Resveratrol-activated SIRT1 in liver and pancreatic ß-cells: A Janus head looking to the same direction of metabolic homeostasis

Aging

Volumn 3, Issue 4, 2011, Pages 444-449

  Vetterli, Laurène ^a   Maechler, Pierre ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Glucose homeostasis; Insulin secretion; Liver; Pancreatic beta cell; Resveratrol; SIRT1

Indexed keywords

ADENYLATE KINASE; ANTIOXIDANT; GLUCOSE; INSULIN; RESVERATROL; SIRTUIN 1; STILBENE DERIVATIVE; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; CYTOLOGY; DRUG EFFECT; ENERGY METABOLISM; ENZYME ACTIVATION; HOMEOSTASIS; LIVER; METABOLISM; PANCREAS ISLET BETA CELL;

ADENYLATE KINASE; ANIMALS; ANTIOXIDANTS; ENERGY METABOLISM; ENZYME ACTIVATION; GLUCOSE; HOMEOSTASIS; INSULIN; INSULIN-SECRETING CELLS; LIVER; SIRTUIN 1; STILBENES; TRANSCRIPTION FACTORS;

EID: 80052083866     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100304     Document Type: Article

References (37)

1. Kaeberlein M, McVey M Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 1999; 13: 2570-2580
2. Tissenbaum HA Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature. 2001; 410: 227-230.
3. Rogina B Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A. 2004; 101: 15998-16003.
4. Frye RA. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun. 1999; 260: 273-279.
5. Frye RA. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun. 2000; 273: 793-798.
6. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003; 425: 191-196.
7. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006; 127: 1109-1122.
8. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, et al. Resveratrol improves health and survival of mice on a highcalorie diet. Nature. 2006; 444: 337-342.
9. Su HC, Hung LM Chen JK. Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats. Am J Physiol Endocrinol Metab. 2006; 290: E1339- 1346.
10. Chi TC, Chen WP, Chi TL, Kuo TF, Lee SS, et al. Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats. Life Sci. 2007; 80: 1713- 1720.
11. Maechler P, Li N, Casimir M, Vetterli L, Frigerio F, et al. Role of mitochondria in beta-cell function and dysfunction. Adv Exp Med Biol. 2010; 654: 193-216.
12. Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, et al. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab. 2005; 2: 105-117.
13. Bordone L, Motta MC, Picard F, Robinson A, Jhala US, et al. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 2006; 4: e31.
14. Vetterli L, Brun T, Giovannoni L, Bosco D Maechler P. Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E {beta}-Cells and Human Islets through a SIRT1-dependent Mechanism. J Biol Chem. 2011; 286: 6049-6060.
15. Hambrock A, de Oliveira Franz CB, Hiller S, Grenz A, Ackermann S, et al. Resveratrol binds to the sulfonylurea receptor (SUR) and induces apoptosis in a SUR subtype-specific manner. J Biol Chem. 2007; 282: 3347-3356.
16. Boj SF, Parrizas M, Maestro MA Ferrer J. A transcription factor regulatory circuit in differentiated pancreatic cells. Proc Natl Acad Sci U S A. 2001; 98: 14481-14486.
17. Waeber G, Thompson N, Nicod P Bonny C. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol. 1996; 10: 1327-1334.
18. Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, et al. Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes. 2006; 55: 2180-2191.
19. Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, et al. SIRT1 regulates hepatocyte lipid metabolism through activating AMPactivated protein kinase. J Biol Chem. 2008; 283: 20015-20026.
20. Dasgupta B Milbrandt J. Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci U S A. 2007; 104: 7217- 7222.
21. Chan AY, Dolinsky VW, Soltys CL, Viollet B, Baksh S, et al. Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt. J Biol Chem. 2008; 283: 24194-24201.
22. Canto C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009; 458: 1056-1060.
23. Canto C, Jiang LQ, Deshmukh AS, Mataki C, Coste A, et al. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab. 2010; 11: 213-219.
24. Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, et al. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell. 2008; 14: 661-673.
25. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004; 305: 390-392.
26. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, et al. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005; 434: 113-118.
27. Ganjam GK, Dimova EY, Unterman TG Kietzmann T. FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol. J Biol Chem. 2009; 284: 30783-30797.
28. Qiang L, Banks AS Accili D. Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization. J Biol Chem. 2010; 285: 27396-27401.
29. Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC- 1alpha interaction. Nature. 2003; 423: 550-555.
30. Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, et al. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci U S A. 2003; 100: 4012-4017.
31. Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, et al. FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab. 2005; 2: 153-163.
32. Harbeck MC, Louie DC, Howland J, Wolf BA Rothenberg PL. Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells. Diabetes. 1996; 45: 711-717.
33. Hennige AM, Ranta F, Heinzelmann I, Dufer M, Michael D, et al. Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction. Diabetes. 2010; 59: 119- 127.
34. Nakae J, Biggs WH, 3rd, Kitamura T, Cavenee WK, Wright CV, et al. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet. 2002; 32: 245-253.
35. Nakae J, Park BC Accili D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem. 1999; 274: 15982-15985.
36. Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, et al. Suppression of beta cell energy metabolism and insulin release by PGC- 1alpha. Dev Cell. 2003; 5: 73-83.
37. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 2001; 413: 131-138.