메뉴 건너뛰기




Volumn 120, Issue 3, 2012, Pages 430-439

Pin1 inhibition activates cyclin D and produces neurodegenerative pathology

Author keywords

cell cycle; cyclin D; juglone; neurodegeneration; Pin1; tau

Indexed keywords

CASPASE 3; CYCLIN D; CYCLIN D1; JUGLONE; PEPTIDYLPROLYL ISOMERASE PIN1; TAU PROTEIN;

EID: 84855712104     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07259.x     Document Type: Article
Times cited : (15)

References (47)
  • 1
    • 20044367108 scopus 로고    scopus 로고
    • Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
    • DOI 10.1523/JNEUROSCI.4637-04.2005
    • Andorfer C., Acker C. M., Kress Y., Hof P. R., Duff K., and, Davies P., (2005) Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J. Neurosci. 25 (22), 5446-5454. (Pubitemid 40770926)
    • (2005) Journal of Neuroscience , vol.25 , Issue.22 , pp. 5446-5454
    • Andorfer, C.1    Acker, C.M.2    Kress, Y.3    Hof, P.R.4    Duff, K.5    Davies, P.6
  • 3
    • 0032864797 scopus 로고    scopus 로고
    • Regeneration and proliferation of embryonic and adult rat hippocampal neurons in culture
    • DOI 10.1006/exnr.1999.7123
    • Brewer G. J., (1999) Regeneration and proliferation of embryonic and adult rat hippocampal neurons in culture. Exp. Neurol. 159 (1), 237-247. (Pubitemid 29444919)
    • (1999) Experimental Neurology , vol.159 , Issue.1 , pp. 237-247
    • Brewer, G.J.1
  • 5
    • 0017280397 scopus 로고
    • Induction of mitosis in mature neurons in central nervous system by sustained depolarization
    • Cone, Jr C. D., and, Cone C. M., (1976) Induction of mitosis in mature neurons in central nervous system by sustained depolarization. Science 192 (4235), 155-158.
    • (1976) Science , vol.192 , Issue.4235 , pp. 155-158
    • Cone, Jr.C.D.1    Cone, C.M.2
  • 6
    • 77953917908 scopus 로고    scopus 로고
    • The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease
    • Currais A., Hortobagyi T., and, Soriano S., (2009) The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease. Aging (Albany NY) 1 (4), 363-371.
    • (2009) Aging (Albany NY) , vol.1 , Issue.4 , pp. 363-371
    • Currais, A.1    Hortobagyi, T.2    Soriano, S.3
  • 7
    • 61449083701 scopus 로고    scopus 로고
    • Primary support cultures of hippocampal and substantia nigra neurons
    • Fath T., Ke Y. D., Gunning P., Gotz J., and, Ittner L. M., (2009) Primary support cultures of hippocampal and substantia nigra neurons. Nat. Protoc. 4 (1), 78-85.
    • (2009) Nat. Protoc. , vol.4 , Issue.1 , pp. 78-85
    • Fath, T.1    Ke, Y.D.2    Gunning, P.3    Gotz, J.4    Ittner, L.M.5
  • 8
    • 65549114029 scopus 로고    scopus 로고
    • Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity
    • Frank C. L., and, Tsai L. H., (2009) Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity. Neuron 62 (3), 312-326.
    • (2009) Neuron , vol.62 , Issue.3 , pp. 312-326
    • Frank, C.L.1    Tsai, L.H.2
  • 9
    • 33745819942 scopus 로고    scopus 로고
    • The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons: Implication in a pathological mechanism related to Alzheimer disease
    • DOI 10.1074/jbc.M601849200
    • Galas M. C., Dourlen P., Begard S., Ando K., Blum D., Hamdane M., and, Buee L., (2006) The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons Implication in a pathological mechanism related to Alzheimer disease. J. Biol. Chem. 281 (28), 19296-19304. (Pubitemid 44035434)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.28 , pp. 19296-19304
    • Galas, M.-C.1    Dourlen, P.2    Begard, S.3    Ando, K.4    Blum, D.5    Hamdane, M.6    Buee, L.7
  • 10
    • 0034088846 scopus 로고    scopus 로고
    • Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease
    • DOI 10.1074/jbc.275.8.5535
    • Gong C. X., Lidsky T., Wegiel J., Zuck L., Grundke-Iqbal I., and, Iqbal K., (2000) Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. J. Biol. Chem. 275 (8), 5535-5544. (Pubitemid 30115189)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.8 , pp. 5535-5544
    • Gong, C.-X.1    Lidsky, T.2    Wegiel, J.3    Zuck, L.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 11
    • 0032926319 scopus 로고    scopus 로고
    • Peptidyl-prolyl cis-trams isomerases, a superfamily of ubiquitous folding catalysts
    • DOI 10.1007/s000180050299
    • Gothel S. F., and, Marahiel M. A., (1999) Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. Cell. Mol. Life Sci. 55 (3), 423-436. (Pubitemid 29178881)
    • (1999) Cellular and Molecular Life Sciences , vol.55 , Issue.3 , pp. 423-436
    • Gothel, S.F.1    Marahiel, M.A.2
  • 12
    • 0032574832 scopus 로고    scopus 로고
    • Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone
    • DOI 10.1021/bi973162p
    • Hennig L., Christner C., Kipping M., Schelbert B., Rucknagel K. P., Grabley S., Kullertz G., and, Fischer G., (1998) Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone. Biochemistry 37 (17), 5953-5960. (Pubitemid 28196748)
    • (1998) Biochemistry , vol.37 , Issue.17 , pp. 5953-5960
    • Hennig, L.1    Christner, C.2    Kipping, M.3    Schelbert, B.4    Rucknagel, K.P.5    Grabley, S.6    Kullertz, G.7    Fischer, G.8
  • 13
    • 7044237034 scopus 로고    scopus 로고
    • Divide and die: Cell cycle events as triggers of nerve cell death
    • DOI 10.1523/JNEUROSCI.3347-04.2004
    • Herrup K., Neve R., Ackerman S. L., and, Copani A., (2004) Divide and die: cell cycle events as triggers of nerve cell death. J. Neurosci. 24 (42), 9232-9239. (Pubitemid 39426158)
    • (2004) Journal of Neuroscience , vol.24 , Issue.42 , pp. 9232-9239
    • Herrup, K.1    Neve, R.2    Ackerman, S.L.3    Copani, A.4
  • 14
  • 15
    • 0032559238 scopus 로고    scopus 로고
    • Prolyl isomerases and nuclear function
    • DOI 10.1016/S0092-8674(00)80906-X
    • Hunter T., (1998) Prolyl isomerases and nuclear function. Cell 92 (2), 141-143. (Pubitemid 28073035)
    • (1998) Cell , vol.92 , Issue.2 , pp. 141-143
    • Hunter, T.1
  • 16
    • 0035882278 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo
    • Ino H., and, Chiba T., (2001) Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo. J. Neurosci. 21 (16), 6086-6094. (Pubitemid 32737742)
    • (2001) Journal of Neuroscience , vol.21 , Issue.16 , pp. 6086-6094
    • Ino, H.1    Chiba, T.2
  • 17
    • 3042853307 scopus 로고    scopus 로고
    • Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules
    • DOI 10.1523/JNEUROSCI.1382-04.2004
    • Karabay A., Yu W., Solowska J. M., Baird D. H., and, Baas P. W., (2004) Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules. J. Neurosci. 24 (25), 5778-5788. (Pubitemid 38857232)
    • (2004) Journal of Neuroscience , vol.24 , Issue.25 , pp. 5778-5788
    • Karabay, A.1    Yu, W.2    Solowska, J.M.3    Baird, D.H.4    Baas, P.W.5
  • 19
    • 0030031514 scopus 로고    scopus 로고
    • Cyclin D1 is an essential mediator of apoptotic neuronal cell death
    • Kranenburg O., van der Eb A. J., and, Zantema A., (1996) Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J. 15 (1), 46-54. (Pubitemid 26020387)
    • (1996) EMBO Journal , vol.15 , Issue.1 , pp. 46-54
    • Kranenburg, O.1    Van Der Eb, A.J.2    Zantema, A.3
  • 21
    • 34848845327 scopus 로고    scopus 로고
    • The binding and phosphorylation of Thr231 is critical for Tau's hyperphosphorylation and functional regulation by glycogen synthase kinase 3beta
    • Lin Y. T., Cheng J. T., Liang L. C., Ko C. Y., Lo Y. K., and, Lu P. J., (2007) The binding and phosphorylation of Thr231 is critical for Tau's hyperphosphorylation and functional regulation by glycogen synthase kinase 3beta. J. Neurochem. 103 (2), 802-813.
    • (2007) J. Neurochem. , vol.103 , Issue.2 , pp. 802-813
    • Lin, Y.T.1    Cheng, J.T.2    Liang, L.C.3    Ko, C.Y.4    Lo, Y.K.5    Lu, P.J.6
  • 24
    • 0035710746 scopus 로고    scopus 로고
    • -ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • Livak K. J., and, Schmittgen T. D., (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25 (4), 402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 25
    • 1842763560 scopus 로고    scopus 로고
    • Pinning down cell signaling, cancer and Alzheimer's disease
    • Lu K. P., (2004) Pinning down cell signaling, cancer and Alzheimer's disease. Trends Biochem. Sci. 29, 4.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 4
    • Lu, K.P.1
  • 26
    • 0029916122 scopus 로고    scopus 로고
    • A human peptidyl-prolyl isomerase essential for regulation of mitosis
    • DOI 10.1038/380544a0
    • Lu K. P., Hanes S. D., and, Hunter T., (1996) A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature 380 (6574), 544-547. (Pubitemid 26111332)
    • (1996) Nature , vol.380 , Issue.6574 , pp. 544-547
    • Lu, K.P.1    Hanes, S.D.2    Hunter, T.3
  • 27
    • 0033600242 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein
    • DOI 10.1038/21650
    • Lu P. J., Wulf G., Zhou X. Z., Davies P., and, Lu K. P., (1999) The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature 399 (6738), 784-788. (Pubitemid 29293174)
    • (1999) Nature , vol.399 , Issue.6738 , pp. 784-788
    • Lu, P.-J.1    Wulf, G.2    Zhou, X.Z.3    Davies, P.4    Lu, K.P.5
  • 28
    • 0036535975 scopus 로고    scopus 로고
    • Pinning down proline-directed phosphorylation signaling
    • DOI 10.1016/S0962-8924(02)02253-5, PII S0962892402022535
    • Lu K. P., Liou Y. C., and, Zhou X. Z., (2002) Pinning down proline-directed phosphorylation signaling. Trends Cell Biol. 12 (4), 164-172. (Pubitemid 34442238)
    • (2002) Trends in Cell Biology , vol.12 , Issue.4 , pp. 164-172
    • Lu, K.P.1    Liou, Y.-C.2    Zhou, X.Z.3
  • 29
    • 67649908864 scopus 로고    scopus 로고
    • Adult neural stem cells in the mammalian central nervous system
    • Ma D. K., Bonaguidi M. A., Ming G. L., and, Song H., (2009) Adult neural stem cells in the mammalian central nervous system. Cell Res. 19 (6), 672-682.
    • (2009) Cell Res. , vol.19 , Issue.6 , pp. 672-682
    • Ma, D.K.1    Bonaguidi, M.A.2    Ming, G.L.3    Song, H.4
  • 30
    • 34247518629 scopus 로고    scopus 로고
    • A fluorescence vital assay for the recognition and quantification of excitotoxic cell death by necrosis and apoptosis using confocal microscopy on neurons in culture
    • DOI 10.1016/j.jneumeth.2007.02.010, PII S0165027007000672
    • Mironova E. V., Evstratova A. A., and, Antonov S. M., (2007) A fluorescence vital assay for the recognition and quantification of excitotoxic cell death by necrosis and apoptosis using confocal microscopy on neurons in culture. J. Neurosci. Methods 163 (1), 1-8. (Pubitemid 46660117)
    • (2007) Journal of Neuroscience Methods , vol.163 , Issue.1 , pp. 1-8
    • Mironova, E.V.1    Evstratova, A.A.2    Antonov, S.M.3
  • 31
    • 33646876851 scopus 로고    scopus 로고
    • The cell cycle as a therapeutic target for Alzheimer's disease
    • DOI 10.1016/j.pharmthera.2005.09.005, PII S0163725805002081
    • Neve R. L., and, McPhie D. L., (2006) The cell cycle as a therapeutic target for Alzheimer's disease. Pharmacol. Ther. 111 (1), 99-113. (Pubitemid 43786202)
    • (2006) Pharmacology and Therapeutics , vol.111 , Issue.1 , pp. 99-113
    • Neve, R.L.1    McPhie, D.L.2
  • 32
    • 0033570320 scopus 로고    scopus 로고
    • Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis
    • Padmanabhan J., Park D. S., Greene L. A., and, Shelanski M. L., (1999) Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. J. Neurosci. 19 (20), 8747-8756. (Pubitemid 30226696)
    • (1999) Journal of Neuroscience , vol.19 , Issue.20 , pp. 8747-8756
    • Padmanabhan, J.1    Park, D.S.2    Greene, L.A.3    Shelanski, M.L.4
  • 33
    • 33645300736 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production
    • Pastorino L., Sun A., Lu P. J., et al. (2006) The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature 440 (7083), 528-534.
    • (2006) Nature , vol.440 , Issue.7083 , pp. 528-534
    • Pastorino, L.1    Sun, A.2    Lu, P.J.3
  • 34
    • 0034840950 scopus 로고    scopus 로고
    • Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC
    • DOI 10.1038/ncb0901-793
    • Ryo A., Nakamura M., Wulf G., Liou Y. C., and, Lu K. P., (2001) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat. Cell Biol. 3 (9), 793-801. (Pubitemid 32842684)
    • (2001) Nature Cell Biology , vol.3 , Issue.9 , pp. 793-801
    • Ryo, A.1    Nakamura, M.2    Wulf, G.3    Liou, Y.-C.4    Lu, K.P.5
  • 35
    • 0036315162 scopus 로고    scopus 로고
    • PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells
    • DOI 10.1128/MCB.22.15.5281-5295.2002
    • Ryo A., Liou Y. C., Wulf G., Nakamura M., Lee S. W., and, Lu K. P., (2002) PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells. Mol. Cell. Biol. 22 (15), 5281-5295. (Pubitemid 34755742)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.15 , pp. 5281-5295
    • Ryo, A.1    Liou, Y.-C.2    Wulf, G.3    Nakamura, M.4    Lee, S.W.5    Lu, K.P.6
  • 36
    • 0033230887 scopus 로고    scopus 로고
    • Up-regulation of cyclin D1 occurs in apoptosis of immature but not mature cerebellar granule neurons in culture
    • DOI 10.1002/(SICI)1097-4547(19991101)58:3<396::AID-JNR5>3.0.CO;2-K
    • Sakai K., Suzuki K., Tanaka S., and, Koike T., (1999) Up-regulation of cyclin D1 occurs in apoptosis of immature but not mature cerebellar granule neurons in culture. J. Neurosci. Res. 58 (3), 396-406. (Pubitemid 29508573)
    • (1999) Journal of Neuroscience Research , vol.58 , Issue.3 , pp. 396-406
    • Sakai, K.1    Suzuki, K.2    Tanaka, S.3    Koike, T.4
  • 37
    • 44949231424 scopus 로고    scopus 로고
    • T method
    • DOI 10.1038/nprot.2008.73, PII NPROT.2008.73
    • Schmittgen T. D., and, Livak K. J., (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc. 3 (6), 1101-1108. (Pubitemid 351818697)
    • (2008) Nature Protocols , vol.3 , Issue.6 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 39
    • 70349920963 scopus 로고    scopus 로고
    • Cell cycle activation and CNS injury
    • Stoica B. A., Byrnes K. R., and, Faden A. I., (2009) Cell cycle activation and CNS injury. Neurotox. Res. 16 (3), 221-237.
    • (2009) Neurotox. Res. , vol.16 , Issue.3 , pp. 221-237
    • Stoica, B.A.1    Byrnes, K.R.2    Faden, A.I.3
  • 41
    • 0346363603 scopus 로고    scopus 로고
    • Role of cyclin D1 cytoplasmic sequestration in the survival of postmitotic neurons
    • DOI 10.1038/sj.onc.1206870
    • Sumrejkanchanakij P., Tamamori-Adachi M., Matsunaga Y., Eto K., and, Ikeda M. A., (2003) Role of cyclin D1 cytoplasmic sequestration in the survival of postmitotic neurons. Oncogene 22 (54), 8723-8730. (Pubitemid 38010496)
    • (2003) Oncogene , vol.22 , Issue.54 , pp. 8723-8730
    • Sumrejkanchanakij, P.1    Tamamori-Adachi, M.2    Matsunaga, Y.3    Eto, K.4    Ikeda, M.-A.5
  • 42
    • 0032921489 scopus 로고    scopus 로고
    • Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: A modulator of in vivo programmed cell death?
    • DOI 10.1046/j.1460-9568.1999.00434.x
    • Timsit S., Rivera S., Ouaghi P., Guischard F., Tremblay E., Ben-Ari Y., and, Khrestchatisky M., (1999) Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death? Eur. J. Neurosci. 11 (1), 263-278. (Pubitemid 29012330)
    • (1999) European Journal of Neuroscience , vol.11 , Issue.1 , pp. 263-278
    • Timsit, S.1
  • 43
    • 68749118423 scopus 로고    scopus 로고
    • Neural cell cycle dysregulation and central nervous system diseases
    • Wang W., Bu B., Xie M., Zhang M., Yu Z., and, Tao D., (2009) Neural cell cycle dysregulation and central nervous system diseases. Prog. Neurobiol. 89 (1), 1-17.
    • (2009) Prog. Neurobiol. , vol.89 , Issue.1 , pp. 1-17
    • Wang, W.1    Bu, B.2    Xie, M.3    Zhang, M.4    Yu, Z.5    Tao, D.6
  • 44
    • 0037073713 scopus 로고    scopus 로고
    • Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage
    • DOI 10.1074/jbc.C200538200
    • Wulf G. M., Liou Y. C., Ryo A., Lee S. W., and, Lu K. P., (2002) Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. J. Biol. Chem. 277 (50), 47976-47979. (Pubitemid 35470742)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.50 , pp. 47976-47979
    • Wulf, G.M.1    Liou, Y.-C.2    Ryo, A.3    Lee, S.W.4    Lu, K.P.5
  • 45
    • 33947289969 scopus 로고    scopus 로고
    • Cell division in the CNS: Protective response or lethal event in post-mitotic neurons?
    • DOI 10.1016/j.bbadis.2006.10.002, PII S0925443906001992
    • Yang Y., and, Herrup K., (2007) Cell division in the CNS: protective response or lethal event in post-mitotic neurons? Biochim. Biophys. Acta 1772 (4), 457-466. (Pubitemid 46420409)
    • (2007) Biochimica et Biophysica Acta - Molecular Basis of Disease , vol.1772 , Issue.4 , pp. 457-466
    • Yang, Y.1    Herrup, K.2
  • 46
    • 0344241479 scopus 로고    scopus 로고
    • Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease
    • Yang Y., Mufson E. J., and, Herrup K., (2003) Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. J. Neurosci. 23 (7), 2557-2563. (Pubitemid 36418589)
    • (2003) Journal of Neuroscience , vol.23 , Issue.7 , pp. 2557-2563
    • Yang, Y.1    Mufson, E.J.2    Herrup, K.3
  • 47
    • 34247490735 scopus 로고    scopus 로고
    • PIN1, the cell cycle and cancer
    • DOI 10.1038/nrc2107, PII NRC2107
    • Yeh E. S., and, Means A. R., (2007) PIN1, the cell cycle and cancer. Nat. Rev. Cancer 7 (5), 381-388. (Pubitemid 46652482)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.5 , pp. 381-388
    • Yeh, E.S.1    Means, A.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.