Lithium-mediated protection of hippocampal cells involves enhancement of DNA-PK-dependent repair in mice

Journal of Clinical Investigation

Volumn 119, Issue 5, 2009, Pages 1124-1135

  Yang, Eddy S ^a   Wang, Hong ^a   Jiang, Guochun ^a   Nowsheen, Somaira ^a   Fu, Allie ^a   Hallahan, Dennis E ^a   Xia, Fen ^a,b  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; HISTONE H2AX; LITHIUM CHLORIDE; PROTEIN KINASE INHIBITOR; THREONINE; 1 (2 HYDROXY 4 MORPHOLIN 4 YLPHENYL)ETHANONE; 1-(2-HYDROXY-4-MORPHOLIN-4-YLPHENYL)ETHANONE; ACETOPHENONE DERIVATIVE; DNA; DNA BINDING PROTEIN; GAMMA H2AX PROTEIN, MOUSE; GAMMA-H2AX PROTEIN, MOUSE; HISTONE; LITHIUM; MORPHOLINE DERIVATIVE; NUCLEAR PROTEIN; PRKDC PROTEIN, MOUSE; RAD51 PROTEIN; RAD51 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATTENUATION; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; DISEASE MARKER; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DRUG EFFECT; DRUG MECHANISM; FEMALE; GLIOMA CELL; HIPPOCAMPUS; IN VIVO STUDY; IRRADIATION; MALE; MOLECULAR GENETICS; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; SKULL IRRADIATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL LINE; DRUG ANTAGONISM; GLIOMA; HUMAN; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; RADIATION EXPOSURE; TUMOR CELL LINE; UPREGULATION; X RAY;

ACETOPHENONES; ANIMALS; APOPTOSIS; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; FEMALE; GLIOMA; HIPPOCAMPUS; HISTONES; HUMANS; LITHIUM; MALE; MICE; MICE, INBRED C57BL; MICE, SCID; MORPHOLINES; NEURONS; NUCLEAR PROTEINS; PROTEIN KINASE INHIBITORS; RAD51 RECOMBINASE; UP-REGULATION; X-RAYS;

EID: 66449131865     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI34051     Document Type: Article

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