The poly(ADP-ribose) polymerase inhibitor ABT-888 reduces radiation-induced nuclear EGFR and augments head and neck tumor response to radiotherapy

Radiotherapy and Oncology

Volumn 99, Issue 3, 2011, Pages 331-338

  Nowsheen, Somaira ^a   Bonner, James A ^a   Yang, Eddy S ^a,b,c  

^a The University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

ABT 888; Biomarker; DNA damage; DNA repair; EGFR; H2AX; Head and neck cancer; Non homologous end joining (NHEJ); Nuclear import; PARP; Radiation

Indexed keywords

CELL DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; GAMMA HISTONE H2AX; HISTONE H2AX; POLY(ADENOSINE DIPHOSPHATE RIBOSE); UNCLASSIFIED DRUG; VELIPARIB;

ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; COLONY FORMATION; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA REPAIR; ENZYME INHIBITION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTON TRANSPORT; RADIATION RESPONSE; RADIOSENSITIZATION; SQUAMOUS CELL CARCINOMA; X IRRADIATION;

ANALYSIS OF VARIANCE; BENZIMIDAZOLES; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL SURVIVAL; COMBINED MODALITY THERAPY; COMET ASSAY; DNA DAMAGE; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; ENZYME INHIBITORS; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; POLY(ADP-RIBOSE) POLYMERASES; RADIATION-SENSITIZING AGENTS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR MARKERS, BIOLOGICAL;

EID: 79960359070     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.05.084     Document Type: Article

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