-
1
-
-
42649145828
-
Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma mRCC: A literature review
-
Gupta K, Miller JD, Li JZ, Russell MW, Charbonneau C. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer Treat. Rev. 34(3), 193-205 (2008
-
(2008)
CancerTreat. Rev.
, vol.34
, Issue.3
, pp. 193-205
-
-
Gupta, K.1
Miller, J.D.2
Li, J.Z.3
Russell, M.W.4
Charbonneau, C.5
-
2
-
-
77955473168
-
Novel targeted therapy for advanced renal carcinoma: Trials in progress
-
Calabró F, Sternberg CN. Novel targeted therapy for advanced renal carcinoma: trials in progress. Curr Opin. Urol. 20(5), 382-387 (2010
-
(2010)
Curr Opin. Urol.
, vol.20
, Issue.5
, pp. 382-387
-
-
Calabró, F.1
Sternberg, C.N.2
-
3
-
-
77954326508
-
On behalf of the ESMO guidelines working group renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis treatment and follow-up
-
Escudier B, Kataja V; on behalf of the ESMO Guidelines Working Group. Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 21(Suppl. 5), v137-v139 (2010
-
(2010)
Ann. Oncol.
, vol.21
, Issue.5
-
-
Escudier, B.1
Kataja, V.2
-
4
-
-
77956546143
-
Validation of the 2009 TNM version in a large multi-institutional cohort of patients treated for renal cell carcinoma: Are further improvements needed
-
Novara G, Ficarra V, Antonelli A et al. Validation of the 2009 TNM version in a large multi-institutional cohort of patients treated for renal cell carcinoma: are further improvements needed? Eur. Urol. 58(4), 588-595 (2010
-
(2010)
Eur. Urol.
, vol.58
, Issue.4
, pp. 588-595
-
-
Novara, G.1
Ficarra, V.2
Antonelli, A.3
-
5
-
-
76749147303
-
Chemo-immunotherapy in RCC: The end of a story
-
Escudier B. Chemo-immunotherapy in RCC: the end of a story. Lancet 375(9715), 613-614 (2010
-
(2010)
Lancet
, vol.375
, Issue.9715
, pp. 613-614
-
-
Escudier, B.1
-
6
-
-
0032772880
-
Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
-
Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A, Ferrara J. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J. Clin. Oncol. 17(8), 2530-2540 (1999 (Pubitemid 29368255)
-
(1999)
Journal of Clinical Oncology
, vol.17
, Issue.8
, pp. 2530-2540
-
-
Motzer, R.J.1
Mazumdar, M.2
Bacik, J.3
Berg, W.4
Amsterdam, A.5
Ferrara, J.6
-
7
-
-
33749238553
-
Discovery and development of sorafenib: A multikinase inhibitor for treating cancer
-
DOI 10.1038/nrd2130, PII NRD2130
-
Wilhelm S, Carter C, Lynch M et al. Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat. Rev. Drug Discov. 5(10), 835-844 (2006 (Pubitemid 44480537)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.10
, pp. 835-844
-
-
Wilhelm, S.1
Carter, C.2
Lynch, M.3
Lowinger, T.4
Dumas, J.5
Smith, R.A.6
Schwartz, B.7
Simantov, R.8
Kelley, S.9
-
8
-
-
0036295515
-
Molecular mechanisms of RET activation in human cancer
-
Santoro M, Melillo RM, Carlomagno F, Fusco A, Vecchio G. Molecular mechanisms of RET activation in human cancer. Ann. NY Acad. Sci. 963, 116-121 (2002 (Pubitemid 34721703)
-
(2002)
Annals of the New York Academy of Sciences
, vol.963
, pp. 116-121
-
-
Santoro, M.1
Melillo, R.M.2
Carlomagno, F.3
Fusco, A.4
Vecchio, G.5
-
9
-
-
41649087031
-
Success and failure on the ras pathway
-
McCormick, F. Success and failure on the ras pathway. Cancer Biol. Ther. 6(10), 1654-1659 (2007 (Pubitemid 351590340)
-
(2007)
Cancer Biology and Therapy
, vol.6
, Issue.10
, pp. 1654-1659
-
-
McCormick, F.1
-
10
-
-
55749088393
-
Preclinical overview of sorafenib a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
-
Wilhelm S, Adnane L, Newell P, Villanueva A, Llovet JM, Lynch M. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol. Cancer Ther. 7(10), 3129-3140 (2008
-
(2008)
Mol. Cancer Ther.
, vol.7
, Issue.10
, pp. 3129-3140
-
-
Wilhelm, S.1
Adnane, L.2
Newell, P.3
Villanueva, A.4
Llovet, J.M.5
Lynch, M.6
-
11
-
-
33846212284
-
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
-
DOI 10.1158/0008-5472.CAN-06-1377
-
Liu L, Cao Y, Chen C et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 66(24), 11851-11858 (2006 (Pubitemid 46094197)
-
(2006)
Cancer Research
, vol.66
, Issue.24
, pp. 11851-11858
-
-
Liu, L.1
Cao, Y.2
Chen, C.3
Zhang, X.4
McNabola, A.5
Wilkie, D.6
Wilhelm, S.7
Lynch, M.8
Carter, C.9
-
12
-
-
33847118123
-
Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models
-
DOI 10.1007/s00280-006-0393-4
-
Chang YS, Adnane J, Trail PA et al. Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models. Cancer Chemother. Pharmacol. 59(5), 561-574 (2007 (Pubitemid 46295136)
-
(2007)
Cancer Chemotherapy and Pharmacology
, vol.59
, Issue.5
, pp. 561-574
-
-
Chang, Y.S.1
Adnane, J.2
Trail, P.A.3
Levy, J.4
Henderson, A.5
Xue, D.6
Bortolon, E.7
Ichetovkin, M.8
Chen, C.9
McNabola, A.10
Wilkie, D.11
Carter, C.A.12
Taylor, I.C.A.13
Lynch, M.14
Wilhelm, S.15
-
13
-
-
33847195060
-
Antitumor activity of sorafenib in FLT3-driven leukemic cells
-
Auclair D, Miller D, Yatsula V et al. Antitumor activity of sorafenib in FLT3-driven leukemic cells. Leukemia 21(3), 439-445 (2007
-
(2007)
Leukemia
, vol.21
, Issue.3
, pp. 439-445
-
-
Auclair, D.1
Miller, D.2
Yatsula, V.3
-
14
-
-
20044382799
-
Phase I clinical and pharmacokinetic study of the novel raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
-
DOI 10.1200/JCO.2005.06.124
-
Strumberg D, Richly H, Hilger RA et al. Phase I clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors? J. Clin. Oncol. 23(5), 965-972 (2005 (Pubitemid 46202316)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.5
, pp. 965-972
-
-
Strumberg, D.1
Richly, H.2
Hilger, R.A.3
Schleucher, N.4
Korfee, S.5
Tewes, M.6
Faghih, M.7
Brendel, E.8
Voliotis, D.9
Haase, C.G.10
Schwartz, B.11
Awada, A.12
Voigtmann, R.13
Scheulen, M.E.14
Seeber, S.15
-
15
-
-
82455192303
-
Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: A Phase I/II pharmacokinetic interaction study
-
In Press
-
Flaherty KT, Lathia C, Frye RF, Schuchter L et al. Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a Phase I/II pharmacokinetic interaction study. Cancer Chemother. Pharmacol. (2011) (In Press
-
(2011)
CancerChemother. Pharmacol.
-
-
Flaherty, K.T.1
Lathia, C.2
Frye, R.F.3
Schuchter, L.4
-
16
-
-
33645648696
-
Lack ofeffect of ketoconazole-mediated CYP3A inhibition on sorafenib clinical pharmacokinetics
-
Lathia C, Lettieri J, Cihon F, Gallentine M, Radtke M, Sundaresan P. Lack ofeffect of ketoconazole-mediated CYP3A inhibition on sorafenib clinical pharmacokinetics. Cancer Chemother. Pharmacol. 57, 685-692 (2006
-
(2006)
CancerChemother. Pharmacol.
, vol.57
, pp. 685-692
-
-
Lathia, C.1
Lettieri, J.2
Cihon, F.3
Gallentine, M.4
Radtke, M.5
Sundaresan, P.6
-
17
-
-
33846020023
-
Results from an in vitro and a clinical/pharmacological phase I study with the combination irinotecan and sorafenib
-
DOI 10.1016/j.ejca.2006.08.032, PII S0959804906008033
-
Mross K, Steinbild S, Baas F et al. Results from an in vitro and a clinical/ pharmacological Phase I study with the combination irinotecan and sorafenib. Eur. J. Cancer. 43(1), 55-63 (2007 (Pubitemid 46054474)
-
(2007)
European Journal of Cancer
, vol.43
, Issue.1
, pp. 55-63
-
-
Mross, K.1
Steinbild, S.2
Baas, F.3
Gmehling, D.4
Radtke, M.5
Voliotis, D.6
Brendel, E.7
Christensen, O.8
Unger, C.9
-
18
-
-
34247857540
-
Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: A review of four phase I trials in patients with advanced refractory solid tumors
-
DOI 10.1634/theoncologist.12-4-426
-
Strumberg D, Clark JW, Awada A et al. Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: a review of four Phase I trials in patients with advanced refractory solid tumors. Oncologist 12(4), 426-437 (2007 (Pubitemid 46698720)
-
(2007)
Oncologist
, vol.12
, Issue.4
, pp. 426-437
-
-
Strumberg, D.1
Clark, J.W.2
Awada, A.3
Moore, M.J.4
Richly, H.5
Hendlisz, A.6
Hirte, H.W.7
Eder, J.P.8
Lenz, H.-J.9
Schwartzh, B.10
-
19
-
-
34248193851
-
The randomized discontinuation trial: A phase II design to assess growth-inhibitory agents
-
DOI 10.1158/1535-7163.MCT-06-0249
-
Stadler W. The randomized discontinuation trial: a Phase II design to assess growth-inhibitory agents. Mol. Cancer Ther. 6(4), 1180-1185 (2007 (Pubitemid 46711981)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.4
, pp. 1180-1185
-
-
Stadler, W.M.1
-
20
-
-
33744984843
-
Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
-
DOI 10.1200/JCO.2005.03.6723
-
Ratain MJ, Eisen T, Stadler WM et al. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 24, 2505-2512 (2006 (Pubitemid 46630627)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.16
, pp. 2505-2512
-
-
Ratain, M.J.1
Eisen, T.2
Stadler, W.M.3
Flaherty, K.T.4
Kaye, S.B.5
Rosner, G.L.6
Gore, M.7
Desai, A.A.8
Patnaik, A.9
Xiong, H.Q.10
Rowinsky, E.11
Abbruzzese, J.L.12
Xia, C.13
Simantov, R.14
Schwartz, B.15
O'Dwyer, P.J.16
-
21
-
-
70249097380
-
Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
-
Escudier B, Eisen T, Stadler WM et al. Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the Phase III treatment approaches in renal cancer global evaluation trial. J. Clin. Oncol. 27, 3312-3318 (2009
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 3312-3318
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
22
-
-
77955917461
-
Long-term safety of sorafenib in advanced renal cell carcinoma: Follow-up of patients from phase III target
-
Hutson TE et al. Long-term safety of sorafenib in advanced renal cell carcinoma: follow-up of patients from Phase III TARGET. Eur. J. Cancer 46(13), 2432-2440 (2010
-
(2010)
Eur. J. Cancer
, vol.46
, Issue.13
, pp. 2432-2440
-
-
Hutson, T.E.1
-
23
-
-
79957802759
-
Final results of the european advanced renal cell carcinoma sorafenib EU-ARCCS expanded-access study: A large open-label study in diverse community settings
-
Press
-
Beck J, Procopio G, Bajetta et al. Final results of the European Advanced Renal Cell Carcinoma Sorafenib (EU-ARCCS) expanded-access study: a large open-label study in diverse community settings. Ann. Oncol. (2011) (In Press
-
(2011)
Ann. Oncol.
-
-
Beck, J.1
Procopio, G.2
Bajetta3
-
24
-
-
77149126422
-
Safety and efficacy results of the advanced renal cell carcinoma sorafenib expanded access program in North America
-
Stadler WM, Figlin R, McDermott D et al. Safety and efficacy results of the advanced renal cell carcinoma sorafenib expanded access program in North America. Cancer 116(5), 1272-1280 (2010
-
(2010)
Cancer
, vol.116
, Issue.5
, pp. 1272-1280
-
-
Stadler, W.M.1
Figlin, R.2
McDermott, D.3
-
25
-
-
62449186539
-
Randomized phase II trial of first-line treatment with sorafenib versus interferon a-2a in patients with metastatic renal cell carcinoma
-
Escudier B, Szczylik C, Hutson TE et al. Randomized Phase II trial of first-line treatment with sorafenib versus interferon a-2a in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 27(8), 1280-1289 (2009
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.8
, pp. 1280-1289
-
-
Escudier, B.1
Szczylik, C.2
Hutson, T.E.3
-
26
-
-
79959810102
-
AMG 386 in combination with sorafenib in patients with metastatic renal cell cancer mRCC: A randomized double-blind placebo-controlled phase II study
-
Orlando FL USA 17-19 February Abstract 70443
-
Rini BI, Szczylik C, Tannir NM et al. AMG 386 in combination with sorafenib in patients with metastatic renal cell cancer (mRCC): a randomized, double-blind, placebo-controlled, Phase II study. Presented at: ASCO. Orlando, FL, USA, 17-19 February 2011 (Abstract 70443
-
(2011)
Presented at: ASCO
-
-
Rini, B.I.1
Szczylik, C.2
Tannir, N.M.3
-
27
-
-
77955470097
-
Clinical outcome in metastatic renal cell carcinoma patients after failure of initial vascular endothelial growth factor-targeted therapy
-
Vickers MM, Choueriri TK, Rogers M, et al. Clinical outcome in metastatic renal cell carcinoma patients after failure of initial vascular endothelial growth factor-targeted therapy. Urology 76(2), 430-434 (2010
-
(2010)
Urology
, vol.76
, Issue.2
, pp. 430-434
-
-
Vickers, M.M.1
Choueriri, T.K.2
Rogers, M.3
-
28
-
-
67349163859
-
Sequential sorafenib and sunitinib for renal cell carcinoma
-
Sablin MP, Negrier S, Ravaud A et al. Sequential sorafenib and sunitinib for renal cell carcinoma. J. Urol. 182(1), 29-34 (2009).
-
(2009)
J. Urol.
, vol.182
, Issue.1
, pp. 29-34
-
-
Sablin, M.P.1
Negrier, S.2
Ravaud, A.3
-
29
-
-
35448934762
-
Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study
-
DOI 10.1016/S1470-2045(07)70285-1, PII S1470204507702851
-
Rixe O, Bukowski RM, Michaelson MD et al. Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a Phase II study. Lancet Oncol. 8(11), 975-984 (2007 (Pubitemid 47629888)
-
(2007)
Lancet Oncology
, vol.8
, Issue.11
, pp. 975-984
-
-
Rixe, O.1
Bukowski, R.M.2
Michaelson, M.D.3
Wilding, G.4
Hudes, G.R.5
Bolte, O.6
Motzer, R.J.7
Bycott, P.8
Liau, K.F.9
Freddo, J.10
Trask, P.C.11
Kim, S.12
Rini, B.I.13
-
30
-
-
78650306863
-
Sequential use of targeted agents in the treatment of renal cell carcinoma
-
Hutson TE, Bukowski RM, Cowey CL et al. Sequential use of targeted agents in the treatment of renal cell carcinoma. Crit. Rev. Oncol. Hematol. 77(1), 48-62 (2011
-
(2011)
Crit. Rev. Oncol. Hematol.
, vol.77
, Issue.1
, pp. 48-62
-
-
Hutson, T.E.1
Bukowski, R.M.2
Cowey, C.L.3
-
31
-
-
77950814307
-
Angiogenesis inhibitor therapies for metastatic renal cell carcinoma: Effectiveness safety and treatment patterns in clinical practice-based on medical chart review
-
Choueiri TK, Duh MS, Clement J et al. Angiogenesis inhibitor therapies for metastatic renal cell carcinoma: effectiveness, safety and treatment patterns in clinical practice-based on medical chart review. BJU Int. 105(9), 1247-1254 (2010
-
(2010)
BJU Int.
, vol.105
, Issue.9
, pp. 1247-1254
-
-
Choueiri, T.K.1
Duh, M.S.2
Clement, J.3
-
32
-
-
79959782949
-
Sequential use of sorafenib and sunitinib in advanced renal cell carcinoma: An Italian multicentre retrospective analysis of 189 patient cases
-
10.1111/j.1464-410X.2011.10186.x Epub ahead of print
-
Porta C, Procopio G, Carteni G et al. Sequential use of sorafenib and sunitinib in advanced renal cell carcinoma: an Italian multicentre retrospective analysis of 189 patient cases. BJU Int. DOI: 10.1111/j.1464-410X.2011.10186.x (2011) (Epub ahead of print
-
(2011)
BJU Int.
-
-
Porta, C.1
Procopio, G.2
Carteni, G.3
-
33
-
-
58949092548
-
Sequential therapy with sorafenib and sunitinib in renal cell carcinoma
-
Dudek AZ, Zolnierek J, Dham A, Lindgren BR, Szczylik C. Sequential therapy with sorafenib and sunitinib in renal cell carcinoma. Cancer 115(1), 61-67 (2009
-
(2009)
Cancer
, vol.115
, Issue.1
, pp. 61-67
-
-
Dudek, A.Z.1
Zolnierek, J.2
Dham, A.3
Lindgren, B.R.4
Szczylik, C.5
-
34
-
-
70349388719
-
Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma
-
Rini BI, Wilding G, Hudes G et al. Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma. J. Clin. Oncol. 27, 4462-4468 (2009
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 4462-4468
-
-
Rini, B.I.1
Wilding, G.2
Hudes, G.3
-
35
-
-
48649107474
-
Record-1 study group efficacy of everolimus in advanced renal cell carcinoma: A double-blind randomised placebo-controlled Phase III trial
-
Motzer RJ, Escudier B, Oudard S et al. RECORD-1 Study Group. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled Phase III trial. Lancet 372, 449-456 (2008
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
36
-
-
34250168681
-
Phase I trial of sorafenib in combination with IFN α-2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma
-
DOI 10.1158/1078-0432.CCR-06-1432
-
Escudier B, Lassau N, Angevin E et al. Phase I trial of sorafenib in combination with IFN a-2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma. Clin. Cancer Res. 13(6), 1801-1809 (2007 (Pubitemid 46952949)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.6
, pp. 1801-1809
-
-
Escudier, B.1
Lassau, N.2
Angevin, E.3
Soria, J.C.4
Chami, L.5
Lamuraglia, M.6
Zafarana, E.7
Landreau, V.8
Schwartz, B.9
Brendel, E.10
Armand, J.-P.11
Robert, C.12
-
37
-
-
34548263735
-
Phase II trial of sorafenib plus interferon alfa-2b as first- or second-line therapy in patients with metastatic renal cell cancer
-
DOI 10.1200/JCO.2007.10.8613
-
Gollob JA, Rathmell WK, Richmond TM et al. Phase II trial of sorafenib plus interferon a-2b as first or second-line therapy in patients with metastatic renal cell cancer. J. Clin. Oncol. 25, 3288-3295 (2007 (Pubitemid 47325614)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.22
, pp. 3288-3295
-
-
Gollob, J.A.1
Rathmell, W.K.2
Richmond, T.M.3
Marino, C.B.4
Miller, E.K.5
Grigson, G.6
Watkins, C.7
Gu, L.8
Peterson, B.L.9
Wright, J.J.10
-
38
-
-
34548229506
-
Sorafenib with interferon alfa-2b as first-line treatment of advanced renal carcinoma: A phase II study of the southwest oncology group
-
DOI 10.1200/JCO.2007.11.1047
-
Ryan CW, Goldman BH, Lara Jr PN et al. Sorafenib with interferon a-2b as first line treatment of advanced renal carcinoma: a Phase II study of the southwest oncology group. J. Clin. Oncol. 3296-3301 (2007 (Pubitemid 47325615)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.22
, pp. 3296-3301
-
-
Ryan, C.W.1
Goldman, B.H.2
Lara Jr., P.N.3
Mack, P.C.4
Beer, T.M.5
Tangen, C.M.6
Lemmon, D.7
Pan, C.-X.8
Drabkin, H.A.9
Crawford, E.D.10
-
39
-
-
55349098735
-
Updated results of Phase I trial of sorafenib and bevacizumab in patients with metastatic renal cell cancer
-
Orlando FL USA 25-27 January Abstract 5011
-
Sosman JA, Flaherty KT, Atkins DF et al. Updated results of Phase I trial of sorafenib and bevacizumab in patients with metastatic renal cell cancer. Presented at: ASCO. Orlando, FL, USA, 25-27 January 2008 (Abstract 5011
-
(2008)
Presented at: ASCO
-
-
Sosman, J.A.1
Flaherty, K.T.2
Atkins, D.F.3
-
40
-
-
74549209552
-
Upfront randomized phase 2 trial of sorafenib versus sorafenib and low-dose interferon a in patients with advanced renal cell carcinoma: Clinical and biomarker analysis
-
Jonasch E. Upfront, randomized, Phase 2 trial of sorafenib versus sorafenib and low-dose interferon a in patients with advanced renal cell carcinoma: clinical and biomarker analysis. Cancer 116(1), 57-65 (2010
-
(2010)
Cancer
, vol.116
, Issue.1
, pp. 57-65
-
-
Jonasch, E.1
-
41
-
-
79959800522
-
Randomized prospective phase II trial of two schedules of sorafenib daily and interferon in metastatic renal cell carcinoma
-
Orlando FL USA 25-27 January Abstract 357
-
Bracarda S, Porta C, Boni C et al. Randomized prospective Phase II trial of two schedules of sorafenib daily and interferon in metastatic renal cell carcinoma. Presented at: ASCO. Orlando, FL, USA, 25-27 January 2008 (Abstract 357
-
(2008)
Presented at: ASCO
-
-
Bracarda, S.1
Porta, C.2
Boni, C.3
-
42
-
-
84861803064
-
A randomized prospective Phase 2 study with sorafenib and interleukin-2 versus sorafenib alone as first line treatment in advanced renal cell cancer: Rosorc trial
-
Berlin Germany 20-24 September Abstraxt O-7107
-
Procopio G, Verzoni E, Bracarda S et al. A randomized, prospective, Phase 2 study, with sorafenib and interleukin-2 versus sorafenib alone as first line treatment in advanced renal cell cancer: ROSORC trial. Presented at: ECCO-ESMO. Berlin, Germany, 20-24 September 2009 (Abstraxt O-7107
-
(2009)
Presented at: ECCO-ESMO
-
-
Procopio, G.1
Verzoni, E.2
Bracarda, S.3
-
43
-
-
77950369616
-
Phase II study of sorafenib combined with gemcitabine and 5-fluorouracil in patients with metastatic renal cell carcinoma: Preliminary results
-
Orlando FL USA 29 May-2 June Abstract e16093
-
Hongyun L, Zhihong C, Xiangqing Y et al. Phase II study of sorafenib combined with gemcitabine and 5-fluorouracil in patients with metastatic renal cell carcinoma: preliminary results. Presented at: ASCO. Orlando, FL, USA, 29 May-2 June 2009 (Abstract e16093
-
(2009)
Presented at: ASCO
-
-
Hongyun, L.1
Zhihong, C.2
Xiangqing, Y.3
-
44
-
-
79959793452
-
A Phase I trial of sorafenib plus gemcitabine and capecitabine for patients with advanced renal cell carcinoma: New York cancer consortium trial nci 6981
-
Epub ahead of print
-
Tawaga ST, Milowsky MI, Jeske S et al. A Phase I trial of sorafenib plus gemcitabine and capecitabine for patients with advanced renal cell carcinoma: New York Cancer Consortium trial NCI 6981. Am. J. Clin. Oncol. (2010) (Epub ahead of print
-
(2010)
Am. J. Clin. Oncol.
-
-
Tawaga, S.T.1
Milowsky, M.I.2
Jeske, S.3
-
45
-
-
79959793084
-
A Phase I study of everolimus plus sorafenib in patients with metastatic renal cell carcinoma mRCC
-
Orlando FL USA 29 May-2 June Abstract e16056
-
Cen P, Daleiden A, Doshi G, Amato R. A Phase I study of everolimus plus sorafenib in patients with metastatic renal cell carcinoma (mRCCPresented at: ASCO. Orlando, FL, USA, 29 May-2 June 2009 (Abstract e16056
-
(2009)
Presented at: ASCO
-
-
Cen, P.1
Daleiden, A.2
Doshi, G.3
Amato, R.4
-
46
-
-
65249102843
-
Phase I study combining treatmentwith temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma
-
Patel PH, Senico PL, Curiel RE, Motzer RJ. Phase I study combining treatmentwith temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma. Clin. Genitourin. Cancer 7, 24-27 (2009
-
(2009)
Clin. Genitourin. Cancer
, vol.7
, pp. 24-27
-
-
Patel, P.H.1
Senico, P.L.2
Curiel, R.E.3
Motzer, R.J.4
-
47
-
-
77649141918
-
Interim results from a phase 1b study of safety pharmacokinetics and tumor response of the angiopoietin1/2- neutralizing peptibody AMG 386 in combination with AMG 706 motesanib bevacizumab or sorafenib in advanced solid tumors
-
Stockholm Sweden 12-16 September Abstract P462
-
Hong D, Gordon M, Appleman L et al. Interim results from a phase 1b study of safety, pharmacokinetics, and tumor response of the angiopoietin1/2- neutralizing peptibody AMG 386 in combination with AMG 706 (motesanib), bevacizumab or sorafenib in advanced solid tumors. Presented at: ESMO. Stockholm, Sweden, 12-16 September 2008 (Abstract P462
-
(2008)
Presented at: ESMO
-
-
Hong, D.1
Gordon, M.2
Appleman, L.3
-
48
-
-
54049134421
-
Sorafenib for older patients with renal cell carcinoma: Subset analysis from a randomized trial
-
Eisen T, Oudard S, Szczylik C et al. Sorafenib for older patients with renal cell carcinoma: subset analysis from a randomized trial. J. Natl. Cancer Inst. 100(20), 1454-1463 (2008
-
(2008)
J. Natl. Cancer Inst.
, vol.100
, Issue.20
, pp. 1454-1463
-
-
Eisen, T.1
Oudard, S.2
Szczylik, C.3
-
49
-
-
67249099246
-
Efficacy and safety of sorafenib in elderly patients: Results from a large open-label non-comparative Phase III study in European patients with advanced RCC EU-ARCCSAnn
-
596P
-
Porta C, Bracarda S, Beck J et al. Efficacy and safety of sorafenib in elderly patients: results from a large open-label, non-comparative Phase III study in European patients with advanced RCC (EU-ARCCSAnn. Oncol. 19(Suppl. 8), viii193, 596P (2008
-
(2008)
Oncol.
, vol.19
, Issue.8
-
-
Porta, C.1
Bracarda, S.2
Beck, J.3
-
50
-
-
77956084780
-
Safety and efficacy of sorafenib in elderly patients treated in the North American advanced renal cell carcinoma sorafenib expanded access program
-
Bukowski RM, Stadler WM, McDermott DF et al. Safety and efficacy of sorafenib in elderly patients treated in the North American advanced renal cell carcinoma sorafenib expanded access program. Oncology 78(5-6), 340-347 (2010
-
(2010)
Oncology
, vol.78
, Issue.5-6
, pp. 340-347
-
-
Bukowski, R.M.1
Stadler, W.M.2
McDermott, D.F.3
-
51
-
-
79959772457
-
Sorafenib in older patients with advanced renal cell carcinoma: Subanalysis by age of an integrated database of 8 company-sponsored clinical trials
-
Milan Italy 8-12 October Abstract 906P
-
Procopio G, Bellmunt J, Dutcher JP et al. Sorafenib in older patients with advanced renal cell carcinoma: subanalysis by age of an integrated database of 8 company-sponsored clinical trials. Presented at: ESMO. Milan, Italy, 8-12 October 2010 (Abstract 906P
-
(2010)
Presented at: ESMO
-
-
Procopio, G.1
Bellmunt, J.2
Dutcher, J.P.3
-
52
-
-
70349391784
-
Large open label non-comparative phase III study of sorafenib in European patients with advanced RCC EU-ARCCS - Subgroup analysis of patients with and without baseline clinical cardiovascular disease
-
602P
-
Eisen T, Beck J, Procopio G et al. Large open label, non-comparative Phase III study of sorafenib in European patients with advanced RCC (EU-ARCCS) - subgroup analysis of patients with and without baseline clinical cardiovascular disease. Ann. Oncol. 19(Suppl. 8), viii194-viii195, 602P (2008
-
(2008)
Ann. Oncol.
, vol.19
, Issue.8
-
-
Eisen, T.1
Beck, J.2
Procopio, G.3
-
53
-
-
23044510046
-
Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors
-
DOI 10.1158/1078-0432.CCR-04-2658
-
Clark JW, Eder JP, Ryan D et al. Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors. Clin. Cancer Res. 11(15), 5472-5480 (2005 (Pubitemid 41060823)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.15
, pp. 5472-5480
-
-
Clark, J.W.1
Eder, J.P.2
Ryan, D.3
Lathia, C.4
Lenz, H.-J.5
-
54
-
-
27144527372
-
Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors
-
DOI 10.1093/annonc/mdi310
-
Moore M, Hirte HW, Siu L et al. Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors. Ann. Oncol. 16(10), 1688-1694 (2005). (Pubitemid 41510145)
-
(2005)
Annals of Oncology
, vol.16
, Issue.10
, pp. 1688-1694
-
-
Moore, M.J.1
Hirte, H.W.2
Siu, L.3
Oza, A.4
Hotte, S.J.5
Petrenciuc, O.6
Cihon, F.7
Lathia, C.8
Schwartz, B.9
-
55
-
-
64649083367
-
Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301
-
Miller AA, Murry DJ, Owzar K et al. Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301. J. Clin. Oncol. 27(11), 1800-1805 (2009
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.11
, pp. 1800-1805
-
-
Miller, A.A.1
Murry, D.J.2
Owzar, K.3
-
56
-
-
77955248323
-
Sunitinib and sorafenib in metastatic renal cell carcinoma patients with renal insufficiency
-
Khan G, Golshayan A, Elson P et al. Sunitinib and sorafenib in metastatic renal cell carcinoma patients with renal insufficiency. Ann. Oncol. 21(8), 1618-1622 (2010
-
(2010)
Ann. Oncol.
, vol.21
, Issue.8
, pp. 1618-1622
-
-
Khan, G.1
Golshayan, A.2
Elson, P.3
-
57
-
-
70449379934
-
Safety and efficacy of sorafenib therapy in patients with metastatic kidney cancer with impaired renal function
-
Parsa V, Heilbrun L, Smith D, Sethi A, Vaishampayan U. Safety and efficacy of sorafenib therapy in patients with metastatic kidney cancer with impaired renal function. Clin. Genitourin. Cancer 7(2), E10-E15 (2009
-
(2009)
Clin. Genitourin. Cancer
, vol.7
, Issue.2
-
-
Parsa, V.1
Heilbrun, L.2
Smith, D.3
Sethi, A.4
Vaishampayan, U.5
-
58
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
DOI 10.1056/NEJMoa060655
-
Escudier B, Eisen T, Stadler WM et al. Sorafenib in advanced clear-cell renal cell carcinoma. N. Engl. J. Med. 356(2), 125-134 (2007 (Pubitemid 46089673)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
59
-
-
77953328875
-
Incidence of brain metastases in renal cell carcinoma treated with sorafenib
-
Massard C, Zonierek J, Gross-Goupil M, Fizazi K, Szczylik C, Escudier B. Incidence of brain metastases in renal cell carcinoma treated with sorafenib. Ann. Oncol. 21(5), 1027-1031 (2009
-
(2009)
Ann. Oncol.
, vol.21
, Issue.5
, pp. 1027-1031
-
-
Massard, C.1
Zonierek, J.2
Gross-Goupil, M.3
Fizazi, K.4
Szczylik, C.5
Escudier, B.6
-
60
-
-
77957570088
-
Biomarkers predicting outcome in patients with advanced renal cell carcinoma: Results from sorafenib phase iii treatment approaches in renal cancer global evaluation trial
-
Pena C, Lathia C, Shan M, Escudier B, Bukowski RM. Biomarkers predicting outcome in patients with advanced renal cell carcinoma: results from sorafenib Phase III Treatment Approaches in Renal Cancer Global Evaluation Trial. Clin. Can. Res. 16(19), 4853-4863 (2010
-
(2010)
Clin. Can. Res.
, vol.16
, Issue.19
, pp. 4853-4863
-
-
Pena, C.1
Lathia, C.2
Shan, M.3
Escudier, B.4
Bukowski, R.M.5
-
61
-
-
79959774138
-
Sorafenib safety profile in >4600 patients with renal cell carcinoma: Assessment at 3 month intervals using an integrated database of 8 company sponsored studies
-
Chicago IL USA 4-8 June Abstract 4605
-
Gore M, Beck J, Knox J et al. Sorafenib safety profile in >4600 patients with renal cell carcinoma: assessment at 3 month intervals using an integrated database of 8 company sponsored studies. Presented at: ASCO. Chicago, IL, USA, 4-8 June 2010 (Abstract 4605
-
(2010)
Presented at: ASCO
-
-
Gore, M.1
Beck, J.2
Knox, J.3
-
62
-
-
79959791136
-
Sorafenib dosage patterns in ≥4600 patients with renal cell carcinoma including the elderly and patients treated for =12 months: Results from an integrated database of 8 company-sponsored trials
-
Milan Italy 8-12 October Abstract 916P
-
Bokemeyer C, Eisen T, Szczylik C et al. Sorafenib dosage patterns in ≥4600 patients with renal cell carcinoma, including the elderly and patients treated for =12 months: results from an integrated database of 8 company-sponsored trials. Presented at: ESMO. Milan, Italy, 8-12 October 2010 (Abstract 916P
-
(2010)
Presented at: ESMO
-
-
Bokemeyer, C.1
Eisen, T.2
Szczylik, C.3
-
63
-
-
79959808639
-
Sorafenib safety over time in >4600 patients with renal cell carcinoma RCC: insights from an integrated database of 8 company-sponsored trials
-
Milan Italy 8-12 October Abstract 905P
-
Eisen T, Hutson TE, Gore M et al. Sorafenib safety over time in >4600 patients with renal cell carcinoma (RCC): insights from an integrated database of 8 company-sponsored trials. Presented at: ESMO. Milan, Italy, 8-12 October 2010 (Abstract 905P
-
(2010)
Presented at: ESMO
-
-
Eisen, T.1
Hutson, T.E.2
Gore, M.3
-
64
-
-
79952281556
-
Experience with sorafenib and adverse event management
-
Bellmunt J, Eisen T, Fishman M, Quinn D. Experience with sorafenib and adverse event management. Crit. Rev. Oncol. Hematol. 78(1), 24-32 (2010).
-
(2010)
Crit. Rev. Oncol. Hematol.
, vol.78
, Issue.1
, pp. 24-32
-
-
Bellmunt, J.1
Eisen, T.2
Fishman, M.3
Quinn, D.4
|