Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

Journal of Clinical Investigation

Volumn 112, Issue 12, 2003, Pages 1831-1842

  Krauss, Stefan ^a   Zhang, Chen Yu ^a   Scorrano, Luca ^a,c   Dalgaard, Louise T ^a   St Pierre, Julie ^a   Grey, Shane T ^a,d   Lowell, Bradford B ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^d GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; COMPLEMENTARY DNA; DNA; GLUCOSE; INSULIN; MESSENGER RNA; SUPEROXIDE; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 2;

ANIMAL MODEL; ARTICLE; DIABETES MELLITUS; DNA CONTENT; GENE EXPRESSION; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; GLUCOSE; HYPERGLYCEMIA; INSULIN; ION CHANNELS; ISLETS OF LANGERHANS; MALE; MEMBRANE POTENTIALS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OBESITY; OXYGEN CONSUMPTION; PROTONS; RHODAMINES; RNA, MESSENGER; SUPEROXIDE DISMUTASE; SUPEROXIDES; THYMUS GLAND; TIME FACTORS;

EID: 0346340042     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200319774     Document Type: Article

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