Cleavage of Tau by calpain in Alzheimer's disease: The quest for the toxic 17 kD fragment

Neurobiology of Aging

Volumn 32, Issue 1, 2011, Pages 1-14

  Garg, Sarika ^a   Timm, Thomas ^a   Mandelkow, Eva Maria ^a,b   Mandelkow, Eckhard ^a,b   Wang, Yipeng ^a  

^a MAX PLANCK UNIT FOR STRUCTURAL MOLECULAR BIOLOGY   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

Amyloid A ; Calpain; Fragmentation; Neurodegeneration; Tau; Toxicity

Indexed keywords

AMYLOID BETA PROTEIN; CALPAIN; EPITOPE; GLUTAMIC ACID; OKADAIC ACID; OLIGOMER; TAU PROTEIN; THAPSIGARGIN;

AGED; ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN HOMOGENATE; BRAIN NERVE CELL; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; GENE MUTATION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MOLECULAR WEIGHT; NERVE CELL CULTURE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CALMODULIN-BINDING PROTEINS; CALPAIN; CELL COUNT; CEREBRAL CORTEX; CRICETINAE; CRICETULUS; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; GLUTAMIC ACID; GREEN FLUORESCENT PROTEINS; HUMANS; IN SITU NICK-END LABELING; MOLECULAR WEIGHT; MUTATION; NEURONS; PEPTIDE FRAGMENTS; PEPTIDES; PHOSPHORYLATION; RATS; TAU PROTEINS; THAPSIGARGIN; TRANSFECTION;

EID: 78449296170     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2010.09.008     Document Type: Article

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