Targeting DNA damage and repair: Embracing the pharmacological era for successful cancer therapy

Pharmacology and Therapeutics

Volumn 133, Issue 3, 2012, Pages 334-350

  Aziz, K ^a   Nowsheen, S ^b   Pantelias, G ^c   Iliakis, G ^d   Gorgoulis, V G ^e   Georgakilas, A G ^f,g  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b The University of Alabama at Birmingham   (United States)

^c INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^d UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

^e UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^f EAST CAROLINA UNIVERSITY   (United States)

^g NATIONAL TECHNICAL UNIVERSITY OF ATHENS   (Greece)

Author keywords

Cancer; DNA damage; DNA repair; Replication stress; Therapy

Indexed keywords

BLEOMYCIN; BREAST CANCER RESISTANCE PROTEIN; CARBOPLATIN; CISPLATIN; DNA BASE; DNA TOPOISOMERASE; DOXORUBICIN; ETOPOSIDE; FREE RADICAL; HYDROGEN PEROXIDE; IRINOTECAN; IRON; METHOTREXATE; MRE11 PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; POLYCYCLIC HYDROCARBON; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PYRIMIDINE; REACTIVE NITROGEN SPECIES; SUNITINIB; TAR; TAXANE DERIVATIVE; TEMOZOLOMIDE; TOPOTECAN; UNINDEXED DRUG; VASCULOTROPIN RECEPTOR; VINYL CHLORIDE; XRCC1 PROTEIN;

ANAPHASE; APOPTOSIS; CANCER CELL; CARCINOGENESIS; CELL CYCLE CHECKPOINT; CELL CYCLE S PHASE; CELL DEATH; CELL PHAGOCYTOSIS; CELL RESPIRATION; CELL STRESS; CHROMOSOME; CHROMOSOME ABERRATION; DEAMINATION; DIETARY INTAKE; DNA ADDUCT; DNA ALKYLATION; DNA BINDING; DNA CLEAVAGE; DNA CROSS LINKING; DNA DAMAGE; DNA END JOINING REPAIR; DNA METHYLATION; DNA PROTEIN COMPLEX; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; DNA TRANSCRIPTION; DRUG RESISTANCE; ENZYME INHIBITION; FENTON REACTION; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENOMIC INSTABILITY; GENOTOXICITY; HUMAN; INFLAMMATION; IONIZING RADIATION; LINEAR ENERGY TRANSFER; LIPID PEROXIDATION; MECHANICAL TORSION; MITOSIS SPINDLE; MOLECULAR DIAGNOSIS; MOLECULARLY TARGETED THERAPY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGENY; PROGNOSIS; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; SINGLE STRANDED DNA BREAK; SMOKE; SOOT; TAUTOMERIZATION; THERMAL EXPOSURE; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; VIRUS INFECTION;

ANIMALS; ANTINEOPLASTIC AGENTS; DNA DAMAGE; DNA REPAIR; HUMANS; NEOPLASMS;

EID: 84856436035     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.11.010     Document Type: Review

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