-
1
-
-
33845866857
-
Inflammation and metabolic disorders
-
G. S. Hotamisligil, Inflammation and metabolic disorders. Nature 444, 860-867 (2006).
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
2
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
J. Hirosumi, G. Tuncman, L. Chang, C. Z. Görgün, K. T. Uysal, K. Maeda, M. Karin,G. S. Hotamisligil, A central role for JNK in obesity and insulin resistance. Nature 420, 333-336 (2002).
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Görgün, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
4
-
-
78649338141
-
Autophagy and the integrated stress response
-
G. Kroemer, G. Mariño, B. Levine, Autophagy and the integrated stress response. Mol. Cell 40, 280-293 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 280-293
-
-
Kroemer, G.1
Mariño, G.2
Levine, B.3
-
5
-
-
75749108288
-
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
-
T. Nakamura, M. Furuhashi, P. Li, H. Cao, G. Tuncman, N. Sonenberg, C. Z. Gorgun, G. S. Hotamisligil, Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 140, 338-348 (2010).
-
(2010)
Cell
, vol.140
, pp. 338-348
-
-
Nakamura, T.1
Furuhashi, M.2
Li, P.3
Cao, H.4
Tuncman, G.5
Sonenberg, N.6
Gorgun, C.Z.7
Hotamisligil, G.S.8
-
6
-
-
33746101818
-
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
-
G. Tuncman, J. Hirosumi, G. Solinas, L. Chang, M. Karin, G. S. Hotamisligil, Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 103, 10741-10746 (2006).
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 10741-10746
-
-
Tuncman, G.1
Hirosumi, J.2
Solinas, G.3
Chang, L.4
Karin, M.5
Hotamisligil, G.S.6
-
7
-
-
52749091008
-
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals
-
G. Boden, X. Duan, C. Homko, E. J. Molina, W. Song, O. Perez, P. Cheung, S. Merali, Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 57, 2438-2444 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 2438-2444
-
-
Boden, G.1
Duan, X.2
Homko, C.3
Molina, E.J.4
Song, W.5
Perez, O.6
Cheung, P.7
Merali, S.8
-
8
-
-
62749178966
-
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss
-
M. F. Gregor, L. Yang, E. Fabbrini, B. S. Mohammed, J. C. Eagon, G. S. Hotamisligil, S. Klein, Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 58, 693-700 (2009).
-
(2009)
Diabetes
, vol.58
, pp. 693-700
-
-
Gregor, M.F.1
Yang, L.2
Fabbrini, E.3
Mohammed, B.S.4
Eagon, J.C.5
Hotamisligil, G.S.6
Klein, S.7
-
9
-
-
66649105191
-
2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-κB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals
-
2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-κB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals. Diabetes 58, 1259-1265 (2009).
-
(2009)
Diabetes
, vol.58
, pp. 1259-1265
-
-
Sourris, K.C.1
Lyons, J.G.2
De Courten, M.P.3
Dougherty, S.L.4
Henstridge, D.C.5
Cooper, M.E.6
Hage, M.7
Dart, A.8
Kingwell, B.A.9
Forbes, J.M.10
De Courten, B.11
-
10
-
-
0034104298
-
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes
-
G.Waeber, J. Delplanque, C. Bonny, V. Mooser, M. Steinmann, C. Widmann, A. Maillard, J. Miklossy, C. Dina, E. H. Hani, N. Vionnet, P. Nicod, P. Boutin, P. Froguel, The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nat. Genet. 24, 291-295 (2000).
-
(2000)
Nat. Genet.
, vol.24
, pp. 291-295
-
-
Waeber, G.1
Delplanque, J.2
Bonny, C.3
Mooser, V.4
Steinmann, M.5
Widmann, C.6
Maillard, A.7
Miklossy, J.8
Dina, C.9
Hani, E.H.10
Vionnet, N.11
Nicod, P.12
Boutin, P.13
Froguel, P.14
-
11
-
-
8544244943
-
Modulation of the JNK pathway in liver affects insulin resistance status
-
Y. Nakatani, H. Kaneto, D. Kawamori, M. Hatazaki, T. Miyatsuka, T. A. Matsuoka, Y. Kajimoto, M. Matsuhisa, Y. Yamasaki, M. Hori, Modulation of the JNK pathway in liver affects insulin resistance status. J. Biol. Chem. 279, 45803-45809 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 45803-45809
-
-
Nakatani, Y.1
Kaneto, H.2
Kawamori, D.3
Hatazaki, M.4
Miyatsuka, T.5
Matsuoka, T.A.6
Kajimoto, Y.7
Matsuhisa, M.8
Yamasaki, Y.9
Hori, M.10
-
12
-
-
58949093454
-
Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance
-
R. Singh, Y. Wang, Y. Xiang, K. E. Tanaka, W. A. Gaarde, M. J. Czaja, Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology 49, 87-96 (2009).
-
(2009)
Hepatology
, vol.49
, pp. 87-96
-
-
Singh, R.1
Wang, Y.2
Xiang, Y.3
Tanaka, K.E.4
Gaarde, W.A.5
Czaja, M.J.6
-
13
-
-
34547942526
-
Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor γ coactivator 1β and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice
-
R. Yang, D. M. Wilcox, D. L. Haasch, P. M. Jung, P. T. Nguyen, M. J. Voorbach, S. Doktor, S. Brodjian, E. N. Bush, E. Lin, P. B. Jacobson, C. A. Collins, K. T. Landschulz, J. M. Trevillyan, C. M. Rondinone, T. K. Surowy, Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor γ coactivator 1β and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice. J. Biol. Chem. 282, 22765-22774 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 22765-22774
-
-
Yang, R.1
Wilcox, D.M.2
Haasch, D.L.3
Jung, P.M.4
Nguyen, P.T.5
Voorbach, M.J.6
Doktor, S.7
Brodjian, S.8
Bush, E.N.9
Lin, E.10
Jacobson, P.B.11
Collins, C.A.12
Landschulz, K.T.13
Trevillyan, J.M.14
Rondinone, C.M.15
Surowy, T.K.16
-
14
-
-
58249093873
-
Induction of hepatitis by JNK-mediated expression of TNF-α
-
M. Das, G. Sabio, F. Jiang, M. Rincón, R. A. Flavell, R. J. Davis, Induction of hepatitis by JNK-mediated expression of TNF-α. Cell 136, 249-260 (2009).
-
(2009)
Cell
, vol.136
, pp. 249-260
-
-
Das, M.1
Sabio, G.2
Jiang, F.3
Rincón, M.4
Flavell, R.A.5
Davis, R.J.6
-
15
-
-
70449927269
-
Prevention of steatosis by hepatic JNK1
-
G. Sabio, J. Cavanagh-Kyros, H. J. Ko, D. Y. Jung, S. Gray, J. Y. Jun, T. Barrett, A. Mora, J. K. Kim, R. J. Davis, Prevention of steatosis by hepatic JNK1. Cell Metab. 10, 491-498 (2009).
-
(2009)
Cell Metab.
, vol.10
, pp. 491-498
-
-
Sabio, G.1
Cavanagh-Kyros, J.2
Ko, H.J.3
Jung, D.Y.4
Gray, S.5
Jun, J.Y.6
Barrett, T.7
Mora, A.8
Kim, J.K.9
Davis, R.J.10
-
16
-
-
0029745782
-
Effects of exercise and insulin on mitogen-activated protein kinase signaling pathways in rat skeletal muscle
-
L. J. Goodyear, P. Y. Chang, D. J. Sherwood, S. D. Dufresne, D. E. Moller, Effects of exercise and insulin on mitogen-activated protein kinase signaling pathways in rat skeletal muscle. Am. J. Physiol. 271, E403-E408 (1996).
-
(1996)
Am. J. Physiol.
, vol.271
-
-
Goodyear, L.J.1
Chang, P.Y.2
Sherwood, D.J.3
Dufresne, S.D.4
Moller, D.E.5
-
17
-
-
2542576429
-
Effects of insulin, contraction, and phorbol esters on mitogen-activated protein kinase signaling in skeletal muscle from lean and ob/ob mice
-
Y. Leng, T. L. Steiler, J. R. Zierath, Effects of insulin, contraction, and phorbol esters on mitogen-activated protein kinase signaling in skeletal muscle from lean and ob/ob mice. Diabetes 53, 1436-1444 (2004).
-
(2004)
Diabetes
, vol.53
, pp. 1436-1444
-
-
Leng, Y.1
Steiler, T.L.2
Zierath, J.R.3
-
18
-
-
73549091444
-
2-terminal kinase 1 in obesity-induced insulin resistance
-
2- terminal kinase 1 in obesity-induced insulin resistance. Mol. Cell. Biol. 30, 106-115 (2010).
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 106-115
-
-
Sabio, G.1
Kennedy, N.J.2
Cavanagh-Kyros, J.3
Jung, D.Y.4
Ko, H.J.5
Ong, H.6
Barrett, T.7
Kim, J.K.8
Davis, R.J.9
-
19
-
-
58149347680
-
Muscle-specific IRS-1 Ser→Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle
-
K. Morino, S. Neschen, S. Bilz, S. Sono, D. Tsirigotis, R. M. Reznick, I. Moore, Y. Nagai, V. Samuel, D. Sebastian, M. White, W. Philbrick, G. I. Shulman, Muscle-specific IRS-1 Ser→Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle. Diabetes 57, 2644-2651 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 2644-2651
-
-
Morino, K.1
Neschen, S.2
Bilz, S.3
Sono, S.4
Tsirigotis, D.5
Reznick, R.M.6
Moore, I.7
Nagai, Y.8
Samuel, V.9
Sebastian, D.10
White, M.11
Philbrick, W.12
Shulman, G.I.13
-
20
-
-
40349096251
-
HSP72 protects against obesity-induced insulin resistance
-
J. Chung, A. K. Nguyen, D. C. Henstridge, A. G. Holmes, M. H. Chan, J. L. Mesa, G. I. Lancaster, R. J. Southgate, C. R. Bruce, S. J. Duffy, I. Horvath, R. Mestril, M. J. Watt, P. L. Hooper, B. A. Kingwell, L. Vigh, A. Hevener, M. A. Febbraio, HSP72 protects against obesity-induced insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 105, 1739-1744 (2008).
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 1739-1744
-
-
Chung, J.1
Nguyen, A.K.2
Henstridge, D.C.3
Holmes, A.G.4
Chan, M.H.5
Mesa, J.L.6
Lancaster, G.I.7
Southgate, R.J.8
Bruce, C.R.9
Duffy, S.J.10
Horvath, I.11
Mestril, R.12
Watt, M.J.13
Hooper, P.L.14
Kingwell, B.A.15
Vigh, L.16
Hevener, A.17
Febbraio, M.A.18
-
21
-
-
48149085566
-
Silencing Jnk1 and Jnk2 accelerates basal lipolysis and promotes fatty acid re-esterification in mouse adipocytes
-
A. V. Rozo, R. Vijayvargia, H. R. Weiss, H. Ruan, Silencing Jnk1 and Jnk2 accelerates basal lipolysis and promotes fatty acid re-esterification in mouse adipocytes. Diabetologia 51, 1493-1504 (2008).
-
(2008)
Diabetologia
, vol.51
, pp. 1493-1504
-
-
Rozo, A.V.1
Vijayvargia, R.2
Weiss, H.R.3
Ruan, H.4
-
22
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
G. Sabio, M. Das, A. Mora, Z. Zhang, J. Y. Jun, H. J. Ko, T. Barrett, J. K. Kim, R. J. Davis, A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322, 1539-1543 (2008).
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
Das, M.2
Mora, A.3
Zhang, Z.4
Jun, J.Y.5
Ko, H.J.6
Barrett, T.7
Kim, J.K.8
Davis, R.J.9
-
23
-
-
57849137363
-
Knockdown of JNK rescues 3T3-L1 adipocytes from insulin resistance induced by mitochondrial dysfunction
-
T. Kim, J. Wayne Leitner, R. Adochio, B. Draznin, Knockdown of JNK rescues 3T3-L1 adipocytes from insulin resistance induced by mitochondrial dysfunction. Biochem. Biophys. Res. Commun. 378, 772-776 (2009).
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.378
, pp. 772-776
-
-
Kim, T.1
Wayne Leitner, J.2
Adochio, R.3
Draznin, B.4
-
24
-
-
0037474274
-
c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
-
Y. H. Lee, J. Giraud, R. J. Davis, M. F. White, c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J. Biol. Chem. 278, 2896-2902 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2896-2902
-
-
Lee, Y.H.1
Giraud, J.2
Davis, R.J.3
White, M.F.4
-
25
-
-
55949119252
-
Muscle as an endocrine organ: Focus on muscle-derived interleukin-6
-
B. K. Pedersen, M. A. Febbraio, Muscle as an endocrine organ: Focus on muscle-derived interleukin-6. Physiol. Rev. 88, 1379-1406 (2008).
-
(2008)
Physiol. Rev.
, vol.88
, pp. 1379-1406
-
-
Pedersen, B.K.1
Febbraio, M.A.2
-
26
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
S. P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R. L. Leibel, A. W. Ferrante Jr., Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112, 1796-1808 (2003).
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante Jr., A.W.6
-
27
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
H. Xu, G. T. Barnes, Q. Yang, G. Tan, D. Yang, C. J. Chou, J. Sole, A. Nichols, J. S. Ross, L. A. Tartaglia, H. Chen, Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112, 1821-1830 (2003).
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
Chou, C.J.6
Sole, J.7
Nichols, A.8
Ross, J.S.9
Tartaglia, L.A.10
Chen, H.11
-
28
-
-
27444445460
-
JNK and tumor necrosis factor-α mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes
-
M. T. Nguyen, H. Satoh, S. Favelyukis, J. L. Babendure, T. Imamura, J. I. Sbodio, J. Zalevsky, B. I. Dahiyat, N. W. Chi, J. M. Olefsky, JNK and tumor necrosis factor-α mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J. Biol. Chem. 280, 35361-35371 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 35361-35371
-
-
Nguyen, M.T.1
Satoh, H.2
Favelyukis, S.3
Babendure, J.L.4
Imamura, T.5
Sbodio, J.I.6
Zalevsky, J.7
Dahiyat, B.I.8
Chi, N.W.9
Olefsky, J.M.10
-
29
-
-
26244448904
-
A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor α
-
T. Suganami, J. Nishida, Y. Ogawa, A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor α. Arterioscler. Thromb. Vasc. Biol. 25, 2062-2068 (2005).
-
(2005)
Arterioscler. Thromb. Vasc. Biol.
, vol.25
, pp. 2062-2068
-
-
Suganami, T.1
Nishida, J.2
Ogawa, Y.3
-
30
-
-
70349416501
-
c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice
-
Y. Kodama, T. Kisseleva, K. Iwaisako, K. Miura, K. Taura, S. De Minicis, C. H. Osterreicher, B. Schnabl, E. Seki, D. A. Brenner, c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology 137, 1467-1477.e5 (2009).
-
(2009)
Gastroenterology
, vol.137
-
-
Kodama, Y.1
Kisseleva, T.2
Iwaisako, K.3
Miura, K.4
Taura, K.5
De Minicis, S.6
Osterreicher, C.H.7
Schnabl, B.8
Seki, E.9
Brenner, D.A.10
-
31
-
-
35548943962
-
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity
-
G. Solinas, C. Vilcu, J. G. Neels, G. K. Bandyopadhyay, J. L. Luo, W. Naugler, S. Grivennikov, A. Wynshaw-Boris, M. Scadeng, J. M. Olefsky, M. Karin, JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 6, 386-397 (2007).
-
(2007)
Cell Metab.
, vol.6
, pp. 386-397
-
-
Solinas, G.1
Vilcu, C.2
Neels, J.G.3
Bandyopadhyay, G.K.4
Luo, J.L.5
Naugler, W.6
Grivennikov, S.7
Wynshaw-Boris, A.8
Scadeng, M.9
Olefsky, J.M.10
Karin, M.11
-
32
-
-
52349105273
-
A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity
-
S. N. Vallerie, M. Furuhashi, R. Fucho, G. S. Hotamisligil, A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. PLoS One 3, e3151 (2008).
-
(2008)
PLoS One
, vol.3
-
-
Vallerie, S.N.1
Furuhashi, M.2
Fucho, R.3
Hotamisligil, G.S.4
-
33
-
-
9444277846
-
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis
-
R. Ricci, G. Sumara, I. Sumara, I. Rozenberg, M. Kurrer, A. Akhmedov, M. Hersberger, U. Eriksson, F. R. Eberli, B. Becher, J. Borén, M. Chen, M. I. Cybulsky, K. J. Moore, M. W. Freeman, E. F. Wagner, C. M. Matter, T. F. Lüscher, Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science 306, 1558-1561 (2004).
-
(2004)
Science
, vol.306
, pp. 1558-1561
-
-
Ricci, R.1
Sumara, G.2
Sumara, I.3
Rozenberg, I.4
Kurrer, M.5
Akhmedov, A.6
Hersberger, M.7
Eriksson, U.8
Eberli, F.R.9
Becher, B.10
Borén, J.11
Chen, M.12
Cybulsky, M.I.13
Moore, K.J.14
Freeman, M.W.15
Wagner, E.F.16
Matter, C.M.17
Lüscher, T.F.18
-
34
-
-
0033553462
-
Chronic hyperglycemia triggers loss of pancreatic b cell differentiation in an animal model of diabetes
-
J. C. Jonas, A. Sharma,W. Hasenkamp, H. Ilkova, G. Patanè, R. Laybutt, S. Bonner-Weir, G. C. Weir, Chronic hyperglycemia triggers loss of pancreatic b cell differentiation in an animal model of diabetes. J. Biol. Chem. 274, 14112-14121 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 14112-14121
-
-
Jonas, J.C.1
Sharma, A.2
Hasenkamp, W.3
Ilkova, H.4
Patanè, G.5
Laybutt, R.6
Bonner-Weir, S.7
Weir, G.C.8
-
35
-
-
0029151863
-
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
-
R. H. Unger, Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44, 863-870 (1995).
-
(1995)
Diabetes
, vol.44
, pp. 863-870
-
-
Unger, R.H.1
-
36
-
-
0031913829
-
Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat
-
A. Pick, J. Clark, C. Kubstrup, M. Levisetti, W. Pugh, S. Bonner-Weir, K. S. Polonsky, Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat. Diabetes 47, 358-364 (1998).
-
(1998)
Diabetes
, vol.47
, pp. 358-364
-
-
Pick, A.1
Clark, J.2
Kubstrup, C.3
Levisetti, M.4
Pugh, W.5
Bonner-Weir, S.6
Polonsky, K.S.7
-
37
-
-
7044230885
-
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
-
H. Kaneto, Y. Nakatani, T. Miyatsuka, D. Kawamori, T. A. Matsuoka, M. Matsuhisa, Y. Kajimoto, H. Ichijo, Y. Yamasaki, M. Hori, Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat. Med. 10, 1128-1132 (2004).
-
(2004)
Nat. Med.
, vol.10
, pp. 1128-1132
-
-
Kaneto, H.1
Nakatani, Y.2
Miyatsuka, T.3
Kawamori, D.4
Matsuoka, T.A.5
Matsuhisa, M.6
Kajimoto, Y.7
Ichijo, H.8
Yamasaki, Y.9
Hori, M.10
-
38
-
-
0037119417
-
Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression
-
H. Kaneto, G. Xu, N. Fujii, S. Kim, S. Bonner-Weir, G. C. Weir, Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J. Biol. Chem. 277, 30010-30018 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30010-30018
-
-
Kaneto, H.1
Xu, G.2
Fujii, N.3
Kim, S.4
Bonner-Weir, S.5
Weir, G.C.6
-
39
-
-
33644865024
-
The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation
-
D. Kawamori, H. Kaneto, Y. Nakatani, T. A. Matsuoka, M. Matsuhisa, M. Hori, Y. Yamasaki, The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J. Biol. Chem. 281, 1091-1098 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 1091-1098
-
-
Kawamori, D.1
Kaneto, H.2
Nakatani, Y.3
Matsuoka, T.A.4
Matsuhisa, M.5
Hori, M.6
Yamasaki, Y.7
-
40
-
-
55649092238
-
c-Jun N-terminal kinase 1 is deleterious to the function and survival of murine pancreatic islets
-
J. L. Varona-Santos, A. Pileggi, R. D. Molano, N. Y. Sanabria, A. Ijaz, M. Atsushi, H. Ichii, R. L. Pastori, L. Inverardi, C. Ricordi, A. Fornoni, c-Jun N-terminal kinase 1 is deleterious to the function and survival of murine pancreatic islets. Diabetologia 51, 2271-2280 (2008).
-
(2008)
Diabetologia
, vol.51
, pp. 2271-2280
-
-
Varona-Santos, J.L.1
Pileggi, A.2
Molano, R.D.3
Sanabria, N.Y.4
Ijaz, A.5
Atsushi, M.6
Ichii, H.7
Pastori, R.L.8
Inverardi, L.9
Ricordi, C.10
Fornoni, A.11
-
41
-
-
68449084306
-
JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis
-
S. Abdelli, J. Puyal, C. Bielmann, V. Buchillier, A. Abderrahmani, P. G. Clarke, J. S. Beckmann, C. Bonny, JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis. Diabetologia 52, 1871-1880 (2009).
-
(2009)
Diabetologia
, vol.52
, pp. 1871-1880
-
-
Abdelli, S.1
Puyal, J.2
Bielmann, C.3
Buchillier, V.4
Abderrahmani, A.5
Clarke, P.G.6
Beckmann, J.S.7
Bonny, C.8
-
42
-
-
21044453408
-
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes
-
A. Jaeschke, M. Rincón, B. Doran, J. Reilly, D. Neuberg, D. L. Greiner, L. D. Shultz, A. A. Rossini, R. A. Flavell, R. J. Davis, Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc. Natl. Acad. Sci. U.S.A. 102, 6931-6935 (2005).
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 6931-6935
-
-
Jaeschke, A.1
Rincón, M.2
Doran, B.3
Reilly, J.4
Neuberg, D.5
Greiner, D.L.6
Shultz, L.D.7
Rossini, A.A.8
Flavell, R.A.9
Davis, R.J.10
-
43
-
-
77950532905
-
Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism
-
B. F. Belgardt, J. Mauer, F. T. Wunderlich, M. B. Ernst, M. Pal, G. Spohn, H. S. Brönneke, S. Brodesser, B. Hampel, A. C. Schauss, J. C. Brüning, Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. Proc. Natl. Acad. Sci. U.S.A. 107, 6028-6033 (2010).
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 6028-6033
-
-
Belgardt, B.F.1
Mauer, J.2
Wunderlich, F.T.3
Ernst, M.B.4
Pal, M.5
Spohn, G.6
Brönneke, H.S.7
Brodesser, S.8
Hampel, B.9
Schauss, A.C.10
Brüning, J.C.11
-
44
-
-
24944438230
-
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
-
C. T. De Souza, E. P. Araujo, S. Bordin, R. Ashimine, R. L. Zollner, A. C. Boschero, M. J. Saad, L. A. Velloso, Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146, 4192-4199 (2005).
-
(2005)
Endocrinology
, vol.146
, pp. 4192-4199
-
-
De Souza, C.T.1
Araujo, E.P.2
Bordin, S.3
Ashimine, R.4
Zollner, R.L.5
Boschero, A.C.6
Saad, M.J.7
Velloso, L.A.8
-
45
-
-
74949093168
-
Functional role of c-Jun-N-terminal kinase in feeding regulation
-
E. K. Unger, M. L. Piper, L. E. Olofsson, A. W. Xu, Functional role of c-Jun-N-terminal kinase in feeding regulation. Endocrinology 151, 671-682 (2010).
-
(2010)
Endocrinology
, vol.151
, pp. 671682
-
-
Unger, E.K.1
Piper, M.L.2
Olofsson, L.E.3
Xu, A.W.4
-
46
-
-
76149090834
-
Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1
-
G. Sabio, J. Cavanagh-Kyros, T. Barrett, D. Y. Jung, H. J. Ko, H. Ong, C. Morel, A. Mora, J. Reilly, J. K. Kim, R. J. Davis, Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev. 24, 256-264 (2010).
-
(2010)
Genes Dev.
, vol.24
, pp. 256-264
-
-
Sabio, G.1
Cavanagh-Kyros, J.2
Barrett, T.3
Jung, D.Y.4
Ko, H.J.5
Ong, H.6
Morel, C.7
Mora, A.8
Reilly, J.9
Kim, J.K.10
Davis, R.J.11
-
47
-
-
77954844177
-
Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity
-
N. Ouchi, A. Higuchi, K. Ohashi, Y. Oshima, N. Gokce, R. Shibata, Y. Akasaki, A. Shimono, K. Walsh, Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science 329, 454-457 (2010).
-
(2010)
Science
, vol.329
, pp. 454-457
-
-
Ouchi, N.1
Higuchi, A.2
Ohashi, K.3
Oshima, Y.4
Gokce, N.5
Shibata, R.6
Akasaki, Y.7
Shimono, A.8
Walsh, K.9
-
48
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
G. S. Hotamisligil, Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140, 900-917 (2010).
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
49
-
-
27544487938
-
JNK: Bridging the insulin signaling and inflammatory pathway
-
G. Liu, C. M. Rondinone, JNK: Bridging the insulin signaling and inflammatory pathway. Curr. Opin. Investig. Drugs 6, 979-987 (2005).
-
(2005)
Curr. Opin. Investig. Drugs
, vol.6
, pp. 979-987
-
-
Liu, G.1
Rondinone, C.M.2
-
51
-
-
59149084125
-
Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes
-
A. Ijaz, T. Tejada, P. Catanuto, X. Xia, S. J. Elliot, O. Lenz, A. Jauregui, M. O. Saenz, R. D. Molano, A. Pileggi, C. Ricordi, A. Fornoni, Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes. Kidney Int. 75, 381-388 (2009).
-
(2009)
Kidney Int.
, vol.75
, pp. 381-388
-
-
Ijaz, A.1
Tejada, T.2
Catanuto, P.3
Xia, X.4
Elliot, S.J.5
Lenz, O.6
Jauregui, A.7
Saenz, M.O.8
Molano, R.D.9
Pileggi, A.10
Ricordi, C.11
Fornoni, A.12
-
52
-
-
57049105164
-
Pharmacological characterization of a small molecule inhibitor of c-Jun kinase
-
H. Cho, S. C. Black, D. Looper, M. Shi, D. Kelly-Sullivan, S. Timofeevski, K. Siegel, X. H. Yu, S. R. McDonnell, P. Chen, J. Yie, K. M. Ogilvie, J. Fraser, C. P. Briscoe, Pharmacological characterization of a small molecule inhibitor of c-Jun kinase. Am. J. Physiol. Endocrinol. Metab. 295, E1142-E1151 (2008).
-
(2008)
Am. J. Physiol. Endocrinol. Metab.
, vol.295
-
-
Cho, H.1
Black, S.C.2
Looper, D.3
Shi, M.4
Kelly-Sullivan, D.5
Timofeevski, S.6
Siegel, K.7
Yu, X.H.8
McDonnell, S.R.9
Chen, P.10
Yie, J.11
Ogilvie, K.M.12
Fraser, J.13
Briscoe, C.P.14
-
53
-
-
55949100580
-
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site
-
J. L. Stebbins, S. K. De, T. Machleidt, B. Becattini, J. Vazquez, C. Kuntzen, L. H. Chen, J. F. Cellitti, M. Riel-Mehan, A. Emdadi, G. Solinas, M. Karin, M. Pellecchia, Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc. Natl. Acad. Sci. U.S.A. 105, 16809-16813 (2008).
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 16809-16813
-
-
Stebbins, J.L.1
De, S.K.2
Machleidt, T.3
Becattini, B.4
Vazquez, J.5
Kuntzen, C.6
Chen, L.H.7
Cellitti, J.F.8
Riel-Mehan, M.9
Emdadi, A.10
Solinas, G.11
Karin, M.12
Pellecchia, M.13
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