Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein

Proteins: Structure, Function and Bioinformatics

Volumn 80, Issue 2, 2012, Pages 454-462

  Sibille, Nathalie ^a   Huvent, Isabelle ^a   Fauquant, Caroline ^b   Verdegem, Dries ^a   Amniai, Laziza ^a   Leroy, Arnaud ^c   Wieruszeski, Jean Michel ^a   Lippens, Guy ^a   Landrieu, Isabelle ^a  

^a UNIVERSITÉ DES SCIENCES ET TECHNOLOGIES DE LILLE   (France)

^b LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Alzheimer's disease; Disordered protein; Kinases; NMR spectroscopy; Phosphorylation; Secondary structure propensity; Tau

Indexed keywords

CYCLIN DEPENDENT KINASE 2; EPITOPE; PROLINE RICH PROTEIN; TAU PROTEIN; TUBULIN; MAPT PROTEIN, HUMAN; PEPTIDE FRAGMENT; PROLINE;

ALPHA HELIX; ARTICLE; CONTROLLED STUDY; MICROTUBULE ASSEMBLY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; HUMAN; METABOLISM; MICROTUBULE; NUCLEAR MAGNETIC RESONANCE; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE;

BINDING SITES; COMPUTER SIMULATION; CYCLIN-DEPENDENT KINASE 2; HUMANS; MICROTUBULES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROLINE; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; TAU PROTEINS; TUBULIN;

EID: 84855648672     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.23210     Document Type: Article

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