Structural Insights and Biological Effects of Glycogen Synthase Kinase 3-specific Inhibitor AR-A014418

Journal of Biological Chemistry

Volumn 278, Issue 46, 2003, Pages 45937-45945

  Bhat, Ratan ^a   Xue, Yafeng ^b   Berg, Stefan ^a   Hellberg, Sven ^a   Ormö, Mats ^b   Nilsson, Yvonne ^a   Radesäter, Ann Cathrin ^a   Jerning, Eva ^a   Markgren, Per Olof ^a   Borgegård, Thomas ^a   Nylöf, Martin ^a   Giménez Cassina, Alfredo ^c   Hernández, Félix ^c   Lucas, Jose J ^c   Díaz Nido, Javier ^c   Avila, Jesús ^c  

^a ASTRAZENECA R AND D   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CELLS; DISEASES; ENZYME INHIBITION; PATHOLOGY;

CELLULAR SIGNALING; PHOSPHORYLATION;

BIOCHEMISTRY;

ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; AR A014418; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; N (4 METHOXYBENZYL) N' (5 NITRO 1,3 THIAZOL 2 YL)UREA; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN SLICE; CELL SURVIVAL; COMPETITIVE INHIBITION; CONTROLLED STUDY; CRYSTALLIZATION; DIABETES MELLITUS; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HIPPOCAMPUS; IC 50; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CDC2-CDC28 KINASES; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRONS; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MICE; MODELS, CHEMICAL; MODELS, MOLECULAR; NEURONS; NIH 3T3 CELLS; PEPTIDES; PROTEIN BINDING; SIGNAL TRANSDUCTION; TAU PROTEINS; THIAZOLES; UREA;

ANIMALIA;

EID: 0242664588     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306268200     Document Type: Article

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