메뉴 건너뛰기




Volumn 2, Issue 12, 2011, Pages 1203-1217

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

Author keywords

Invasion; Mutant p53; P63; Secretome

Indexed keywords

PROTEIN P53; TP53 PROTEIN, HUMAN; TP63 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSCRIPTOME; TUMOR SUPPRESSOR PROTEIN;

EID: 84862864843     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.382     Document Type: Article
Times cited : (98)

References (45)
  • 1
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • Lane DP. Cancer. p53, guardian of the genome. Nature. 1992; 358:15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 2
    • 33144464295 scopus 로고    scopus 로고
    • Regulation of the p53 transcriptional activity
    • Liu G, Chen X. Regulation of the p53 transcriptional activity. J Cell Biochem. 2006; 97:448-458.
    • (2006) J Cell Biochem , vol.97 , pp. 448-458
    • Liu, G.1    Chen, X.2
  • 7
    • 30544452870 scopus 로고    scopus 로고
    • Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression
    • Bossi G, Lapi E, Strano S, Rinaldo C, Blandino G, Sacchi A. Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression. Oncogene. 2006; 25:304-309.
    • (2006) Oncogene , vol.25 , pp. 304-309
    • Bossi, G.1    Lapi, E.2    Strano, S.3    Rinaldo, C.4    Blandino, G.5    Sacchi, A.6
  • 9
    • 0034671945 scopus 로고    scopus 로고
    • Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome
    • Sigal A, Rotter V. Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. Cancer Res. 2000; 60:6788-6793.
    • (2000) Cancer Res , vol.60 , pp. 6788-6793
    • Sigal, A.1    Rotter, V.2
  • 12
    • 0033552948 scopus 로고    scopus 로고
    • Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy
    • Blandino G, Levine AJ, Oren M. Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene. 1999; 18:477-485.
    • (1999) Oncogene , vol.18 , pp. 477-485
    • Blandino, G.1    Levine, A.J.2    Oren, M.3
  • 13
    • 34247329362 scopus 로고    scopus 로고
    • p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
    • Song H, Hollstein M, Xu Y. p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol. 2007; 9:573-580.
    • (2007) Nat Cell Biol , vol.9 , pp. 573-580
    • Song, H.1    Hollstein, M.2    Xu, Y.3
  • 14
    • 44849106090 scopus 로고    scopus 로고
    • Induction of genetic instability by gain-of-function p53 cancer mutants
    • Xu Y. Induction of genetic instability by gain-of-function p53 cancer mutants. Oncogene. 2008; 27:3501-3507.
    • (2008) Oncogene , vol.27 , pp. 3501-3507
    • Xu, Y.1
  • 16
    • 80051789515 scopus 로고    scopus 로고
    • p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
    • Melino G. p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ. 2011.
    • (2011) Cell Death Differ
    • Melino, G.1
  • 22
    • 0042132030 scopus 로고    scopus 로고
    • Silencing of the Novel p53 Target Gene Snk/Plk2 Leads to Mitotic Catastrophe in Paclitaxel (Taxol)-Exposed Cells
    • Burns TF, Fei P, Scata KA, Dicker DT, El-Deiry WS. Silencing of the Novel p53 Target Gene Snk/Plk2 Leads to Mitotic Catastrophe in Paclitaxel (Taxol)-Exposed Cells. Mol Cell Biol. 2003; 23:5556-5571.
    • (2003) Mol Cell Biol , vol.23 , pp. 5556-5571
    • Burns, T.F.1    Fei, P.2    Scata, K.A.3    Dicker, D.T.4    El-Deiry, W.S.5
  • 23
    • 0034732151 scopus 로고    scopus 로고
    • Dickkopf-1 an inhibitor of the Wnt signaling pathway, is induced by p53
    • Wang J, Shou J, Chen X. Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53. Oncogene. 2000; 19:1843-1848.
    • (2000) Oncogene , vol.19 , pp. 1843-1848
    • Wang, J.1    Shou, J.2    Chen, X.3
  • 29
    • 44049092395 scopus 로고    scopus 로고
    • The dark side of a tumor suppressor: anti-apoptotic p53
    • Janicke RU, Sohn D, Schulze-Osthoff K. The dark side of a tumor suppressor: anti-apoptotic p53. Cell Death Differ. 2008; 15:959-976.
    • (2008) Cell Death Differ , vol.15 , pp. 959-976
    • Janicke, R.U.1    Sohn, D.2    Schulze-Osthoff, K.3
  • 30
    • 33748211158 scopus 로고    scopus 로고
    • Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
    • Di Agostino S, Strano S, Emiliozzi V, Zerbini V, Mottolese M, Sacchi A, Blandino G, Piaggio G. Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. Cancer Cell. 2006; 10:191-202.
    • (2006) Cancer Cell , vol.10 , pp. 191-202
    • Di Agostino, S.1    Strano, S.2    Emiliozzi, V.3    Zerbini, V.4    Mottolese, M.5    Sacchi, A.6    Blandino, G.7    Piaggio, G.8
  • 32
    • 33847057887 scopus 로고    scopus 로고
    • Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells
    • Yang A, Zhu Z, Kapranov P, McKeon F, Church GM, Gingeras TR, Struhl K. Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell. 2006; 24:593-602.
    • (2006) Mol Cell , vol.24 , pp. 593-602
    • Yang, A.1    Zhu, Z.2    Kapranov, P.3    McKeon, F.4    Church, G.M.5    Gingeras, T.R.6    Struhl, K.7
  • 34
    • 77951982002 scopus 로고    scopus 로고
    • Mutant p53-induced Up-regulation of Mitogen-activated Protein Kinase Kinase 3 Contributes to Gain of Function
    • Gurtner A, Starace G, Norelli G, Piaggio G, Sacchi A, Bossi G. Mutant p53-induced Up-regulation of Mitogen-activated Protein Kinase Kinase 3 Contributes to Gain of Function. Journal of Biological Chemistry. 2010; 285:14160-14169.
    • (2010) Journal of Biological Chemistry , vol.285 , pp. 14160-14169
    • Gurtner, A.1    Starace, G.2    Norelli, G.3    Piaggio, G.4    Sacchi, A.5    Bossi, G.6
  • 36
  • 37
    • 78650093044 scopus 로고    scopus 로고
    • P53 and aging: A fresh look at an old paradigm
    • Poyurovsky MV, Prives C. P53 and aging: A fresh look at an old paradigm. Aging (Albany NY). 2010; 2:380-382.
    • (2010) Aging (Albany NY) , vol.2 , pp. 380-382
    • Poyurovsky, M.V.1    Prives, C.2
  • 39
    • 79952691843 scopus 로고    scopus 로고
    • The p53 inducing drug dosage may determine quiescence or senescence
    • Lane DP, Verma C, Fang CC. The p53 inducing drug dosage may determine quiescence or senescence. Aging (Albany NY). 2010; 2:748.
    • (2010) Aging (Albany NY) , vol.2 , pp. 748
    • Lane, D.P.1    Verma, C.2    Fang, C.C.3
  • 40
    • 78650152988 scopus 로고    scopus 로고
    • p53 ROS and senescence in the control of aging
    • Vigneron A, Vousden KH. p53, ROS and senescence in the control of aging. Aging (Albany NY). 2010; 2:471-474.
    • (2010) Aging (Albany NY) , vol.2 , pp. 471-474
    • Vigneron, A.1    Vousden, K.H.2
  • 41
    • 0035818596 scopus 로고    scopus 로고
    • Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor
    • Stolarov J, Chang K, Reiner A, Rodgers L, Hannon GJ, Wigler MH, Mittal V. Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proc Natl Acad Sci U S A. 2001; 98:13043-13048.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 13043-13048
    • Stolarov, J.1    Chang, K.2    Reiner, A.3    Rodgers, L.4    Hannon, G.J.5    Wigler, M.H.6    Mittal, V.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.