BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions

Chemico-Biological Interactions

Volumn 188, Issue 2, 2010, Pages 350-358

  Hair, Jessica M ^a   Terzoudi, Georgia I ^b   Hatzi, Vasiliki I ^b   Lehockey, Katie A ^a   Srivastava, Devika ^a   Wang, Weixin ^c   Pantelias, Gabriel E ^b   Georgakilas, Alexandros G ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

BRCA1; Chromosomal instability; Clustered DNA lesions; Human breast cancer; Oxidative stress; Radiotoxicity

Indexed keywords

BACTERIAL ENZYME; BRCA1 PROTEIN; DNA; ESCHERICHIA COLI ENZYME; GAMMA HISTONE H2AX; HISTONE H2AX; UNCLASSIFIED DRUG; H2AFX PROTEIN, HUMAN; HISTONE;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE G0 PHASE; CELL CYCLE G2 PHASE; CELL STRAIN MCF 7; CHROMATID ABERRATION; CHROMOSOMAL INSTABILITY; COMET ASSAY; CONTROLLED STUDY; DICENTRIC CHROMOSOME; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GAMMA RADIATION; GENE EXPRESSION; HCC1937 CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; METAPHASE; OXIDATION; PULSED FIELD GEL ELECTROPHORESIS; RADIOSENSITIVITY; SINGLE STRANDED DNA BREAK; BREAST TUMOR; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; RADIATION RESPONSE; TUMOR CELL LINE;

BRCA1 PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMOSOMAL INSTABILITY; DNA DAMAGE; DNA REPAIR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONES; HUMANS;

ESCHERICHIA COLI;

EID: 77956652485     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.03.046     Document Type: Article

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