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Volumn 252, Issue 1, 2007, Pages 9-18

Cellular response to etoposide treatment

Author keywords

Alternative splicing; Anticancer drugs; Apoptosis; ATM; ATR; Cell cycle; Chromatin; DNA damage checkpoint; DNA repair; DNA replication; DNA topoisomerase; Double stranded breaks; Etoposide; PCNA; Replication factories; Topoisomerase poisons

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE;

EID: 34248356003     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2006.11.005     Document Type: Review
Times cited : (204)

References (60)
  • 1
    • 0034923502 scopus 로고    scopus 로고
    • DNA topoisomerases: structure, function, and mechanism
    • Champoux J.J. DNA topoisomerases: structure, function, and mechanism. Annu. Rev. Biochem. 70 (2001) 369-413
    • (2001) Annu. Rev. Biochem. , vol.70 , pp. 369-413
    • Champoux, J.J.1
  • 2
    • 0035029153 scopus 로고    scopus 로고
    • Tumor cell death induced by topoisomerase-targeting drugs
    • Li T.K., and Liu L.F. Tumor cell death induced by topoisomerase-targeting drugs. Annu. Rev. Pharmacol. Toxicol. 41 (2001) 53-77
    • (2001) Annu. Rev. Pharmacol. Toxicol. , vol.41 , pp. 53-77
    • Li, T.K.1    Liu, L.F.2
  • 3
    • 0032168167 scopus 로고    scopus 로고
    • Etoposide: four decades of development of a topoisomerase II inhibitor
    • Hande K.R. Etoposide: four decades of development of a topoisomerase II inhibitor. Eur. J. Cancer 34 (1998) 1514-1521
    • (1998) Eur. J. Cancer , vol.34 , pp. 1514-1521
    • Hande, K.R.1
  • 4
    • 0029802613 scopus 로고    scopus 로고
    • Topoisomerase II. Etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes
    • Burden D.A., Kingma P.S., Froelich-Ammon S.J., et al. Topoisomerase II. Etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes. J. Biol. Chem. 271 (1996) 29238-29244
    • (1996) J. Biol. Chem. , vol.271 , pp. 29238-29244
    • Burden, D.A.1    Kingma, P.S.2    Froelich-Ammon, S.J.3
  • 5
    • 0037470042 scopus 로고    scopus 로고
    • A two-drug model for etoposide action against human topoisomerase IIalpha
    • Bromberg K.D., Burgin A.B., and Osheroff N. A two-drug model for etoposide action against human topoisomerase IIalpha. J. Biol. Chem. 278 (2003) 7406-7412
    • (2003) J. Biol. Chem. , vol.278 , pp. 7406-7412
    • Bromberg, K.D.1    Burgin, A.B.2    Osheroff, N.3
  • 6
    • 0141940254 scopus 로고    scopus 로고
    • Modulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalpha
    • Vilain N., Tsai-Pflugfelder M., Benoit A., Gasser S.M., and Leroy D. Modulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalpha. Nucleic Acids Res. 31 (2003) 5714-5722
    • (2003) Nucleic Acids Res. , vol.31 , pp. 5714-5722
    • Vilain, N.1    Tsai-Pflugfelder, M.2    Benoit, A.3    Gasser, S.M.4    Leroy, D.5
  • 7
    • 1242339593 scopus 로고    scopus 로고
    • Repair of DNA covalently linked to protein
    • Connelly J.C., and Leach D.R. Repair of DNA covalently linked to protein. Mol. Cell 13 (2004) 307-316
    • (2004) Mol. Cell , vol.13 , pp. 307-316
    • Connelly, J.C.1    Leach, D.R.2
  • 8
    • 23944459784 scopus 로고    scopus 로고
    • Endonucleolytic processing of covalent protein-linked DNA double-strand breaks
    • Neale M.J., Pan J., and Keeney S. Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. Nature 436 (2005) 1053-1057
    • (2005) Nature , vol.436 , pp. 1053-1057
    • Neale, M.J.1    Pan, J.2    Keeney, S.3
  • 9
    • 0037130170 scopus 로고    scopus 로고
    • Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex
    • Stracker T.H., Carson C.T., and Weitzman M.D. Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature 418 (2002) 348-352
    • (2002) Nature , vol.418 , pp. 348-352
    • Stracker, T.H.1    Carson, C.T.2    Weitzman, M.D.3
  • 10
    • 0035798622 scopus 로고    scopus 로고
    • 26 S proteasome-mediated degradation of topoisomerase II cleavable complexes
    • Mao Y., Desai S.D., Ting C.Y., Hwang J., and Liu L.F. 26 S proteasome-mediated degradation of topoisomerase II cleavable complexes. J. Biol. Chem. 276 (2001) 40652-40658
    • (2001) J. Biol. Chem. , vol.276 , pp. 40652-40658
    • Mao, Y.1    Desai, S.D.2    Ting, C.Y.3    Hwang, J.4    Liu, L.F.5
  • 11
    • 0025147256 scopus 로고
    • DNA double-strand break repair pathways and cellular tolerance to inhibitors of topoisomerase II
    • Caldecott K., Banks G., and Jeggo P. DNA double-strand break repair pathways and cellular tolerance to inhibitors of topoisomerase II. Cancer Res. 50 (1990) 5778-5783
    • (1990) Cancer Res. , vol.50 , pp. 5778-5783
    • Caldecott, K.1    Banks, G.2    Jeggo, P.3
  • 12
    • 32944479182 scopus 로고    scopus 로고
    • The dispersal of replication proteins after Etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway
    • Rossi R., Lidonnici M.R., Soza S., Biamonti G., and Montecucco A. The dispersal of replication proteins after Etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway. Cancer Res. 66 (2006) 1675-1683
    • (2006) Cancer Res. , vol.66 , pp. 1675-1683
    • Rossi, R.1    Lidonnici, M.R.2    Soza, S.3    Biamonti, G.4    Montecucco, A.5
  • 13
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., and Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273 (1998) 5858-5868
    • (1998) J. Biol. Chem. , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 14
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints: preventing an identity crisis
    • Elledge S.J. Cell cycle checkpoints: preventing an identity crisis. Science 274 (1996) 1664-1672
    • (1996) Science , vol.274 , pp. 1664-1672
    • Elledge, S.J.1
  • 16
    • 3242708425 scopus 로고    scopus 로고
    • Regulation of DNA replication by ATR: signaling in response to DNA intermediates
    • Shechter D., Costanzo V., and Gautier J. Regulation of DNA replication by ATR: signaling in response to DNA intermediates. DNA Repair(Amst) 3 (2004) 901-908
    • (2004) DNA Repair(Amst) , vol.3 , pp. 901-908
    • Shechter, D.1    Costanzo, V.2    Gautier, J.3
  • 17
    • 9244231805 scopus 로고    scopus 로고
    • Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway
    • Agner J., Falck J., Lukas J., and Bartek J. Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway. Exp. Cell Res. 302 (2005) 162-169
    • (2005) Exp. Cell Res. , vol.302 , pp. 162-169
    • Agner, J.1    Falck, J.2    Lukas, J.3    Bartek, J.4
  • 18
    • 12444250680 scopus 로고    scopus 로고
    • DNA repair rate and etoposide (VP16) resistance of tumor cell subpopulations derived from a single human small cell lung cancer
    • Hansen L.T., Lundin C., Helleday T., et al. DNA repair rate and etoposide (VP16) resistance of tumor cell subpopulations derived from a single human small cell lung cancer. Lung Cancer 40 (2003) 157-164
    • (2003) Lung Cancer , vol.40 , pp. 157-164
    • Hansen, L.T.1    Lundin, C.2    Helleday, T.3
  • 19
    • 0027496657 scopus 로고
    • Hypersensitivity of lymphoblastoid lines derived from ataxia telangiectasia patients to the induction of chromosomal aberrations by etoposide (VP-16)
    • Caporossi D., Porfirio B., Nicoletti B., et al. Hypersensitivity of lymphoblastoid lines derived from ataxia telangiectasia patients to the induction of chromosomal aberrations by etoposide (VP-16). Mutat. Res. 290 (1993) 265-272
    • (1993) Mutat. Res. , vol.290 , pp. 265-272
    • Caporossi, D.1    Porfirio, B.2    Nicoletti, B.3
  • 20
    • 0026663777 scopus 로고
    • Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells
    • Pandita T.K., and Hittelman W.N. Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells. Radiat. Res. 130 (1992) 94-103
    • (1992) Radiat. Res. , vol.130 , pp. 94-103
    • Pandita, T.K.1    Hittelman, W.N.2
  • 21
    • 0030764691 scopus 로고    scopus 로고
    • hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks
    • Maser R.S., Monsen K.J., Nelms B.E., and Petrini J.H. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol. Cell Biol. 17 (1997) 6087-6096
    • (1997) Mol. Cell Biol. , vol.17 , pp. 6087-6096
    • Maser, R.S.1    Monsen, K.J.2    Nelms, B.E.3    Petrini, J.H.4
  • 22
    • 16844384184 scopus 로고    scopus 로고
    • DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci
    • Robison J.G., Lu L., Dixon K., and Bissler J.J. DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci. J. Biol. Chem. 280 (2005) 12927-12934
    • (2005) J. Biol. Chem. , vol.280 , pp. 12927-12934
    • Robison, J.G.1    Lu, L.2    Dixon, K.3    Bissler, J.J.4
  • 23
    • 0037245862 scopus 로고    scopus 로고
    • An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
    • Costanzo V., Shechter D., Lupardus P.J., Cimprich K.A., Gottesman M., and Gautier J. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol. Cell 11 (2003) 203-213
    • (2003) Mol. Cell , vol.11 , pp. 203-213
    • Costanzo, V.1    Shechter, D.2    Lupardus, P.J.3    Cimprich, K.A.4    Gottesman, M.5    Gautier, J.6
  • 24
    • 2442563650 scopus 로고    scopus 로고
    • Rad9 protects cells from topoisomerase poison-induced cell death
    • Loegering D., Arlander S.J., Hackbarth J., et al. Rad9 protects cells from topoisomerase poison-induced cell death. J. Biol. Chem. 279 (2004) 18641-18647
    • (2004) J. Biol. Chem. , vol.279 , pp. 18641-18647
    • Loegering, D.1    Arlander, S.J.2    Hackbarth, J.3
  • 26
    • 0032189275 scopus 로고    scopus 로고
    • DNA gyrase and topoisomerase IV: biochemical activities, physiological roles during chromosome replication, and drug sensitivities
    • Levine C., Hiasa H., and Marians K.J. DNA gyrase and topoisomerase IV: biochemical activities, physiological roles during chromosome replication, and drug sensitivities. Biochim. Biophys. Acta 1400 (1998) 29-43
    • (1998) Biochim. Biophys. Acta , vol.1400 , pp. 29-43
    • Levine, C.1    Hiasa, H.2    Marians, K.J.3
  • 27
    • 28244433817 scopus 로고    scopus 로고
    • Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks
    • McClendon A.K., Rodriguez A.C., and Osheroff N. Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks. J. Biol. Chem. 280 (2005) 39337-39345
    • (2005) J. Biol. Chem. , vol.280 , pp. 39337-39345
    • McClendon, A.K.1    Rodriguez, A.C.2    Osheroff, N.3
  • 28
    • 0037628627 scopus 로고    scopus 로고
    • Endonuclease cleavage of blocked replication forks: An indirect pathway of DNA damage from antitumor drug-topoisomerase complexes
    • Hong G., and Kreuzer K.N. Endonuclease cleavage of blocked replication forks: An indirect pathway of DNA damage from antitumor drug-topoisomerase complexes. Proc. Natl. Acad. Sci. USA 100 (2003) 5046-5051
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 5046-5051
    • Hong, G.1    Kreuzer, K.N.2
  • 29
    • 0024388737 scopus 로고
    • Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells
    • Holm C., Covey J.M., Kerrigan D., and Pommier Y. Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells. Cancer Res. 49 (1989) 6365-6368
    • (1989) Cancer Res. , vol.49 , pp. 6365-6368
    • Holm, C.1    Covey, J.M.2    Kerrigan, D.3    Pommier, Y.4
  • 30
    • 0036085460 scopus 로고    scopus 로고
    • Cellular roles of DNA topoisomerases: a molecular perspective
    • Wang J.C. Cellular roles of DNA topoisomerases: a molecular perspective. Nat. Rev. Mol. Cell Biol. 3 (2002) 430-440
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 430-440
    • Wang, J.C.1
  • 31
    • 0037416210 scopus 로고    scopus 로고
    • A role of topoisomerase II in linking DNA replication to chromosome condensation
    • Cuvier O., and Hirano T. A role of topoisomerase II in linking DNA replication to chromosome condensation. J. Cell Biol. 160 (2003) 645-655
    • (2003) J. Cell Biol. , vol.160 , pp. 645-655
    • Cuvier, O.1    Hirano, T.2
  • 33
    • 0035890272 scopus 로고    scopus 로고
    • Topoisomerase II can unlink replicating DNA by precatenane removal
    • Lucas I., Germe T., Chevrier-Miller M., and Hyrien O. Topoisomerase II can unlink replicating DNA by precatenane removal. EMBO J. 20 (2001) 6509-6519
    • (2001) EMBO J. , vol.20 , pp. 6509-6519
    • Lucas, I.1    Germe, T.2    Chevrier-Miller, M.3    Hyrien, O.4
  • 34
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 411 (2001) 366-374
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 35
    • 0035997368 scopus 로고    scopus 로고
    • DNA replication in eukaryotic cells
    • Bell S.P., and Dutta A. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71 (2002) 333-374
    • (2002) Annu. Rev. Biochem. , vol.71 , pp. 333-374
    • Bell, S.P.1    Dutta, A.2
  • 37
    • 0026596327 scopus 로고
    • Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences
    • O'Keefe R.T., Henderson S.C., and Spector D.L. Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences. J. Cell Biol. 116 (1992) 1095-1110
    • (1992) J. Cell Biol. , vol.116 , pp. 1095-1110
    • O'Keefe, R.T.1    Henderson, S.C.2    Spector, D.L.3
  • 38
    • 0034306184 scopus 로고    scopus 로고
    • Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis
    • Dimitrova D.S., and Gilbert D.M. Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis. Nat. Cell Biol. 2 (2000) 686-694
    • (2000) Nat. Cell Biol. , vol.2 , pp. 686-694
    • Dimitrova, D.S.1    Gilbert, D.M.2
  • 39
    • 0032053394 scopus 로고    scopus 로고
    • DNA loop anchorage region colocalizes with the replication origin located downstream to the human gene encoding lamin B2
    • Lagarkova M.A., Svetlova E., Giacca M., Falaschi A., and Razin S.V. DNA loop anchorage region colocalizes with the replication origin located downstream to the human gene encoding lamin B2. J. Cell Biochem. 69 (1998) 13-18
    • (1998) J. Cell Biochem. , vol.69 , pp. 13-18
    • Lagarkova, M.A.1    Svetlova, E.2    Giacca, M.3    Falaschi, A.4    Razin, S.V.5
  • 40
    • 12144287048 scopus 로고    scopus 로고
    • Modular structure of the human lamin B2 replicator
    • Paixao S., Colaluca I.N., Cubells M., et al. Modular structure of the human lamin B2 replicator. Mol. Cell Biol. 24 (2004) 2958-2967
    • (2004) Mol. Cell Biol. , vol.24 , pp. 2958-2967
    • Paixao, S.1    Colaluca, I.N.2    Cubells, M.3
  • 41
    • 1642421759 scopus 로고    scopus 로고
    • BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint
    • Dierov J., Dierova R., and Carroll M. BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint. Cancer Cell 5 (2004) 275-285
    • (2004) Cancer Cell , vol.5 , pp. 275-285
    • Dierov, J.1    Dierova, R.2    Carroll, M.3
  • 42
    • 33646177549 scopus 로고    scopus 로고
    • At the heart of the chromosome: SMC proteins in action
    • Hirano T. At the heart of the chromosome: SMC proteins in action. Nat. Rev. Mol. Cell Biol. 7 (2006) 311-322
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 311-322
    • Hirano, T.1
  • 43
    • 0035954251 scopus 로고    scopus 로고
    • Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae
    • Sjogren C., and Nasmyth K. Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr. Biol. 11 (2001) 991-995
    • (2001) Curr. Biol. , vol.11 , pp. 991-995
    • Sjogren, C.1    Nasmyth, K.2
  • 44
    • 0036500555 scopus 로고    scopus 로고
    • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
    • Kim S.T., Xu B., and Kastan M.B. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 16 (2002) 560-570
    • (2002) Genes Dev. , vol.16 , pp. 560-570
    • Kim, S.T.1    Xu, B.2    Kastan, M.B.3
  • 45
    • 0036500690 scopus 로고    scopus 로고
    • SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
    • Yazdi P.T., Wang Y., Zhao S., Patel N., Lee E.Y., and Qin J. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 16 (2002) 571-582
    • (2002) Genes Dev. , vol.16 , pp. 571-582
    • Yazdi, P.T.1    Wang, Y.2    Zhao, S.3    Patel, N.4    Lee, E.Y.5    Qin, J.6
  • 46
    • 14044258550 scopus 로고    scopus 로고
    • SMC1 involvement in fragile site expression
    • Musio A., Montagna C., Mariani T., et al. SMC1 involvement in fragile site expression. Hum. Mol. Genet. 14 (2005) 525-533
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 525-533
    • Musio, A.1    Montagna, C.2    Mariani, T.3
  • 47
  • 48
    • 0035895909 scopus 로고    scopus 로고
    • Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis
    • Johnson C.A., Padget K., Austin C.A., and Turner B.M. Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis. J. Biol. Chem. 276 (2001) 4539-4542
    • (2001) J. Biol. Chem. , vol.276 , pp. 4539-4542
    • Johnson, C.A.1    Padget, K.2    Austin, C.A.3    Turner, B.M.4
  • 49
    • 20144366325 scopus 로고    scopus 로고
    • E2F-dependent repression of topoisomerase II regulates heterochromatin formation and apoptosis in cells with melanoma-prone mutation
    • Jiao W., Lin H.M., Timmons J., et al. E2F-dependent repression of topoisomerase II regulates heterochromatin formation and apoptosis in cells with melanoma-prone mutation. Cancer Res. 65 (2005) 4067-4077
    • (2005) Cancer Res. , vol.65 , pp. 4067-4077
    • Jiao, W.1    Lin, H.M.2    Timmons, J.3
  • 50
    • 8444220527 scopus 로고    scopus 로고
    • Molecular mechanisms of caspase regulation during apoptosis
    • Riedl S.J., and Shi Y. Molecular mechanisms of caspase regulation during apoptosis. Nat. Rev. Mol. Cell Biol. 5 (2004) 897-907
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , pp. 897-907
    • Riedl, S.J.1    Shi, Y.2
  • 51
    • 0034630167 scopus 로고    scopus 로고
    • Induction of apoptosis by cancer chemotherapy
    • Kaufmann S.H., and Earnshaw W.C. Induction of apoptosis by cancer chemotherapy. Exp. Cell Res. 256 (2000) 42-49
    • (2000) Exp. Cell Res. , vol.256 , pp. 42-49
    • Kaufmann, S.H.1    Earnshaw, W.C.2
  • 52
    • 33744800048 scopus 로고    scopus 로고
    • Role of death receptor and mitochondrial pathways in conventional chemotherapy drug induction of apoptosis
    • Wang P., Song J.H., Song D.K., Zhang J., and Hao C. Role of death receptor and mitochondrial pathways in conventional chemotherapy drug induction of apoptosis. Cell Signal. 18 (2006) 1528-1535
    • (2006) Cell Signal. , vol.18 , pp. 1528-1535
    • Wang, P.1    Song, J.H.2    Song, D.K.3    Zhang, J.4    Hao, C.5
  • 53
    • 0032189262 scopus 로고    scopus 로고
    • Cell death induced by topoisomerase-targeted drugs: more questions than answers
    • Kaufmann S.H. Cell death induced by topoisomerase-targeted drugs: more questions than answers. Biochim. Biophys. Acta 1400 (1998) 195-211
    • (1998) Biochim. Biophys. Acta , vol.1400 , pp. 195-211
    • Kaufmann, S.H.1
  • 55
    • 0035544583 scopus 로고    scopus 로고
    • Two-color fluorescence detection of poly (ADP-ribose) polymerase-1 (PARP-1) cleavage and DNA strand breaks in etoposide-induced apoptotic cells
    • Soldani C., Bottone M.G., Pellicciari C., and Scovassi A.I. Two-color fluorescence detection of poly (ADP-ribose) polymerase-1 (PARP-1) cleavage and DNA strand breaks in etoposide-induced apoptotic cells. Eur. J. Histochem. 45 (2001) 389-392
    • (2001) Eur. J. Histochem. , vol.45 , pp. 389-392
    • Soldani, C.1    Bottone, M.G.2    Pellicciari, C.3    Scovassi, A.I.4
  • 57
    • 0029897419 scopus 로고    scopus 로고
    • The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis
    • Morana S.J., Wolf C.M., Li J., Reynolds J.E., Brown M.K., and Eastman A. The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis. J. Biol. Chem. 271 (1996) 18263-18271
    • (1996) J. Biol. Chem. , vol.271 , pp. 18263-18271
    • Morana, S.J.1    Wolf, C.M.2    Li, J.3    Reynolds, J.E.4    Brown, M.K.5    Eastman, A.6
  • 58
    • 0034461638 scopus 로고    scopus 로고
    • Influence of cell cycle and oncogene activity upon topoisomerase IIalpha expression and drug toxicity
    • Stacey D.W., Hitomi M., and Chen G. Influence of cell cycle and oncogene activity upon topoisomerase IIalpha expression and drug toxicity. Mol. Cell Biol. 20 (2000) 9127-9137
    • (2000) Mol. Cell Biol. , vol.20 , pp. 9127-9137
    • Stacey, D.W.1    Hitomi, M.2    Chen, G.3
  • 59
    • 0037191508 scopus 로고    scopus 로고
    • Differential influence of etoposide on two caspase-2 mRNA isoforms in leukemic cells
    • Wotawa A., Solier S., Logette E., Solary E., and Corcos L. Differential influence of etoposide on two caspase-2 mRNA isoforms in leukemic cells. Cancer Lett. 185 (2002) 181-189
    • (2002) Cancer Lett. , vol.185 , pp. 181-189
    • Wotawa, A.1    Solier, S.2    Logette, E.3    Solary, E.4    Corcos, L.5
  • 60
    • 0842304139 scopus 로고    scopus 로고
    • Topoisomerase I and II inhibitors control caspase-2 pre-messenger RNA splicing in human cells
    • Solier S., Lansiaux A., Logette E., et al. Topoisomerase I and II inhibitors control caspase-2 pre-messenger RNA splicing in human cells. Mol. Cancer Res. 2 (2004) 53-61
    • (2004) Mol. Cancer Res. , vol.2 , pp. 53-61
    • Solier, S.1    Lansiaux, A.2    Logette, E.3


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