Spatial coupling of mTOR and autophagy augments secretory phenotypes

Science

Volumn 332, Issue 6032, 2011, Pages 966-970

  Narita, Masako ^a   Young, Andrew R J ^a   Arakawa, Satoko ^b   Samarajiwa, Shamith A ^a,c   Nakashima, Takayuki ^a,e   Yoshida, Sei ^d   Hong, Sungki ^d   Berry, Lorraine S ^a   Reichelt, Stefanie ^a   Ferreira, Manuela ^a,f   Tavaré, Simon ^a,c   Inoki, Ken ^d   Shimizu, Shigeomi ^b   Narita, Masashi ^a  

^a CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF MICHIGAN   (United States)

^e KYOWA HAKKO KOGYO CO LTD   (Japan)

^f INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; INTERLEUKIN 6; INTERLEUKIN 8; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MAMMALIAN TARGET OF RAPAMYCIN; PEPSTATIN; RAS PROTEIN; SECRETORY PROTEIN;

DRUG; MAMMAL; PHENOTYPE; PROTEIN; PROTEROZOIC; SECRETION; SENESCENCE;

AMINO ACID ANALYSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; BIOACCUMULATION; CELL COMPARTMENTALIZATION; CELL PROLIFERATION; CYTOKINE PRODUCTION; ELECTRON MICROSCOPY; FLUORESCENCE ANALYSIS; GOLGI COMPLEX; IMMUNOFLUORESCENCE; INTRACELLULAR SPACE; MACROPHAGE; PHENOTYPE; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; ROUGH ENDOPLASMIC RETICULUM; SENESCENCE; TOR AUTOPHAGY SPATIAL COUPLING COMPARTMENT; TRANS GOLGI NETWORK;

AMINO ACIDS; ANIMALS; AUTOPHAGY; CELL AGING; CELL LINE; CYTOPLASM; CYTOPLASMIC VESICLES; ENDOPLASMIC RETICULUM, ROUGH; GENES, RAS; GOLGI APPARATUS; HL-60 CELLS; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; LYSOSOMES; MICE; MONOMERIC GTP-BINDING PROTEINS; NOCODAZOLE; PHAGOSOMES; PHENOTYPE; PODOCYTES; PROTEIN BIOSYNTHESIS; PROTEINS; TOR SERINE-THREONINE KINASES; TRANS-GOLGI NETWORK; VACUOLES;

MAMMALIA;

EID: 79956325949     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1205407     Document Type: Article

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