Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks

DNA Repair

Volumn 9, Issue 8, 2010, Pages 929-936

  Heacock, Michelle L ^a   Stefanick, Donna F ^a   Horton, Julie K ^a   Wilson, Samuel H ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

H2A.X; Cell cycle; Double strand breaks; Methyl methanesulfonate; PARP inhibitor; PARP 1

Indexed keywords

GENOMIC DNA; HISTONE H2AX; HISTONE H2AX GAMMA; MESYLIC ACID METHYL ESTER; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA ALKYLATION; DNA DAMAGE; DNA STRUCTURE; DOUBLE STRANDED DNA BREAK; EXCISION REPAIR; FIBROBLAST; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS;

1-NAPHTHYLAMINE; ALKYLATION; ANIMALS; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA-BINDING PROTEINS; ELECTROPHORESIS, GEL, PULSED-FIELD; FIBROBLASTS; FLOW CYTOMETRY; HISTONES; HUMANS; METHYL METHANESULFONATE; MICE; NAPHTHALIMIDES; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN-SERINE-THREONINE KINASES; QUINOLONES; S PHASE; TUMOR SUPPRESSOR PROTEINS;

EID: 77955272550     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2010.05.007     Document Type: Article

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