메뉴 건너뛰기




Volumn 8, Issue 1, 2009, Pages 7-15

The role of microglia in antibody-mediated clearance of amyloid-beta from the brain

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN[25-35]; CARBOXY TERMINAL AMYLOID BETA PROTEIN X 40 ANTIBODY FAB FRAGMENT; CD45 ANTIGEN; FC RECEPTOR; MINOCYCLINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2H6; MONOCLONAL ANTIBODY 6E10; UNCLASSIFIED DRUG; ANTIBODY;

EID: 65649098369     PISSN: 18715273     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152709787601821     Document Type: Article
Times cited : (49)

References (55)
  • 3
    • 0030058382 scopus 로고    scopus 로고
    • Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide
    • Solomon, B.; Koppel, R.; Hanan, E.; Katzav, T. Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc. Natl. Acad. Sci. USA, 1996, 93(1), 452-455.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , Issue.1 , pp. 452-455
    • Solomon, B.1    Koppel, R.2    Hanan, E.3    Katzav, T.4
  • 4
    • 84880189986 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer's disease
    • Morgan, D. Immunotherapy for Alzheimer's disease. J. Alzheimers Dis., 2006, 9(3 Suppl), 425-432.
    • (2006) J. Alzheimers Dis , vol.9 , Issue.3 SUPPL. , pp. 425-432
    • Morgan, D.1
  • 6
    • 0035877075 scopus 로고    scopus 로고
    • Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q
    • Webster, S.D.; Galvan, M.D.; Ferran, E.; Garzon-Rodriguez, W.; Glabe, C.G.; Tenner, A. J. Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q. J. Immunol., 2001, 166(12), 7496-7503.
    • (2001) J. Immunol , vol.166 , Issue.12 , pp. 7496-7503
    • Webster, S.D.1    Galvan, M.D.2    Ferran, E.3    Garzon-Rodriguez, W.4    Glabe, C.G.5    Tenner, A.J.6
  • 7
    • 24744467358 scopus 로고    scopus 로고
    • Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines
    • Koenigsknecht-Talboo, J.; Landreth, G.E. Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines. J. Neurosci., 2005, 25(36), 8240-8249.
    • (2005) J. Neurosci , vol.25 , Issue.36 , pp. 8240-8249
    • Koenigsknecht-Talboo, J.1    Landreth, G.E.2
  • 8
    • 0141457897 scopus 로고    scopus 로고
    • Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice
    • Das, P.; Howard, V.; Loosbrock, N.; Dickson, D.; Murphy, M.P.; Golde, T.E. Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice. J. Neurosci., 2003, 23(24), 8532-8538.
    • (2003) J. Neurosci , vol.23 , Issue.24 , pp. 8532-8538
    • Das, P.1    Howard, V.2    Loosbrock, N.3    Dickson, D.4    Murphy, M.P.5    Golde, T.E.6
  • 9
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos, R.B.; Bales, K.R.; Cummins, D.J.; Dodart, J.C.; Paul, S.M.; Holtzman, D.M. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA, 2001, 98(15), 8850-8855.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , Issue.15 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 10
    • 30844472909 scopus 로고    scopus 로고
    • IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor
    • Deane, R.; Sagare, A.; Hamm, K.; Parisi, M.; LaRue, B.; Guo, H.; Wu, Z.; Holtzman, D.M.; Zlokovic, B. V. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J. Neurosci., 2005, 25(50), 11495-11503.
    • (2005) J. Neurosci , vol.25 , Issue.50 , pp. 11495-11503
    • Deane, R.1    Sagare, A.2    Hamm, K.3    Parisi, M.4    LaRue, B.5    Guo, H.6    Wu, Z.7    Holtzman, D.M.8    Zlokovic, B.V.9
  • 11
    • 0034612175 scopus 로고    scopus 로고
    • Akiyama, H.; Barger, S.; Barnum, S.; Bradt, B.; Bauer, J.; Cole, G.M.; Cooper, N.R.; Eikelenboom, P.; Emmerling, M.; Fiebich, B.L.; Finch, C.E.; Frautschy, S.; Griffin, W.S.; Hampel, H.; Hull, M.; Landreth, G.; Lue, L.; Mrak, R.; Mackenzie, I.R.; McGeer, P.L.; O'Banion, M. K.; Pachter, J.; Pasinetti, G.; Plata-Salaman, C.; Rogers, J.; Rydel, R.; Shen, Y.; Streit, W.; Strohmeyer, R.; Tooyoma, I.; Van Muiswinkel, F.L.; Veerhuis, R.; Walker, D.; Webster, S.; Wegrzyniak, B.; Wenk, G.; Wyss-Coray, T. Inflammation and Alzheimer's disease. Neurobiol. Aging, 2000, 21(3), 383-421.
    • Akiyama, H.; Barger, S.; Barnum, S.; Bradt, B.; Bauer, J.; Cole, G.M.; Cooper, N.R.; Eikelenboom, P.; Emmerling, M.; Fiebich, B.L.; Finch, C.E.; Frautschy, S.; Griffin, W.S.; Hampel, H.; Hull, M.; Landreth, G.; Lue, L.; Mrak, R.; Mackenzie, I.R.; McGeer, P.L.; O'Banion, M. K.; Pachter, J.; Pasinetti, G.; Plata-Salaman, C.; Rogers, J.; Rydel, R.; Shen, Y.; Streit, W.; Strohmeyer, R.; Tooyoma, I.; Van Muiswinkel, F.L.; Veerhuis, R.; Walker, D.; Webster, S.; Wegrzyniak, B.; Wenk, G.; Wyss-Coray, T. Inflammation and Alzheimer's disease. Neurobiol. Aging, 2000, 21(3), 383-421.
  • 15
    • 5044222305 scopus 로고    scopus 로고
    • Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice
    • Herber, D.L.; Roth, L.M.; Wilson, D.; Wilson, N.; Mason, J.E.; Morgan, D.; Gordon, M.N. Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice. Exp. Neurol., 2004, 190(1), 245-253.
    • (2004) Exp. Neurol , vol.190 , Issue.1 , pp. 245-253
    • Herber, D.L.1    Roth, L.M.2    Wilson, D.3    Wilson, N.4    Mason, J.E.5    Morgan, D.6    Gordon, M.N.7
  • 16
    • 0035696328 scopus 로고    scopus 로고
    • Intrahippocampal LPS injections reduce Aá load in APP+PS1 transgenic mice
    • DiCarlo, G.; Wilcock, D.; Henderson, D.; Gordon, M.; Morgan, D. Intrahippocampal LPS injections reduce Aá load in APP+PS1 transgenic mice. Neurobiol. Aging, 2001, 22, 1007-1012.
    • (2001) Neurobiol. Aging , vol.22 , pp. 1007-1012
    • DiCarlo, G.1    Wilcock, D.2    Henderson, D.3    Gordon, M.4    Morgan, D.5
  • 17
    • 11844255779 scopus 로고    scopus 로고
    • Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice
    • Malm, T.M.; Koistinaho, M.; Parepalo, M.; Vatanen, T.; Ooka, A.; Karlsson, S.; Koistinaho, J. Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice. Neurobiol. Dis., 2005, 18(1), 134-142.
    • (2005) Neurobiol. Dis , vol.18 , Issue.1 , pp. 134-142
    • Malm, T.M.1    Koistinaho, M.2    Parepalo, M.3    Vatanen, T.4    Ooka, A.5    Karlsson, S.6    Koistinaho, J.7
  • 18
    • 0037376760 scopus 로고    scopus 로고
    • Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease
    • Quinn, J.; Montine, T.; Morrow, J.; Woodward, W.R.; Kulhanek, D.; Eckenstein, F. Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease. J. Neuroimmunol., 2003, 137(1-2), 32-41.
    • (2003) J. Neuroimmunol , vol.137 , Issue.1-2 , pp. 32-41
    • Quinn, J.1    Montine, T.2    Morrow, J.3    Woodward, W.R.4    Kulhanek, D.5    Eckenstein, F.6
  • 19
    • 34249899174 scopus 로고    scopus 로고
    • Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
    • Shaftel, S.S.; Kyrkanides, S.; Olschowka, J.A.; Miller, J.N.; Johnson, R.E.; O'Banion, M.K. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J. Clin. Invest., 2007, 117(6), 1595-1604.
    • (2007) J. Clin. Invest , vol.117 , Issue.6 , pp. 1595-1604
    • Shaftel, S.S.1    Kyrkanides, S.2    Olschowka, J.A.3    Miller, J.N.4    Johnson, R.E.5    O'Banion, M.K.6
  • 22
    • 46749087854 scopus 로고    scopus 로고
    • Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/ macrophage phenotype in amyloid precursor protein transgenic mice
    • Maier, M.; Peng, Y.; Jiang, L.; Seabrook, T.J.; Carroll, M.C.; Lemere, C.A. Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/ macrophage phenotype in amyloid precursor protein transgenic mice. J. Neurosci., 2008, 28(25), 6333-6341.
    • (2008) J. Neurosci , vol.28 , Issue.25 , pp. 6333-6341
    • Maier, M.1    Peng, Y.2    Jiang, L.3    Seabrook, T.J.4    Carroll, M.C.5    Lemere, C.A.6
  • 23
    • 24644438615 scopus 로고    scopus 로고
    • Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: Implications for Alzheimer therapeutics
    • Morgan, D.; Gordon, M.N.; Tan, J.; Wilcock, D.; Rojiani, A.M. Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. J. Neuropathol. Exp. Neurol., 2005, 64(9), 743-753.
    • (2005) J. Neuropathol. Exp. Neurol , vol.64 , Issue.9 , pp. 743-753
    • Morgan, D.1    Gordon, M.N.2    Tan, J.3    Wilcock, D.4    Rojiani, A.M.5
  • 24
    • 44149083565 scopus 로고    scopus 로고
    • Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease
    • Farfara, D.; Lifshitz, V.; Frenkel, D. Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease. J. Cell Mol. Med., 2008, 12(3), 762-780.
    • (2008) J. Cell Mol. Med , vol.12 , Issue.3 , pp. 762-780
    • Farfara, D.1    Lifshitz, V.2    Frenkel, D.3
  • 25
    • 34547380204 scopus 로고    scopus 로고
    • Rogers, J.; Mastroeni, D.; Leonard, B.; Joyce, J.; Grover, A. Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder? Int. Rev. Neurobiol., 2007, 82, 235-246.
    • Rogers, J.; Mastroeni, D.; Leonard, B.; Joyce, J.; Grover, A. Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder? Int. Rev. Neurobiol., 2007, 82, 235-246.
  • 26
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: Driving force, bystander or beneficial response?
    • Wyss-Coray, T. Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat. Med., 2006, 12(9), 1005-1015.
    • (2006) Nat. Med , vol.12 , Issue.9 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 27
  • 28
    • 0037531198 scopus 로고    scopus 로고
    • Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation
    • Wilcock, D.M.; DiCarlo, G.; Henderson, D.; Jackson, J.; Clarke, K.; Ugen, K.E.; Gordon, M.N.; Morgan, D. Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. J. Neurosci., 2003, 23(9), 3745-3751.
    • (2003) J. Neurosci , vol.23 , Issue.9 , pp. 3745-3751
    • Wilcock, D.M.1    DiCarlo, G.2    Henderson, D.3    Jackson, J.4    Clarke, K.5    Ugen, K.E.6    Gordon, M.N.7    Morgan, D.8
  • 29
    • 1642497601 scopus 로고    scopus 로고
    • Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration
    • Wilcock, D.M.; Munireddy, S.K.; Rosenthal, A.; Ugen, K.E.; Gordon, M.N.; Morgan, D. Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration. Neurobiol. Dis., 2004, 15(1), 11-20.
    • (2004) Neurobiol. Dis , vol.15 , Issue.1 , pp. 11-20
    • Wilcock, D.M.1    Munireddy, S.K.2    Rosenthal, A.3    Ugen, K.E.4    Gordon, M.N.5    Morgan, D.6
  • 30
    • 0037107177 scopus 로고    scopus 로고
    • Non-Fcmediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy
    • Bacskai, B.J.; Kajdasz, S.T.; McLellan, M.E.; Games, D.; Seubert, P.; Schenk, D.; Hyman, B.T. Non-Fcmediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J. Neurosci., 2002, 22(18), 7873-7878.
    • (2002) J. Neurosci , vol.22 , Issue.18 , pp. 7873-7878
    • Bacskai, B.J.1    Kajdasz, S.T.2    McLellan, M.E.3    Games, D.4    Seubert, P.5    Schenk, D.6    Hyman, B.T.7
  • 31
    • 34547451145 scopus 로고    scopus 로고
    • Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model
    • Garcia-Alloza, M.; Borrelli, L. A.; Rozkalne, A.; Hyman, B.T.; Bacskai, B. J. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J. Neurochem., 2007, 102(4), 1095-1104.
    • (2007) J. Neurochem , vol.102 , Issue.4 , pp. 1095-1104
    • Garcia-Alloza, M.1    Borrelli, L.A.2    Rozkalne, A.3    Hyman, B.T.4    Bacskai, B.J.5
  • 33
    • 27144450504 scopus 로고    scopus 로고
    • Deglycosylation of anti-beta amyloid antibodies inhibits microglia activation in BV-2 cellular model
    • Rebe, S.; Solomon, B. Deglycosylation of anti-beta amyloid antibodies inhibits microglia activation in BV-2 cellular model. Am. J. Alzheimers Dis. Demen., 2005, 20(5), 303-313.
    • (2005) Am. J. Alzheimers Dis. Demen , vol.20 , Issue.5 , pp. 303-313
    • Rebe, S.1    Solomon, B.2
  • 35
    • 33745111586 scopus 로고    scopus 로고
    • Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice
    • Carty, N.C.; Wilcock, D.M.; Rosenthal, A.; Grimm, J.; Pons, J.; Ronan, V.; Gottschall, P.E.; Gordon, M.N.; Morgan, D. Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice. J. Neuroinflammation, 2006, 3(1), 11.
    • (2006) J. Neuroinflammation , vol.3 , Issue.1 , pp. 11
    • Carty, N.C.1    Wilcock, D.M.2    Rosenthal, A.3    Grimm, J.4    Pons, J.5    Ronan, V.6    Gottschall, P.E.7    Gordon, M.N.8    Morgan, D.9
  • 37
    • 14244255355 scopus 로고    scopus 로고
    • Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage
    • Wilcock, D.M.; Rojiani, A.; Rosenthal, A.; Subbarao, S.; Freeman, M.J.; Gordon, M.N.; Morgan, D. Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage. J. Neuroinflammation, 2004, 1(1), 24.
    • (2004) J. Neuroinflammation , vol.1 , Issue.1 , pp. 24
    • Wilcock, D.M.1    Rojiani, A.2    Rosenthal, A.3    Subbarao, S.4    Freeman, M.J.5    Gordon, M.N.6    Morgan, D.7
  • 39
    • 33845904135 scopus 로고    scopus 로고
    • Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid
    • Wilcock, D.M.; Jantzen, P.T.; Li, Q.; Morgan, D.; Gordon, M.N. Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid. Neuroscience, 2007, 144(3), 950-960.
    • (2007) Neuroscience , vol.144 , Issue.3 , pp. 950-960
    • Wilcock, D.M.1    Jantzen, P.T.2    Li, Q.3    Morgan, D.4    Gordon, M.N.5
  • 40
    • 33745001453 scopus 로고    scopus 로고
    • Deglycosylated antiamyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice
    • Wilcock, D.M.; Alamed, J.; Gottschall, P.E.; Grimm, J.; Rosenthal, A.; Pons, J.; Ronan, V.; Symmonds, K.; Gordon, M. N.; Morgan, D. Deglycosylated antiamyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice. J. Neurosci., 2006, 26(20), 5340-5346.
    • (2006) J. Neurosci , vol.26 , Issue.20 , pp. 5340-5346
    • Wilcock, D.M.1    Alamed, J.2    Gottschall, P.E.3    Grimm, J.4    Rosenthal, A.5    Pons, J.6    Ronan, V.7    Symmonds, K.8    Gordon, M.N.9    Morgan, D.10
  • 44
    • 41149149333 scopus 로고    scopus 로고
    • The role of the immune system in clearance of Abeta from the brain
    • Boche, D.; Nicoll, J.A. The role of the immune system in clearance of Abeta from the brain. Brain Pathol., 2008, 18(2), 267-278.
    • (2008) Brain Pathol , vol.18 , Issue.2 , pp. 267-278
    • Boche, D.1    Nicoll, J.A.2
  • 48
    • 0026440987 scopus 로고
    • Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group
    • DeKosky, S.T.; Harbaugh, R.E.; Schmitt, F.A.; Bakay, R.A.; Chui, H.C.; Knopman, D.S.; Reeder, T.M.; Shetter, A.G.; Senter, H.J.; Markesbery, W.R. Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group. Ann. Neurol., 1992, 32, 625-632.
    • (1992) Ann. Neurol , vol.32 , pp. 625-632
    • DeKosky, S.T.1    Harbaugh, R.E.2    Schmitt, F.A.3    Bakay, R.A.4    Chui, H.C.5    Knopman, D.S.6    Reeder, T.M.7    Shetter, A.G.8    Senter, H.J.9    Markesbery, W.R.10
  • 49
    • 0035168927 scopus 로고    scopus 로고
    • Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease
    • Morris, J.C.; Price, A.L. Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease. J. Mol. Neurosci., 2001, 17(2), 101-118.
    • (2001) J. Mol. Neurosci , vol.17 , Issue.2 , pp. 101-118
    • Morris, J.C.1    Price, A.L.2
  • 51
    • 3042845492 scopus 로고    scopus 로고
    • Microglia and Alzheimer's disease pathogenesis
    • Streit, W.J. Microglia and Alzheimer's disease pathogenesis. J. Neurosci. Res., 2004, 77(1), 1-8.
    • (2004) J. Neurosci. Res , vol.77 , Issue.1 , pp. 1-8
    • Streit, W.J.1
  • 52
    • 37149008108 scopus 로고    scopus 로고
    • Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice
    • Vasilevko, V.; Xu, F.; Previti, M.L.; Van Nostrand, W.E.; Cribbs, D.H. Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice. J. Neurosci., 2007, 27(49), 13376-13383.
    • (2007) J. Neurosci , vol.27 , Issue.49 , pp. 13376-13383
    • Vasilevko, V.1    Xu, F.2    Previti, M.L.3    Van Nostrand, W.E.4    Cribbs, D.H.5
  • 54
    • 0036953160 scopus 로고    scopus 로고
    • Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease
    • Banks, W.A.; Terrell, B.; Farr, S.A.; Robinson, S.M.; Nonaka, N.; Morley, J.E. Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease. Peptides, 2002, 23(12), 2223-2226.
    • (2002) Peptides , vol.23 , Issue.12 , pp. 2223-2226
    • Banks, W.A.1    Terrell, B.2    Farr, S.A.3    Robinson, S.M.4    Nonaka, N.5    Morley, J.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.