An oncogene-induced DNA damage model for cancer development

Science

Volumn 319, Issue 5868, 2008, Pages 1352-1355

  Halazonetis, Thanos D ^a   Gorgoulis, Vassilis G ^b   Bartek, Jiri ^c  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

APOPTOSIS; CANCER; DNA; EXPERIMENTAL STUDY; GENE EXPRESSION; GENOME; MODEL; MUTATION;

APOPTOSIS; CARCINOGENESIS; DNA DAMAGE; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; NEOPLASM; NONHUMAN; ONCOGENE; PRECANCER; PRIORITY JOURNAL; REVIEW; SENESCENCE; TUMOR GROWTH;

CELL PROLIFERATION; DISEASE PROGRESSION; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPLICATION; GENES, P53; GENOMIC INSTABILITY; HUMANS; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; ONCOGENES; PRECANCEROUS CONDITIONS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 40449120350     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1140735     Document Type: Review

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30. We apologize for not being able to include all relevant concepts and references. We thank all our collaborators for their contributions to the development of the oncogene-induced DNA damage model. The authors are supported by grants from the Swiss National Foundation and the U.S. National Cancer Institute (T.D.H.); the Greek General Secretariat for Research and Technology Program to Enhance Research (V.G.G.); and the Danish Cancer Society, the Danish National Research Foundation, the Czech Ministry of Education (MSM6198959216), and the European Commission "Active p53" and "Mutant p53" Integrated Projects (J.B.).