The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology

Journal of Biological Chemistry

Volumn 271, Issue 51, 1996, Pages 32789-32795

  Carmel, Gilles ^a,b   Mager, Edward M ^a   Binder, Lester I ^a   Kuret, Jeff ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b GENOME THERAPEUTICS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY ALZ 50; TAU PROTEIN;

ALZHEIMER DISEASE; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN POLYMERIZATION;

ALZHEIMER DISEASE; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BINDING SITES; EPITOPE MAPPING; HUMANS; MACROMOLECULAR SUBSTANCES; MICROTUBULES; NEUROFIBRILLARY TANGLES; PROTEIN CONFORMATION; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP; TAU PROTEINS;

EID: 12644260802     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.51.32789     Document Type: Article

References (62)

1. Wolozin, B. L., Pruchnicki, A., Dickson, D. W., and Davies, P. (1986) Science 232, 648-650
2. Wolozin, B. L., and Davies, P. (1987) Ann. Neurol. 22, 521-526
3. Braak, E., Braak, H., and Mandelkow, E. M. (1994) Acta Neuropathol. 87, 554-567
4. Benzing, W. C., Ikonomovic, I. M., Brady, D. R., Mufson, E. J., and Armstrong, D. M. (1993) J. Comp. Neurol. 334, 176-191
5. Kidd, M. (1963) Nature 197, 192-193
6. Grundke-Iqbal, I., Iqbal, K., Tung, Y.-C., Quinlan, M., Wisnewski, H., and Binder, L. I. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 4913-4817
7. Kosik, K. S., Joachim, C. L., and Selkoe, D. J. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 4044-4048
8. Wood, J. G., Mirra, S. S., Pollock, N. J., and Binder, L. I. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 4040-4043
9. Greenberg, S. G., and Davies, P. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 5827-5831
10. Lee, V. M.-Y., Balin, B. J., Otvos, L., Jr., and Trojanowski, J. Q. (1991) Science 251, 675-678
11. Ksiezak-Reding, H., Davies, P., and Yen, S.-H. (1988) J. Biol. Chem. 263, 7943-7947
12. Goedert, M., Spillantini, M. G., and Jakes, R. (1991) Neurosci. Lett. 126, 149-154
13. Ksiezak-Reding, H., Leibowitz, R. L., Bowser, R., and Davies, P. (1995) Brain Res. 897, 63-75
14. Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., and Crowther, R. A. (1989) Neuron 3, 519-526
15. Ksiezak-Reding, H., Chien, C.-H., Lee, V. M.-Y., and Yen, S.-H. (1990) J. Neurosci. Res. 25, 412-419
16. Rye, D. B., Leverenz, J., Greenberg, S. G., Davies, P., and Saper, C. B. (1993) Neuroscience 56, 109-127
17. Wolozin, B. L., Scicutella, A., and Davies, P. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 6202-6206
18. Hyman, B. T., Van Hoesen, G. W., Wolozin, B. L., Davies, P., Kromer, J. L., and Damasio, A. R. (1988) Ann. Neurol. 23, 371-379
19. Harlow, E., and Lane, D. (1988) Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
20. Binder, L. I., Frankfurter, A., and Rebhun, L. I. (1985) J. Cell Biol. 101, 1371-1378
21. Papasozomenos, S. C., and Binder, L. I. (1987) Cell Motil. Cytoskeleton 8, 210-226
22. LoPresti, P., Szuchet, S., Papasozomenos, S. C., Zinkowski, R. P., and Binder, L. I. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 10369-10373
23. Kowall, N. W., and Kosik, K. S. (1987) Ann. Neurol. 22, 639-643
24. Kosik, K. S., Orecchio, L. D., Binder, L., Trojanowski, J. Q., Lee, V. M.-Y., and Lee, G. (1988) Neuron 1, 817-825
25. Vincent, I., Rosado, M., and Davies, P. (1996) J. Cell Biol. 132, 413-425
26. Vincent, I. J., and Davies, P. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 2878-2882
27. Kunkel, T. A., Roberts, J. D., and Zakour, R. A. (1987) Methods Enzymol. 154, 367-382
28. Studier, F. W., Rosenberg, A. H., and Dunn, J. J. (1990) Methods Enzymol. 188, 60-89
29. Meselson, M., and Yuan, R. (1968) Nature 217, 1110-1114
30. Wang, P. C., Vancura, A., Mitcheson, T. G. M., and Kuret, J. (1992) Mol. Biol. Cell 3, 275-286
31. Carmel, G., and Kuret, J. (1992) Anal. Biochem. 203, 274-280
32. Carmel, G., Leichus, B., Cheng, X., Patterson, S. D., Mirza, U., Chait, B. T., and Kuret, J. (1994) J. Biol. Chem. 269, 7304-7309
33. Vancura, A., Sessler, A., Leichus, B., and Kuret, J. (1994) J. Biol. Chem. 269, 19271-19278
34. Perkins, S. J. (1986) Eur. J. Biochem. 157, 169-180
35. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
36. Friguet, B., Chaffotte, A. F., Djavadi-Ohaniance, L., and Goldberg, M. E. (1985) J. Immunol. Methods 77, 305-319
37. Dahlquist, F. W. (1978) Methods Enzymol. 48, 270-299
38. Henderson, P. J. F. (1972) Biochem. J. 127, 321-333
39. Hulme, E. C., and Birdsall, J. M. (1992) in Receptor-Ligand Interactions: A Practical Approach (Hulme, E. C., ed), pp. 63-176, IRL Press, NY
40. Watanabe, N., Takio, K., Hasegawa, M., Arai, T., Titani, K., and Ihara, Y. (1992) J. Neurochem. 58, 960-966
41. Papasozomenos, S. C. (1989) Lab. Invest. 60, 375-388
42. Liu, W. K., Moore, W. T., Williams, R. T., Hall, F. L., and Yen, S. H. (1993) J. Neurosci. Res. 34, 371-376
43. Szendrei, G. I., Lee, V. M., and Otvos, L. (1993) J. Neurosci. Res. 34, 243-249
44. Dekeyser, F., Demol, H., Raymaeckers, J., Brasseur, R., Borremans, F., Vanmechelen, E., and Van de Voorde, A. (1996) in Peptides in Immunology (Schneider, C. H., ed), pp. 239-244, Wiley, Chichester
45. Vandermeeren, M., Mercken, M., Vanmechelen, E., Six, J., van de Voorde A., Martin, J. J., and Cras, P. (1993) J. Neurochem. 61, 1828-1834
46. Skoog, I., Vanmechelen, E., Andreasson, L. A., Palmertz, B., Davidsson, P., Hesse, C., and Blennow, K. (1995) Neurodegeneration 4, 433-442
47. Goedert, M., Spillantini, M. G., Potier, M. C., Ulrich, J., and Crowther, R. A. (1989) EMBO J. 8, 393-399
48. Wang, P.-C., Vancura, A., Desai, A, Carmel, G., and Kuret, J. (1994) J. Biol. Chem. 269, 12014-12023
49. Ikonomovic, M. D., Armstrong, D. M., Yen, S. H., Obcemea, C., and Vidic, B. (1995) Am. J. Pathol. 147, 516-528
50. Wischik, C. M., Crowther, R. A., Stewart, M., and Roth, M. (1985) J. Cell Biol. 100, 1905-1912
51. Ruben, G. C., Iqbal, K., Grundke-Iqbal, I., and Johnson, J. E. (1993) Brain Res. 602, 1-13
52. Ruben, G. C., Novak, M., Edwards, P. C., and Iqbal, K. (1995) Brain Res. 675, 1-12
53. Ghanbari, H. A., Miller, B. E., Haigler, H. J., Arato, M., Bissette, G., Davies, P., Nemeroff, C. B., Perry, E. K., Perry, R., Ravid, R., Swaab, D. F., Whetsell, W. O., and Semlan, F. P. (1990) J. Am. Med. Assoc. 263, 2907-2910
54. Schweers, O., Schonhrunn-Hanebeck, E., Marx, A., and Mandelkow, E. (1994) J. Biol. Chem. 269, 24290-24297
55. Davis, P. K., and Johnson, G. V. W. (1995) J. Neurosci. Res. 39, 589-594
56. Bowser, R., Giambrone, A., and Davies, P. (1995) Dev. Neurosci. 17, 20-37
57. Ueda, K., Masliah, E., Saitoh, T., Bakalis, S. K., Scoble, H., and Kosik, K. S. (1990) J. Neurosci. 10, 3295-3304
58. Trojanowski, J. Q., and Lee, V. M. (1994) Am. J. Pathol. 144, 449-453
59. Goedert, M. (1993) Trends Neurosci. 16, 460-465
60. LeVine, H. (1993) Protein Sci. 2, 404-410
61. Hwang, S. C., Jhon, D.-Y., Bae, Y. S., Kim, J. H., and Rhee, S. G. (1996) J. Biol. Chem. 271, 18342-18349
62. Andreadis, A., Brown, W. M., and Kosik, K. S. (1992) Biochemistry 31, 10626-10633