopus 로고
    • Effect of Bu-Zhong-Yi-Qi-Tang on deficiency of N-glycan/nitric oxide and islet damage induced by streptozotocin in diabetic rats
    • Liu XQ, Wu L, Guo XJ. Effect of Bu-Zhong-Yi-Qi-Tang on deficiency of N-glycan/nitric oxide and islet damage induced by streptozotocin in diabetic rats. World J Gastroenterol 2009; 15:1730-7.
    • (2009) World J Gastroenterol , vol.15 , pp. 1730-1737
    • Liu, X.Q.1    Wu, L.2    Guo, X.J.3
  • 65
    • 37549012209 scopus 로고    scopus 로고
    • The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells
    • Ropolo A, Grasso D, Pardo R, Sacchetti ML, Archange C, Lo Re A, et al. The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells. J Biol Chem 2007; 282:37124-33.
    • (2007) J Biol Chem , vol.282 , pp. 37124-37133
    • Ropolo, A.1    Grasso, D.2    Pardo, R.3    Sacchetti, M.L.4    Archange, C.5    Lo Re, A.6
  • 66
    • 35848963392 scopus 로고    scopus 로고
    • The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
    • Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, et al. The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia 2007; 50:2486-94.
    • (2007) Diabetologia , vol.50 , pp. 2486-2494
    • Marchetti, P.1    Bugliani, M.2    Lupi, R.3    Marselli, L.4    Masini, M.5    Boggi, U.6
  • 67
    • 47949127583 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via upregulation of orphan nuclear receptor small heterodimer partner
    • Seo HY, Kim YD, Lee KM, Min AK, Kim MK, Kim HS, et al. Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via upregulation of orphan nuclear receptor small heterodimer partner. Endocrinology 2008; 149:3832-41.
    • (2008) Endocrinology , vol.149 , pp. 3832-3841
    • Seo, H.Y.1    Kim, Y.D.2    Lee, K.M.3    Min, A.K.4    Kim, M.K.5    Kim, H.S.6
  • 68
    • 77949350953 scopus 로고    scopus 로고
    • High glucose induces suppression of insulin signaling and apoptosis via upregulation of endogenous IL-1β and suppressor of cytokine signaling-1 in mouse pancreatic beta cells
    • Venieratos PD, Drossopoulou GI, Kapodistria KD, Tsilibary EC, Kitsiou PV. High glucose induces suppression of insulin signaling and apoptosis via upregulation of endogenous IL-1β and suppressor of cytokine signaling-1 in mouse pancreatic beta cells. Cell Signal 2010; 22:791-800.
    • (2010) Cell Signal , vol.22 , pp. 791-800
    • Venieratos, P.D.1    Drossopoulou, G.I.2    Kapodistria, K.D.3    Tsilibary, E.C.4    Kitsiou, P.V.5
  • 69
    • 70350028224 scopus 로고    scopus 로고
    • Signaling by IL-1β + IFNγ and ER stress converge on DP5/Hrk activation: A novel mechanism for pancreatic β-cell apoptosis
    • Gurzov EN, Ortis F, Cunha DA, Gosset G, Li M, Cardozo AK, Eizirik DL. Signaling by IL-1β + IFNγ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis. Cell Death Differ 2009; 16:1539-50.
    • (2009) Cell Death Differ , vol.16 , pp. 1539-1550
    • Gurzov, E.N.1    Ortis, F.2    Cunha, D.A.3    Gosset, G.4    Li, M.5    Cardozo, A.K.6    Eizirik, D.L.7
  • 70
    • 43549105167 scopus 로고    scopus 로고
    • The unfolded protein response: A pathway that links insulin demand with beta-cell failure and diabetes
    • DOI 10.1210/er.2007-0039
    • Scheuner D, Kaufman RJ. The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev 2008; 29:317-33. (Pubitemid 351679702)
    • (2008) Endocrine Reviews , vol.29 , Issue.3 , pp. 317-333
    • Scheuner, D.1    Kaufman, R.J.2
  • 72
    • 53749100698 scopus 로고    scopus 로고
    • Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta-cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation
    • Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J, et al. Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta-cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation. J Clin Endocrinol Metab 2008; 93:4065-74.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4065-4074
    • Böni-Schnetzler, M.1    Thorne, J.2    Parnaud, G.3    Marselli, L.4    Ehses, J.A.5    Kerr-Conte, J.6
  • 73
    • 71949118923 scopus 로고    scopus 로고
    • Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I
    • Böni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier DT, Prazak R, et al. Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I. Endocrinology 2009; 150:5218-29.
    • (2009) Endocrinology , vol.150 , pp. 5218-5229
    • Böni-Schnetzler, M.1    Boller, S.2    Debray, S.3    Bouzakri, K.4    Meier, D.T.5    Prazak, R.6
  • 75
    • 0032586826 scopus 로고    scopus 로고
    • Apoptosis of pancreatic B-cells detected in accelerated diabetes of NOD mice: No role of Fas-Fas ligand interaction in autoimmune diabetes
    • DOI 10.1002/(SICI)1521-4141(199902)29:02<455::AID-IMMU455>3.0.CO;2- A
    • Kim YH, Kim S, Kim KA, Yagita H, Kayagaki N, Kim KW, Lee MS. Apoptosis of pancreatic β-cells detected in accelerated diabetes of nod mice: No role of Fas-Fas ligand interaction in autoimmune diabetes. Eur J Immunol 1999; 29:455-65. (Pubitemid 29078506)
    • (1999) European Journal of Immunology , vol.29 , Issue.2 , pp. 455-465
    • Kim, Y.-H.1    Kim, S.2    Kim, K.-A.3    Yagita, H.4    Kayagaki, N.5    Kim, K.-W.6    Lee, M.-S.7
  • 76
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation and tumorigenesis
    • Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation and tumorigenesis. Cancer Cell 2006; 10:51-64.
    • (2006) Cancer Cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3    Bray, K.4    Anderson, D.5    Chen, G.6
  • 77
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • DOI 10.1038/nrm2239, PII NRM2239
    • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: Crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007; 8:741-52. (Pubitemid 47312826)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 78
    • 59749088634 scopus 로고    scopus 로고
    • Diabetes and cardiovascular disease: The role of glycemic control
    • Cheng AY, Leiter LA. Diabetes and cardiovascular disease: the role of glycemic control. Curr Diab Rep 2009; 9:65-72.
    • (2009) Curr Diab Rep , vol.9 , pp. 65-72
    • Cheng, A.Y.1    Leiter, L.A.2
  • 79
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • DOI 10.1038/414813a
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414:813-20. (Pubitemid 34000785)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 813-820
    • Brownlee, M.1
  • 80
    • 27644537437 scopus 로고    scopus 로고
    • Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: The importance of lesion stage and phagocytic efficiency
    • Tabas I. Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency. Arterioscler Thromb Vasc Biol 2005; 25:2255-64.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2255-2264
    • Tabas, I.1
  • 81
    • 33846108367 scopus 로고    scopus 로고
    • Phagocytosis in atherosclerosis: Molecular mechanisms and implications for plaque progression and stability
    • Schrijvers DM, De Meyer GRY, Herman AG, Martinet W. Phagocytosis in atherosclerosis: molecular mechanisms and implications for plaque progression and stability. Cardiovasc Res 2007; 73:470-80.
    • (2007) Cardiovasc Res , vol.73 , pp. 470-480
    • Schrijvers, D.M.1    De Meyer, G.R.Y.2    Herman, A.G.3    Martinet, W.4
  • 84
    • 61949233502 scopus 로고    scopus 로고
    • Autophagy in atherosclerosis: A cell survival and death phenomenon with therapeutic potential
    • Martinet W, De Meyer GR. Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential. Circ Res 2009; 104:304-17.
    • (2009) Circ Res , vol.104 , pp. 304-317
    • Martinet, W.1    De Meyer, G.R.2
  • 86
    • 0026663037 scopus 로고
    • A novel hypothesis of lipofuscinogenesis and celular aging based on interactions between oxidative stress and autophagocytosis
    • Brunk UT, Jones CB, Sohal RS. A novel hypothesis of lipofuscinogenesis and celular aging based on interactions between oxidative stress and autophagocytosis. Mutat Res 1992; 275:395-403.
    • (1992) Mutat Res , vol.275 , pp. 395-403
    • Brunk, U.T.1    Jones, C.B.2    Sohal, R.S.3
  • 87
    • 41149116150 scopus 로고    scopus 로고
    • Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells
    • Hill BG, Haberzettl P, Ahmed Y, Srivastava S, Bhatnagar A. Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells. Biochem J 2000; 410:525-34.
    • (2000) Biochem J , vol.410 , pp. 525-534
    • Hill, B.G.1    Haberzettl, P.2    Ahmed, Y.3    Srivastava, S.4    Bhatnagar, A.5
  • 88
    • 49949105827 scopus 로고    scopus 로고
    • The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells
    • Li J, Ni M, Lee B, Barron E, Hinton DR, Lee AS. The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ 2008; 15:1460-71.
    • (2008) Cell Death Differ , vol.15 , pp. 1460-1471
    • Li, J.1    Ni, M.2    Lee, B.3    Barron, E.4    Hinton, D.R.5    Lee, A.S.6
  • 89
    • 33646840681 scopus 로고    scopus 로고
    • Autophagy: A protective mechanism in response to stress and inflammation
    • Heymann D. Autophagy: A protective mechanism in response to stress and inflammation. Curr Opin Investig Drugs 2006; 7:443-50. (Pubitemid 43772984)
    • (2006) Current Opinion in Investigational Drugs , vol.7 , Issue.5 , pp. 443-450
    • Heymann, D.1
  • 90
    • 33747863220 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and TNF-α regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells
    • DOI 10.1111/j.1440-1711.2006.01454.x
    • Jia G, Cheng G, Gangahar DM, Agrawal DK. Insulin-like growth factor-1 and TNFα regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells. Immunol Cell Biol 2006; 8:448-54. (Pubitemid 44286038)
    • (2006) Immunology and Cell Biology , vol.84 , Issue.5 , pp. 448-454
    • Jia, G.1    Cheng, G.2    Gangahar, D.M.3    Agrawal, D.K.4
  • 91
    • 64049086218 scopus 로고    scopus 로고
    • Multiple regulatory and effector roles of autophagy in immunity
    • Deretic V. Multiple regulatory and effector roles of autophagy in immunity. Curr Opin Immunol 2009; 21:53-62.
    • (2009) Curr Opin Immunol , vol.21 , pp. 53-62
    • Deretic, V.1
  • 92
    • 48249094225 scopus 로고    scopus 로고
    • Autophagy of an oxidized, aggregated protein beyond the ER: A pathway for remarkably late-stage quality control
    • A
    • A Fisher EA, Williams KJ. Autophagy of an oxidized, aggregated protein beyond the ER: a pathway for remarkably late-stage quality control. Autophagy 2008; 4:721-3.
    • (2008) Autophagy , vol.4 , pp. 721-723
    • Fisher, E.A.1    Williams, K.J.2
  • 93
    • 85047692761 scopus 로고    scopus 로고
    • Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production
    • Pan M, Cederbaum AI, Zhang YL, Ginsberg HN, Williams KJ, Fisher EA. Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. J Clin Invest 2004; 113:1277-87.
    • (2004) J Clin Invest , vol.113 , pp. 1277-1287
    • Pan, M.1    Cederbaum, A.I.2    Zhang, Y.L.3    Ginsberg, H.N.4    Williams, K.J.5    Fisher, E.A.6
  • 94
    • 61949233502 scopus 로고    scopus 로고
    • Autophagy in Atherosclerosis. A cell survival and death phenomenon with therapeutic potential
    • Martinet W, De Meyer RY. Autophagy in Atherosclerosis. A cell survival and death phenomenon with therapeutic potential. Circ Res 2009; 104:304-17.
    • (2009) Circ Res , vol.104 , pp. 304-317
    • Martinet, W.1    De Meyer, R.Y.2
  • 95
    • 34249714158 scopus 로고    scopus 로고
    • The role of autophagy in cardiomycytes in the basal state and in response to hemodynamic stress
    • Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, et al. The role of autophagy in cardiomycytes in the basal state and in response to hemodynamic stress. Nat Med 2007; 13:619-24.
    • (2007) Nat Med , vol.13 , pp. 619-624
    • Nakai, A.1    Yamaguchi, O.2    Takeda, T.3    Higuchi, Y.4    Hikoso, S.5    Taniike, M.6
  • 96
    • 0035929337 scopus 로고    scopus 로고
    • Insulin antagonizes AMP-activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides
    • Beauloye C, Marsin AS, Bertrand L, Krause U, Hardie DG, Vanoverschelde JL, Hue L. Insulin antagonizes AMP-activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides. FEBS Lett 2001; 505:348-52.
    • (2001) FEBS Lett , vol.505 , pp. 348-352
    • Beauloye, C.1    Marsin, A.S.2    Bertrand, L.3    Krause, U.4    Hardie, D.G.5    Vanoverschelde, J.L.6    Hue, L.7
  • 98
    • 0026575717 scopus 로고
    • Cellular autophagy in proximal tubules of early diabetic rats following insulin treatment and islet transplantation
    • Han K, Lehringer-Polzin M, Zhou H, Pfeifer U. Cellular autophagy in proximal tubules of early diabetic rats following insulin treatment and islet transplantation. Virchows Arch B Cell Pathol Incl Mol Pathol 1992; 61:367-73.
    • (1992) Virchows Arch B Cell Pathol Incl Mol Pathol , vol.61 , pp. 367-373
    • Han, K.1    Lehringer-Polzin, M.2    Zhou, H.3    Pfeifer, U.4
  • 99
    • 60649093524 scopus 로고    scopus 로고
    • Bcl-2 protects tubular epithelial cells from ischemia/reperfusion injury by dual mechanisms
    • Isaka Y, Suzuki C, Abe T, Okumi M, Ichimaru N, Imamura R, et al. Bcl-2 protects tubular epithelial cells from ischemia/reperfusion injury by dual mechanisms. Transplant Proc 2009; 41:52-4.
    • (2009) Transplant Proc , vol.41 , pp. 52-54
    • Isaka, Y.1    Suzuki, C.2    Abe, T.3    Okumi, M.4    Ichimaru, N.5    Imamura, R.6
  • 100
    • 35948998805 scopus 로고    scopus 로고
    • Preventing kidney cell suicide
    • Brownlee M. Preventing kidney cell suicide. Nat Med 2007; 13:1349-58.
    • (2007) Nat Med , vol.13 , pp. 1349-1358
    • Brownlee, M.1
  • 101
    • 77952091220 scopus 로고    scopus 로고
    • Diabetes Alters Aromatase Enzyme levels in sciatic nerve and hippocanpus tissues of rats
    • Burul-Bozkurt N, Pekiner C, Kelicen P. Diabetes Alters Aromatase Enzyme levels in sciatic nerve and hippocanpus tissues of rats. Cell Mol Neurobiol 2010; 30:445-51.
    • (2010) Cell Mol Neurobiol , vol.30 , pp. 445-451
    • Burul-Bozkurt, N.1    Pekiner, C.2    Kelicen, P.3
  • 103
    • 72949103912 scopus 로고    scopus 로고
    • Concurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochmical deficits in experimental diabetic neuropathy
    • Negi G, Kumar A, Sharma SS. Concurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochmical deficits in experimental diabetic neuropathy. Biochem Biophys Res Commun 2010; 391:102-6.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 102-106
    • Negi, G.1    Kumar, A.2    Sharma, S.S.3
  • 104
    • 69049098304 scopus 로고    scopus 로고
    • Oxidative stress and dysregulation of the taurine transporter in high-glucose-exposed human Schwann cells: Implications for pathogenesis of diabetic neuropathy
    • Askwith T, Zeng W, Effo MC, Stevens MJ. Oxidative stress and dysregulation of the taurine transporter in high-glucose-exposed human Schwann cells: implications for pathogenesis of diabetic neuropathy. Am J Physiol Endocrinol Metab 2009; 297:620-8.
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , pp. 620-628
    • Askwith, T.1    Zeng, W.2    Effo, M.C.3    Stevens, M.J.4
  • 105
    • 70349297369 scopus 로고    scopus 로고
    • Diabetes and the peripheral nerve
    • Obrosova IG. Diabetes and the peripheral nerve. Biochim Biophys Acta 2009; 1792:931-40.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 931-940
    • Obrosova, I.G.1
  • 106
    • 33847652900 scopus 로고    scopus 로고
    • Autophagy and neurodegeneration: When the cleaning crew goes on strike
    • Martinez-Vicente M, Cuervo AM. Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol 2007; 6:352-61.
    • (2007) Lancet Neurol , vol.6 , pp. 352-361
    • Martinez-Vicente, M.1    Cuervo, A.M.2
  • 107
    • 41449108666 scopus 로고    scopus 로고
    • Drosophila Atg7: Required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis
    • Juhasz G, Neufeld TP. Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis. Autophagy 2008; 4:357-8. (Pubitemid 351458099)
    • (2008) Autophagy , vol.4 , Issue.3 , pp. 357-358
    • Juhasz, G.1    Neufeld, T.P.2
  • 108
    • 61649122814 scopus 로고    scopus 로고
    • Insulin withdrawal-induced cell death in adult hippocampal neural stem cells as a model of autopahgic cell death
    • Baek SH, Kim EK, Goudreau JL, Lookingland KJ, Kim Sw, Yu SW. Insulin withdrawal-induced cell death in adult hippocampal neural stem cells as a model of autopahgic cell death. Autophagy 2009; 5:277-9.
    • (2009) Autophagy , vol.5 , pp. 277-279
    • Baek, S.H.1    Kim, E.K.2    Goudreau, J.L.3    Lookingland, K.J.4    Kim, Sw.5    Yu, S.W.6
  • 109
    • 33847666791 scopus 로고    scopus 로고
    • Sera from patients with type 2 diabetes and neuropathy induce autophagy and colocalization with mitocondria in SY5Y cells
    • Towns R, Kabeya Y, Yoshimori T, Guo C, Shangguan Y, Hong S, et al. Sera from patients with type 2 diabetes and neuropathy induce autophagy and colocalization with mitocondria in SY5Y cells. Autophagy 2005; 1:163-70.
    • (2005) Autophagy , vol.1 , pp. 163-170
    • Towns, R.1    Kabeya, Y.2    Yoshimori, T.3    Guo, C.4    Shangguan, Y.5    Hong, S.6
  • 110
    • 20144381544 scopus 로고    scopus 로고
    • Essential roles of Atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death
    • Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, et al. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 2005; 280:20722-9.
    • (2005) J Biol Chem , vol.280 , pp. 20722-20729
    • Pyo, J.O.1    Jang, M.H.2    Kwon, Y.K.3    Lee, H.J.4    Jun, J.I.5    Woo, H.N.6
  • 111
    • 33845483093 scopus 로고    scopus 로고
    • Immunological and functional evidence for anti-Siglec-9 autoantibodies in intravenous immunoglobulin (IVIg) preparations
    • von Gunten S, Schaub A, Vogel M, Stadler BM, Miescher S, Simon HU. Immunological and functional evidence for anti-Siglec-9 autoantibodies in intravenous immunoglobulin (IVIg) preparations. Blood 2006; 108:4255-9.
    • (2006) Blood , vol.108 , pp. 4255-4259
    • Von Gunten, S.1    Schaub, A.2    Vogel, M.3    Stadler, B.M.4    Miescher, S.5    Simon, H.U.6
  • 112
    • 40049111838 scopus 로고    scopus 로고
    • Type 2 diabetes with neuropathy: Autoantibody stimulation of autophagy via Fas
    • DOI 10.1097/WNR.0b013e3282f4cb50, PII 0000175620080212000002
    • Towns R, Guo C, Shangguan Y, Hong S, Wiley JW. Type 2 diabetes with neuropathy: autoantibody stimulation of autophagy via Fas. Neuroreport 2008; 19:265-9. (Pubitemid 351322960)
    • (2008) NeuroReport , vol.19 , Issue.3 , pp. 265-269
    • Towns, R.1    Guo, C.2    Shangguan, Y.3    Hong, S.4    Wiley, J.W.5
  • 114
    • 63449111894 scopus 로고    scopus 로고
    • A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
    • Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 2009; 9:311-26.
    • (2009) Cell Metab , vol.9 , pp. 311-326
    • Newgard, C.B.1    An, J.2    Bain, J.R.3    Muehlbauer, M.J.4    Stevens, R.D.5    Lien, L.F.6
  • 115
    • 34248561123 scopus 로고    scopus 로고
    • Everolimus-induced mTOR inhibition selectively depletes macrophages in atherosclerotic plaques by autophagy
    • Martinet W, Verheye S, De Meyer GR. Everolimus-induced mTOR inhibition selectively depletes macrophages in atherosclerotic plaques by autophagy. Autophagy 2007; 3:241-4.
    • (2007) Autophagy , vol.3 , pp. 241-244
    • Martinet, W.1    Verheye, S.2    De Meyer, G.R.3
  • 118
    • 63849149937 scopus 로고    scopus 로고
    • LKB1 and AMP-activated protein kinase control of mTOR signaling and growth
    • Oxf
    • Shaw RJ. LKB1 and AMP-activated protein kinase control of mTOR signaling and growth. Acta Physiol (Oxf) 2009; 196:65-80.
    • (2009) Acta Physiol , vol.196 , pp. 65-80
    • Shaw, R.J.1
  • 119
    • 77955287742 scopus 로고    scopus 로고
    • Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
    • Kalender A, Selvaraj A, Kim SY, Gulati P, Brûlé S, Viollet B, et al. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner Cell Metab 2010; 11:390-401.
    • (2010) Cell Metab , vol.11 , pp. 390-401
    • Kalender, A.1    Selvaraj, A.2    Kim, S.Y.3    Gulati, P.4    Brûlé, S.5    Viollet, B.6
  • 120
    • 34447640712 scopus 로고    scopus 로고
    • The different mechanisms of insulin sensitizers to prevent type 2 diabetes in OLETF rats
    • Choi SH, Zhao ZS, Lee YJ, Kim SK, Kim DJ, Ahn CW, et al. The different mechanisms of insulin sensitizers to prevent type 2 diabetes in OLETF rats. Diabetes Metab Res Rev 2007; 23:411-8.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 411-418
    • Choi, S.H.1    Zhao, Z.S.2    Lee, Y.J.3    Kim, S.K.4    Kim, D.J.5    Ahn, C.W.6
  • 121
    • 63849224233 scopus 로고    scopus 로고
    • AMPK activators-potential therapeutics for metabolic and other diseases
    • Oxf
    • Zhou G, Sebhat IK, Zhang BB. AMPK activators-potential therapeutics for metabolic and other diseases. Acta Physiol (Oxf) 2009; 196:175-90.
    • (2009) Acta Physiol , vol.196 , pp. 175-190
    • Zhou, G.1    Sebhat, I.K.2    Zhang, B.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.