Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic tau mutant

Journal of Neuroscience

Volumn 31, Issue 7, 2011, Pages 2511-2525

  Sydow, Astrid ^a   Van Der Jeugd, Ann ^c   Zheng, Fang ^d   Ahmed, Tariq ^c   Balschun, Detlef ^c   Petrova, Olga ^a   Drexler, Dagmar ^a   Zhou, Lepu ^e   Rune, Gabriele ^e   Mandelkow, Eckhard ^a,b   D'Hooge, Rudi ^c   Alzheimer, Christian ^d   Mandelkow, Eva Maria ^a,b  

^a DESY   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e University of Medical School Hamburg Eppendorf   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TAU PROTEIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; HISTOPATHOLOGY; LEARNING DISORDER; LONG TERM POTENTIATION; MALE; MEMORY DISORDER; MOTONEURON; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; TASK PERFORMANCE; TRANSGENIC MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; DOXYCYCLINE; HAND STRENGTH; HIPPOCAMPUS; HUMANS; LONG-TERM POTENTIATION; MAZE LEARNING; MEMORY; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; NEUROPSYCHOLOGICAL TESTS; PROTEIN STRUCTURE, TERTIARY; SPACE PERCEPTION; SYNAPSES; TAU PROTEINS; TAUOPATHIES; TIME FACTORS;

EID: 79951818085     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5245-10.2011     Document Type: Article

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