Oxidation of the sugar moiety of DNA by ionizing radiation or bleomycin could induce the formation of a cluster DNA lesion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 35, 2007, Pages 14032-14037

  Regulus, Peggy ^a   Duroux, Benoit ^a   Bayle, Pierre Alain ^a   Favier, Alain ^a   Cadet, Jean ^a   Ravanat, Jean Luc ^a  

^a CEA GRENOBLE   (France)

Author keywords

Cluster lesions; DNA damage; DNA repair

Indexed keywords

2 DEOXYRIBOSE; 6 (2 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 2 HYDROXY 3 (3 HYDROXY 2 OXOPROPYL) 2,6 DIHYDROIMIDAZO[1,2 C]PYRIMIDIN 5(3H) ONE; ALDEHYDE; BLEOMYCIN; CARBON; CELL DNA; CYTOSINE; DOUBLE STRANDED DNA; HYDROGEN; NUCLEOSIDE; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG; DEOXYRIBOSE; DNA;

ARTICLE; CONTROLLED STUDY; DIASTEREOISOMER; DNA EXTRACTION; DNA REPAIR; DNA STRAND BREAKAGE; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IONIZING RADIATION; ISOMER; LYMPHOCYTE; MASS SPECTROMETRY; MONOCYTE; OXIDATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TANDEM MASS SPECTROMETRY; ANIMAL; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DNA DAMAGE; DRUG EFFECT; RADIATION EXPOSURE;

ANIMALS; BLEOMYCIN; CATTLE; DEOXYRIBOSE; DNA; DNA DAMAGE; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; RADIATION, IONIZING;

EID: 35348826722     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0706044104     Document Type: Article

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