A standardized G2-assay for the prediction of individual radiosensitivity

Radiotherapy and Oncology

Volumn 101, Issue 1, 2011, Pages 28-34

  Pantelias, Gabriel E ^a   Terzoudi, Georgia I ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

Author keywords

Ataxia Telangiectasia (AT); Caffeine; Cancer predisposition; Chromatid breaks; DNA damage repair; G2 assay; G2 checkpoint; Individual radiosensitivity

Indexed keywords

DEMECOLCINE;

ARTICLE; BLOOD DONOR; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CHROMATID; CHROMOSOME BREAKAGE; CONTROLLED STUDY; G2 ASSAY; HUMAN; HUMAN CELL; LYMPHOCYTE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RADIOASSAY; RADIOSENSITIVITY;

CASE-CONTROL STUDIES; CHROMOSOME ABERRATIONS; DNA DAMAGE; DNA REPAIR; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; LYMPHOCYTES; MALE; NEOPLASMS; PREDICTIVE VALUE OF TESTS; RADIATION DOSAGE; RADIATION TOLERANCE; REFERENCE VALUES; SAMPLING STUDIES;

EID: 80655133070     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.09.021     Document Type: Article

References (54)

1. A. Baeyens, H. Thierens, and K. Claes Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition Br J Cancer 87 2002 1379 1385 (Pubitemid 36044311)
2. K. Baria, C. Warren, O.B. Eden, S.A. Roberts, C.M. West, and D. Scott Chromosomal radiosensitivity in young cancer patients: possible evidence of genetic predisposition Int J Radiat Biol 78 2002 341 346 (Pubitemid 34496886)
3. K. Baria, C. Warren, S.A. Roberts, C.M. West, and D. Scott Chromosomal radiosensitivity as a marker of predisposition to common cancers? Br J Cancer 84 2001 892 896 (Pubitemid 32385830)
4. K. Borgmann, D. Haeberle, T. Doerk, A. Busjahn, G. Stephan, and E. Dikomey Genetic determination of chromosomal radiosensitivities in G0- and G2-phase human lymphocytes Radiother Oncol 83 2007 196 202 (Pubitemid 46776925)
5. K. Borgmann, U. Hoeller, and S. Nowack Individual radiosensitivity measured with lymphocytes may predict the risk of acute reaction after radiotherapy Int J Radiat Oncol Biol Phys 71 2008 256 264 (Pubitemid 351491410)
6. K. Borgmann, A. Raabe, and S. Reuther The potential role of G2- but not of G0-radiosensitivity for predisposition of prostate cancer Radiother Oncol 96 2010 19 24
7. P.E. Bryant, L. Gray, and A.C. Riches The G2 chromosomal radiosensitivity assay Int J Radiat Biol 78 2002 863 866
8. N.G. Burnet, J. Johansen, I. Turesson, J. Nyman, and J.H. Peacock Describing patients' normal tissue reactions: concerning the possibility of individualising radiotherapy dose prescriptions based on potential predictive assays of normal tissue radiosensitivity. Steering Committee of the BioMed2 European Union Concerted Action Programme on the Development of Predictive Tests of Normal Tissue Response to Radiation Therapy Int J Cancer 79 1998 606 613 (Pubitemid 28549472)
9. K.K. Cadwell, G.B. Curwen, E.J. Tawn,.J.F. Winther, and J.D. Boice Jr. G2 checkpoint control and G2 chromosomal radiosensitivity in cancer survivors and their families Mutagenesis 26 2010 291 294
10. X. Cheng, G.E. Pantelias, R. Okayasu, N. Cheong, and G. Iliakis Mitosis-promoting factor activity of inducer mitotic cells may affect radiation yield of interphase chromosome breaks in the premature chromosome condensation assay Cancer Res 53 1993 5592 5596 (Pubitemid 23360254)
11. H.H. Chun, and R.A. Gatti Ataxia-telangiectasia, an evolving phenotype DNA Repair (Amst) 3 2004 1187 1196 (Pubitemid 38997962)
12. D. Deckbar, J. Birraux, and A. Krempler Chromosome breakage after G2 checkpoint release J Cell Biol 176 2007 749 755 (Pubitemid 46425534)
13. D. Deckbar, M. Jeggo, and PA. Lobrich Understanding the limitations of radiation-induced cell cycle checkpoints Crit Rev Biochem Mol Biol 46 2011 271 283
14. B. Ernestos, P. Nikolaos, and G. Koulis Increased chromosomal radiosensitivity in women carrying BRCA1/BRCA2 mutations assessed with the G2 assay Int J Radiat Oncol Biol Phys 76 2010 1199 1205
15. A. Franchitto, P. Pichierri, M. Genuardi, A. De Santis, and F. Palitti Investigation of G2-phase chromosomal radiosensitivity in hereditary non-polyposis colorectal cancer cells Int J Radiat Biol 77 2001 773 780 (Pubitemid 32625545)
16. J.M. Hair, G.I. Terzoudi, and V.I. Hatzi BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions Chem Biol Interact 188 2010 350 358
17. O.L. Howe, P.A. Daly, C. Seymour, W. Ormiston, C. Nolan, and C. Mothersill Elevated G2 chromosomal radiosensitivity in Irish breast cancer patients: a comparison with other studies Int J Radiat Biol 81 2005 373 378 (Pubitemid 41117007)
18. G. Iliakis Backup pathways of NHEJ in cells of higher eukaryotes: cell cycle dependence Radiother Oncol 92 2009 310 315
19. G. Iliakis, H. Wang, and A.R. Perrault Mechanisms of DNA double strand break repair and chromosome aberration formation Cytogenet Genome Res 104 2004 14 20 (Pubitemid 38721048)
20. P.A. Jeggo, V. Geuting, and M. Lobrich The role of homologous recombination in radiation-induced double-strand break repair Radiother Oncol 101 2011 7 12
21. K. Koch, A. Wrona, E. Dikomey, and K. Borgmann Impact of homologous recombination on individual cellular radiosensitivity Radiother Oncol 90 2009 265 272
22. M. Kuhne, E. Riballo, N. Rief, K. Rothkamm, P.A. Jeggo, and M. Lobrich A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity Cancer Res 64 2004 500 508 (Pubitemid 38120888)
23. M.F. Lavin, and K.K. Khanna ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia Int J Radiat Biol 75 1999 1201 1214 (Pubitemid 29500002)
24. H. Lisowska, A. Lankoff, and A. Wieczorek Enhanced chromosomal radiosensitivity in peripheral blood lymphocytes of larynx cancer patients Int J Radiat Oncol Biol Phys 66 2006 1245 1252 (Pubitemid 44633533)
25. A.T. Natarajan, A. Berni, K.M. Marimuthu, and F. Palitti The type and yield of ionising radiation induced chromosomal aberrations depend on the efficiency of different DSB repair pathways in mammalian cells Mutat Res 642 2008 80 85
26. A.T. Natarajan, M. Meijers, A.A. van Zeeland, and J.W. Simons Attempts to detect ataxia telangiectasia (AT) heterozygotes by cytogenetical techniques Cytogenet Cell Genet 33 1982 145 151 (Pubitemid 12038938)
27. A.T. Natarajan, G. Obe, and F.N. Dulout The effect of caffeine posttreatment on X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro Hum Genet 54 1980 183 189 (Pubitemid 10111812)
28. A.T. Natarajan, and F. Palitti DNA repair and chromosomal alterations Mutat Res 657 2008 3 7
29. V. Ortenzi, R. Meschini, A. Berni, P. Mancinelli, and F. Palitti Study on X-ray-induced apoptosis and chromosomal damage in G2 human lymphocytes in the presence of pifithrin-alpha, an inhibitor of p53 Mutat Res 726 2011 29 35
30. F. Palitti Mechanisms of formation of chromosomal aberrations: insights from studies with DNA repair-deficient cells Cytogenet Genome Res 104 2004 95 99 (Pubitemid 38721058)
31. F. Palitti, P. Pichierri, A. Franchitto, L. Proietti De Santis, and P. Mosesso Chromosome radiosensitivity in human G2 lymphocytes and cell-cycle progression Int J Radiat Biol 75 1999 621 627 (Pubitemid 29243140)
32. G.E. Pantelias, and G.I. Terzoudi Functional cell-cycle chromatin conformation changes in the presence of DNA damage result into chromatid breaks: a new insight in the formation of radiation-induced chromosomal aberrations based on the direct observation of interphase chromatin Mutat Res 701 2010 27 37
33. R. Papworth, N. Slevin, S.A. Roberts, and D. Scott Sensitivity to radiation-induced chromosome damage may be a marker of genetic predisposition in young head and neck cancer patients Br J Cancer 84 2001 776 782 (Pubitemid 32275650)
34. R. Parshad, R. Gantt, K.K. Sanford, and G.M. Jones Chromosomal radiosensitivity of human tumor cells during the G2 cell cycle period Cancer Res 44 1984 5577 5582 (Pubitemid 15183560)
35. E. Riballo, M. Kuhne, and N. Rief A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci Mol Cell 16 2004 715 724 (Pubitemid 39586530)
36. K.K. Sanford, R. Parshad, R. Gantt, R.E. Tarone, G.M. Jones, and F.M. Price Factors affecting and significance of G2 chromatin radiosensitivity in predisposition to cancer Int J Radiat Biol 55 1989 963 981 (Pubitemid 19154259)
37. D. Scott Chromosomal radiosensitivity and low penetrance predisposition to cancer Cytogenet Genome Res 104 2004 365 370 (Pubitemid 38721104)
38. D. Scott, J.B. Barber, A.R. Spreadborough, W. Burrill, and S.A. Roberts Increased chromosomal radiosensitivity in breast cancer patients: a comparison of two assays Int J Radiat Biol 75 1999 1 10 (Pubitemid 29057038)
39. D. Scott, Q. Hu, and S.A. Roberts Dose-rate sparing for micronucleus induction in lymphocytes of controls and ataxia-telangiectasia heterozygotes exposed to 60Co gamma-irradiation in vitro Int J Radiat Biol 70 1996 521 527 (Pubitemid 26388944)
40. D. Scott, A.R. Spreadborough, L.A. Jones, S.A. Roberts, and C.J. Moore Chromosomal radiosensitivity in G2-phase lymphocytes as an indicator of cancer predisposition Radiat Res 145 1996 3 16 (Pubitemid 26006168)
41. D. Scott, A.R. Spreadborough, and S.A. Roberts Less G(2) arrest in irradiated cells of breast cancer patients than in female controls: a contribution to their enhanced chromosomal radiosensitivity? Int J Radiat Biol 79 2003 405 411 (Pubitemid 37153542)
42. V. Smart, G.B. Curwen, C.A. Whitehouse, A. Edwards, and E.J. Tawn Chromosomal radiosensitivity: a study of the chromosomal G(2) assay in human blood lymphocytes indicating significant inter-individual variability Mutat Res 528 2003 105 110 (Pubitemid 36868998)
43. G.I. Terzoudi, V.I. Hatzi, and K. Barszczewska G2-checkpoint abrogation in irradiated lymphocytes: A new cytogenetic approach to assess individual radiosensitivity and predisposition to cancer Int J Oncol 35 2009 1223 1230
44. G.I. Terzoudi, V.I. Hatzi, C. Donta-Bakoyianni, and G.E. Pantelias Chromatin dynamics during cell cycle mediate conversion of DNA damage into chromatid breaks and affect formation of chromosomal aberrations: biological and clinical significance Mutat Res 711 2011 174 186
45. G.I. Terzoudi, T. Jung, and J. Hain Increased G2 chromosomal radiosensitivity in cancer patients: the role of cdk1/cyclin-B activity level in the mechanisms involved Int J Radiat Biol 76 2000 607 615 (Pubitemid 30345161)
46. G.I. Terzoudi, K.N. Manola, G.E. Pantelias, and G. Iliakis Checkpoint abrogation in G2 compromises repair of chromosomal breaks in ataxia telangiectasia cells Cancer Res 65 2005 11292 11296 (Pubitemid 41821685)
47. G.I. Terzoudi, S.K. Singh, G.E. Iliakis, and G. Pantelias Premature chromosome condensation reveals DNA-PK independent pathways of chromosome break repair Int J Oncol 33 2008 871 879
48. A. Vral, H. Thierens, A. De Baeyens, and L. Ridder Chromosomal aberrations and in vitro radiosensitivity: intra-individual versus inter-individual variability Toxicol Lett 149 2004 345 352 (Pubitemid 38469852)
49. A. Vral, H. Thierens, A. De Baeyens, and L. Ridder The micronucleus and G2-phase assays for human blood lymphocytes as biomarkers of individual sensitivity to ionizing radiation: limitations imposed by intraindividual variability Radiat Res 157 2002 472 477 (Pubitemid 34267262)
50. X. Wang, J. Khadpe, B. Hu, G. Iliakis, and Y. Wang An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells J Biol Chem 278 2003 30869 30874 (Pubitemid 36994597)
51. X. Wang, H. Wang, G. Iliakis, and Y. Wang Caffeine-induced radiosensitization is independent of nonhomologous end joining of DNA double-strand breaks Radiat Res 159 2003 426 432 (Pubitemid 36314958)
52. W. Wu, M. Wang, T. Mussfeldt, and G. Iliakis Enhanced use of backup pathways of NHEJ in G2 in Chinese hamster mutant cells with defects in the classical pathway of NHEJ Radiat Res 170 2008 512 520
53. B. Xu, S.T. Kim, D.S. Lim, and M.B. Kastan Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation Mol Cell Biol 22 2002 1049 1059 (Pubitemid 34094842)
54. F. Zampetti-Bosseler, and D. Scott Cell death, chromosome damage and mitotic delay in normal human, ataxia telangiectasia and retinoblastoma fibroblasts after x-irradiation Int J Radiat Biol Relat Stud Phys Chem Med 39 1981 547 558 (Pubitemid 11156039)