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Volumn 3, Issue 12, 2012, Pages 1522-1532

Recent progress in genetics of aging, senescence and longevity: Focusing on cancer-related genes

Author keywords

Cancer; Diseases; Quasi Programmed aging; Senescence

Indexed keywords

EVEROLIMUS; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN P53; PROTEIN P63; PROTEIN P73; RAPAMYCIN; RAS PROTEIN; SOMATOMEDIN C; TARGET OF RAPAMYCIN KINASE; TEMSIROLIMUS;

EID: 84874747285     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.889     Document Type: Review
Times cited : (18)

References (230)
  • 1
    • 67949102053 scopus 로고    scopus 로고
    • Recent progress in the biology and physiology of sirtuins
    • Finkel T, Deng CX, Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature. 2009; 460: 587-591.
    • (2009) Nature , vol.460 , pp. 587-591
    • Finkel, T.1    Deng, C.X.2    Mostoslavsky, R.3
  • 3
    • 84863328591 scopus 로고    scopus 로고
    • The journey of resveratrol from yeast to human
    • Timmer S, Auwerx J, Schrauwen P. The journey of resveratrol from yeast to human. Aging (Albany NY). 2012; 4: 146-158.
    • (2012) Aging (Albany NY) , vol.4 , pp. 146-158
    • Timmer, S.1    Auwerx, J.2    Schrauwen, P.3
  • 5
    • 36249016246 scopus 로고    scopus 로고
    • A therapeutic role for sirtuins in diseases of aging?
    • Westphal CH, Dipp MA, Guarente L. A therapeutic role for sirtuins in diseases of aging? Trends Biochem Sci. 2007; 555-60: 555-560.
    • (2007) Trends Biochem Sci , vol.555-560 , pp. 555-560
    • Westphal, C.H.1    Dipp, M.A.2    Guarente, L.3
  • 6
    • 56349122687 scopus 로고    scopus 로고
    • Aging: a sirtuin shake-up?
    • Vijg J, Maslov AY, Suh Y. Aging: a sirtuin shake-up? Cell. 2008; 135: 797-798.
    • (2008) Cell , vol.135 , pp. 797-798
    • Vijg, J.1    Maslov, A.Y.2    Suh, Y.3
  • 7
    • 79959542360 scopus 로고    scopus 로고
    • SirT1 brings stemness closer to cancer and aging
    • Calvanese V, Fraga MF. SirT1 brings stemness closer to cancer and aging. Aging (Albany NY). 2011; 3: 162-167.
    • (2011) Aging (Albany NY) , vol.3 , pp. 162-167
    • Calvanese, V.1    Fraga, M.F.2
  • 8
    • 80053123777 scopus 로고    scopus 로고
    • Interference between PARPs and SIRT1: a novel approach to healthy ageing?
    • Canto C, Auwerx J. Interference between PARPs and SIRT1: a novel approach to healthy ageing? Aging (Albany NY). 2011; 3: 543-547.
    • (2011) Aging (Albany NY) , vol.3 , pp. 543-547
    • Canto, C.1    Auwerx, J.2
  • 9
    • 79959567900 scopus 로고    scopus 로고
    • Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat
    • Choudhury M, Jonscher KR, Friedman JE. Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat. Aging (Albany NY). 2011; 3: 175-178.
    • (2011) Aging (Albany NY) , vol.3 , pp. 175-178
    • Choudhury, M.1    Jonscher, K.R.2    Friedman, J.E.3
  • 10
    • 80051662823 scopus 로고    scopus 로고
    • The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae
    • Ha CW, Huh WK. The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae. Aging (Albany NY). 2011; 3: 319-324.
    • (2011) Aging (Albany NY) , vol.3 , pp. 319-324
    • Ha, C.W.1    Huh, W.K.2
  • 11
    • 77957579920 scopus 로고    scopus 로고
    • Impact of Sirt1 on mammalian aging
    • Herranz D, Serrano M. Impact of Sirt1 on mammalian aging. Aging (Albany NY). 2010; 2: 315-316.
    • (2010) Aging (Albany NY) , vol.2 , pp. 315-316
    • Herranz, D.1    Serrano, M.2
  • 12
    • 70350441907 scopus 로고    scopus 로고
    • The role of sirtuins in the control of metabolic homeostasis
    • Yu J, Auwerx J. The role of sirtuins in the control of metabolic homeostasis. Ann N Y Acad Sci. 2009; 1173 Suppl 1: E10-19.
    • (2009) Ann N Y Acad Sci. , vol.1173 , Issue.SUPPL 1
    • Yu, J.1    Auwerx, J.2
  • 13
    • 82755165191 scopus 로고    scopus 로고
    • Genetics. Aging genes: the sirtuin story unravels
    • Couzin-Frankel J. Genetics. Aging genes: the sirtuin story unravels. Science. 2011; 334: 1194-1198.
    • (2011) Science , vol.334 , pp. 1194-1198
    • Couzin-Frankel, J.1
  • 14
    • 79952109655 scopus 로고    scopus 로고
    • Controlling SIRT1 expression by microRNAs in health and metabolic disease
    • Lee J, Kemper JK. Controlling SIRT1 expression by microRNAs in health and metabolic disease. Aging (Albany NY). 2010; 2: 527-534.
    • (2010) Aging (Albany NY) , vol.2 , pp. 527-534
    • Lee, J.1    Kemper, J.K.2
  • 15
    • 79958247717 scopus 로고    scopus 로고
    • SIRT3: Striking at the heart of aging
    • Liu Y Zhang D, Chen D. SIRT3: Striking at the heart of aging. Aging (Albany NY). 2011; 3: 1-2.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1-2
    • Liu, Y.1    Zhang, D.2    Chen, D.3
  • 16
    • 84864985379 scopus 로고    scopus 로고
    • Will the real aging Sirtuin please stand up
    • Liao CY, Kennedy BK. Will the real aging Sirtuin please stand up? Cell Res. 2012; 22: 1215-1217.
    • (2012) Cell Res , vol.22 , pp. 1215-1217
    • Liao, C.Y.1    Kennedy, B.K.2
  • 17
    • 80052078788 scopus 로고    scopus 로고
    • The physiological roles of Sirt1 in skeletal muscle
    • Pardo PS, Boriek AM. The physiological roles of Sirt1 in skeletal muscle. Aging (Albany NY). 2011; 3: 430-437.
    • (2011) Aging (Albany NY) , vol.3 , pp. 430-437
    • Pardo, P.S.1    Boriek, A.M.2
  • 18
    • 80052083866 scopus 로고    scopus 로고
    • Resveratrol-activated SIRT1 in liver and pancreatic beta-cells: a Janus head looking to the same direction of metabolic homeostasis
    • Vetterli L, Maechler P. Resveratrol-activated SIRT1 in liver and pancreatic beta-cells: a Janus head looking to the same direction of metabolic homeostasis. Aging (Albany NY). 2011; 3: 444-449.
    • (2011) Aging (Albany NY) , vol.3 , pp. 444-449
    • Vetterli, L.1    Maechler, P.2
  • 21
    • 79959562760 scopus 로고    scopus 로고
    • SIRT-ain relief from age-inducing stress
    • Zhang D, Liu Y, Chen D. SIRT-ain relief from age-inducing stress. Aging (Albany NY). 2011; 3: 158-161.
    • (2011) Aging (Albany NY) , vol.3 , pp. 158-161
    • Zhang, D.1    Liu, Y.2    Chen, D.3
  • 22
    • 79954547381 scopus 로고    scopus 로고
    • Complex roles of Sirtuin 1 in cancer and aging
    • Liu Z, Sun LY. Complex roles of Sirtuin 1 in cancer and aging. Transl Res. 2011; 157: 273-275.
    • (2011) Transl Res. , vol.157 , pp. 273-275
    • Liu, Z.1    Sun, L.Y.2
  • 28
    • 80051662211 scopus 로고    scopus 로고
    • Does hypothalamic SIRT1 regulate aging?
    • Ramadori G, Coppari R. Does hypothalamic SIRT1 regulate aging? Aging (Albany NY). 2011; 3: 325-328.
    • (2011) Aging (Albany NY) , vol.3 , pp. 325-328
    • Ramadori, G.1    Coppari, R.2
  • 30
    • 79958273469 scopus 로고    scopus 로고
    • Sirt3 targets mPTP and prevents aging in the heart
    • Sadoshima J. Sirt3 targets mPTP and prevents aging in the heart. Aging (Albany NY). 2011; 3: 12-13.
    • (2011) Aging (Albany NY) , vol.3 , pp. 12-13
    • Sadoshima, J.1
  • 31
    • 84855670218 scopus 로고    scopus 로고
    • Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair
    • Van Meter M, Mao Z, Gorbunova V, Seluanov A. Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair. Aging (Albany NY). 2011; 3: 829-835.
    • (2011) Aging (Albany NY) , vol.3 , pp. 829-835
    • Van Meter, M.1    Mao, Z.2    Gorbunova, V.3    Seluanov, A.4
  • 32
    • 84859482891 scopus 로고    scopus 로고
    • Sir2 plays a key role in cell fate determination upon SAPK activation
    • Vendrell A, Posas F. Sir2 plays a key role in cell fate determination upon SAPK activation. Aging (Albany NY). 2011; 3: 1163-1168.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1163-1168
    • Vendrell, A.1    Posas, F.2
  • 33
    • 79952642191 scopus 로고    scopus 로고
    • Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila
    • Antosh M, Whitaker R, Kroll A, Hosier S, Chang C, Bauer J, Cooper L, Neretti N, Helfand SL. Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila. Cell Cycle. 2011; 10: 904-911.
    • (2011) Cell Cycle , vol.10 , pp. 904-911
    • Antosh, M.1    Whitaker, R.2    Kroll, A.3    Hosier, S.4    Chang, C.5    Bauer, J.6    Cooper, L.7    Neretti, N.8    Helfand, S.L.9
  • 34
    • 79960005365 scopus 로고    scopus 로고
    • Limited role of Sirt1 in cancer protection by dietary restriction
    • Herranz D, Iglesias G, Munoz-Martin M, Serrano M. Limited role of Sirt1 in cancer protection by dietary restriction. Cell Cycle. 2011; 10: 2215-2217.
    • (2011) Cell Cycle , vol.10 , pp. 2215-2217
    • Herranz, D.1    Iglesias, G.2    Munoz-Martin, M.3    Serrano, M.4
  • 35
    • 79960466223 scopus 로고    scopus 로고
    • Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation
    • Fatoba ST, Okorokov AL. Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation. Cell Cycle. 2011; 10: 2317-2322.
    • (2011) Cell Cycle , vol.10 , pp. 2317-2322
    • Fatoba, S.T.1    Okorokov, A.L.2
  • 36
    • 80052897214 scopus 로고    scopus 로고
    • SIRT1, p53 and mitotic chromosomes
    • Milner J, Allison SJ. SIRT1, p53 and mitotic chromosomes. Cell Cycle. 2011;10: 3049.
    • (2011) Cell Cycle , vol.10 , pp. 3049
    • Milner, J.1    Allison, S.J.2
  • 37
    • 79952266729 scopus 로고    scopus 로고
    • Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy
    • Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, Sinclair DA. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY). 2010; 2: 914-923.
    • (2010) Aging (Albany NY) , vol.2 , pp. 914-923
    • Hafner, A.V.1    Dai, J.2    Gomes, A.P.3    Xiao, C.Y.4    Palmeira, C.M.5    Rosenzweig, A.6    Sinclair, D.A.7
  • 39
    • 79951881254 scopus 로고    scopus 로고
    • Protective roles of SIRT1 in atherosclerosis
    • Stein S, Matter CM. Protective roles of SIRT1 in atherosclerosis. Cell Cycle. 2011; 10: 640-647.
    • (2011) Cell Cycle , vol.10 , pp. 640-647
    • Stein, S.1    Matter, C.M.2
  • 43
    • 35648995939 scopus 로고    scopus 로고
    • MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae
    • Medvedik O, Lamming DW, Kim KD, Sinclair DA. MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae. PLoS Biol. 2007; 5: e261.
    • (2007) PLoS Biol. , vol.5
    • Medvedik, O.1    Lamming, D.W.2    Kim, K.D.3    Sinclair, D.A.4
  • 45
    • 80052908853 scopus 로고    scopus 로고
    • SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells
    • Van Meter M, Mao Z, Gorbunova V, Seluanov A. SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle. 2011; 10: 3153-3158.
    • (2011) Cell Cycle , vol.10 , pp. 3153-3158
    • Van Meter, M.1    Mao, Z.2    Gorbunova, V.3    Seluanov, A.4
  • 46
    • 77953624320 scopus 로고    scopus 로고
    • Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR
    • doi:101038/cddis200917
    • Blagosklonny MV. Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR. Cell Death Dis 1:e12;doi:101038/cddis200917. 2010.
    • (2010) Cell Death Dis , vol.1
    • Blagosklonny, M.V.1
  • 51
    • 84858342119 scopus 로고    scopus 로고
    • Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1beta and enhancing NMDA signaling
    • Majumder S, Caccamo A, Medina DX, Benavides AD, Javors MA, Kraig E, Strong R, Richardson A, Oddo S. Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1beta and enhancing NMDA signaling. Aging Cell. 2012; 11: 326-52. Spong A, Bartke A. Rapamycin slows aging in mice. Cell Cycle. 2012; 11:845.
    • (2012) Aging Cell , vol.11 , pp. 326-352
    • Majumder, S.1    Caccamo, A.2    Medina, D.X.3    Benavides, A.D.4    Javors, M.A.5    Kraig, E.6    Strong, R.7    Richardson, A.8    Oddo, S.9
  • 52
    • 84857926653 scopus 로고    scopus 로고
    • Rapamycin slows aging in mice.
    • Spong A, Bartke A.Rapamycin slows aging in mice. Cell Cycle. 2012; 11:845.
    • (2012) Cell Cycle , vol.11 , pp. 845
    • Spong, A.1    Bartke, A.2
  • 53
    • 84855690358 scopus 로고    scopus 로고
    • A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice
    • Selman C, Partridge L. A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice. Cell Cycle. 2012; 11: 17-18.
    • (2012) Cell Cycle , vol.11 , pp. 17-18
    • Selman, C.1    Partridge, L.2
  • 57
    • 67650825231 scopus 로고    scopus 로고
    • Ageing: A midlife longevity drug?
    • Kaeberlein M, Kennedy BK. Ageing: A midlife longevity drug? Nature. 2009; 460: 331-332.
    • (2009) Nature , vol.460 , pp. 331-332
    • Kaeberlein, M.1    Kennedy, B.K.2
  • 59
  • 60
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol. 2004; 14: 885-890.
    • (2004) Curr Biol. , vol.14 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 61
    • 79954632599 scopus 로고    scopus 로고
    • Role of TOR signaling in aging and related biological processes in Drosophila melanogaster
    • Katewa SD, Kapahi P. Role of TOR signaling in aging and related biological processes in Drosophila melanogaster. Exp Gerontol. 2011; 46: 382-390.
    • (2011) Exp Gerontol. , vol.46 , pp. 382-390
    • Katewa, S.D.1    Kapahi, P.2
  • 62
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
    • Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle. 2006; 5: 2087-2102.
    • (2006) Cell Cycle , vol.5 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 63
    • 0038441503 scopus 로고    scopus 로고
    • Cell senescence and hypermitogenic arrest
    • Blagosklonny MV. Cell senescence and hypermitogenic arrest. EMBO Rep. 2003; 4: 358-362.
    • (2003) EMBO Rep. , vol.4 , pp. 358-362
    • Blagosklonny, M.V.1
  • 64
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle. 2008; 7: 3355-3361.
    • (2008) Cell Cycle , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 65
    • 67649347537 scopus 로고    scopus 로고
    • Growth and aging: a common molecular mechanism
    • Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging. 2009; 1: 357-362.
    • (2009) Aging. , vol.1 , pp. 357-362
    • Blagosklonny, M.V.1    Hall, M.N.2
  • 66
    • 78650352864 scopus 로고    scopus 로고
    • Increasing healthy lifespan by suppressing aging in our lifetime: Preliminary proposal
    • Blagosklonny MV. Increasing healthy lifespan by suppressing aging in our lifetime: Preliminary proposal. Cell Cycle. 2010; 9: 4788-4794.
    • (2010) Cell Cycle , vol.9 , pp. 4788-4794
    • Blagosklonny, M.V.1
  • 67
    • 77953149043 scopus 로고    scopus 로고
    • Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)
    • Blagosklonny MV. Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans). Cell Cycle. 2010; 9: 683-688.
    • (2010) Cell Cycle , vol.9 , pp. 683-688
    • Blagosklonny, M.V.1
  • 68
    • 77953645579 scopus 로고    scopus 로고
    • Rapamycin and quasi-programmed aging: Four years later
    • Blagosklonny MV. Rapamycin and quasi-programmed aging: Four years later. Cell Cycle. 2010; 9: 1859-1862.
    • (2010) Cell Cycle , vol.9 , pp. 1859-1862
    • Blagosklonny, M.V.1
  • 69
    • 84866494334 scopus 로고    scopus 로고
    • Prospective treatment of age-related diseases by slowing down aging
    • Blagosklonny MV. Prospective treatment of age-related diseases by slowing down aging. Am J Pathol. 2012; 181: 1142-1146.
    • (2012) Am J Pathol. , vol.181 , pp. 1142-1146
    • Blagosklonny, M.V.1
  • 70
    • 77955722198 scopus 로고    scopus 로고
    • Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
    • Blagosklonny MV. Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program. Cell Cycle. 2010; 9: 3151-3156.
    • (2010) Cell Cycle , vol.9 , pp. 3151-3156
    • Blagosklonny, M.V.1
  • 71
    • 79952264996 scopus 로고    scopus 로고
    • Why the disposable soma theory cannot explain why women live longer and why we age
    • Blagosklonny MV. Why the disposable soma theory cannot explain why women live longer and why we age. Aging (Albany NY). 2010; 2: 884-887.
    • (2010) Aging (Albany NY) , vol.2 , pp. 884-887
    • Blagosklonny, M.V.1
  • 72
    • 83755206847 scopus 로고    scopus 로고
    • Hormesis does not make sense except in the light of TOR-driven aging
    • Blagosklonny MV. Hormesis does not make sense except in the light of TOR-driven aging. Aging (Albany NY). 2011; 3: 1051-1062.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1051-1062
    • Blagosklonny, M.V.1
  • 73
    • 84874802960 scopus 로고    scopus 로고
    • Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts
    • Epub 2012 Nov 26
    • Gems D, Partridge L. Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts. Annu Rev Physiol. Epub 2012 Nov 26.
    • Annu Rev Physiol.
    • Gems, D.1    Partridge, L.2
  • 74
    • 84874726175 scopus 로고    scopus 로고
    • Alternative Perspectives on Aging in C.elegans: Reactive Oxygen Species or Hyperfunction
    • Gems DH, de la Guardia YI. Alternative Perspectives on Aging in C. elegans: Reactive Oxygen Species or Hyperfunction? Antioxid Redox Signal. 2012.
    • (2012) Antioxid Redox Signal
    • Gems, D.H.1    de la Guardia, Y.I.2
  • 75
    • 79957880743 scopus 로고    scopus 로고
    • Cell cycle arrest is not senescence
    • Blagosklonny MV. Cell cycle arrest is not senescence. Aging (Albany NY). 2011; 3: 94-101
    • (2011) Aging (Albany NY) , vol.3 , pp. 94-101
    • Blagosklonny, M.V.1
  • 76
    • 84862891914 scopus 로고    scopus 로고
    • Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
    • Blagosklonny MV. Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging. Aging (Albany NY). 2012; 4: 159-165.
    • (2012) Aging (Albany NY) , vol.4 , pp. 159-165
    • Blagosklonny, M.V.1
  • 79
    • 79952269372 scopus 로고    scopus 로고
    • DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
    • Leontieva OV, Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging (Albany NY). 2010; 2: 924-935.
    • (2010) Aging (Albany NY) , vol.2 , pp. 924-935
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 84
    • 80655140600 scopus 로고    scopus 로고
    • mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging
    • Menendez JA, Vellon L, Oliveras-Ferraros C, Cufi S, Vazquez-Martin A. mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging. Cell Cycle. 2011; 10: 3658-3677.
    • (2011) Cell Cycle , vol.10 , pp. 3658-3677
    • Menendez, J.A.1    Vellon, L.2    Oliveras-Ferraros, C.3    Cufi, S.4    Vazquez-Martin, A.5
  • 85
    • 84862881961 scopus 로고    scopus 로고
    • Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence
    • Kolesnichenko M, Hong L, Liao R, Vogt PK, Sun P. Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle. 2012; 11: 2391-2401.
    • (2012) Cell Cycle , vol.11 , pp. 2391-2401
    • Kolesnichenko, M.1    Hong, L.2    Liao, R.3    Vogt, P.K.4    Sun, P.5
  • 86
    • 79959776029 scopus 로고    scopus 로고
    • Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
    • Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells. Sci Transl Med. 2011; 3: 89ra58.
    • (2011) Sci Transl Med. , vol.3
    • Cao, K.1    Graziotto, J.J.2    Blair, C.D.3    Mazzulli, J.R.4    Erdos, M.R.5    Krainc, D.6    Collins, F.S.7
  • 87
    • 84863430906 scopus 로고    scopus 로고
    • Status of mTOR activity may phenotypically differentiate senescence and quiescence
    • Cho S, Hwang ES. Status of mTOR activity may phenotypically differentiate senescence and quiescence. Mol Cells. 2012; 33: 597-604.
    • (2012) Mol Cells , vol.33 , pp. 597-604
    • Cho, S.1    Hwang, E.S.2
  • 88
    • 79961099905 scopus 로고    scopus 로고
    • From growing to secreting: new roles for mTOR in aging cells
    • Pani G. From growing to secreting: new roles for mTOR in aging cells. Cell Cycle. 2011; 10: 2450-2453.
    • (2011) Cell Cycle , vol.10 , pp. 2450-2453
    • Pani, G.1
  • 89
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000; 103: 253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 90
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012; 149: 274-293.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 91
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006; 124: 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 92
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: from growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011; 12: 21-35.
    • (2011) Nat Rev Mol Cell Biol. , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 93
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell. 2010; 40: 310-322.
    • (2010) Mol Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 97
    • 79953668112 scopus 로고    scopus 로고
    • The physiology and pathophysiology of rapamycin resistance: implications for cancer
    • Gruppuso PA, Boylan JM, Sanders JA. The physiology and pathophysiology of rapamycin resistance: implications for cancer. Cell Cycle. 2011; 10: 1050-1058.
    • (2011) Cell Cycle , vol.10 , pp. 1050-1058
    • Gruppuso, P.A.1    Boylan, J.M.2    Sanders, J.A.3
  • 100
    • 34047095297 scopus 로고    scopus 로고
    • The Two TORCs and Akt
    • Bhaskar PT, Hay N. The Two TORCs and Akt. Dev Cell. 2007; 12: 487-502.
    • (2007) Dev Cell. , vol.12 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 102
    • 81855224569 scopus 로고    scopus 로고
    • High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1
    • Yellen P, Saqcena M, Salloum D, Feng J, Preda A, Xu L, Rodrik-Outmezguine V, Foster DA. High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1. Cell Cycle. 2011; 10: 3948-3956.
    • (2011) Cell Cycle , vol.10 , pp. 3948-3956
    • Yellen, P.1    Saqcena, M.2    Salloum, D.3    Feng, J.4    Preda, A.5    Xu, L.6    Rodrik-Outmezguine, V.7    Foster, D.A.8
  • 104
    • 84865805718 scopus 로고    scopus 로고
    • Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
    • Martelli AM, Chiarini F, Evangelisti C, Cappellini A, Buontempo F, Bressanin D, Fini M, McCubrey JA. Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment. Oncotarget. 2012; 3: 371-394.
    • (2012) Oncotarget , vol.3 , pp. 371-394
    • Martelli, A.M.1    Chiarini, F.2    Evangelisti, C.3    Cappellini, A.4    Buontempo, F.5    Bressanin, D.6    Fini, M.7    McCubrey, J.8
  • 106
    • 84865722534 scopus 로고    scopus 로고
    • PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma
    • Ho AL, Vasudeva SD, Lae M, Saito T, Barbashina V, Antonescu CR, Ladanyi M, Schwartz GK. PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma. Cancer Res. 2012; 72: 4515-4525.
    • (2012) Cancer Res. , vol.72 , pp. 4515-4525
    • Ho, A.L.1    Vasudeva, S.D.2    Lae, M.3    Saito, T.4    Barbashina, V.5    Antonescu, C.R.6    Ladanyi, M.7    Schwartz, G.K.8
  • 107
    • 84859876030 scopus 로고    scopus 로고
    • Will PI3K pathway inhibitors be effective as single agents in patients with cancer
    • Garrett JT, Chakrabarty A, Arteaga CL. Will PI3K pathway inhibitors be effective as single agents in patients with cancer? Oncotarget. 2011; 2: 1314-1321.
    • (2011) Oncotarget , vol.2 , pp. 1314-1321
    • Garrett, J.T.1    Chakrabarty, A.2    Arteaga, C.L.3
  • 109
    • 83755206860 scopus 로고    scopus 로고
    • Rapamycin: killing two birds with one stone
    • Khanna A, Kapahi P. Rapamycin: killing two birds with one stone. Aging (Albany NY). 2011; 3: 1043-1044.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1043-1044
    • Khanna, A.1    Kapahi, P.2
  • 111
    • 79951670258 scopus 로고    scopus 로고
    • Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines
    • Wang Y, Wang XY, Subjeck JR, Shrikant PA, Kim HL. Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines. Br J Cancer. 2011; 104: 643-652.
    • (2011) Br J Cancer. , vol.104 , pp. 643-652
    • Wang, Y.1    Wang, X.Y.2    Subjeck, J.R.3    Shrikant, P.A.4    Kim, H.L.5
  • 112
    • 80555154901 scopus 로고    scopus 로고
    • Targeting mTOR for the treatment of AML. New agents and new directions
    • Altman JK, Sassano A, Platanias LC. Targeting mTOR for the treatment of AML. New agents and new directions. Oncotarget. 2011; 2: 510-517.
    • (2011) Oncotarget. , vol.2 , pp. 510-517
    • Altman, J.K.1    Sassano, A.2    Platanias, L.C.3
  • 114
    • 80051606004 scopus 로고    scopus 로고
    • Potential of mTOR inhibitors for the treatment of subependymal giant cell astrocytomas in tuberous sclerosis complex
    • Major P. Potential of mTOR inhibitors for the treatment of subependymal giant cell astrocytomas in tuberous sclerosis complex. Aging (Albany NY). 2011; 3: 189-191.
    • (2011) Aging (Albany NY) , vol.3 , pp. 189-191
    • Major, P.1
  • 115
    • 84866761624 scopus 로고    scopus 로고
    • Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin
    • Armstrong AJ, George DJ, Halabi S. Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin. J Clin Oncol. 2012; 30: 3402-3407.
    • (2012) J Clin Oncol. , vol.30 , pp. 3402-3407
    • Armstrong, A.J.1    George, D.J.2    Halabi, S.3
  • 117
    • 33644507693 scopus 로고    scopus 로고
    • Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging
    • Bartke A. Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging. Trends Endocrinol Metab. 2006; 17: 33-35.
    • (2006) Trends Endocrinol Metab. , vol.17 , pp. 33-35
    • Bartke, A.1
  • 118
    • 80052092443 scopus 로고    scopus 로고
    • A role for Ras signaling in modulating mammalian aging by the GH/IGF1 axis
    • de Magalhaes JP. A role for Ras signaling in modulating mammalian aging by the GH/IGF1 axis. Aging (Albany NY). 2011; 3: 336-337.
    • (2011) Aging (Albany NY) , vol.3 , pp. 336-337
    • de Magalhaes, J.P.1
  • 119
    • 0037238644 scopus 로고    scopus 로고
    • Body size, insulin/IGF signaling and aging in the nematode Caenorhabditis elegans
    • McCulloch D, Gems D. Body size, insulin/IGF signaling and aging in the nematode Caenorhabditis elegans. Exp Gerontol. 2003; 38: 129-136.
    • (2003) Exp Gerontol. , vol.38 , pp. 129-136
    • McCulloch, D.1    Gems, D.2
  • 120
    • 79954628932 scopus 로고    scopus 로고
    • Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network
    • Partridge L, Alic N, Bjedov I, Piper MD. Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Exp Gerontol. 2011; 46: 376-381.
    • (2011) Exp Gerontol. , vol.46 , pp. 376-381
    • Partridge, L.1    Alic, N.2    Bjedov, I.3    Piper, M.D.4
  • 121
    • 79952201520 scopus 로고    scopus 로고
    • Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans
    • Chateau MT, Araiz C, Descamps S, Galas S. Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans. Aging (Albany NY). 2010; 2: 567-581.
    • (2010) Aging (Albany NY) , vol.2 , pp. 567-581
    • Chateau, M.T.1    Araiz, C.2    Descamps, S.3    Galas, S.4
  • 122
    • 80052397117 scopus 로고    scopus 로고
    • Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions
    • Liu B, Fan Z, Edgerton SM, Yang X, Lind SE, Thor AD. Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions. Cell Cycle. 2011; 10: 2959-2966.
    • (2011) Cell Cycle , vol.10 , pp. 2959-2966
    • Liu, B.1    Fan, Z.2    Edgerton, S.M.3    Yang, X.4    Lind, S.E.5    Thor, A.D.6
  • 123
    • 84866521341 scopus 로고    scopus 로고
    • A phase 2 study of the insulin-like growth factor-1 receptor inhibitor MK-0646 in patients with metastatic well-differentiated neuroendocrine tumors
    • Reidy-Lagunes DL, Vakiani E, Segal MF, Hollywood EM, Tang LH, Solit DB, Pietanza MC, Capanu M, Saltz LB. A phase 2 study of the insulin-like growth factor-1 receptor inhibitor MK-0646 in patients with metastatic, well-differentiated neuroendocrine tumors. Cancer. 2012; 118: 4795-4800.
    • (2012) Cancer. , vol.118 , pp. 4795-4800
    • Reidy-Lagunes, D.L.1    Vakiani, E.2    Segal, M.F.3    Hollywood, E.M.4    Tang, L.H.5    Solit, D.B.6    Pietanza, M.C.7    Capanu, M.8    Saltz, L.B.9
  • 125
    • 79957916298 scopus 로고    scopus 로고
    • The insulin receptor substrate (IRS) proteins: at the intersection of metabolism and cancer
    • Shaw LM. The insulin receptor substrate (IRS) proteins: at the intersection of metabolism and cancer. Cell Cycle. 2011; 10: 1750-1756.
    • (2011) Cell Cycle , vol.10 , pp. 1750-1756
    • Shaw, L.M.1
  • 126
    • 79959209982 scopus 로고    scopus 로고
    • The type 1 insulin-like growth factor receptor and resistance to DACH1
    • DeAngelis T, Wu K, Pestell R, Baserga R. The type 1 insulin-like growth factor receptor and resistance to DACH1. Cell Cycle. 2011; 10: 1956-1959.
    • (2011) Cell Cycle , vol.10 , pp. 1956-1959
    • DeAngelis, T.1    Wu, K.2    Pestell, R.3    Baserga, R.4
  • 130
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK1A
    • Serrano M, Lim AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK1A. Cell. 1997; 88: 593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lim, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 132
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic Raf
    • Zhu JY, Woods D, McMahon M, Bishop JM. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 1998; 12: 2997-3007.
    • (1998) Genes Dev. , vol.12 , pp. 2997-3007
    • Zhu, J.Y.1    Woods, D.2    McMahon, M.3    Bishop, J.M.4
  • 135
    • 77956830341 scopus 로고    scopus 로고
    • Pathways of oncogene-induced senescence in human melanocytic cells
    • Bansal R, Nikiforov MA. Pathways of oncogene-induced senescence in human melanocytic cells. Cell Cycle. 2010; 9: 2782-2788.
    • (2010) Cell Cycle , vol.9 , pp. 2782-2788
    • Bansal, R.1    Nikiforov, M.A.2
  • 137
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 1998; 12: 3008-3019.
    • (1998) Genes Dev. , vol.12 , pp. 3008-3019
    • Lin, A.W.1    Barradas, M.2    Stone, J.C.3    van Aelst, L.4    Serrano, M.5    Lowe, S.W.6
  • 138
    • 79851493300 scopus 로고    scopus 로고
    • Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a)
    • Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J, Bartek J. Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Cell Cycle. 2011; 10: 457-468.
    • (2011) Cell Cycle , vol.10 , pp. 457-468
    • Kosar, M.1    Bartkova, J.2    Hubackova, S.3    Hodny, Z.4    Lukas, J.5    Bartek, J.6
  • 139
    • 79956028916 scopus 로고    scopus 로고
    • Ras, autophagy and glycolysis
    • Lock R, Debnath J. Ras, autophagy and glycolysis. Cell Cycle. 2011; 10: 1516-1517.
    • (2011) Cell Cycle , vol.10 , pp. 1516-1517
    • Lock, R.1    Debnath, J.2
  • 142
    • 80052082672 scopus 로고    scopus 로고
    • Conserved role of Ras-GEFs in promoting aging: from yeast to mice
    • Mirisola MG, Longo VD. Conserved role of Ras-GEFs in promoting aging: from yeast to mice. Aging (Albany NY). 2011; 3: 340-343.
    • (2011) Aging (Albany NY) , vol.3 , pp. 340-343
    • Mirisola, M.G.1    Longo, V.D.2
  • 146
    • 84858415416 scopus 로고    scopus 로고
    • Phosphoinositide 3'-kinase delta: turning off BCR signaling in Chronic Lymphocytic Leukemia
    • Burger JA, Hoellenriegel J. Phosphoinositide 3'-kinase delta: turning off BCR signaling in Chronic Lymphocytic Leukemia. Oncotarget. 2011; 2: 737-738.
    • (2011) Oncotarget. , vol.2 , pp. 737-738
    • Burger, J.A.1    Hoellenriegel, J.2
  • 149
    • 84860299268 scopus 로고    scopus 로고
    • Systemic rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study
    • Mendiburu-Elicabe M, Yin D, Hadaczek P, Zhai Y, Forsayeth J, Bankiewicz KS. Systemic rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study. J Neurooncol. 2012; 108: 53-58.
    • (2012) J Neurooncol. , vol.108 , pp. 53-58
    • Mendiburu-Elicabe, M.1    Yin, D.2    Hadaczek, P.3    Zhai, Y.4    Forsayeth, J.5    Bankiewicz, K.S.6
  • 150
    • 80555154907 scopus 로고    scopus 로고
    • Phosphorylation of AKT: a mutational analysis
    • Hart JR, Vogt PK. Phosphorylation of AKT: a mutational analysis. Oncotarget. 2011; 2: 467-476.
    • (2011) Oncotarget. , vol.2 , pp. 467-476
    • Hart, J.R.1    Vogt, P.K.2
  • 151
    • 79960028514 scopus 로고    scopus 로고
    • MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks
    • Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG. MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks. Cell Cycle. 2011; 10: 2218-2232.
    • (2011) Cell Cycle , vol.10 , pp. 2218-2232
    • Fraser, M.1    Harding, S.M.2    Zhao, H.3    Coackley, C.4    Durocher, D.5    Bristow, R.G.6
  • 153
    • 84867116494 scopus 로고    scopus 로고
    • Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway
    • Ramaswamy B, Lu Y, Teng KY, Nuovo G, Li X, Shapiro CL, Majumder S. Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway. Cancer Res. 2012; 72: 5048-5059.
    • (2012) Cancer Res. , vol.72 , pp. 5048-5059
    • Ramaswamy, B.1    Lu, Y.2    Teng, K.Y.3    Nuovo, G.4    Li, X.5    Shapiro, C.L.6    Majumder, S.7
  • 155
    • 80053307869 scopus 로고    scopus 로고
    • Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers
    • Corcoran RB, Settleman J, Engelman JA. Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers. Oncotarget. 2011; 2: 336-346.
    • (2011) Oncotarget. , vol.2 , pp. 336-346
    • Corcoran, R.B.1    Settleman, J.2    Engelman, J.A.3
  • 157
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
    • Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell. 2005; 120: 513-522.
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 158
    • 0034832956 scopus 로고    scopus 로고
    • Regulation of cellular senescence by p53
    • Itahana K, Dimri G, Campisi J. Regulation of cellular senescence by p53. Eur J Biochem. 2001; 268: 2784-2791.
    • (2001) Eur J Biochem. , vol.268 , pp. 2784-2791
    • Itahana, K.1    Dimri, G.2    Campisi, J.3
  • 159
    • 78650152988 scopus 로고    scopus 로고
    • p53, ROS and senescence in the control of aging
    • Vigneron A, Vousden KH. p53, ROS and senescence in the control of aging. Aging (Albany NY). 2010; 2: 471-474.
    • (2010) Aging (Albany NY) , vol.2 , pp. 471-474
    • Vigneron, A.1    Vousden, K.H.2
  • 160
    • 79952111177 scopus 로고    scopus 로고
    • SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence
    • Mallette FA, Calabrese V, Ilangumaran S, Ferbeyre G. SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence. Aging (Albany NY). 2010; 2: 445-452.
    • (2010) Aging (Albany NY) , vol.2 , pp. 445-452
    • Mallette, F.A.1    Calabrese, V.2    Ilangumaran, S.3    Ferbeyre, G.4
  • 161
    • 79954538151 scopus 로고    scopus 로고
    • p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells
    • Pinho AV, Rooman I, Real FX. p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells. Cell Cycle. 2011; 10: 1312-1321.
    • (2011) Cell Cycle , vol.10 , pp. 1312-1321
    • Pinho, A.V.1    Rooman, I.2    Real, F.X.3
  • 163
    • 32044435126 scopus 로고    scopus 로고
    • Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
    • Levine AJ, Feng Z, Mak TW, You H, Jin S. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev. 2006; 20: 267-164. Demidenko ZN, Korotchkina LG, Gudkov AV, Blagosklonny MV. Paradoxical suppression of cellular senescence by p53. Proc Natl Acad Sci U S A. 2010; 107: 9660-9664.
    • (2006) Genes Dev. , vol.20 , pp. 267-164
    • Levine, A.J.1    Feng, Z.2    Mak, T.W.3    You, H.4    Jin, S.5
  • 165
    • 78349286289 scopus 로고    scopus 로고
    • Weak p53 permits senescence during cell cycle arrest
    • Leontieva O, Gudkov A, Blagosklonny M. Weak p53 permits senescence during cell cycle arrest. Cell Cycle. 2010; 9: 4323-4327.
    • (2010) Cell Cycle , vol.9 , pp. 4323-4327
    • Leontieva, O.1    Gudkov, A.2    Blagosklonny, M.3
  • 166
    • 79952691843 scopus 로고    scopus 로고
    • The p53 inducing drug dosage may determine quiescence or senescence
    • Lane DP, Verma C, Fang CC. The p53 inducing drug dosage may determine quiescence or senescence. Aging (Albany NY). 2010; 2: 748.
    • (2010) Aging (Albany NY) , vol.2 , pp. 748
    • Lane, D.P.1    Verma, C.2    Fang, C.C.3
  • 167
    • 79952116991 scopus 로고    scopus 로고
    • TP53 and MTOR crosstalk to regulate cellular senescence
    • Galluzzi L, Kepp O, Kroemer G. TP53 and MTOR crosstalk to regulate cellular senescence. Aging (Albany NY). 2010; 2: 535-537.
    • (2010) Aging (Albany NY) , vol.2 , pp. 535-537
    • Galluzzi, L.1    Kepp, O.2    Kroemer, G.3
  • 168
    • 77957004697 scopus 로고    scopus 로고
    • Another "Janus paradox" of p53: induction of cell senescence versus quiescence
    • Darzynkiewicz Z. Another "Janus paradox" of p53: induction of cell senescence versus quiescence. Aging (Albany NY). 2010; 2: 329-330.
    • (2010) Aging (Albany NY) , vol.2 , pp. 329-330
    • Darzynkiewicz, Z.1
  • 169
    • 78650826262 scopus 로고    scopus 로고
    • Linking Nek6 to p53-induced senescence
    • Yin MJ. Linking Nek6 to p53-induced senescence. Cell Cycle. 2011; 10: 18.
    • (2011) Cell Cycle , vol.10 , pp. 18
    • Yin, M.J.1
  • 170
    • 79958248002 scopus 로고    scopus 로고
    • Be quiet and you'll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?
    • Dulic V. Be quiet and you'll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence? Aging (Albany NY). 2011; 3: 3-4.
    • (2011) Aging (Albany NY) , vol.3 , pp. 3-4
    • Dulic, V.1
  • 171
    • 77957012074 scopus 로고    scopus 로고
    • Decision-making by p53 and mTOR
    • Maki CG. Decision-making by p53 and mTOR. Aging (Albany NY). 2010; 2: 324-326.
    • (2010) Aging (Albany NY) , vol.2 , pp. 324-326
    • Maki, C.G.1
  • 175
    • 33747588775 scopus 로고    scopus 로고
    • Mutations that increase the life span of C. elegans inhibit tumor growth
    • Pinkston JM, Garigan D, Hansen M, Kenyon C. Mutations that increase the life span of C. elegans inhibit tumor growth. Science. 2006; 313: 971-975.
    • (2006) Science. , vol.313 , pp. 971-975
    • Pinkston, J.M.1    Garigan, D.2    Hansen, M.3    Kenyon, C.4
  • 176
    • 78650093044 scopus 로고    scopus 로고
    • P53 and aging: A fresh look at an old paradigm
    • Poyurovsky MV, Prives C. P53 and aging: A fresh look at an old paradigm. Aging (Albany NY). 2010; 2: 380-382.
    • (2010) Aging (Albany NY) , vol.2 , pp. 380-382
    • Poyurovsky, M.V.1    Prives, C.2
  • 178
    • 40549146556 scopus 로고    scopus 로고
    • The common germline Arg72Pro polymorphism of p53 and increased longevity in humans
    • Bojesen SE, Nordestgaard BG. The common germline Arg72Pro polymorphism of p53 and increased longevity in humans. Cell Cycle. 2008; 7.
    • (2008) Cell Cycle , vol.7
    • Bojesen, S.E.1    Nordestgaard, B.G.2
  • 182
    • 79960454735 scopus 로고    scopus 로고
    • The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo
    • Kuribayashi K, Finnberg N, Jeffers JR, Zambetti GP, El-Deiry WS. The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo. Cell Cycle. 2011; 10: 2380-2389.
    • (2011) Cell Cycle , vol.10 , pp. 2380-2389
    • Kuribayashi, K.1    Finnberg, N.2    Jeffers, J.R.3    Zambetti, G.P.4    El-Deiry, W.S.5
  • 185
    • 84866017821 scopus 로고    scopus 로고
    • Strategies for p53 reactivation in human sarcoma
    • Hupp TR, Hayward RL, Vojtesek B. Strategies for p53 reactivation in human sarcoma. Cancer Cell. 2012; 22: 283-285.
    • (2012) Cancer Cell. , vol.22 , pp. 283-285
    • Hupp, T.R.1    Hayward, R.L.2    Vojtesek, B.3
  • 189
    • 84863011183 scopus 로고    scopus 로고
    • Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
    • Li L, Wang L, Wang Z, Ho Y, McDonald T, Holyoake TL, Chen W, Bhatia R. Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell. 2012; 21: 266-281.
    • (2012) Cancer Cell. , vol.21 , pp. 266-281
    • Li, L.1    Wang, L.2    Wang, Z.3    Ho, Y.4    McDonald, T.5    Holyoake, T.L.6    Chen, W.7    Bhatia, R.8
  • 190
    • 78650831721 scopus 로고    scopus 로고
    • Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma
    • Stegh AH, DePinho RA. Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma. Cell Cycle. 2011; 10: 33-38.
    • (2011) Cell Cycle , vol.10 , pp. 33-38
    • Stegh, A.H.1    DePinho, R.A.2
  • 191
    • 79551544267 scopus 로고    scopus 로고
    • PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo
    • Bao W, Chen M, Zhao X, Kumar R, Spinnler C, Thullberg M, Issaeva N, Selivanova G, Stromblad S. PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo. Cell Cycle. 2011; 10: 301-307.
    • (2011) Cell Cycle , vol.10 , pp. 301-307
    • Bao, W.1    Chen, M.2    Zhao, X.3    Kumar, R.4    Spinnler, C.5    Thullberg, M.6    Issaeva, N.7    Selivanova, G.8    Stromblad, S.9
  • 193
    • 84861973567 scopus 로고    scopus 로고
    • Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
    • Li T, Kon N, Jiang L, Tan M, Ludwig T, Zhao Y, Baer R, Gu W. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell. 2012; 149: 1269-1283.
    • (2012) Cell , vol.149 , pp. 1269-1283
    • Li, T.1    Kon, N.2    Jiang, L.3    Tan, M.4    Ludwig, T.5    Zhao, Y.6    Baer, R.7    Gu, W.8
  • 194
    • 84862127178 scopus 로고    scopus 로고
    • Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells
    • Davoli T, de Lange T. Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells. Cancer Cell. 2012; 21: 765-776.
    • (2012) Cancer Cell. , vol.21 , pp. 765-776
    • Davoli, T.1    de Lange, T.2
  • 195
    • 79958289721 scopus 로고    scopus 로고
    • HIF-1alpha antagonizes p53-mediated apoptosis by triggering HIPK2 degradation
    • Nardinocchi L, Puca R, D'Orazi G. HIF-1alpha antagonizes p53-mediated apoptosis by triggering HIPK2 degradation. Aging (Albany NY). 2011; 3: 33-43.
    • (2011) Aging (Albany NY) , vol.3 , pp. 33-43
    • Nardinocchi, L.1    Puca, R.2    D'Orazi, G.3
  • 196
    • 0035432151 scopus 로고    scopus 로고
    • Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy (review)
    • Blagosklonny MV. Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy (review). Int J Oncol. 2001; 19: 257-262.
    • (2001) Int J Oncol. , vol.19 , pp. 257-262
    • Blagosklonny, M.V.1
  • 197
    • 79956014865 scopus 로고    scopus 로고
    • The purpose of the HIF-1/PHD feedback loop: to limit mTOR-induced HIF-1alpha
    • Demidenko ZN, Blagosklonny MV. The purpose of the HIF-1/PHD feedback loop: to limit mTOR-induced HIF-1alpha. Cell Cycle. 2011; 10: 1557-1562.
    • (2011) Cell Cycle , vol.10 , pp. 1557-1562
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 198
    • 1642472018 scopus 로고    scopus 로고
    • Antiangiogenic therapy and tumor progression
    • Blagosklonny MV. Antiangiogenic therapy and tumor progression. Cancer Cell. 2004; 5: 13-17.
    • (2004) Cancer Cell. , vol.5 , pp. 13-17
    • Blagosklonny, M.V.1
  • 199
    • 60549092506 scopus 로고    scopus 로고
    • Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
    • Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci U S A. 2009; 106: 2353-2358.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , pp. 2353-2358
    • Lee, K.1    Qian, D.Z.2    Rey, S.3    Wei, H.4    Liu, J.O.5    Semenza, G.L.6
  • 200
    • 35048875691 scopus 로고    scopus 로고
    • Evaluation of HIF-1 inhibitors as anticancer agents
    • Semenza GL. Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov Today. 2007; 12: 853-859.
    • (2007) Drug Discov Today. , vol.12 , pp. 853-859
    • Semenza, G.L.1
  • 202
    • 72849115544 scopus 로고    scopus 로고
    • Development of HIF-1 inhibitors for cancer therapy
    • Onnis B, Rapisarda A, Melillo G. Development of HIF-1 inhibitors for cancer therapy. J Cell Mol Med. 2009; 13: 2780-2786.
    • (2009) J Cell Mol Med. , vol.13 , pp. 2780-2786
    • Onnis, B.1    Rapisarda, A.2    Melillo, G.3
  • 203
    • 0033997563 scopus 로고    scopus 로고
    • Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs
    • Blagosklonny MV, Robey R, Bates S, Fojo T. Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs. J Clin Invest. 2000; 105: 533-539.
    • (2000) J Clin Invest. , vol.105 , pp. 533-539
    • Blagosklonny, M.V.1    Robey, R.2    Bates, S.3    Fojo, T.4
  • 204
    • 79956022145 scopus 로고    scopus 로고
    • Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs
    • Puca R, Nardinocchi L, Porru M, Simon AJ, Rechavi G, Leonetti C, Givol D, D'Orazi G. Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs. Cell Cycle. 2011; 10: 1679-1689.
    • (2011) Cell Cycle , vol.10 , pp. 1679-1689
    • Puca, R.1    Nardinocchi, L.2    Porru, M.3    Simon, A.J.4    Rechavi, G.5    Leonetti, C.6    Givol, D.7    D'Orazi, G.8
  • 205
    • 16444380911 scopus 로고    scopus 로고
    • Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors
    • Carvajal D, Tovar C, Yang H, Vu BT, Heimbrook DC, Vassilev LT. Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors. Cancer Res. 2005; 65: 1918-1924.
    • (2005) Cancer Res. , vol.65 , pp. 1918-1924
    • Carvajal, D.1    Tovar, C.2    Yang, H.3    Vu, B.T.4    Heimbrook, D.C.5    Vassilev, L.T.6
  • 206
    • 69749128490 scopus 로고    scopus 로고
    • Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy
    • Choong ML, Yang H, Lee MA, Lane DP. Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy. Cell Cycle. 2009; 8: 2810-2818.
    • (2009) Cell Cycle , vol.8 , pp. 2810-2818
    • Choong, M.L.1    Yang, H.2    Lee, M.A.3    Lane, D.P.4
  • 207
    • 79960464440 scopus 로고    scopus 로고
    • Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture
    • Apontes P, Leontieva OV, Demidenko ZN, Li F, Blagosklonny MV. Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture. Oncotarget. 2011; 2: 222-233.
    • (2011) Oncotarget. , vol.2 , pp. 222-233
    • Apontes, P.1    Leontieva, O.V.2    Demidenko, Z.N.3    Li, F.4    Blagosklonny, M.V.5
  • 208
  • 209
    • 79960453735 scopus 로고    scopus 로고
    • Pharmacological manipulation of the cell cycle and metabolism to protect normal tissues against conventional anticancer drugs
    • van Leeuwen IM, Lain S. Pharmacological manipulation of the cell cycle and metabolism to protect normal tissues against conventional anticancer drugs. Oncotarget. 2011; 2: 274-276.
    • (2011) Oncotarget. , vol.2 , pp. 274-276
    • van Leeuwen, I.M.1    Lain, S.2
  • 210
  • 212
    • 84866485840 scopus 로고    scopus 로고
    • The p53 family grows old
    • Flores ER, Lozano G. The p53 family grows old. Genes Dev. 2012; 26: 1997-2000.
    • (2012) Genes Dev. , vol.26 , pp. 1997-2000
    • Flores, E.R.1    Lozano, G.2
  • 217
    • 79952271270 scopus 로고    scopus 로고
    • Phospho-DeltaNp63alpha/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells
    • Huang Y, Ratovitski EA. Phospho-DeltaNp63alpha/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells. Aging (Albany NY). 2010; 2: 959-968.
    • (2010) Aging (Albany NY) , vol.2 , pp. 959-968
    • Huang, Y.1    Ratovitski, E.A.2
  • 219
    • 80051789515 scopus 로고    scopus 로고
    • p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
    • Melino G. p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ. 2011; 18: 1487-1499.
    • (2011) Cell Death Differ. , vol.18 , pp. 1487-1499
    • Melino, G.1
  • 221
    • 84864380567 scopus 로고    scopus 로고
    • MiR-1246: a new link of the p53 family with cancer and Down syndrome
    • Liao JM, Zhou X, Zhang Y, Lu H. MiR-1246: a new link of the p53 family with cancer and Down syndrome. Cell Cycle. 2012; 11: 2624-2630.
    • (2012) Cell Cycle , vol.11 , pp. 2624-2630
    • Liao, J.M.1    Zhou, X.2    Zhang, Y.3    Lu, H.4
  • 222
    • 80052045437 scopus 로고    scopus 로고
    • A microRNA-dependent circuit controlling p63/p73 homeostasis: p53 family cross-talk meets therapeutic opportunity
    • Ory B, Ellisen LW. A microRNA-dependent circuit controlling p63/p73 homeostasis: p53 family cross-talk meets therapeutic opportunity. Oncotarget. 2011; 2: 259-264.
    • (2011) Oncotarget. , vol.2 , pp. 259-264
    • Ory, B.1    Ellisen, L.W.2
  • 223
    • 77953170345 scopus 로고    scopus 로고
    • p73 tumor suppressor protein: a close relative of p53 not only in structure but also in anti-cancer approach
    • Zawacka-Pankau J, Kostecka A, Sznarkowska A, Hedstrom E, Kawiak A. p73 tumor suppressor protein: a close relative of p53 not only in structure but also in anti-cancer approach? Cell Cycle. 2010; 9: 720-728.
    • (2010) Cell Cycle , vol.9 , pp. 720-728
    • Zawacka-Pankau, J.1    Kostecka, A.2    Sznarkowska, A.3    Hedstrom, E.4    Kawiak, A.5
  • 224
    • 84857709131 scopus 로고    scopus 로고
    • Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise
    • Soleimani R, Heytens E, Darzynkiewicz Z, Oktay K. Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise. Aging (Albany NY). 2011; 3: 782-793.
    • (2011) Aging (Albany NY) , vol.3 , pp. 782-793
    • Soleimani, R.1    Heytens, E.2    Darzynkiewicz, Z.3    Oktay, K.4
  • 225
    • 84863008665 scopus 로고    scopus 로고
    • TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death
    • Muppani N, Nyman U, Joseph B. TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death. Oncotarget. 2011; 2: 1145-1154.
    • (2011) Oncotarget. , vol.2 , pp. 1145-1154
    • Muppani, N.1    Nyman, U.2    Joseph, B.3
  • 226
    • 84865267943 scopus 로고    scopus 로고
    • A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma
    • D'Agostino L, Giordano A. A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma. Oncotarget. 2011; 2: 1055-1074.
    • (2011) Oncotarget. , vol.2 , pp. 1055-1074
    • D'Agostino, L.1    Giordano, A.2
  • 227
    • 79953645745 scopus 로고    scopus 로고
    • p73 as a pharmaceutical target for cancer therapy
    • Bisso A, Collavin L, Del Sal G. p73 as a pharmaceutical target for cancer therapy. Curr Pharm Des. 2011; 17: 578-590.
    • (2011) Curr Pharm Des. , vol.17 , pp. 578-590
    • Bisso, A.1    Collavin, L.2    Del Sal, G.3
  • 230
    • 53049094623 scopus 로고    scopus 로고
    • Therapeutic prospects for p73 and p63: rising from the shadow of p53
    • Vilgelm A, El-Rifai W, Zaika A. Therapeutic prospects for p73 and p63: rising from the shadow of p53. Drug Resist Updat. 2008; 11: 152-163.
    • (2008) Drug Resist Updat. , vol.11 , pp. 152-163
    • Vilgelm, A.1    El-Rifai, W.2    Zaika, A.3


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