-
1
-
-
12844281121
-
Analysis of FDA approved anticancer drugs reveals the future of cancer therapy
-
Blagosklonny MV. Analysis of FDA approved anticancer drugs reveals the future of cancer therapy. Cell Cycle. 2004; 3:1035-1042.
-
(2004)
Cell Cycle
, vol.3
, pp. 1035-1042
-
-
Blagosklonny, M.V.1
-
2
-
-
0036083301
-
Mechanism of action of antitumor drugs thatinteract with microtubules and tubulin
-
Jordan MA. Mechanism of action of antitumor drugs thatinteract with microtubules and tubulin. Curr Med Chem Anticancer Agents. 2002; 2:1-17.
-
(2002)
Curr Med Chem Anticancer Agents
, vol.2
, pp. 1-17
-
-
Jordan, M.A.1
-
3
-
-
33746471989
-
Novel agents that target tublin and related elements
-
Rowinsky EK, Calvo E. Novel agents that target tublin and related elements. Semin Oncol. 2006; 33:421-435.
-
(2006)
Semin Oncol
, vol.33
, pp. 421-435
-
-
Rowinsky, E.K.1
Calvo, E.2
-
4
-
-
58149347705
-
Microtubule active agents: beyond the taxane frontier
-
Morris PG, Fornier MN. Microtubule active agents: beyond the taxane frontier. Clin Cancer Res. 2008; 14:7167-7172.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7167-7172
-
-
Morris, P.G.1
Fornier, M.N.2
-
5
-
-
68849087436
-
Microtubule inhibitors: Differentiating tubulininhibiting agents based on mechanisms of action, clinical activity, and resistance
-
Perez EA. Microtubule inhibitors: Differentiating tubulininhibiting agents based on mechanisms of action, clinical activity, and resistance. Mol Cancer Ther. 2009; 8:2086-2095.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2086-2095
-
-
Perez, E.A.1
-
6
-
-
0025824979
-
Mechanism of inhibition of cell proliferation by Vinca alkaloids
-
Jordan MA, Thrower D, Wilson L. Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer Res. 1991; 51:2212-2222.
-
(1991)
Cancer Res
, vol.51
, pp. 2212-2222
-
-
Jordan, M.A.1
Thrower, D.2
Wilson, L.3
-
7
-
-
47949114405
-
Mechanism of G1-like arrest by low concentrations of paclitaxel: next cell cycle p53-dependent arrest with sub G1 DNA content mediated by prolonged mitosis
-
Demidenko ZN, Kalurupalle S, Hanko C, Lim CU, Broude E, Blagosklonny MV. Mechanism of G1-like arrest by low concentrations of paclitaxel: next cell cycle p53-dependent arrest with sub G1 DNA content mediated by prolonged mitosis. Oncogene. 2008; 27:4402-4410.
-
(2008)
Oncogene
, vol.27
, pp. 4402-4410
-
-
Demidenko, Z.N.1
Kalurupalle, S.2
Hanko, C.3
Lim, C.U.4
Broude, E.5
Blagosklonny, M.V.6
-
8
-
-
33846584645
-
Mitotic arrest and cell fate: why and how mitotic inhibition of transcription drives mutually exclusive events
-
Blagosklonny MV. Mitotic arrest and cell fate: why and how mitotic inhibition of transcription drives mutually exclusive events. Cell Cycle. 2007; 6:70-74.
-
(2007)
Cell Cycle
, vol.6
, pp. 70-74
-
-
Blagosklonny, M.V.1
-
9
-
-
67649362238
-
Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit
-
Bekier ME, Fischbach R, Lee J, Taylor WR. Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit. Mol Cancer Ther. 2009; 8:1646-1654.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1646-1654
-
-
Bekier, M.E.1
Fischbach, R.2
Lee, J.3
Taylor, W.R.4
-
11
-
-
0035359505
-
Exploiting cancer cell cycling for selective protection of normal cells
-
Blagosklonny MV, Pardee AB. Exploiting cancer cell cycling for selective protection of normal cells. Cancer Res. 2001; 61:4301-4305.
-
(2001)
Cancer Res
, vol.61
, pp. 4301-4305
-
-
Blagosklonny, M.V.1
Pardee, A.B.2
-
12
-
-
0347480457
-
Matching targets for selective cancer therapy
-
Blagosklonny MV. Matching targets for selective cancer therapy. Drug Discov Today. 2003; 8:1104-1107.
-
(2003)
Drug Discov Today
, vol.8
, pp. 1104-1107
-
-
Blagosklonny, M.V.1
-
13
-
-
45749117120
-
"Targeting the absence" and therapeutic engineering for cancer therapy
-
Blagosklonny MV. "Targeting the absence" and therapeutic engineering for cancer therapy. Cell Cycle. 2008; 7:1307-1312.
-
(2008)
Cell Cycle
, vol.7
, pp. 1307-1312
-
-
Blagosklonny, M.V.1
-
14
-
-
0033997563
-
Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs
-
Blagosklonny MV, Robey R, Bates S, Fojo T. Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs. J Clin Invest. 2000; 105:533-539.
-
(2000)
J Clin Invest
, vol.105
, pp. 533-539
-
-
Blagosklonny, M.V.1
Robey, R.2
Bates, S.3
Fojo, T.4
-
15
-
-
0037068773
-
Sequential activation and inactivation of G2 checkpoints for selective killing of p53-deficient cells by microtubule-active drugs
-
Blagosklonny MV. Sequential activation and inactivation of G2 checkpoints for selective killing of p53-deficient cells by microtubule-active drugs. Oncogene. 2002; 21:6249-6254.
-
(2002)
Oncogene
, vol.21
, pp. 6249-6254
-
-
Blagosklonny, M.V.1
-
16
-
-
69749128490
-
Specific activation of the p53 pathway by low dose actinomycin D: A new route to p53 based cyclotherapy
-
Choong ML, Yang H, Lee MA, Lane DP. Specific activation of the p53 pathway by low dose actinomycin D: A new route to p53 based cyclotherapy. Cell Cycle. 2009; 8:2810-8
-
(2009)
Cell Cycle
, vol.8
, pp. 2810-2818
-
-
Choong, M.L.1
Yang, H.2
Lee, M.A.3
Lane, D.P.4
-
17
-
-
79956035239
-
Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy
-
Rao B, van Leeuwen IMM, Higgins M, Campbel J, Thompson AM, Lane DP, Lain S, Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy. Oncotarget. 2010; 1:639-650.
-
(2010)
Oncotarget
, vol.1
, pp. 639-650
-
-
Rao, B.1
van Leeuwen, I.M.M.2
Higgins, M.3
Campbel, J.4
Thompson, A.M.5
Lane, D.P.6
Lain, S.7
-
18
-
-
4344610526
-
Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics
-
Vassilev LT. Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics. CellCycle. 2004; 3:419-421.
-
(2004)
CellCycle
, vol.3
, pp. 419-421
-
-
Vassilev, L.T.1
-
19
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004; 303:844-848.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
Fotouhi, N.11
Liu, E.A.12
-
20
-
-
62649112876
-
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
-
Sur S, Pagliarini R, Bunz F, Rago C, Diaz LA, Jr., Kinzler KW, Vogelstein B, Papadopoulos N. A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53. Proc Natl Acad Sci U S A. 2009; 106:3964-3969.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 3964-3969
-
-
Sur, S.1
Pagliarini, R.2
Bunz, F.3
Rago, C.4
Diaz Jr., L.A.5
Kinzler, K.W.6
Vogelstein, B.7
Papadopoulos, N.8
-
21
-
-
16444380911
-
Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors
-
Carvajal D, Tovar C, Yang H, Vu BT, Heimbrook DC, Vassilev LT. Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors. Cancer Res. 2005; 65:1918-1924.
-
(2005)
Cancer Res
, vol.65
, pp. 1918-1924
-
-
Carvajal, D.1
Tovar, C.2
Yang, H.3
Vu, B.T.4
Heimbrook, D.C.5
Vassilev, L.T.6
-
22
-
-
77955709042
-
Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53
-
Cheok CF, Kua N, Kaldis P, Lane DP. Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53. Cell Death Differ. 2010:1486-1500.
-
(2010)
Cell Death Differ
, pp. 1486-1500
-
-
Cheok, C.F.1
Kua, N.2
Kaldis, P.3
Lane, D.P.4
-
23
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004; 10:789-799.
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
24
-
-
25444482837
-
Mutated PI 3-kinases: cancer targets on a silver platter
-
Kang S, Bader AG, Zhao L, Vogt PK. Mutated PI 3-kinases: cancer targets on a silver platter. Cell Cycle. 2005; 4:578-581.
-
(2005)
Cell Cycle
, vol.4
, pp. 578-581
-
-
Kang, S.1
Bader, A.G.2
Zhao, L.3
Vogt, P.K.4
-
25
-
-
33745307617
-
Ras PI(3)K and mTOR signalling controls tumour cell growth
-
Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006; 441:424-430.
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
26
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell. 2007; 12:9-22.
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
27
-
-
1842832314
-
Four birds with one stone: RAPA as potential anticancer therapy
-
Blagosklonny MV, Darzynkiewicz Z. Four birds with one stone: RAPA as potential anticancer therapy. Cancer Biol Ther. 2002; 1:359-361.
-
(2002)
Cancer Biol Ther
, vol.1
, pp. 359-361
-
-
Blagosklonny, M.V.1
Darzynkiewicz, Z.2
-
28
-
-
46149107882
-
Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy
-
Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A. 2008; 105:8215-8220.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 8215-8220
-
-
Raffaghello, L.1
Lee, C.2
Safdie, F.M.3
Wei, M.4
Madia, F.5
Bianchi, G.6
Longo, V.D.7
-
29
-
-
78649882284
-
Fasting and differential chemotherapy protection in patients
-
Raffaghello L, Safdie F, Bianchi G, Dorff T, Fontana L, Longo VD. Fasting and differential chemotherapy protection in patients. Cell Cycle. 2010; 9:4474-4476.
-
(2010)
Cell Cycle
, vol.9
, pp. 4474-4476
-
-
Raffaghello, L.1
Safdie, F.2
Bianchi, G.3
Dorff, T.4
Fontana, L.5
Longo, V.D.6
-
30
-
-
76749169812
-
Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index
-
Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res. 2010; 70:1564-1572.
-
(2010)
Cancer Res
, vol.70
, pp. 1564-1572
-
-
Lee, C.1
Safdie, F.M.2
Raffaghello, L.3
Wei, M.4
Madia, F.5
Parrella, E.6
Hwang, D.7
Cohen, P.8
Bianchi, G.9
Longo, V.D.10
-
31
-
-
77953642929
-
Fasting and cancer treatment in humans: A case series report
-
Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo VD. Fasting and cancer treatment in humans: A case series report. Aging. 2009; 1:988-1007.
-
(2009)
Aging
, vol.1
, pp. 988-1007
-
-
Safdie, F.M.1
Dorff, T.2
Quinn, D.3
Fontana, L.4
Wei, M.5
Lee, C.6
Cohen, P.7
Longo, V.D.8
-
32
-
-
0035851205
-
Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
-
Tremblay F, Marette A. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem. 2001; 276:38052-38060.
-
(2001)
J Biol Chem
, vol.276
, pp. 38052-38060
-
-
Tremblay, F.1
Marette, A.2
-
33
-
-
24144446404
-
Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
-
Tremblay F, Krebs M, Dombrowski L, Brehm A, Bernroider E, Roth E, Nowotny P, Waldhšusl W, Marette A, Roden M. Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes. 2005; 54:2674-2684.
-
(2005)
Diabetes
, vol.54
, pp. 2674-2684
-
-
Tremblay, F.1
Krebs, M.2
Dombrowski, L.3
Brehm, A.4
Bernroider, E.5
Roth, E.6
Nowotny, P.7
Waldhšusl, W.8
Marette, A.9
Roden, M.10
-
34
-
-
22844438330
-
Tuberous sclerosis and insulin resistance Unlikely bedfellows reveal a TORrid affair
-
Shah OJ, Hunter T. Tuberous sclerosis and insulin resistance. Unlikely bedfellows reveal a TORrid affair. Cell Cycle. 2005; 4:46-51.
-
(2005)
Cell Cycle
, vol.4
, pp. 46-51
-
-
Shah, O.J.1
Hunter, T.2
-
35
-
-
14244256097
-
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance
-
Khamzina L, Veilleux A, Bergeron S, Marette A. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology. 2005; 146:1473-1481.
-
(2005)
Endocrinology
, vol.146
, pp. 1473-1481
-
-
Khamzina, L.1
Veilleux, A.2
Bergeron, S.3
Marette, A.4
-
36
-
-
33644886769
-
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptordependent mTOR-mediated insulin receptor substrate 1 phosphorylation
-
Tzatsos A, Kandror KV. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptordependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol. 2006; 26:63-76.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 63-76
-
-
Tzatsos, A.1
Kandror, K.V.2
-
37
-
-
34249679233
-
The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man
-
Krebs M, Brunmair B, Brehm A, Artwohl M, Szendroedi J, Nowotny P, Roth E, Fÿrnsinn C, Promintzer M, Anderwald C, Bischof M, Roden M. The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man. Diabetes. 2007; 56:1600-1607.
-
(2007)
Diabetes
, vol.56
, pp. 1600-1607
-
-
Krebs, M.1
Brunmair, B.2
Brehm, A.3
Artwohl, M.4
Szendroedi, J.5
Nowotny, P.6
Roth, E.7
Fÿrnsinn, C.8
Promintzer, M.9
Anderwald, C.10
Bischof, M.11
Roden, M.12
-
38
-
-
60549102941
-
Insulin-lowering effects of metformin in women with early breast cancer
-
Goodwin PJ, Pritchard KI, Ennis M, Clemons M, Graham M, Fantus IG. Insulin-lowering effects of metformin in women with early breast cancer. Clin Breast Cancer. 2008; 8:501-505.
-
(2008)
Clin Breast Cancer
, vol.8
, pp. 501-505
-
-
Goodwin, P.J.1
Pritchard, K.I.2
Ennis, M.3
Clemons, M.4
Graham, M.5
Fantus, I.G.6
-
39
-
-
77956312069
-
Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond
-
Berstein LM. Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond. Future Oncol. 2010; 6:1313-1323.
-
(2010)
Future Oncol
, vol.6
, pp. 1313-1323
-
-
Berstein, L.M.1
-
40
-
-
67650088379
-
Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia
-
Erdemoglu E, Guney M, Giray SG, Take G, Mungan T. Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia. Eur J Obstet Gynecol Reprod Biol. 2009; 145:195-199.
-
(2009)
Eur J Obstet Gynecol Reprod Biol
, vol.145
, pp. 195-199
-
-
Erdemoglu, E.1
Guney, M.2
Giray, S.G.3
Take, G.4
Mungan, T.5
-
41
-
-
36348950449
-
Metformin inhibits mammalian target of rapamycindependent translation initiation in breast cancer cells
-
Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N. Metformin inhibits mammalian target of rapamycindependent translation initiation in breast cancer cells. Cancer Res. 2007; 67:10804-10812.
-
(2007)
Cancer Res
, vol.67
, pp. 10804-10812
-
-
Dowling, R.J.1
Zakikhani, M.2
Fantus, I.G.3
Pollak, M.4
Sonenberg, N.5
-
42
-
-
60749108023
-
The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells
-
Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells. Cell Cycle. 2009; 8:88-96.
-
(2009)
Cell Cycle
, vol.8
, pp. 88-96
-
-
Vazquez-Martin, A.1
Oliveras-Ferraros, C.2
Menendez, J.A.3
-
43
-
-
70450021431
-
mTOR inhibitors and the anti-diabetic biguanide metformin: new insights into the molecular management of breast cancer resistance to the HER2 tyrosine kinase inhibitor lapatinib (Tykerb)
-
Vazquez-Martin A, Oliveras-Ferraros C, del Barco S, Martin-Castillo B, Menendez JA. mTOR inhibitors and the anti-diabetic biguanide metformin: new insights into the molecular management of breast cancer resistance to the HER2 tyrosine kinase inhibitor lapatinib (Tykerb). Clin Transl Oncol. 2009; 11:455-459.
-
(2009)
Clin Transl Oncol
, vol.11
, pp. 455-459
-
-
Vazquez-Martin, A.1
Oliveras-Ferraros, C.2
del Barco, S.3
Martin-Castillo, B.4
Menendez, J.A.5
-
44
-
-
65949091346
-
Targeting mTOR in renal cell carcinoma
-
Hudes GR. Targeting mTOR in renal cell carcinoma. Cancer. 2009; 115:2313-2320.
-
(2009)
Cancer
, vol.115
, pp. 2313-2320
-
-
Hudes, G.R.1
-
45
-
-
78349261103
-
Targeting TOR dependence in cancer
-
Janes MR, Fruman DA. Targeting TOR dependence in cancer. Oncotarget. 2010; 1:69-76.
-
(2010)
Oncotarget
, vol.1
, pp. 69-76
-
-
Janes, M.R.1
Fruman, D.A.2
-
46
-
-
34447124424
-
Combined therapeutic effects of vinblastine and rapamycin on human neuroblastoma growth, apoptosis, and angiogenesis
-
Marimpietri D, Brignole C, Nico B, Pastorino F, Pezzolo A, Piccardi F, Cilli M, Di Paolo D, Pagnan G, Longo L, Perri P, Ribatti D, Ponzoni M. Combined therapeutic effects of vinblastine and rapamycin on human neuroblastoma growth, apoptosis, and angiogenesis. Clin Cancer Res.2007; 13:3977-3988.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3977-3988
-
-
Marimpietri, D.1
Brignole, C.2
Nico, B.3
Pastorino, F.4
Pezzolo, A.5
Piccardi, F.6
Cilli, M.7
Di Paolo, D.8
Pagnan, G.9
Longo, L.10
Perri, P.11
Ribatti, D.12
Ponzoni, M.13
-
47
-
-
77956848562
-
Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer
-
Ramalingam SS, Harvey RD, Saba N, Owonikoko TK, Kauh J, Shin DM, Sun SY, Strychor S, Tighiouart M, Egorin MJ, Fu H, Khuri FR. Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer. Cancer. 2010; 116:3903-3909.
-
(2010)
Cancer
, vol.116
, pp. 3903-3909
-
-
Ramalingam, S.S.1
Harvey, R.D.2
Saba, N.3
Owonikoko, T.K.4
Kauh, J.5
Shin, D.M.6
Sun, S.Y.7
Strychor, S.8
Tighiouart, M.9
Egorin, M.J.10
Fu, H.11
Khuri, F.R.12
-
48
-
-
78650984926
-
Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab
-
Andre F, Campone M, O'Regan R, Manlius C, Massacesi C, Sahmoud T, Mukhopadhyay P, Soria JC, Naughton M, Hurvitz SA. Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab. J Clin Oncol. 28:5110-5115.
-
J Clin Oncol
, vol.28
, pp. 5110-5115
-
-
Andre, F.1
Campone, M.2
O'Regan, R.3
Manlius, C.4
Massacesi, C.5
Sahmoud, T.6
Mukhopadhyay, P.7
Soria, J.C.8
Naughton, M.9
Hurvitz, S.A.10
-
49
-
-
78049513393
-
Phase IB study of the mTOR inhibitor ridaforolimus with capecitabine
-
Perotti A, Locatelli A, Sessa C, Hess D, Vigano L, Capri G, Maur M, Cerny T, Cresta S, Rojo F, Albanell J, Marsoni S, Corradino I, Berk L, Rivera VM, Haluska F et al. Phase IB study of the mTOR inhibitor ridaforolimus with capecitabine. J Clin Oncol. 28:4554-4561.
-
J Clin Oncol
, vol.28
, pp. 4554-4561
-
-
Perotti, A.1
Locatelli, A.2
Sessa, C.3
Hess, D.4
Vigano, L.5
Capri, G.6
Maur, M.7
Cerny, T.8
Cresta, S.9
Rojo, F.10
Albanell, J.11
Marsoni, S.12
Corradino, I.13
Berk, L.14
Rivera, V.M.15
Haluska, F.16
-
50
-
-
73849119080
-
Phase Ib study of weekly mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) with weekly paclitaxel
-
Sessa C, Tosi D, Vigano L, Albanell J, Hess D, Maur M, Cresta S, Locatelli A, Angst R, Rojo F, Coceani N, Rivera VM, Berk L, Haluska F, Gianni L. Phase Ib study of weekly mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) with weekly paclitaxel. Ann Oncol. 21:1315-1322.
-
Ann Oncol
, vol.21
, pp. 1315-1322
-
-
Sessa, C.1
Tosi, D.2
Vigano, L.3
Albanell, J.4
Hess, D.5
Maur, M.6
Cresta, S.7
Locatelli, A.8
Angst, R.9
Rojo, F.10
Coceani, N.11
Rivera, V.M.12
Berk, L.13
Haluska, F.14
Gianni, L.15
-
51
-
-
0035963277
-
Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity
-
Giannakakou P, Robey R, Fojo T, Blagosklonny MV. Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity. Oncogene. 2001; 20:3806-3813.
-
(2001)
Oncogene
, vol.20
, pp. 3806-3813
-
-
Giannakakou, P.1
Robey, R.2
Fojo, T.3
Blagosklonny, M.V.4
-
52
-
-
33646437275
-
Prolonged mitosis versus tetraploid checkpoint: how p53 measures the duration of mitosis
-
Blagosklonny MV. Prolonged mitosis versus tetraploid checkpoint: how p53 measures the duration of mitosis. Cell Cycle. 2006; 5:971-975.
-
(2006)
Cell Cycle
, vol.5
, pp. 971-975
-
-
Blagosklonny, M.V.1
-
53
-
-
78349286289
-
Weak p53 permits senescence during cell cycle arrest
-
Leontieva O, Gudkov A, Blagosklonny M. Weak p53 permits senescence during cell cycle arrest. Cell Cycle. 2010; 9:4323-4327.
-
(2010)
Cell Cycle
, vol.9
, pp. 4323-4327
-
-
Leontieva, O.1
Gudkov, A.2
Blagosklonny, M.3
-
54
-
-
77955747085
-
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
-
Korotchkina LG, Leontieva OV, Bukreeva EI, Demidenko ZN, Gudkov AV, Blagosklonny MV. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging (Albany NY). 2010; 2:344-352.
-
(2010)
Aging (Albany NY)
, vol.2
, pp. 344-352
-
-
Korotchkina, L.G.1
Leontieva, O.V.2
Bukreeva, E.I.3
Demidenko, Z.N.4
Gudkov, A.V.5
Blagosklonny, M.V.6
-
55
-
-
0012177733
-
Cyclotherapy: Protection of normal cells and unshielding of cancer cells
-
Blagosklonny MV, Darzynkiewicz Z. Cyclotherapy: Protection of normal cells and unshielding of cancer cells. Cell Cycle. 2002; 1:375-382.
-
(2002)
Cell Cycle
, vol.1
, pp. 375-382
-
-
Blagosklonny, M.V.1
Darzynkiewicz, Z.2
-
56
-
-
70450270900
-
Awakening guardian angels: drugging the p53 pathway
-
Brown CJ, Lain S, Verma CS, Fersht AR, Lane DP. Awakening guardian angels: drugging the p53 pathway. Nat Rev Cancer. 2009; 9:862-873.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 862-873
-
-
Brown, C.J.1
Lain, S.2
Verma, C.S.3
Fersht, A.R.4
Lane, D.P.5
-
58
-
-
70349492724
-
Pharmacologic p53 Activation Blocks Cell Cycle Progression but Fails to Induce Senescence in Epithelial Cancer Cells
-
Huang B, Deo D, Xia M, Vassilev LT. Pharmacologic p53 Activation Blocks Cell Cycle Progression but Fails to Induce Senescence in Epithelial Cancer Cells. Mol Cancer Res. 2009; 7:1497-1509.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1497-1509
-
-
Huang, B.1
Deo, D.2
Xia, M.3
Vassilev, L.T.4
-
60
-
-
34547625742
-
Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin
-
Efeyan A, Ortega-Molina A, Velasco-Miguel S, Herranz D, Vassilev LT, Serrano M. Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin. Cancer Res. 2007; 67:7350-7357.
-
(2007)
Cancer Res
, vol.67
, pp. 7350-7357
-
-
Efeyan, A.1
Ortega-Molina, A.2
Velasco-Miguel, S.3
Herranz, D.4
Vassilev, L.T.5
Serrano, M.6
-
61
-
-
53849118108
-
Metformin attenuates the stimulatory effect of a highenergy diet on in vivo LLC1 carcinoma growth
-
Algire C, Zakikhani M, Blouin MJ, Shuai JH, Pollak M. Metformin attenuates the stimulatory effect of a highenergy diet on in vivo LLC1 carcinoma growth. Endocr Relat Cancer. 2008; 15:833-839.
-
(2008)
Endocr Relat Cancer
, vol.15
, pp. 833-839
-
-
Algire, C.1
Zakikhani, M.2
Blouin, M.J.3
Shuai, J.H.4
Pollak, M.5
-
62
-
-
77953589054
-
Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase
-
Algire C, Amrein L, Zakikhani M, Panasci L, Pollak M. Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase. Endocr Relat Cancer. 2010; 17:351-360.
-
(2010)
Endocr Relat Cancer
, vol.17
, pp. 351-360
-
-
Algire, C.1
Amrein, L.2
Zakikhani, M.3
Panasci, L.4
Pollak, M.5
-
63
-
-
77955770568
-
Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
-
Zakikhani M, Blouin MJ, Piura E, Pollak MN. Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. Breast Cancer Res Treat. 2010; 123:271-279.
-
(2010)
Breast Cancer Res Treat
, vol.123
, pp. 271-279
-
-
Zakikhani, M.1
Blouin, M.J.2
Piura, E.3
Pollak, M.N.4
-
65
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A. 2004; 101:3329-3335.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
Cantley, L.C.7
-
66
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer. 2004; 4:891-899.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
67
-
-
52649107626
-
Cancer cell metabolism: Warburg and beyond
-
Hsu PP, Sabatini DM. Cancer cell metabolism: Warburg and beyond. Cell. 2008; 134:703-707.
-
(2008)
Cell
, vol.134
, pp. 703-707
-
-
Hsu, P.P.1
Sabatini, D.M.2
-
68
-
-
66949122181
-
Cancer's craving for sugar: an opportunity for clinical exploitation
-
Yeluri S, Madhok B, Prasad KR, Quirke P, Jayne DG. Cancer's craving for sugar: an opportunity for clinical exploitation. J Cancer Res Clin Oncol. 2009; 135:867-877.
-
(2009)
J Cancer Res Clin Oncol
, vol.135
, pp. 867-877
-
-
Yeluri, S.1
Madhok, B.2
Prasad, K.R.3
Quirke, P.4
Jayne, D.G.5
-
69
-
-
44849137874
-
Sugar and fat - that's where it's at: metabolic changes in tumors
-
Young CD, Anderson SM. Sugar and fat - that's where it's at: metabolic changes in tumors. Breast Cancer Res. 2008; 10:202.
-
(2008)
Breast Cancer Res
, vol.10
, pp. 202
-
-
Young, C.D.1
Anderson, S.M.2
-
71
-
-
33749478922
-
Cancer's molecular sweet tooth and the Warburg effect
-
Kim JW, Dang CV. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res. 2006; 66:8927-8930.
-
(2006)
Cancer Res
, vol.66
, pp. 8927-8930
-
-
Kim, J.W.1
Dang, C.V.2
-
72
-
-
33744826296
-
Cancer's sweet tooth
-
Bui T, Thompson CB. Cancer's sweet tooth. Cancer Cell. 2006; 9:419-420.
-
(2006)
Cancer Cell
, vol.9
, pp. 419-420
-
-
Bui, T.1
Thompson, C.B.2
-
73
-
-
34547114031
-
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
-
Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res. 2007; 67:6745-6752.
-
(2007)
Cancer Res
, vol.67
, pp. 6745-6752
-
-
Buzzai, M.1
Jones, R.G.2
Amaravadi, R.K.3
Lum, J.J.4
DeBerardinis, R.J.5
Zhao, F.6
Viollet, B.7
Thompson, C.B.8
-
74
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell. 2005; 18:283-293.
-
(2005)
Mol Cell
, vol.18
, pp. 283-293
-
-
Jones, R.G.1
Plas, D.R.2
Kubek, S.3
Buzzai, M.4
Mu, J.5
Xu, Y.6
Birnbaum, M.J.7
Thompson, C.B.8
-
75
-
-
70449698491
-
Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature
-
Dell'Aglio DM, Perino LJ, Kazzi Z, Abramson J, Schwartz MD, Morgan BW. Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature. Ann Emerg Med. 2009; 54:818-823.
-
(2009)
Ann Emerg Med
, vol.54
, pp. 818-823
-
-
Dell'Aglio, D.M.1
Perino, L.J.2
Kazzi, Z.3
Abramson, J.4
Schwartz, M.D.5
Morgan, B.W.6
-
76
-
-
0034870203
-
Clinical pharmacokinetics of sirolimus
-
Mahalati K, Kahan BD. Clinical pharmacokinetics of sirolimus. Clin Pharmacokinet. 2001; 40:573-585.
-
(2001)
Clin Pharmacokinet
, vol.40
, pp. 573-585
-
-
Mahalati, K.1
Kahan, B.D.2
-
77
-
-
27444444778
-
Role of oral rapamycin to prevent restenosis in patients with de novo lesions undergoing coronary stenting: results of the Argentina single centre study (ORAR trial)
-
Rodriguez AE, Rodriguez Alemparte M, Vigo CF, Fernandez Pereira C, Llaurado C, Vetcher D, Pocovi A, Ambrose J. Role of oral rapamycin to prevent restenosis in patients with de novo lesions undergoing coronary stenting: results of the Argentina single centre study (ORAR trial). Heart. 2005; 91:1433-1437.
-
(2005)
Heart
, vol.91
, pp. 1433-1437
-
-
Rodriguez, A.E.1
Rodriguez Alemparte, M.2
Vigo, C.F.3
Fernandez Pereira, C.4
Llaurado, C.5
Vetcher, D.6
Pocovi, A.7
Ambrose, J.8
-
78
-
-
38849208347
-
Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma
-
Cloughesy TF, Yoshimoto K, Nghiemphu P, Brown K, Dang J, Zhu S, Hsueh T, Chen Y, Wang W, Youngkin D, Liau L, Martin N, Becker D, Bergsneider M, Lai A, Green R et al. Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med. 2008; 5:e8.
-
(2008)
PLoS Med
, vol.5
-
-
Cloughesy, T.F.1
Yoshimoto, K.2
Nghiemphu, P.3
Brown, K.4
Dang, J.5
Zhu, S.6
Hsueh, T.7
Chen, Y.8
Wang, W.9
Youngkin, D.10
Liau, L.11
Martin, N.12
Becker, D.13
Bergsneider, M.14
Lai, A.15
Green, R.16
-
79
-
-
70350569949
-
Evaluation of in vivo antineoplastic effects of rapamycin in patients with chemotherapy-refractory AML
-
Boehm A, Mayerhofer M, Herndlhofer S, Knoebl P, Sillaber C, Sperr WR, Jaeger U, Valent P. Evaluation of in vivo antineoplastic effects of rapamycin in patients with chemotherapy-refractory AML. Eur J Intern Med. 2009; 20:775-778.
-
(2009)
Eur J Intern Med
, vol.20
, pp. 775-778
-
-
Boehm, A.1
Mayerhofer, M.2
Herndlhofer, S.3
Knoebl, P.4
Sillaber, C.5
Sperr, W.R.6
Jaeger, U.7
Valent, P.8
-
80
-
-
77953100029
-
A pharmacodynamic study of rapamycin in men with intermediate- to high-risk localized prostate cancer
-
Armstrong AJ, Netto GJ, Rudek MA, Halabi S, Wood DP, Creel PA, Mundy K, Davis SL, Wang T, Albadine R, Schultz L, Partin AW, Jimeno A, Fedor H, Febbo PG, George DJ et al. A pharmacodynamic study of rapamycin in men with intermediate- to high-risk localized prostate cancer. Clin Cancer Res. 2010; 16:3057-3066.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3057-3066
-
-
Armstrong, A.J.1
Netto, G.J.2
Rudek, M.A.3
Halabi, S.4
Wood, D.P.5
Creel, P.A.6
Mundy, K.7
Davis, S.L.8
Wang, T.9
Albadine, R.10
Schultz, L.11
Partin, A.W.12
Jimeno, A.13
Fedor, H.14
Febbo, P.G.15
George, D.J.16
-
81
-
-
50549087736
-
Growth stimulation leads to cellular senescence when the cell cycle is blocked
-
Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle. 2008; 7:3355-3361.
-
(2008)
Cell Cycle
, vol.7
, pp. 3355-3361
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
|