Tau as a therapeutic target in neurodegenerative disease

Pharmacology and Therapeutics

Volumn 136, Issue 1, 2012, Pages 8-22

  Himmelstein, Diana S ^a   Ward, Sarah M ^a   Lancia, Jody K ^a   Patterson, Kristina R ^a   Binder, Lester I ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Aggregation inhibitors; Alzheimer's disease; Immunotherapy; Microtubule stabilization; Phosphorylation effectors; Tauopathy

Indexed keywords

1 (4 METHOXYBENZYL) 3 (5 NITRO 2 THIAZOLYL)UREA; 2 AMINOTHIAZOLE INHIBITOR; ALSTERPAULLONE; BISARYLMALEIMIDE DERIVATIVE; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE INHIBITOR; EPALRESTAT; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; INDIRUBIN; INDIRUBIN 3' MONOXIME; K 252A; LITHIUM; MALEIMIDE DERIVATIVE; MEMANTINE; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PERTUSSIS TOXIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN ANTIBODY; PROTEIN ANTIBODY MC1; PROTEIN ANTIBODY PHF1; RHODANINE; SRN 003 556; TAU 195 213; TAU 207 220; TAU 224 238; TAU 379 408; TAU PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CENTRAL NERVOUS SYSTEM; DEGENERATIVE DISEASE; DRUG ADSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; HUMAN; IC 50; IMMUNOTHERAPY; LEUKEMIA; MICROTUBULE; NERVE FIBER TRANSPORT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW; TAUOPATHY;

CYCLIN-DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOTHERAPY; MICROTUBULES; MITOGEN-ACTIVATED PROTEIN KINASE 1; NEURODEGENERATIVE DISEASES; TAU PROTEINS;

EID: 84865608483     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2012.07.001     Document Type: Review

References (160)

1. A. Abraha, N. Ghoshal, T.C. Gamblin, V. Cryns, R.W. Berry, J. Kuret, and L.I. Binder C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease Journal of Cell Science 113 2000 3737 3745
2. B. Allen, E. Ingram, M. Takao, M.J. Smith, R. Jakes, K. Virdee, H. Yoshida, M. Holzer, M. Craxton, P.C. Emson, C. Atzori, A. Migheli, R.A. Crowther, B. Ghetti, M.G. Spillantini, and M. Goedert Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 22 2002 9340 9351 (Pubitemid 35356177)
3. A.C. Alonso, I. Grundke-Iqbal, and K. Iqbal Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules Nature Medicine 2 1996 783 787 (Pubitemid 26225094)
4. A. Alonso, T. Zaidi, M. Novak, I. Grundke-Iqbal, and K. Iqbal Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments Proceedings of the National Academy of Sciences of the United States of America 98 2001 6923 6928 (Pubitemid 32538318)
5. C. Andorfer, C.M. Acker, Y. Kress, P.R. Hof, K. Duff, and P. Davies Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 25 2005 5446 5454 (Pubitemid 40770926)
6. C. Andorfer, Y. Kress, M. Espinoza, R. de Silva, K.L. Tucker, Y.A. Barde, K. Duff, and P. Davies Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms Journal of Neurochemistry 86 2003 582 590 (Pubitemid 36897439)
7. P.V. Arriagada, J.H. Growdon, E.T. Hedley-Whyte, and B.T. Hyman Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease Neurology 42 1992 631 639
8. J.B. Ashman, E.S. Hall, J. Eveleth, and K. Boekelheide Tau, the neuronal heat-stable microtubule-associated protein, is also present in the cross-linked microtubule network of the testicular spermatid manchette Biology of Reproduction 46 1992 120 129
9. A.A. Asuni, A. Boutajangout, D. Quartermain, and E.M. Sigurdsson Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 27 2007 9115 9129 (Pubitemid 47312068)
10. K.D. Atabay, and A. Karabay Pin1 inhibition activates cyclin D and produces neurodegenerative pathology Journal of Neurochemistry 120 2012 430 439
11. S. Barghorn, P. Davies, and E. Mandelkow Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain Biochemistry 43 2004 1694 1703 (Pubitemid 38200576)
12. K.F. Bell, and A. Claudio Cuello Altered synaptic function in Alzheimer's disease European Journal of Pharmacology 545 2006 11 21 (Pubitemid 44219049)
13. Z. Berger, H. Roder, A. Hanna, A. Carlson, V. Rangachari, M. Yue, Z. Wszolek, K. Ashe, J. Knight, D. Dickson, C. Andorfer, T.L. Rosenberry, J. Lewis, M. Hutton, and C. Janus Accumulation of pathological tau species and memory loss in a conditional model of tauopathy The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 27 2007 3650 3662 (Pubitemid 46557687)
14. R.W. Berry, A. Abraha, S. Lagalwar, N. LaPointe, T.C. Gamblin, V.L. Cryns, and L.I. Binder Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment Biochemistry 42 2003 8325 8331 (Pubitemid 36858993)
15. R. Bhat, Y. Xue, S. Berg, S. Hellberg, M. Ormo, Y. Nilsson, A.C. Radesater, E. Jerning, P.O. Markgren, T. Borgegard, M. Nylof, A. Gimenez-Cassina, F. Hernandez, J.J. Lucas, J. Diaz-Nido, and J. Avila Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418 Journal of Biological Chemistry 278 2003 45937 45945 (Pubitemid 37432740)
16. J. Biernat, N. Gustke, G. Drewes, E.M. Mandelkow, and E. Mandelkow Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding Neuron 11 1993 153 163 (Pubitemid 23222542)
17. L.I. Binder, A. Frankfurter, and L.I. Rebhun The distribution of tau in the mammalian central nervous system The Journal of Cell Biology 101 1985 1371 1378 (Pubitemid 16203754)
18. L.I. Binder, A.L. Guillozet-Bongaarts, F. Garcia-Sierra, and R.W. Berry Tau, tangles, and Alzheimer's disease Biochimica et Biophysica Acta 1739 2005 216 223 (Pubitemid 40018540)
19. M. Boimel, N. Grigoriadis, A. Lourbopoulos, E. Haber, O. Abramsky, and H. Rosenmann Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice Experimental Neurology 224 2010 472 485
20. A. Boutajangout, J. Ingadottir, P. Davies, and E.M. Sigurdsson Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain Journal of Neurochemistry 118 2011 658 667
21. A. Boutajangout, D. Quartermain, and E.M. Sigurdsson Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 30 2010 16559 16566
22. H. Braak, and E. Braak Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections Brain Pathology 1 1991 213 216
23. G.T. Bramblett, J.Q. Trojanowski, and V.M. Lee Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins) Laboratory Investigation; a Journal of Technical Methods and Pathology 66 1992 212 222
24. R. Brandt, J. Leger, and G. Lee Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain The Journal of Cell Biology 131 1995 1327 1340
25. K.R. Brunden, Y. Yao, J.S. Potuzak, N.I. Ferrer, C. Ballatore, M.J. James, A.M. Hogan, J.Q. Trojanowski, A.B. Smith 3rd, and V.M. Lee The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies Pharmacological Research: the Official Journal of the Italian Pharmacological Society 63 2011 341 351
26. K.R. Brunden, B. Zhang, J. Carroll, Y. Yao, J.S. Potuzak, A.M. Hogan, M. Iba, M.J. James, S.X. Xie, C. Ballatore, A.B. Smith 3rd, V.M. Lee, and J.Q. Trojanowski Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 30 2010 13861 13866
27. L. Buee, and A. Delacourte Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease Brain Pathology 9 1999 681 693 (Pubitemid 29470961)
28. B. Bulic, M. Pickhardt, E.M. Mandelkow, and E. Mandelkow Tau protein and tau aggregation inhibitors Neuropharmacology 59 2010 276 289
29. J.M. Bunker, K. Kamath, L. Wilson, M.A. Jordan, and S.C. Feinstein FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells Journal of Biological Chemistry 281 2006 11856 11863 (Pubitemid 43855446)
30. G. Carmel, E.M. Mager, L.I. Binder, and J. Kuret The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology Journal of Biological Chemistry 271 1996 32789 32795 (Pubitemid 27008707)
31. A.D. Cash, G. Aliev, S.L. Siedlak, A. Nunomura, H. Fujioka, X. Zhu, A.K. Raina, H.V. Vinters, M. Tabaton, A.B. Johnson, M. Paula-Barbosa, J. Avila, P.K. Jones, R.J. Castellani, M.A. Smith, and G. Perry Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation The American Journal of Pathology 162 2003 1623 1627 (Pubitemid 36512845)
32. X. Chai, S. Wu, T.K. Murray, R. Kinley, C.V. Cella, H. Sims, N. Buckner, J. Hanmer, P. Davies, M.J. O'Neill, M.L. Hutton, and M. Citron Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression Journal of Biological Chemistry 286 2011 34457 34467
33. E. Chang, E.E. Congdon, N.S. Honson, K.E. Duff, and J. Kuret Structure-activity relationship of cyanine tau aggregation inhibitors Journal of Medicinal Chemistry 52 2009 3539 3547
34. E. Chang, and J. Kuret Detection and quantification of tau aggregation using a membrane filter assay Analytical Biochemistry 373 2008 330 336
35. M.O. Chohan, S. Khatoon, I.G. Iqbal, and K. Iqbal Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine FEBS Letters 580 2006 3973 3979 (Pubitemid 43946883)
36. E.E. Congdon, M. Necula, R.D. Blackstone, and J. Kuret Potency of a tau fibrillization inhibitor is influenced by its aggregation state Archives of Biochemistry and Biophysics 465 2007 127 135 (Pubitemid 47283987)
37. E.E. Congdon, J.W. Wu, N. Myeku, Y.H. Figueroa, M. Herman, P.S. Marinec, J.E. Gestwicki, C.A. Dickey, W.H. Yu, and K. Duff Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo Autophagy 8 2012
38. R.A. Crowther Straight and paired helical filaments in Alzheimer disease have a common structural unit Proceedings of the National Academy of Sciences of the United States of America 88 1991 2288 2292 (Pubitemid 21916401)
39. J. Delrieu, P.J. Ousset, C. Caillaud, and B. Vellas 'Clinical trials in Alzheimer's disease': immunotherapy approaches Journal of Neurochemistry 120 Suppl. 1 2012 186 193
40. C.A. Dickey, P. Ash, N. Klosak, W.C. Lee, L. Petrucelli, M. Hutton, and C.B. Eckman Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression Molecular Neurodegeneration 1 2006 6
41. D.N. Drechsel, A.A. Hyman, M.H. Cobb, and M.W. Kirschner Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau Molecular Biology of the Cell 3 1992 1141 1154 (Pubitemid 23088964)
42. D.G. Drubin, and M.W. Kirschner Tau protein function in living cells The Journal of Cell Biology 103 1986 2739 2746 (Pubitemid 17008019)
43. K. Duff, C. Eckman, C. Zehr, X. Yu, C.M. Prada, J. Perez-tur, M. Hutton, L. Buee, Y. Harigaya, D. Yager, D. Morgan, M.N. Gordon, L. Holcomb, L. Refolo, B. Zenk, J. Hardy, and S. Younkin Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1 Nature 383 1996 710 713 (Pubitemid 26360645)
44. J. Eidenmuller, T. Fath, T. Maas, M. Pool, E. Sontag, and R. Brandt Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein Biochemical Journal 357 2001 759 767 (Pubitemid 32735156)
45. D. Eliezer, P. Barre, M. Kobaslija, D. Chan, X. Li, and L. Heend Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation Biochemistry 44 2005 1026 1036 (Pubitemid 40129662)
46. T.A. Engler, S. Malhotra, T.P. Burkholder, J.R. Henry, D. Mendel, W.J. Porter, K. Furness, C. Diefenbacher, A. Marquart, J.K. Reel, Y. Li, J. Clayton, B. Cunningham, J. McLean, J.C. O'Toole, J. Brozinick, E. Hawkins, E. Misener, D. Briere, R.A. Brier, J.R. Wagner, R.M. Campbell, B.D. Anderson, R. Vaughn, D.B. Bennett, T.I. Meier, and J.A. Cook The development of potent and selective bisarylmaleimide GSK3 inhibitors Bioorganic & Medicinal Chemistry Letters 15 2005 899 903 (Pubitemid 40458620)
47. S. Fellner, B. Bauer, D.S. Miller, M. Schaffrik, M. Fankhanel, T. Spruss, G. Bernhardt, C. Graeff, L. Farber, H. Gschaidmeier, A. Buschauer, and G. Fricker Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo The Journal of Clinical Investigation 110 2002 1309 1318 (Pubitemid 35285757)
48. A. Ferreira, and E.H. Bigio Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies Molecular Medicine 17 2011 676 685
49. R. Furlan, E. Brambilla, F. Sanvito, L. Roccatagliata, S. Olivieri, A. Bergami, S. Pluchino, A. Uccelli, G. Comi, and G. Martino Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice Brain 126 2003 285 291 (Pubitemid 36172736)
50. T.C. Gamblin, R.W. Berry, and L.I. Binder Modeling tau polymerization in vitro: a review and synthesis Biochemistry 42 2003 15009 15017 (Pubitemid 38031698)
51. T.C. Gamblin, R.W. Berry, and L.I. Binder Tau polymerization: role of the amino terminus Biochemistry 42 2003 2252 2257 (Pubitemid 36258700)
52. T.C. Gamblin, M.E. King, H. Dawson, M.P. Vitek, J. Kuret, R.W. Berry, and L.I. Binder In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants Biochemistry 39 2000 6136 6144 (Pubitemid 30327089)
53. S. Garg, T. Timm, E.M. Mandelkow, E. Mandelkow, and Y. Wang Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment Neurobiology of Aging 32 2011 1 14
54. M. Goedert Tau gene mutations and their effects Movement Disorders: Official Journal of the Movement Disorder Society 20 Suppl. 12 2005 S45 S52
55. M. Goedert, R. Jakes, R.A. Crowther, M. Hasegawa, M.J. Smith, and M.G. Spillantini Intraneuronal filamentous tau protein and alpha-synuclein deposits in neurodegenerative diseases Biochemical Society Transactions 26 1998 463 471 (Pubitemid 28423107)
56. M. Goedert, and M.G. Spillantini Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease Biochimica et Biophysica Acta 1502 2000 110 121 (Pubitemid 30433860)
57. M. Goedert, M.G. Spillantini, R. Jakes, D. Rutherford, and R.A. Crowther Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease Neuron 3 1989 519 526
58. E.G. Gray, M. Paula-Barbosa, and A. Roher Alzheimer's disease: paired helical filaments and cytomembranes Neuropathology and Applied Neurobiology 13 1987 91 110 (Pubitemid 17115921)
59. I. Grundke-Iqbal, K. Iqbal, Y.C. Tung, M. Quinlan, H.M. Wisniewski, and L.I. Binder Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology Proceedings of the National Academy of Sciences of the United States of America 83 1986 4913 4917
60. H.N. Hafez, and A.B. El-Gazzar Design and synthesis of 3-pyrazolyl-thiophene, thieno[2,3-d]pyrimidines as new bioactive and pharmacological activities Bioorganic & Medicinal Chemistry Letters 18 2008 5222 5227
61. T. Hagestedt, B. Lichtenberg, H. Wille, E.M. Mandelkow, and E. Mandelkow Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation The Journal of Cell Biology 109 1989 1643 1651 (Pubitemid 19251214)
62. H. Hampel, M. Ewers, K. Burger, P. Annas, A. Mortberg, A. Bogstedt, L. Frolich, J. Schroder, P. Schonknecht, M.W. Riepe, I. Kraft, T. Gasser, T. Leyhe, H.J. Moller, A. Kurz, and H. Basun Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study The Journal of Clinical Psychiatry 70 2009 922 931
63. J. Hardy, K. Duff, K.G. Hardy, J. Perez-Tur, and M. Hutton Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau [published erratum appears in Nat Neurosci 1998 Dec;1(8):743] Nature Neuroscience 1 1998 355 358
64. M. Hattori, E. Sugino, K. Minoura, Y. In, M. Sumida, T. Taniguchi, K. Tomoo, and T. Ishida Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain Biochemical and Biophysical Research Communications 374 2008 158 163
65. C.J. Helal, M.A. Sanner, C.B. Cooper, T. Gant, M. Adam, J.C. Lucas, Z. Kang, S. Kupchinsky, M.K. Ahlijanian, B. Tate, F.S. Menniti, K. Kelly, and M. Peterson Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease Bioorganic & Medicinal Chemistry Letters 14 2004 5521 5525 (Pubitemid 39346337)
66. M. Hogg, Z.M. Grujic, M. Baker, S. Demirci, A.L. Guillozet, A.P. Sweet, L.L. Herzog, S. Weintraub, M.M. Mesulam, N.E. LaPointe, T.C. Gamblin, R.W. Berry, L.I. Binder, R. de Silva, A. Lees, M. Espinoza, P. Davies, A. Grover, N. Sahara, T. Ishizawa, D. Dickson, S.H. Yen, M. Hutton, and E.H. Bigio The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy Acta Neuropathologica 106 2003 323 336 (Pubitemid 37265312)
67. C. Holmes, D. Boche, D. Wilkinson, G. Yadegarfar, V. Hopkins, A. Bayer, R.W. Jones, R. Bullock, S. Love, J.W. Neal, E. Zotova, and J.A. Nicoll Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial Lancet 372 2008 216 223 (Pubitemid 351978111)
68. N.S. Honson, J.R. Jensen, M.V. Darby, and J. Kuret Potent inhibition of tau fibrillization with a multivalent ligand Biochemical and Biophysical Research Communications 363 2007 229 234 (Pubitemid 47430117)
69. G. Hubinger, S. Geis, S. LeCorre, S. Muhlbacher, S. Gordon, R.P. Fracasso, F. Hoffman, S. Ferrand, H.W. Klafki, and H.M. Roder Inhibition of PHF-like tau hyperphosphorylation in SH-SY5Y cells and rat brain slices by K252a Journal of Alzheimer's Disease 13 2008 281 294 (Pubitemid 352039036)
70. T. Ishihara, M. Hong, B. Zhang, Y. Nakagawa, M.K. Lee, J.Q. Trojanowski, and V.M. Lee Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform Neuron 24 1999 751 762
71. S. Jeganathan, M. von Bergen, H. Brutlach, H.J. Steinhoff, and E. Mandelkow Global hairpin folding of tau in solution Biochemistry 45 2006 2283 2293 (Pubitemid 43271328)
72. G.A. Jicha, R. Bowser, I.G. Kazam, and P. Davies Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau Journal of Neuroscience Research 48 1997 128 132 (Pubitemid 27181338)
73. N.M. Kanaan, G.A. Morfini, N.E. Lapointe, G.F. Pigino, K.R. Patterson, Y. Song, A. Andreadis, Y. Fu, S.T. Brady, and L.I. Binder Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 31 2011 9858 9868
74. N.M. Kanaan, G. Morfini, G. Pigino, N.E. Lapointe, A. Andreadis, Y. Song, E. Leitman, L.I. Binder, and S.T. Brady Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport Neurobiology of Aging 33 2011 826.e15-30
75. E. Kickstein, S. Krauss, P. Thornhill, D. Rutschow, R. Zeller, J. Sharkey, R. Williamson, M. Fuchs, A. Kohler, H. Glossmann, R. Schneider, C. Sutherland, and S. Schweiger Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling Proceedings of the National Academy of Sciences of the United States of America 107 2010 21830 21835
76. W.E. Klunk, H. Engler, A. Nordberg, Y. Wang, G. Blomqvist, D.P. Holt, M. Bergstrom, I. Savitcheva, G.F. Huang, S. Estrada, B. Ausen, M.L. Debnath, J. Barletta, J.C. Price, J. Sandell, B.J. Lopresti, A. Wall, P. Koivisto, G. Antoni, C.A. Mathis, and B. Langstrom Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B Annals of Neurology 55 2004 306 319 (Pubitemid 38269583)
77. P.K. Krishnamurthy, Y. Deng, and E.M. Sigurdsson Mechanistic studies of antibody-mediated clearance of tau aggregates using an ex vivo brain slice model Front Psychiatry 2 2011 59
78. I. Lagoja, C. Pannecouque, G. Griffioen, S. Wera, V.M. Rojasdelaparra, and A. Van Aerschot Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer's disease European Journal of Pharmaceutical Sciences 43 2011 386 392
79. N.E. LaPointe, G. Morfini, G. Pigino, I.N. Gaisina, A.P. Kozikowski, L.I. Binder, and S.T. Brady The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity Journal of Neuroscience Research 87 2009 440 451
80. C.A. Lasagna-Reeves, D.L. Castillo-Carranza, M.J. Guerrero-Muoz, G.R. Jackson, and R. Kayed Preparation and characterization of neurotoxic tau oligomers Biochemistry 49 2010 10039 10041
81. C.A. Lasagna-Reeves, D.L. Castillo-Carranza, U. Sengupta, J. Sarmiento, J. Troncoso, G.R. Jackson, and R. Kayed Identification of oligomers at early stages of tau aggregation in Alzheimer's disease The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 26 2012 1949 1956
82. S. Le Corre, H.W. Klafki, N. Plesnila, G. Hubinger, A. Obermeier, H. Sahagun, B. Monse, P. Seneci, J. Lewis, J. Eriksen, C. Zehr, M. Yue, E. McGowan, D.W. Dickson, M. Hutton, and H.M. Roder An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice Proceedings of the National Academy of Sciences of the United States of America 103 2006 9673 9678 (Pubitemid 43955883)
83. S. Leclerc, M. Garnier, R. Hoessel, D. Marko, J.A. Bibb, G.L. Snyder, P. Greengard, J. Biernat, Y.Z. Wu, E.M. Mandelkow, G. Eisenbrand, and L. Meijer Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? Journal of Biological Chemistry 276 2001 251 260 (Pubitemid 32050314)
84. V.M. Lee, M. Goedert, and J.Q. Trojanowski Neurodegenerative tauopathies Annual Review of Neuroscience 24 2001 1121 1159 (Pubitemid 32695256)
85. G. Lee, S.T. Newman, D.L. Gard, H. Band, and G. Panchamoorthy Tau interacts with src-family non-receptor tyrosine kinases Journal of Cell Science 111 1998 3167 3177 (Pubitemid 28532427)
86. A.C. Leite, R.S. de Lima, D.R. Moreira, M.V. Cardoso, A.C. Gouveia de Brito, L.M. Farias Dos Santos, M.Z. Hernandes, A.C. Kiperstok, and M.B. Soares Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi Bioorganic & Medicinal Chemistry 14 2006 3749 3757
87. M. Leost, C. Schultz, A. Link, Y.Z. Wu, J. Biernat, E.M. Mandelkow, J.A. Bibb, G.L. Snyder, P. Greengard, D.W. Zaharevitz, R. Gussio, A.M. Senderowicz, E.A. Sausville, C. Kunick, and L. Meijer Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25 European Journal of Biochemistry 267 2000 5983 5994
88. J. Lewis, E. McGowan, J. Rockwood, H. Melrose, P. Nacharaju, M. Van Slegtenhorst, K. Gwinn-Hardy, M. Paul Murphy, M. Baker, X. Yu, K. Duff, J. Hardy, A. Corral, W.L. Lin, S.H. Yen, D.W. Dickson, P. Davies, and M. Hutton Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein Nature Genetics 25 2000 402 405 (Pubitemid 32983430)
89. L. Li, A. Sengupta, N. Haque, I. Grundke-Iqbal, and K. Iqbal Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration FEBS Letters 566 2004 261 269 (Pubitemid 38625969)
90. J. Lim, M. Balastik, T.H. Lee, K. Nakamura, Y.C. Liou, A. Sun, G. Finn, L. Pastorino, V.M. Lee, and K.P. Lu Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy The Journal of Clinical Investigation 118 2008 1877 1889 (Pubitemid 351632390)
91. G. Lindwall, and R.D. Cole The purification of tau protein and the occurrence of two phosphorylation states of tau in brain Journal of Biological Chemistry 259 1984 12241 12245 (Pubitemid 14019763)
92. Y.C. Liou, A. Sun, A. Ryo, X.Z. Zhou, Z.X. Yu, H.K. Huang, T. Uchida, R. Bronson, G. Bing, X. Li, T. Hunter, and K.P. Lu Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration Nature 424 2003 556 561 (Pubitemid 36975777)
93. B.H. Long, and C.R. Fairchild Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase Cancer Research 54 1994 4355 4361 (Pubitemid 24273147)
94. P.A. Loomis, T.H. Howard, R.P. Castleberry, and L.I. Binder Identification of nuclear tau isoforms in human neuroblastoma cells Proceedings of the National Academy of Sciences of the United States of America 87 1990 8422 8426
95. P.J. Lu, G. Wulf, X.Z. Zhou, P. Davies, and K.P. Lu The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein Nature 399 1999 784 788 (Pubitemid 29293174)
96. M.H. Luo, S.W. Tse, J. Memmott, and A. Andreadis Novel isoforms of tau that lack the microtubule-binding domain Journal of Neurochemistry 90 2004 340 351 (Pubitemid 38938220)
97. S. Maeda, N. Sahara, Y. Saito, S. Murayama, A. Ikai, and A. Takashima Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease Neuroscience Research 54 2006 197 201 (Pubitemid 43276078)
98. S. Maeda, N. Sahara, Y. Saito, M. Murayama, Y. Yoshiike, H. Kim, T. Miyasaka, S. Murayama, A. Ikai, and A. Takashima Granular tau oligomers as intermediates of tau filaments Biochemistry 46 2007 3856 3861 (Pubitemid 46493485)
99. M.P. Mazanetz, and P.M. Fischer Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases Nature Reviews. Drug Discovery 6 2007 464 479 (Pubitemid 47064569)
100. K. Minoura, F. Mizushima, M. Tokimasa, S. Hiraoka, K. Tomoo, M. Sumida, T. Taniguchi, and T. Ishida Structural evaluation of conformational transition state responsible for self-assembly of tau microtubule-binding domain Biochemical and Biophysical Research Communications 327 2005 1100 1104 (Pubitemid 40137982)
101. K. Minoura, T.M. Yao, K. Tomoo, M. Sumida, M. Sasaki, T. Taniguchi, and T. Ishida Different associational and conformational behaviors between the second and third repeat fragments in the tau microtubule-binding domain European Journal of Biochemistry 271 2004 545 552 (Pubitemid 38183628)
102. D. Morgan The role of microglia in antibody-mediated clearance of amyloid-beta from the brain CNS & Neurological Disorders Drug Targets 8 2009 7 15
103. R. Morsch, W. Simon, and P.D. Coleman Neurons may live for decades with neurofibrillary tangles Journal of Neuropathology and Experimental Neurology 58 1999 188 197 (Pubitemid 29088942)
104. M.D.B.J. Mukrasch, M. von Bergen, C. Griesinger, E. Mandelkow, and M. Zweckstetter Sites of tau important for aggregation populate beta structure and bind to microtubules and polyanions Journal of Biological Chemistry 280 2005 24978 24986 (Pubitemid 40934590)
105. J.R. Murrell, M.G. Spillantini, P. Zolo, M. Guazzelli, M.J. Smith, M. Hasegawa, F. Redi, R.A. Crowther, P. Pietrini, B. Ghetti, and M. Goedert Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits Journal of Neuropathology and Experimental Neurology 58 1999 1207 1226
106. K. Nakamura, A. Greenwood, L. Binder, E.H. Bigio, S. Denial, L. Nicholson, X.Z. Zhou, and K.P. Lu Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease Cell 149 2012 232 244
107. M. Necula, C.N. Chirita, and J. Kuret Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: implications for the treatment of tauopathic neurodegenerative diseases Biochemistry 44 2005 10227 10237 (Pubitemid 41076818)
108. R.L. Neve, P. Harris, K.S. Kosik, D.M. Kurnit, and T.A. Donlon Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2 Brain Research 387 1986 271 280 (Pubitemid 17220131)
109. S. Oddo, A. Caccamo, J.D. Shepherd, M.P. Murphy, T.E. Golde, R. Kayed, R. Metherate, M.P. Mattson, Y. Akbari, and F.M. LaFerla Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction Neuron 39 2003 409 421 (Pubitemid 36937044)
110. J.M. Orgogozo, S. Gilman, J.F. Dartigues, B. Laurent, M. Puel, L.C. Kirby, P. Jouanny, B. Dubois, L. Eisner, S. Flitman, B.F. Michel, M. Boada, A. Frank, and C. Hock Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization Neurology 61 2003 46 54 (Pubitemid 36818745)
111. L. Otvos Jr., L. Feiner, E. Lang, G.I. Szendrei, M. Goedert, and V.M. Lee Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404 Journal of Neuroscience Research 39 1994 669 673
112. M. Oz, D.E. Lorke, and G.A. Petroianu Methylene blue and Alzheimer's disease Biochemical Pharmacology 78 2009 927 932
113. D. Panda, B.L. Goode, S.C. Feinstein, and L. Wilson Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau Biochemistry 34 1995 11117 11127
114. S.C. Papasozomenos, and L.I. Binder Phosphorylation determines two distinct species of Tau in the central nervous system Cell Motility and the Cytoskeleton 8 1987 210 226
115. S.-Y. Park, and A. Ferreira The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates {beta}-amyloid-induced neurodegeneration Journal of Neuroscience 25 2005 5365 5375 (Pubitemid 40770916)
116. K.R. Patterson, C. Remmers, Y. Fu, S. Brooker, N.M. Kanaan, L. Vana, S. Ward, J.F. Reyes, K. Philibert, M.J. Glucksman, and L.I. Binder Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease Journal of Biological Chemistry 286 2011 23063 23076
117. K.R. Patterson, S.M. Ward, B. Combs, K. Voss, N.M. Kanaan, G. Morfini, S.T. Brady, T.C. Gamblin, and L.I. Binder Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport Biochemistry 50 2011 10300 10310
118. M. Pickhardt, Z. Gazova, M. von Bergen, I. Khlistunova, Y. Wang, A. Hascher, E.M. Mandelkow, J. Biernat, and E. Mandelkow Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells Journal of Biological Chemistry 280 2005 3628 3635 (Pubitemid 40223830)
119. M. Pickhardt, G. Larbig, I. Khlistunova, A. Coksezen, B. Meyer, E.M. Mandelkow, B. Schmidt, and E. Mandelkow Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells Biochemistry 46 2007 10016 10023 (Pubitemid 47378592)
120. P. Preziosi Isoniazid: metabolic aspects and toxicological correlates Current Drug Metabolism 8 2007 839 851 (Pubitemid 350238914)
121. G. Raciti, P. Mazzone, A. Raudino, G. Mazzone, and A. Cambria Inhibition of rat liver mitochondrial monoamine oxidase by hydrazine-thiazole derivatives: structure-activity relationships Bioorganic & Medicinal Chemistry 3 1995 1485 1491
122. M. Rapoport, H.N. Dawson, L.I. Binder, M.P. Vitek, and A. Ferreira Tau is essential to beta-amyloid-induced neurotoxicity Proceedings of the National Academy of Sciences of the United States of America 99 2002 6364 6369
123. E.D. Roberson, B. Halabisky, J.W. Yoo, J. Yao, J. Chin, F. Yan, T. Wu, P. Hamto, N. Devidze, G.Q. Yu, J.J. Palop, J.L. Noebels, and L. Mucke Amyloid-beta/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 31 2011 700 711
124. E.D. Roberson, K. Scearce-Levie, J.J. Palop, F. Yan, I.H. Cheng, T. Wu, H. Gerstein, G.Q. Yu, and L. Mucke Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model Science 316 2007 750 754 (Pubitemid 46717684)
125. H. Rosenmann, N. Grigoriadis, D. Karussis, M. Boimel, O. Touloumi, H. Ovadia, and O. Abramsky Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein Archives of Neurology 63 2006 1459 1467 (Pubitemid 44547559)
126. P. Rudrabhatla, and H.C. Pant Phosphorylation-specific peptidyl-prolyl isomerization of neuronal cytoskeletal proteins by Pin1: implications for
127. N. Sahara, S. Maeda, M. Murayama, T. Suzuki, N. Dohmae, S.H. Yen, and A. Takashima Assembly of two distinct dimers and higher-order oligomers from full-length tau The European Journal of Neuroscience 25 2007 3020 3029 (Pubitemid 46888808)
128. K. Santacruz, J. Lewis, T. Spires, J. Paulson, L. Kotilinek, M. Ingelsson, A. Guimaraes, M. DeTure, M. Ramsden, E. McGowan, C. Forster, M. Yue, J. Orne, C. Janus, A. Mariash, M. Kuskowski, B. Hyman, M. Hutton, and K.H. Ashe Tau suppression in a neurodegenerative mouse model improves memory function Science 309 2005 476 481 (Pubitemid 40994688)
129. D. Schenk Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning Nature Reviews Neuroscience 3 2002 824 828 (Pubitemid 135706694)
130. A. Schneider, J. Biernat, M. von Bergen, E. Mandelkow, and E.M. Mandelkow Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments Biochemistry 38 1999 3549 3558
131. O. Schweers, E. Schonbrunn-Hanebeck, A. Marx, and E. Mandelkow Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure Journal of Biological Chemistry 269 1994 24290 24297
132. N. Sibille, I. Huvent, C. Fauquant, D. Verdegem, L. Amniai, A. Leroy, J.M. Wieruszeski, G. Lippens, and I. Landrieu Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein Proteins 80 2011 454 462
133. M.G. Spillantini, T.D. Bird, and B. Ghetti Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies Brain Pathology 8 1998 387 402 (Pubitemid 28186074)
134. M.G. Spillantini, and M. Goedert Tau protein pathology in neurodegenerative diseases Trends in Neurosciences 21 1998 428 433 (Pubitemid 28449072)
135. T.L. Spires, J.D. Orne, K. SantaCruz, R. Pitstick, G.A. Carlson, K.H. Ashe, and B.T. Hyman Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy The American Journal of Pathology 168 2006 1598 1607
136. A. Sultan, F. Nesslany, M. Violet, S. Begard, A. Loyens, S. Talahari, Z. Mansuroglu, D. Marzin, N. Sergeant, S. Humez, M. Colin, E. Bonnefoy, L. Buee, and M.C. Galas Nuclear tau, a key player in neuronal DNA protection Journal of Biological Chemistry 286 2011 4566 4575
137. A. Sydow, A. Van der Jeugd, F. Zheng, T. Ahmed, D. Balschun, O. Petrova, D. Drexler, L. Zhou, G. Rune, E. Mandelkow, R. D'Hooge, C. Alzheimer, and E.M. Mandelkow Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 31 2011 2511 2525
138. M. Tokimasa, K. Minoura, S. Hiraoka, K. Tomoo, M. Sumida, T. Taniguchi, and T. Ishida Importance of local structures of second and third repeat fragments of microtubule-binding domain for tau filament formation FEBS Letters 579 2005 3481 3486 (Pubitemid 40897680)
139. B. Trinczek, J. Biernat, K. Baumann, E.M. Mandelkow, and E. Mandelkow Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules Molecular Biology of the Cell 6 1995 1887 1902
140. L. Troquier, M. Caillierez, S. Burnouf, F.J. Fernandez-Gomez, M.J. Grosjean, N. Zommer, N. Sergeant, S. Schraen-Maschke, D. Blum, and L. Buee Targeting phospho-Ser422 by active Tau immunotherapy in the THY-Tau22 mouse model: a suitable therapeutic approach Current Alzheimer Research 9 2012 397 405
141. L.H. Tsai, I. Delalle, V.S. Caviness Jr., T. Chae, and E. Harlow p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 Nature 371 1994 419 423 (Pubitemid 24302556)
142. H.C. Tseng, Y. Zhou, Y. Shen, and L.H. Tsai A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains FEBS Letters 523 2002 58 62 (Pubitemid 34786058)
143. L. Vana, N.M. Kanaan, I.C. Ugwu, J. Wuu, E.J. Mufson, and L.I. Binder Progression of tau pathology in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease The American Journal of Pathology 179 2011 2533 2550
144. M. von Bergen, S. Barghorn, L. Li, A. Marx, J. Biernat, E.M. Mandelkow, and E. Mandelkow Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure Journal of Biological Chemistry 276 2001 48165 48174
145. M. von Bergen, P. Friedhoff, J. Biernat, J. Heberle, and E. Mandelkow Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif (306VQIVYK311) forming beta structure Proceedings of the National Academy of Sciences of the United States of America 97 2000 5129 5134 (Pubitemid 30313683)
146. K.A. Vossel, K. Zhang, J. Brodbeck, A.C. Daub, P. Sharma, S. Finkbeiner, B. Cui, and L. Mucke Tau reduction prevents Abeta-induced defects in axonal transport Science 330 2010 198
147. Y. Wang, P.A. Loomis, R.P. Zinkowski, and L.I. Binder A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau The Journal of Cell Biology 121 1993 257 267 (Pubitemid 23110871)
148. M.D. Weingarten, A.H. Lockwood, S.Y. Hwo, and M.W. Kirschner A protein factor essential for microtubule assembly Proceedings of the National Academy of Sciences of the United States of America 72 1975 1858 1862
149. C.M. Wischik, P.C. Edwards, R.Y. Lai, M. Roth, and C.R. Harrington Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines Proceedings of the National Academy of Sciences of the United States of America 93 1996 11213 11218 (Pubitemid 26333144)
150. C.M. Wischik, M. Novak, P.C. Edwards, A. Klug, W. Tichelaar, and R.A. Crowther Structural characterization of the core of the paired helical filament of Alzheimer disease Proceedings of the National Academy of Sciences of the United States of America 85 1988 4884 4888
151. C.M. Wischik, M. Novak, H.C. Thogersen, P.C. Edwards, M.J. Runswick, R. Jakes, J.E. Walker, C. Milstein, M. Roth, and A. Klug Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease Proceedings of the National Academy of Sciences of the United States of America 85 1988 4506 4510
152. C.W. Wittmann, M.F. Wszolek, J.M. Shulman, P.M. Salvaterra, J. Lewis, M. Hutton, and M.B. Feany Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles Science 293 2001 711 714 (Pubitemid 32728676)
153. J.G. Wood, S.S. Mirra, N.J. Pollock, and L.I. Binder Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau) [published erratum appears in Proc Natl Acad Sci U S A 1986 Dec;83(24):9773] Proceedings of the National Academy of Sciences of the United States of America 83 1986 4040 4043 (Pubitemid 16062418)
154. A.M. Yvon, P. Wadsworth, and M.A. Jordan Taxol suppresses dynamics of individual microtubules in living human tumor cells Molecular Biology of the Cell 10 1999 947 959 (Pubitemid 29193723)
155. B. Zhang, J. Carroll, J.Q. Trojanowski, Y. Yao, M. Iba, J.S. Potuzak, A.M. Hogan, S.X. Xie, C. Ballatore, A.B. Smith III, V.M. Lee, and K.R. Brunden The microtubule-stabilizing agent, epothilone d, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 32 2012 3601 3611
156. B. Zhang, A. Maiti, S. Shively, F. Lakhani, G. McDonald-Jones, J. Bruce, E.B. Lee, S.X. Xie, S. Joyce, C. Li, P.M. Toleikis, V.M. Lee, and J.Q. Trojanowski Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model Proceedings of the National Academy of Sciences of the United States of America 102 2005 227 231 (Pubitemid 40094457)
157. Y.L. Zheng, S. Kesavapany, M. Gravell, R.S. Hamilton, M. Schubert, N. Amin, W. Albers, P. Grant, and H.C. Pant A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons EMBO Journal 24 2005 209 220 (Pubitemid 40188478)
158. Y.L. Zheng, B.S. Li, N.D. Amin, W. Albers, and H.C. Pant A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells European Journal of Biochemistry 269 2002 4427 4434
159. X.Z. Zhou, O. Kops, A. Werner, P.J. Lu, M. Shen, G. Stoller, G. Kullertz, M. Stark, G. Fischer, and K.P. Lu Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins Molecular Cell 6 2000 873 883
160. B. Zlokovic Can blood-brain barrier play a role in the development of cerebral amyloidosis and Alzheimer's disease pathology Neurobiology of Disease 4 1997 23 26