Sites of tau important for aggregation populate β-structure and bind to microtubules and polyanions

Journal of Biological Chemistry

Volumn 280, Issue 26, 2005, Pages 24978-24986

  Mukrasch, Marco D ^a   Biernat, Jacek ^b   Von Bergen, Martin ^b   Griesinger, Christian ^a   Mandelkow, Eckhard ^b   Zweckstetter, Markus ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b MAX PLANCK UNIT FOR STRUCTURAL MOLECULAR BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; BINDING ENERGY; NEGATIVE IONS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PERTURBATION TECHNIQUES;

CHEMICAL SHIFTS; HELICAL FILAMENTS; MICROTUBULES; POLYANIONS;

PROTEINS;

MICROTUBULE ASSOCIATED PROTEIN; POLYANION; TAU PROTEIN;

ALZHEIMER DISEASE; ARTICLE; BETA SHEET; BINDING SITE; NEUROFIBRILLARY TANGLE; NEUROTOXICITY; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMALS; ANIONS; BRAIN; CRYSTALLOGRAPHY, X-RAY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; LYSINE; MAGNETIC RESONANCE SPECTROSCOPY; MICROTUBULES; MOLECULAR SEQUENCE DATA; MUTATION; NEUROFIBRILLARY TANGLES; POLYMERS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SWINE; TAU PROTEINS; TEMPERATURE; TUBULIN;

EID: 21644446496     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501565200     Document Type: Article

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