Mutations of Tau Protein in Frontotemporal Dementia Promote Aggregation of Paired Helical Filaments by Enhancing Local β-Structure

Journal of Biological Chemistry

Volumn 276, Issue 51, 2001, Pages 48165-48174

  Von Bergen, Martin ^b   Barghorn, Stefan ^a   Li, Li ^a   Marx, Alexander ^a   Biernat, Jacek ^a   Mandelkow, Eva Maria ^a   Mandelkow, Eckhard ^a  

^a MAX PLANCK UNIT FOR STRUCTURAL MOLECULAR BIOLOGY   (Germany)

^b Mice and More GmbH and Co KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; DISEASES; POLYMERIZATION; POLYPEPTIDES;

PAIRED HELICAL FILAMENTS (PHF);

PROTEINS;

HEXAPEPTIDE; TAU PROTEIN; UNCLASSIFIED DRUG; VALYLGLUTAMINYLISOLEUCYLISOLEUCYLASPARAGINYLLYSINE; VALYLGLUTAMINYLISOLEUCYLVALYLTYROSYLLYSINE; BIOPOLYMER; OLIGOPEPTIDE;

ALTERNATIVE RNA SPLICING; ALZHEIMER DISEASE; ARTICLE; BETA SHEET; EXON; FRONTOTEMPORAL DEMENTIA; HUMAN; MOLECULAR INTERACTION; MUTATION; NONHUMAN; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN POLYMERIZATION; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; CHEMISTRY; DEMENTIA; ELECTRON MICROSCOPY; GENETICS; INFRARED SPECTROSCOPY; METABOLISM; MOLECULAR GENETICS; PATHOLOGY; PROTEIN CONFORMATION; PROTEIN MOTIF; ULTRASTRUCTURE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BIOPOLYMERS; DEMENTIA; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; MUTATION; OLIGOPEPTIDES; PROTEIN CONFORMATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SUPPORT, NON-U.S. GOV'T; TAU PROTEINS;

EID: 0035930625     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105196200     Document Type: Article

References (67)

1. Lansbury, P. T., Jr., and Kosik, K. S. (2000) Chem. Biol. 7, R9-R12
2. Wanker, E. E. (2000) Biol. Chem. 381, 937-942
3. Prusiner, S. B. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13363-13383
4. Rochet, J. C., and Lansbury, P. T., Jr. (2000) Curr. Opin. Struct. Biol. 10, 60-68
5. Goedert, M. (1998) Prog. Brain Res. 117, 287-306
6. Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., Kholodenko, D., Lee, M., Liao, Z., Lieberburg, I., Motter, R., Mutter, L., Soriano, F., Shopp, G., Vasquez, N., Vandevert, C., Walker, S., Wogulis, M., Yednock, T., Games, D., and Seubert, P. (1999) Nature 400, 173-177
7. Tremblay, P., Meiner, Z., Galou, M., Heinrich, C., Petromilli, C., Lisse, T., Cayetano, J., Torchia, M., Mobley, W., Bujard, H., DeArmond, S. J., and Prusiner, S. B. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 12580-12585
8. Dobson, C. M. (1999) Trends Biochem. Sci. 24, 329-332
9. Harada, M., Isersky, C., Cuatrecasas, P., Page, D., Bladen, H. A., Eanes, E. D., Keiser, H. R., and Glenner, G. G. (1971) J. Histochem. Cytochem. 19, 1-15
10. Kirschner, D. A., Abraham, C., and Selkoe, D. J. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 503-507
11. Serpell, L. C., Fraser, P. E., and Sunde, M. (1999) Methods Enzymol. 309, 526-536
12. Cleveland, D. W., Hwo, S. Y., and Kirschner, M. W. (1977) J. Mol. Biol. 116, 227-247
13. Lindwall, G., and Cole, R. D. (1984) J. Biol. Chem. 259, 12241-12245
14. Wille, H., Drewes, G., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (1992) J. Cell Biol. 118, 573-584
15. Wischik, C. M., Novak, M., Thogersen, H. C., Edwards, P. C., Runswick, M. J., Jakes, R., Walker, J. E., Milstein, C., Roth, M., and Klug, A. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 4506-4510
16. Schweers, O., Mandelkow, E. M., Biernat, J., and Mandelkow, E. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 8463-8467
17. Perez, M., Valpuesta, J. M., Medina, M., Montejo de Garcini, E., and Avila, J. (1996) J. Neurochem. 67, 1183-1190
18. Goedert, M., Jakes, R., Spillantini, M. G., Hasegawa, M., Smith, M. J., and Crowther, R. A. (1996) Nature 383, 550-553
19. Kampers, T., Friedhoff, P., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (1996) FEBS Lett. 399, 344-349
20. Wilson, D. M., and Binder, L. I. (1997) Am. J. Pathol. 150, 2181-2195
21. King, M. E., Gamblin, T. C., Kuret, J., and Binder, L. I. (2000) J. Neurochem. 74, 1749-1757
22. Friedhoff, P., Schneider, A., Mandelkow, E. M., and Mandelkow, E. (1998) Biochemistry 37, 10223-10230
23. Gamblin, T. C., King, M. E., Dawson, H., Vitek, M. P., Kuret, J., Berry, R. W., and Binder, L. I. (2000) Biochemistry 39, 6136-6144
24. Schweers, O., Schonbrunn-Hanebeck, E., Marx, A., and Mandelkow, E. (1994) J. Biol. Chem. 269, 24290-24297
25. Giannetti, A. M., Lindwall, G., Chau, M. F., Radeke, M. J., Feinstein, S. C., and Kohlstaedt, L. A. (2000) Protein Sci. 9, 2427-2435
26. von Bergen, M., Friedhoff, P., Biernat, J., Heberle, J., Mandelkow, E. M., and Mandelkow, E. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 5129-5134
27. Delacourte, A., and Defossez, A. (1986) J. Neurol. Sci. 76, 173-186
28. Jakes, R., Novak, M., Davison, M., and Wischik, C. M. (1991) EMBO J. 10, 2725-2729
29. Lee, G., Cowan, N., and Kirschner, M. (1988) Science 239, 285-288
30. Goedert, M., Spillantini, M. G., Potier, M. C., Ulrich, J., and Crowther, R. A. (1989) EMBO J. 8, 393-399
31. Hutton, M. (2000) Ann. N. Y. Acad. Sci. 920, 63-73
32. Goedert, M., and Spillantini, M. G. (2000) Biochim. Biophys. Acta 1502, 110-121
33. Barghorn, S., Zheng-Fischhofer, Q., Ackmann, M., Biernat, J., von Bergen, M., Mandelkow, E. M., and Mandelkow, E. (2000) Biochemistry 39, 11714-11721
34. Nacharaju, P., Lewis, J., Easson, C., Yen, S., Hackett, J., Hutton, M., and Yen, S. H. (1999) FEBS Lett. 447, 195-199
35. Goedert, M., Jakes, R., and Crowther, R. A. (1999) FEBS Lett. 450, 306-311
36. Biernat, J., Mandelkow, E. M., Schroter, C., Lichtenberg-Kraag, B., Steiner, B., Berling, B., Meyer, H., Mercken, M., Vandermeeren, A., Goedert, M., and Mandelkow, E. (1992) EMBO J. 11, 1593-1597
37. Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., and Crowther, R. A. (1989) Neuron 3, 519-526
38. Gustke, N., Trinczek, B., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (1994) Biochemistry 33, 9511-9522
39. Goode, B. L., and Feinstein, S. C. (1994) J. Cell Biol. 124, 769-782
40. D'Souza, I., Poorkaj, P., Hong, M., Nochlin, D., Lee, V. M., Bird, T. D., and Schellenberg, G. D. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 5598-5603
41. Hong, M., Zhukareva, V., Vogelsberg-Ragaglia, V., Wszolek, Z., Reed, L., Miller, B. L., Geschwind, D. H., Bird, T. D., McKeel, D., Goate, A., Morris, J. C., Wilhelmsen, K. C., Schellenberg, G. D., Trojanowski, J. Q., and Lee, V. M. (1998) Science 282, 1914-1917
42. DeTure, M., Ko, L. W., Yen, S., Nacharaju, P., Easson, C., Lewis, J., van Slegtenhorst, M., Hutton, M., and Yen, S. H. (2000) Brain Res. 853, 5-14
43. Hasegawa, M., Smith, M. J., and Goedert, M. (1998) FEBS Lett. 437, 207-210
44. Hasegawa, M., Smith, M. J., Iijima, M., Tabira, T., and Goedert, M. (1999) FEBS Lett. 443, 93-96
45. Dayanandan, R., Van Slegtenhorst, M., Mack, T. G., Ko, L., Yen, S. H., Leroy, K., Brion, J. P., Anderton, B. H., Hutton, M., and Lovestone, S. (1999) FEBS Lett. 446, 228-232
46. Arrasate, M., Perez, M., Armas-Portela, R., and Avila, J. (1999) FEBS Lett. 446, 199-202
47. Jicha, G. A., Rockwood, J. M., Berenfeld, B., Hutton, M., and Davies, P. (1999) Neurosci. Lett. 260, 153-156
48. Eidenmuller, J., Fath, T., Hellwig, A., Reed, J., Sontag, E., and Brandt, R. (2000) Biochemistry 39, 13166-13175
49. Byler, D. M., and Susi, H. (1986) Biopolymers 25, 469-487
50. Fraser, P. E., McLachlan, D. R., Surewicz, W. K., Mizzen, C. A., Snow, A. D., Nguyen, J. T., and Kirschner, D. A. (1994) J. Mol. Biol. 244, 64-73
51. Sunde, M., Serpell, L. C., Bartlam, M., Fraser, P. E., Pepys, M. B., and Blake, C. G. (1997) J. Mol. Biol. 273, 729-739
52. Susi, H., and Byler, D. M. (1983) Biochem. Biophys. Res. Commun. 115, 391-397
53. Wille, H., Zhang, G. F., Baldwin, M. A., Cohen, F. E., and Prusiner, S. B. (1996) J. Mol. Biol. 259, 608-621
54. Koo, E. H., Lansbury, P. T., Jr., and Kelly, J. W. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 9989-9990
55. Hecht, M. H. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 8729-8730
56. West, M. W., Wang, W., Patterson, J., Mandas, J. D., Beasley, J. R., and Hecht, M. H. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11211-11216
57. Goode, B. L., Chau, M., Denis, P. E., and Feinstein, S. C. (2000) J. Biol. Chem. 275, 38182-38189
58. Rizzu, P., Joosse, M., Ravid, R., Hoogeveen, A., Kamphorst, W., van Swieten, J. C., Willemsen, R., and Heutink, P. (2000) Hum. Mol. Genet. 9, 3075-3082
59. Esler, W. P., Stimson, E. R., Jennings, J. M., Vinters, H. V., Ghilardi, J. R., Lee, J. P., Mantyh, P. W., and Maggio, J. E. (2000) Biochemistry 39, 6288-6295
60. Jordan, M. A., and Wilson, L. (1998) Curr. Opin. Cell Biol. 10, 123-130
61. Lee, V. M., and Trojanowski, J. Q. (1999) Neuron 24, 507-510
62. Goedert, M., Spillantini, M. G., Crowther, R. A., Chen, S. G., Parchi, P., Tabaton, M., Lanska, D. J., Markesbery, W. R., Wilhelmsen, K. C., Dickson, D. W., Petersen, R. B., and Gambetti, P. (1999) Nat. Med. 5, 454-457
63. Rizzu, P., Van Swieten, J. C., Joosse, M., Hasegawa, M., Stevens, M., Tibben, A., Niermeijer, M. F., Hillebrand, M., Ravid, R., Oostra, B. A., Goedert, M., van Duijn, C. M., and Heutink, P. (1999) Am. J. Hum. Genet. 64, 414-421
64. D'Souza, I., and Schellenberg, G. D. (2000) J. Biol. Chem. 275, 17700-17709
65. Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., Hackett, J., Adamson, J., Lincoln, S., Dickson, D., Davies, P., Petersen, R. C., Stevens, M., de Graaff, E., Wauters, E., van Baren, J., Hillebrand, M., Joosse, M., Kwon, J. M., Nowotny, P., Che, L. K., Norton, J., Morris, J., Reed, L., Trojanowski, J., Basun, H., Lannfelt, H., Neystat, M., Fahn, S., Dark, F., Tannenberg, T., Dodd, P., Hayward, N., Kwok, J., Schofield, P., Andreadis, A., Snowden, J., van Swieten, J., Mann, D., Lynch, T., and Heutink, P. (1998) Nature 393, 702-705
66. Ebneth, A., Godemann, R., Stamer, K., Illenberger, S., Trinczek, B., and Mandelkow, E. (1998) J. Cell Biol. 143, 777-794
67. Kirschner, D. A., Teplow, D. B., and Damas, A. M. (2000) J. Struct. Biol. 130, 87