A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation

BMC Cancer

Volumn 11, Issue , 2011, Pages

  Valentine, Jane M ^a,b   Kumar, Sonia ^a   Moumen, Abdeladim ^a  

^a DNA Damage Response Group   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; BRCA1 PROTEIN; CHECKPOINT KINASE 2; HISTONE H2AX; NUTLIN 3; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; SERINE; IMIDAZOLE DERIVATIVE; MDM2 PROTEIN, HUMAN; PIPERAZINE DERIVATIVE; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; DRUG STRUCTURE; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CELL STRAIN HCT116; DNA DAMAGE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; CELLS, CULTURED; DNA DAMAGE; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HCT116 CELLS; HUMANS; IMIDAZOLES; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PIPERAZINES; PROTEIN STABILITY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79951696692     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-11-79     Document Type: Article

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