Tau, tangles, and Alzheimer's disease

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1739, Issue 2, 2005, Pages 216-223

  Binder, Lester I ^a   Guillozet Bongaarts, Angela L ^a   Garcia Sierra, Francisco ^b   Berry, Robert W ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Alzheimer's disease; Neurofibrillary tangle; Tau

Indexed keywords

CASPASE; TAU PROTEIN;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FRONTOTEMPORAL DEMENTIA; MICROTUBULE; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN POLYMERIZATION; PROTEIN STRUCTURE; REVIEW; WESTERN BLOTTING;

ALZHEIMER DISEASE; CASPASES; HUMANS; MODELS, BIOLOGICAL; NEUROFIBRILLARY TANGLES; NEUROFIBRILS; PROTEIN CONFORMATION; TAU PROTEINS;

EID: 10944248857     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2004.08.014     Document Type: Review

References (53)

1. I. Grundke-Iqbal, K. Iqbal, Y.C. Tung, M. Quinlan, H.M. Wisniewski, and L.I. Binder Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology Proc. Natl. Acad. Sci. U. S. A. 83 1986 4913 4917
2. K.S. Kosik, C.L. Joachim, and D.J. Selkoe Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease Proc. Natl. Acad. Sci. U. S. A. 83 1986 4044 4048
3. J.G. Wood, S.S. Mirra, N.J. Pollock, and L.I. Binder Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau) [published erratum appears in Proc. Natl. Acad. Sci. U. S. A. 1986 Dec.; 83 (24): 9773] Proc. Natl. Acad. Sci. U. S. A. 83 1986 4040 4043
4. M. Goedert, M.G. Spillantini, and S.W. Davies Filamentous nerve cell inclusions in neurodegenerative diseases Curr. Opin. Neurobiol. 8 1998 619 632
5. P.V. Arriagada, J.H. Growdon, E.T. Hedley-Whyte, and B.T. Hyman Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease Neurology 42 1992 631 639
6. N. Ghoshal, F. Garcia-Sierra, J. Wuu, S. Leurgans, D.A. Bennett, R.W. Berry, and L.I. Binder Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease Exp. Neurol. 177 2002 475 493
7. T.W. Mitchell, E.J. Mufson, J.A. Schneider, E.J. Cochran, J. Nissanov, L.Y. Han, J.L. Bienias, V.M. Lee, J.Q. Trojanowski, D.A. Bennett, and S.E. Arnold Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease Ann. Neurol. 51 2002 182 189
8. J.Q. Trojanowski, and V.M. Lee Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases FASEB J. 9 1995 1570 1576
9. J.Q. Trojanowski, M.L. Schmidt, R.W. Shin, G.T. Bramblett, D. Rao, and V.M. Lee Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias Brain Pathol. 3 1993 45 54
10. P. Friedhoff, M. von Bergen, E.M. Mandelkow, and E. Mandelkow Structure of tau protein and assembly into paired helical filaments Biochim. Biophys. Acta 1502 2000 122 132
11. M.L. Billingsley, and R.L. Kincaid Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration Biochem. J. 323 1997 577 591
12. J. Avila Tau aggregation into fibrillar polymers: taupathies FEBS Lett. 476 2000 89 92
13. C.M. Wischik, M. Novak, P.C. Edwards, A. Klug, W. Tichelaar, and R.A. Crowther Structural characterization of the core of the paired helical filament of Alzheimer disease Proc. Natl. Acad. Sci. U. S. A. 85 1988 4884 4888
14. C.M. Wischik, M. Novak, H.C. Thogersen, P.C. Edwards, M.J. Runswick, R. Jakes, J.E. Walker, C. Milstein, M. Roth, and A. Klug Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease Proc. Natl. Acad. Sci. U. S. A. 85 1988 4506 4510
15. M.G. Spillantini, and M. Goedert Tau protein pathology in neurodegenerative diseases Trends Neurosci. 21 1998 428 433
16. M.G. Spillantini, T.D. Bird, and B. Ghetti Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies Brain Pathol. 8 1998 387 402
17. P. Nacharaju, J. Lewis, C. Easson, S. Yen, J. Hackett, M. Hutton, and S.H. Yen Accelerated filament formation from tau protein with specific FTDP-17 missense mutations FEBS Lett. 447 1999 195 199
18. T.C. Gamblin, M.E. King, H. Dawson, M.P. Vitek, J. Kuret, R.W. Berry, and L.I. Binder In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants Biochemistry 39 2000 6136 6144
19. M.E. King, T.C. Gamblin, J. Kuret, and L.I. Binder Differential assembly of human tau isoforms in the presence of arachidonic acid J. Neurochem. 74 2000 1749 1757
20. G.F. Hall, J. Yao, and G. Lee Human tau becomes phosphorylated and forms filamentous deposits when overexpressed in lamprey central neurons in situ Proc. Natl. Acad. Sci. U. S. A. 94 1997 4733 4738
21. G.F. Hall, B. Chu, G. Lee, and J. Yao Human tau filaments induce microtubule and synapse loss in an in vivo model of neurofibrillary degenerative disease J. Cell. Sci. 113 2000 1373 1387
22. J. Hardy, K. Duff, K.G. Hardy, J. Perez-Tur, and M. Hutton Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau [published erratum appears in Nat. Neurosci. 1998 Dec.; 1 (8): 743] Nat. Neurosci. 1 1998 355 358
23. G. Carmel, E.M. Mager, L.I. Binder, and J. Kuret The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology J. Biol. Chem. 271 1996 32789 32795
24. G.A. Jicha, R. Bowser, I.G. Kazam, and P. Davies Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau J. Neurosci. Res. 48 1997 128 132
25. E.M. Mandelkow, O. Schweers, G. Drewes, J. Biernat, N. Gustke, B. Trinczek, and E. Mandelkow Structure, microtubule interactions, and phosphorylation of tau protein Ann. N.Y. Acad. Sci. 777 1996 96 106
26. N. Ghoshal, F. García-Sierra, Y. Fu, L.A. Beckett, E.J. Mufson, J. Kuret, R.W. Berry, and L.I. Binder Tau-66: evidence for a novel tau conformation in Alzheimer's disease J. Neurochem. 77 2001 1372 1385
27. F. García-Sierra, N. Ghoshal, B. Quinn, R. Berry, and L.I. Binder Conformational changes and truncation of tau protein during tangle evolution in Alzheimer's disease J. Alzheimer's Dis. 5 2003 65 77
28. M. Novak, J. Kabat, and C.M. Wischik Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament EMBO J. 12 1993 365 370
29. J.P. Brion, D.P. Hanger, A.M. Couck, and B.H. Anderton A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities Biochem. J. 279 Pt 3 1991 831 836
30. V.M. Lee, B.J. Balin, L. Otvos Jr., and J.Q. Trojanowski A68: a major subunit of paired helical filaments and derivatized forms of normal tau Science 251 1991 675 678
31. T.C. Gamblin, R.W. Berry, and L.I. Binder Tau polymerization: role of the amino terminus Biochemistry 42 2003 2252 2257
32. A. Abraha, N. Ghoshal, T.C. Gamblin, V. Cryns, R.W. Berry, J. Kuret, and L.I. Binder C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease J. Cell. Sci. 113 2000 3737 3745
33. C.M. Wischik Cell biology of the Alzheimer tangle Curr. Opin. Cell Biol. 1 1989 115 122
34. T.C. Gamblin, F. Chen, A. Abraha, R. Miller, Y. Fu, F. Garcia-Sierra, S. Lagalwar, R.W. Berry, L.I. Binder, and V.L. Cryns Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's Disease Proc. Natl. Acad. Sci. U. S. A. 100 2003 10032 10037
35. R.W. Berry, A. Abraha, S. Lagalwar, N. La Pomte, T.C. Gamblin, V.L. Cryns, and L.I. Binder Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment Biochemistry 42 2003 8325 8331
36. V. Cryns, and J. Yuan Proteases to die for Genes Dev. 12 1998 1551 1570
37. F.G. Gervais, D. Xu, G.S. Robertson, J.P. Vaillancourt, Y. Zhu, J. Huang, A. LeBlanc, D. Smith, M. Rigby, M.S. Shearman, E.E. Clarke, H. Zheng, L.H. Van Der Ploeg, S.C. Ruffolo, N.A. Thornberry, S. Xanthoudakis, R.J. Zamboni, S. Roy, and D.W. Nicholson Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation Cell 97 1999 395 406
38. C.M. Troy, S.A. Rabacchi, W.J. Friedman, T.F. Frappier, K. Brown, and M.L. Shelanski Caspase-2 mediates neuronal cell death induced by beta-amyloid J. Neurosci. 20 2000 1386 1392
39. C.W. Cotman, and J.H. Su Mechanisms of neuronal death in Alzheimer's disease Brain Pathol. 6 1996 493 506
40. G. Smale, N.R. Nichols, D.R. Brady, C.E. Finch, and W.E. Horton Jr. Evidence for apoptotic cell death in Alzheimer's disease Exp. Neurol. 133 1995 225 230
41. J.H. Su, G. Deng, and C.W. Cotman Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology J. Neuropathol. Exp. Neurol. 56 1997 86 93
42. E. Masliah, M. Mallory, M. Alford, S. Tanaka, and L.A. Hansen Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease J. Neuropathol. Exp. Neurol. 57 1998 1041 1052
43. L.A. Selznick, D.M. Holtzman, B.H. Han, M. Gokden, A.N. Srinivasan, E.M. Johnson Jr., and K.A. Roth In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease J. Neuropathol. Exp. Neurol. 58 1999 1020 1026
44. L.A. Selznick, T.S. Zheng, R.A. Flavell, P. Rakic, and K.A. Roth Amyloid beta-induced neuronal death is bax-dependent but caspase-independent J. Neuropathol. Exp. Neurol. 59 2000 271 279
45. S.L. Chan, W.S. Griffin, and M.P. Mattson Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease J. Neurosci. Res. 57 1999 315 323
46. N. Canu, L. Dus, C. Barbato, M.T. Ciotti, C. Brancolini, A.M. Rinaldi, M. Novak, A. Cattaneo, A. Bradbury, and P. Calissano Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis J. Neurosci. 18 1998 7061 7074
47. A.L. Guillozet-Bongaarts, F. Garcia-Sierra, M.R. Reynolds, P.H. Horowitz, Y. Fu, T. Wang, M.E. Cahill, E.H. Bigio, R.W. Berry, and L.I. Binder Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease Neurobiol. Aging 2004 (in press)
48. R.A. Rissman, W.W. Poon, M. Blurton-Jones, S. Oddo, R. Torp, M.P. Vitek, F.M. LaFerla, T.T. Rohn, and C.W. Cotman Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology J. Clin. Invest. 114 2004 121 130
49. P.H. Horowitz, K.R. Patterson, A.L. Guillozet-Bongaarts, M.R. Reynolds, C.A. Carroll, S.T. Weintraub, D.A. Bennett, V.L. Cryns, R.W. Berry, and L.I. Binder Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease J. Neurosci. 24 2004 7895 7902
50. L. Fasulo, M. Visintin, M. Novak, and A. Cattaneo Tau truncation in Alzheimer's disease: expression of a fragment encompassing PHF core tau induces apoptosis in COS cells Alzheimer's Rep. 1 1998 25 32
51. L. Fasulo, G. Ugolini, M. Visintin, A. Bradbury, C. Brancolini, V. Verzillo, M. Novak, and A. Cattaneo The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis J. Neurochem. 75 2000 624 633
52. M. Rapoport, H.N. Dawson, L.I. Binder, M.P. Vitek, and A. Ferreira Tau is essential to beta-amyloid-induced neurotoxicity Proc. Natl. Acad. Sci. U. S. A. 99 2002 6364 6369
53. E. Braak, H. Braak, and E.M. Mandelkow A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads Acta Neuropathol. 87 1994 554 567