-
1
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel, D. B., Laird, A. D., Xin, X., Louie, S. G., Christensen, J. G., Li, G., Schreck, R. E., Abrams, T. J., Ngai, T. J., Lee, L. B., Murray, L. J., Carver, J., Chan, E., Moss, K. G., Haznedar, J. O., Sukbuntherng, J., Blake, R. A., Sun, C., Tang, C., Miller, T., Shirazian, S., McMahon, G., and Cherrington, J. M. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin. Cancer Res., 9: 327-337, 2003. (Pubitemid 36109749)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.1 I
, pp. 327-337
-
-
Mendel, D.B.1
Douglas, L.A.2
Xin, X.3
Louie, S.G.4
Christensen, J.G.5
Li, G.6
Schreck, R.E.7
Abrams, T.J.8
Ngai, T.J.9
Lee, L.B.10
Murray, L.J.11
Carver, J.12
Chan, E.13
Moss, K.G.14
Haznedar, J.O.15
Sukbuntherng, J.16
Blake, R.A.17
Sun, L.18
Tang, C.19
Miller, T.20
Shirazian, S.21
McMahon, G.22
Cherrington, J.M.23
more..
-
2
-
-
0038204144
-
SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
-
DOI 10.1182/blood-2002-07-2307
-
O'Farrell, A. M., Abrams, T. J., Yuen, H. A., Ngai, T. J., Louie, S. G., Yee, K. W. H., Wong, L. M., Hong, W. M., Lee, L. B., Town, A., Smolich, B. D., Manning, W. C., Murray, L. J., Heinrich, M. C., and Cherrington, J. M. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo . Blood, 101: 3597-3605, 2003. (Pubitemid 36857948)
-
(2003)
Blood
, vol.101
, Issue.9
, pp. 3597-3605
-
-
O'Farrell, A.-M.1
Abrams, T.J.2
Yuen, H.A.3
Ngai, T.J.4
Louie, S.G.5
Yee, K.W.H.6
Wong, L.M.7
Hong, W.8
Lee, L.B.9
Town, A.10
Smolich, B.D.11
Manning, W.C.12
Murray, L.J.13
Heinrich, M.C.14
Cherrington, J.M.15
-
3
-
-
78650874372
-
SU11248 inhibits KIT and platelet derived growth factor receptor β in preclinical models of human small cell lung cancer
-
Abrams, T., Lee, L. B., Murray, L. J., Pryer, N. K., and Cherrington, J. M. SU11248 inhibits KIT and platelet derived growth factor receptor β in preclinical models of human small cell lung cancer. Mol. Cancer Ther., 2: 471-478, 2003.
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 471-478
-
-
Abrams, T.1
Lee, L.B.2
Murray, L.J.3
Pryer, N.K.4
Cherrington, J.M.5
-
4
-
-
0033650988
-
New paradigms for the treatment of cancer; the role of anti-angiogenesis agents
-
G. F. Vande Woude (ed.), 1st edition, San Diego, CA: Academic Press
-
Cherrington, J. M., Strawn, L. M., and Shawver, L. K. New paradigms for the treatment of cancer; the role of anti-angiogenesis agents. In: G. F. Vande Woude (ed.), Advances in Cancer Res., 1st edition, vol. 79, pp. 1-38. San Diego, CA: Academic Press, 2000.
-
(2000)
Advances in Cancer Res.
, vol.79
, pp. 1-38
-
-
Cherrington, J.M.1
Strawn, L.M.2
Shawver, L.K.3
-
5
-
-
0036740955
-
Expression of the vascular endothelial growth factor receptor-2/Flk-1 in breast carcinomas: Correlation with proliferation
-
Comment
-
Nakopoulou, L., Stefanaki, K., Panayotopoulou, E., Giannopoulou, I., Athanassiadou, P., Gakiopoulou-Givalou, H., and Louvrou, A. Expression of the vascular endothelial growth factor receptor-2/Flk-1 in breast carcinomas: correlation with proliferation (Comment). Hum. Pathol., 33: 863-870, 2002.
-
(2002)
Hum. Pathol.
, vol.33
, pp. 863-870
-
-
Nakopoulou, L.1
Stefanaki, K.2
Panayotopoulou, E.3
Giannopoulou, I.4
Athanassiadou, P.5
Gakiopoulou-Givalou, H.6
Louvrou, A.7
-
6
-
-
0031910169
-
Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I: An inventory in search of autocrine and paracrine loops
-
DOI 10.1002/(SICI)1096-9896(199801)184:1<44::AID
-
de Jong, J. S., van Diest, P. J., van der Valk, P., and Baak, J. P. Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I. An inventory in search of autocrine and paracrine loops. J. Pathol., 184: 44-52, 1998. (Pubitemid 28086152)
-
(1998)
Journal of Pathology
, vol.184
, Issue.1
, pp. 44-52
-
-
De Jong, J.S.1
Van Diest, P.J.2
Van Der, V.P.3
Baak, J.P.A.4
-
7
-
-
0028861231
-
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer
-
Brown, L. F., Berse, B., Jackman, R. W., Tognazzi, K., Guidi, A. J., Dvorak, H. F., Senger, D. R., Connolly, J. L., and Schnitt, S. J. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum. Pathol., 26: 86-91, 1995.
-
(1995)
Hum. Pathol.
, vol.26
, pp. 86-91
-
-
Brown, L.F.1
Berse, B.2
Jackman, R.W.3
Tognazzi, K.4
Guidi, A.J.5
Dvorak, H.F.6
Senger, D.R.7
Connolly, J.L.8
Schnitt, S.J.9
-
8
-
-
0033032991
-
Molecular mediators of tumor angiogenesis: Enhanced expression and activation of vascular endothelial growth factor receptor KDR in primary breast cancer
-
DOI 10.1002/(SICI)1097-0215(19990621)84:3<293::AID
-
Kranz, A., Mattfeldt, T., and Waltenberger, J. Molecular mediators of tumor angiogenesis: enhanced expression and activation of vascular endothelial growth factor receptor KDR in primary breast cancer. Int. J. Cancer, 84: 293-298, 1999. (Pubitemid 29256757)
-
(1999)
International Journal of Cancer
, vol.84
, Issue.3
, pp. 293-298
-
-
Kranz, A.1
Mattfeldt, T.2
Waltenberger, J.3
-
9
-
-
0037163646
-
The prognostic value of vascular endothelial growth factor in 574 node-negative breast cancer patients who did not receive adjuvant systemic therapy
-
DOI 10.1038/sj.bjc.6600555
-
Manders, P., Beex, L. V., Tjan-Heijnen, V. C., Geurts-Moespot, J., Van Tienoven, T. H., Foekens, J. A., and Sweep, C. G. The prognostic value of vascular endothelial growth factor in 574 node-negative breast cancer patients who did not receive adjuvant systemic therapy. Br. J. Cancer, 87: 772-778, 2002. (Pubitemid 35178755)
-
(2002)
British Journal of Cancer
, vol.87
, Issue.7
, pp. 772-778
-
-
Manders, P.1
Beex, L.V.A.M.2
Tjan-Heijnen, V.C.G.3
Geurts-Moespot, J.4
Van Tienoven, T.H.5
Foekens, J.A.6
Sweep, C.G.J.7
-
10
-
-
0029039982
-
Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor β subunit in human breast tissue and breast carcinoma
-
Coltrera, M. D., Wang, J., Porter, P. L., and Gown, A. M. Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor β subunit in human breast tissue and breast carcinoma. Cancer Res., 55: 2703-2708, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 2703-2708
-
-
Coltrera, M.D.1
Wang, J.2
Porter, P.L.3
Gown, A.M.4
-
11
-
-
0029015913
-
Coexpression of the c-kit and stem cell factor genes in breast carcinomas
-
Hines, S. J., Organ, C., Kornstein, M. J., and Krystal, G. W. Coexpression of the c-kit and stem cell factor genes in breast carcinomas. Cell Growth & Differ., 6: 769-779, 1995.
-
(1995)
Cell Growth & Differ.
, vol.6
, pp. 769-779
-
-
Hines, S.J.1
Organ, C.2
Kornstein, M.J.3
Krystal, G.W.4
-
12
-
-
0036250019
-
Expression of C-KIT and HER-2 tyrosine kinase receptors in poor-prognosis breast cancer
-
Palmu, S., Soderstrom, K. O., Quazi, K., Isola, J., and Salminen, E. Expression of C-KIT and HER-2 tyrosine kinase receptors in poor-prognosis breast cancer. Anticancer Res., 22: 411-414, 2002. (Pubitemid 34475331)
-
(2002)
Anticancer Research
, vol.22
, Issue.1 A
, pp. 411-414
-
-
Palmu, S.1
Soderstrom, K.O.2
Quazi, K.3
Isola, J.4
Salminen, E.5
-
13
-
-
0026471638
-
Breast cancer is associated with loss of the c-kit oncogene product
-
Natali, P. G., Nicotra, M. R., Sures, I., Mottolese, M., Botti, C., and Ullrich, A. Breast cancer is associated with loss of the c-kit oncogene product. Int. J. Cancer, 52: 713-717, 1992.
-
(1992)
Int. J. Cancer
, vol.52
, pp. 713-717
-
-
Natali, P.G.1
Nicotra, M.R.2
Sures, I.3
Mottolese, M.4
Botti, C.5
Ullrich, A.6
-
14
-
-
0030013525
-
Immunohistochemical expression of the c-kit proto-oncogene product in human malignant and non-malignant breast tissues
-
Chui, X., Egami, H., Yamashita, J., Kurizaki, T., Ohmachi, H., Yamamoto, S., and Ogawa, M. Immunohistochemical expression of the c-kit proto-oncogene product in human malignant and non-malignant breast tissues. Br. J. Cancer, 73: 1233-1236, 1996. (Pubitemid 26162338)
-
(1996)
British Journal of Cancer
, vol.73
, Issue.10
, pp. 1233-1236
-
-
Chui, X.1
Egami, H.2
Yamashita, J.3
Kurizaki, T.4
Ohmachi, H.5
Yamamoto, S.6
Ogawa, M.7
-
15
-
-
0036268221
-
Expression of c-kit protein in proliferative lesions of human breast: Sexual difference and close association with phosphotyrosine status
-
DOI 10.1007/s00432-002-0329-2
-
Tsuura, Y., Suzuki, T., Honma, K., and Sano, M. Expression of c-kit protein in proliferative lesions of human breast: sexual difference and close association with phosphotyrosine status. J. Cancer Res. Clin. Oncol., 128: 239-246, 2002. (Pubitemid 34591581)
-
(2002)
Journal of Cancer Research and Clinical Oncology
, vol.128
, Issue.5
, pp. 239-246
-
-
Tsuura, Y.1
Suzuki, T.2
Honma, K.3
Sano, M.4
-
16
-
-
0023631608
-
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo
-
DOI 10.1016/0092-8674(87)90449-1
-
Sinn, E., Muller, W., Pattengale, P., Tepler, I., Wallace, R., and Leder, P. Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo . Cell, 49: 465-475, 1987. (Pubitemid 18091823)
-
(1987)
Cell
, vol.49
, Issue.4
, pp. 465-475
-
-
Sinn, E.1
Muller, W.2
Pattengale, P.3
Tepler, I.4
Wallace, R.5
Leder, P.6
-
17
-
-
0022004418
-
Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: A review and tribute to Charles Brenton Huggins
-
Welsch, C. W. Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins. Cancer Res., 45: 3415-3443, 1985. (Pubitemid 15226403)
-
(1985)
Cancer Research
, vol.45
, Issue.8
, pp. 3415-3443
-
-
Welsch, C.W.1
-
18
-
-
0033510649
-
Characterization of spontaneous metastasis in an aggressive breast carcinoma model using flow cytometry
-
DOI 10.1023/A:1006719800907
-
Schmidt, C. M., Settle, S. L., Keene, J. L., Westlin, W. F., Nickols, G. A., and Griggs, D. W. Characterization of spontaneous metastasis in an aggressive breast carcinoma model using flow cytometry. Clin. & Exp. Metastasis, 17: 537-544, 1999. (Pubitemid 30182749)
-
(1999)
Clinical and Experimental Metastasis
, vol.17
, Issue.6
, pp. 537-544
-
-
Schmidt, C.M.1
Settle, S.L.2
Keene, J.L.3
Westlin, W.F.4
Nickols, G.A.5
Griggs, D.W.6
-
19
-
-
0029101805
-
Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice
-
Sasaki, A., Boyce, B. F., Story, B., Wright, K. R., Chapman, M., Boyce, R., Mundy, G. R., and Yoneda, T. Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice. Cancer Res., 55: 3551-3557, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 3551-3557
-
-
Sasaki, A.1
Boyce, B.F.2
Story, B.3
Wright, K.R.4
Chapman, M.5
Boyce, R.6
Mundy, G.R.7
Yoneda, T.8
-
20
-
-
0036898250
-
Chemotherapy for metastatic breast cancer - Report of a European expert panel
-
DOI 10.1016/S1470-2045(02)00927-0
-
Crown, J., Dieras, V., Kaufmann, M., von Minckwitz, G., Kaye, S., Leonard, R., Marty, M., Misset, J. L., Osterwalder, B., and Piccart, M. Chemotherapy for metastatic breast cancer-report of a European expert panel. Lancet Oncol., 3: 719-727, 2002. (Pubitemid 35446740)
-
(2002)
Lancet Oncology
, vol.3
, Issue.12
, pp. 719-727
-
-
Crown, J.1
Dieras, V.2
Kaufmann, M.3
Von, M.G.4
Kaye, S.5
Leonard, R.6
Marty, M.7
Misset, J.-L.8
Osterwalder, B.9
Piccard, M.10
-
21
-
-
0025083071
-
Critical factors in the biology of human cancer metastasis: Twenty-eighth G.H.A. Clowes Memorial Award Lecture
-
Fidler, I. J. Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. Cancer Res., 50: 6130-6138, 1990. (Pubitemid 20323663)
-
(1990)
Cancer Research
, vol.50
, Issue.19
, pp. 6130-6138
-
-
Fidler, I.J.1
-
22
-
-
0032907687
-
Vascular endothelial growth factor (VEGF) and its receptors
-
Neufeld, G., Cohen, T., Gengrinovitch, S., and Poltorak, Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J., 13: 9-22, 1999. (Pubitemid 29038270)
-
(1999)
FASEB Journal
, vol.13
, Issue.1
, pp. 9-22
-
-
Neufeld, G.1
Cohen, T.2
Gengrinovitch, S.3
Poltorak, Z.4
-
23
-
-
0027744498
-
Microvascular pericytes express platelet-derived growth factor-β receptors in human healing wounds and colorectal adenocarcinoma
-
Sundberg, C., Ljungstrom, M., Lindmark, G., Gerdin, B., and Rubin, K. Microvascular pericytes express platelet-derived growth factor-β receptors in human healing wounds and colorectal adenocarcinoma. Am. J. Pathol., 143: 1377-1388, 1993. (Pubitemid 24057108)
-
(1993)
American Journal of Pathology
, vol.143
, Issue.5
, pp. 1377-1388
-
-
Sundberg, C.1
Ljungstrom, M.2
Lindmark, G.3
Gerdin, B.4
Rubin, K.5
-
24
-
-
0031054990
-
Epidermal growth factor receptor family and chemosensitization
-
Mendelsohn, J. and Fan, Z. Epidermal growth factor receptor family and chemosensitization (Comment) J. Natl. Cancer Inst., 89: 341-343, 1997. (Pubitemid 27102599)
-
(1997)
Journal of the National Cancer Institute
, vol.89
, Issue.5
, pp. 341-343
-
-
Mendelsohn, J.1
Fan, Z.2
-
25
-
-
0029986283
-
Metastasis from human breast cancer cell lines
-
DOI 10.1007/BF01806081
-
Price, J. E. Metastasis from human breast cancer cell lines. Breast Cancer Res. Treat., 39: 93-102, 1996. (Pubitemid 26136507)
-
(1996)
Breast Cancer Research and Treatment
, vol.39
, Issue.1
, pp. 93-102
-
-
Price, J.E.1
-
26
-
-
0025945122
-
Bone metastases in breast cancer patients
-
Hortobagyi, G. N. Bone metastases in breast cancer patients. Semin. Oncol., 18: 11-15, 1991.
-
(1991)
Semin. Oncol.
, vol.18
, pp. 11-15
-
-
Hortobagyi, G.N.1
-
28
-
-
9044219839
-
Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma
-
DOI 10.1056/NEJM199602223340802
-
Berenson, J. R., Lichtenstein, A., Porter, L., Dimopoulos, M. A., Bordoni, R., George, S., Lipton, A., Keller, A., Ballester, O., Kovacs, M. J., Blacklock, H. A., Bell, R., Simeone, J., Reitsma, D. J., Heffernan, M., Seaman, J., and Knight, R. D. Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group (Comment). N. Engl. J. Med., 334: 488-493, 1996. (Pubitemid 26067736)
-
(1996)
New England Journal of Medicine
, vol.334
, Issue.8
, pp. 488-493
-
-
Berenson, J.R.1
Lichtenstein, A.2
Porter, L.3
Dimopoulos, M.A.4
Bordoni, R.5
George, S.6
Lipton, A.7
Keller, A.8
Ballester, O.9
Kovacs, M.J.10
Blacklock, H.A.11
Bell, R.12
Simeone, J.13
Reitsma, D.J.14
Heffernan, M.15
Seaman, J.16
Knight, R.D.17
-
29
-
-
0022996159
-
Bone destruction and hypercalcemia in plasma cell myeloma
-
Mundy, G. R. and Bertolini, D. R. Bone destruction and hypercalcemia in plasma cell myeloma (Erratum appears in Semin. Oncol. 13 (4): lxiii, 1986). Semin. Oncol., 13: 291-299, 1986. (Pubitemid 17204707)
-
(1986)
Seminars in Oncology
, vol.13
, Issue.3
, pp. 291-299
-
-
Mundy, G.R.1
Bertolini, D.R.2
|