메뉴 건너뛰기




Volumn 32, Issue 2, 2012, Pages 294-325

Prophylactic and therapeutic implications of toll-like receptor ligands

Author keywords

Adjuvant vaccine; Pattern recognition receptors; Therapeutic strategy; TLR signaling; Toll like receptors

Indexed keywords

AGATOLIMOD; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; AMINOALKYL GLUCOSAMINIDE 4 PHOSPHATE; AS 01; AS 02; AS 04; CBLB 502; CPG OLIGODEOXYNUCLEOTIDE; ERITORAN; FLAGELLIN; FREUND ADJUVANT; GAMMA INTERFERON; GLYCOPROTEIN GP 120; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; IMIQUIMOD; INFLUENZA VACCINE; INTERLEUKIN 12; ISATORIBINE; MALARIA VACCINE; MELAN A; PEGINTERFERON ALPHA; POLYINOSINIC POLYCYTIDYLIC ACID; RADIOPROTECTIVE AGENT; RECOMBINANT HEPATITIS B VACCINE; RESIQUIMOD; RIBAVIRIN; RINTATOLIMOD; TOLL LIKE RECEPTOR AGONIST; TOLL LIKE RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG; VAX 125; WART VIRUS VACCINE;

EID: 84855184185     PISSN: 01986325     EISSN: 10981128     Source Type: Journal    
DOI: 10.1002/med.20214     Document Type: Article
Times cited : (74)

References (248)
  • 1
    • 63649108380 scopus 로고    scopus 로고
    • The roles of TLRs, RLRs and NLRs in pathogen recognition
    • Kawai T, Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol 2009;21:317-337.
    • (2009) Int Immunol , vol.21 , pp. 317-337
    • Kawai, T.1    Akira, S.2
  • 2
    • 20344389060 scopus 로고    scopus 로고
    • Toll-like receptors: Linking innate and adaptive immunity
    • Pasare C, Medzhitov R. Toll-like receptors: Linking innate and adaptive immunity. Adv Exp Med Biol 2005;560:11-18.
    • (2005) Adv Exp Med Biol , vol.560 , pp. 11-18
    • Pasare, C.1    Medzhitov, R.2
  • 3
    • 3142779901 scopus 로고    scopus 로고
    • Therapeutics targeting the innate immune system
    • Ulevitch RJ. Therapeutics targeting the innate immune system. Nat Rev Immunol 2004;4:512-520.
    • (2004) Nat Rev Immunol , vol.4 , pp. 512-520
    • Ulevitch, R.J.1
  • 4
    • 33646478589 scopus 로고    scopus 로고
    • Therapeutic targeting of pattern-recognition receptors
    • Rezaei N. Therapeutic targeting of pattern-recognition receptors. Int Immunopharmacol 2006;6:863-869.
    • (2006) Int Immunopharmacol , vol.6 , pp. 863-869
    • Rezaei, N.1
  • 5
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    • Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007;13:552-559.
    • (2007) Nat Med , vol.13 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3    Coffman, R.L.4
  • 6
    • 67649422321 scopus 로고    scopus 로고
    • Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer
    • O'Neill LA, Bryant CE, Doyle SL. Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev 2009;61:177-197.
    • (2009) Pharmacol Rev , vol.61 , pp. 177-197
    • O'Neill, L.A.1    Bryant, C.E.2    Doyle, S.L.3
  • 7
    • 17344370677 scopus 로고    scopus 로고
    • Evolution and integration of innate immune recognition systems: The Toll-like receptors
    • Takeda K. Evolution and integration of innate immune recognition systems: The Toll-like receptors. J Endotoxin Res 2005;11:51-55.
    • (2005) J Endotoxin Res , vol.11 , pp. 51-55
    • Takeda, K.1
  • 8
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004;4:499-511.
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 9
    • 68749115366 scopus 로고    scopus 로고
    • Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins
    • Carpenter S, O'Neill LA. Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins. Biochem J 2009;422:1-10.
    • (2009) Biochem J , vol.422 , pp. 1-10
    • Carpenter, S.1    O'Neill, L.A.2
  • 10
    • 23044445303 scopus 로고    scopus 로고
    • Crystal structure of human toll-like receptor 3 (TLR3) ectodomain
    • Choe J, Kelker MS, Wilson IA. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 2005;309:581-585.
    • (2005) Science , vol.309 , pp. 581-585
    • Choe, J.1    Kelker, M.S.2    Wilson, I.A.3
  • 12
    • 34548608447 scopus 로고    scopus 로고
    • Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
    • Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 2007;130:1071-1082.
    • (2007) Cell , vol.130 , pp. 1071-1082
    • Jin, M.S.1    Kim, S.E.2    Heo, J.Y.3    Lee, M.E.4    Kim, H.M.5    Paik, S.G.6    Lee, H.7    Lee, J.O.8
  • 15
    • 67349182481 scopus 로고    scopus 로고
    • The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
    • Park BS, Song DH, Kim HM, Choi BS, Lee H, Lee JO. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 2009;458:1191-1195.
    • (2009) Nature , vol.458 , pp. 1191-1195
    • Park, B.S.1    Song, D.H.2    Kim, H.M.3    Choi, B.S.4    Lee, H.5    Lee, J.O.6
  • 16
    • 48749128643 scopus 로고    scopus 로고
    • Structures of the toll-like receptor family and its ligand complexes
    • Jin MS, Lee JO. Structures of the toll-like receptor family and its ligand complexes. Immunity 2008;29:182-191.
    • (2008) Immunity , vol.29 , pp. 182-191
    • Jin, M.S.1    Lee, J.O.2
  • 17
    • 33748871535 scopus 로고    scopus 로고
    • New insights into the regulation of TLR signaling
    • Miggin SM, O'Neill LA. New insights into the regulation of TLR signaling. J Leukoc Biol 2006;80:220-226.
    • (2006) J Leukoc Biol , vol.80 , pp. 220-226
    • Miggin, S.M.1    O'Neill, L.A.2
  • 19
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol 2005;17:1-14.
    • (2005) Int Immunol , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 21
    • 1842607467 scopus 로고    scopus 로고
    • Innate immunity and toll-like receptors: Clinical implications of basic science research
    • Abreu MT, Arditi M. Innate immunity and toll-like receptors: Clinical implications of basic science research. J Pediatr 2004;144:421-429.
    • (2004) J Pediatr , vol.144 , pp. 421-429
    • Abreu, M.T.1    Arditi, M.2
  • 23
    • 0141923690 scopus 로고    scopus 로고
    • Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling
    • Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K, Akira S. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J Immunol 2003;171:4304-4310.
    • (2003) J Immunol , vol.171 , pp. 4304-4310
    • Sato, S.1    Sugiyama, M.2    Yamamoto, M.3    Watanabe, Y.4    Kawai, T.5    Takeda, K.6    Akira, S.7
  • 26
    • 18844457095 scopus 로고    scopus 로고
    • Mechanisms of type-I- and type-II-interferon-mediated signalling
    • Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol 2005;5:375-386.
    • (2005) Nat Rev Immunol , vol.5 , pp. 375-386
    • Platanias, L.C.1
  • 27
    • 0037205084 scopus 로고    scopus 로고
    • The global impact of vaccines containing aluminium adjuvants
    • Clements CJ, Griffiths E. The global impact of vaccines containing aluminium adjuvants. Vaccine 2002;20:S24-S33.
    • (2002) Vaccine , vol.20
    • Clements, C.J.1    Griffiths, E.2
  • 29
    • 56649108016 scopus 로고    scopus 로고
    • Engagement of TLR signaling as adjuvant: Towards smarter vaccine and beyond
    • Lahiri A, Das P, Chakravortty D. Engagement of TLR signaling as adjuvant: Towards smarter vaccine and beyond. Vaccine 2008;26:6777-6783.
    • (2008) Vaccine , vol.26 , pp. 6777-6783
    • Lahiri, A.1    Das, P.2    Chakravortty, D.3
  • 30
    • 0038282518 scopus 로고    scopus 로고
    • Toll-like receptors and T-helper-1/T-helper-2 responses
    • Dabbagh K, Lewis DB. Toll-like receptors and T-helper-1/T-helper-2 responses. Curr Opin Infect Dis 2003;16:199-204.
    • (2003) Curr Opin Infect Dis , vol.16 , pp. 199-204
    • Dabbagh, K.1    Lewis, D.B.2
  • 33
    • 35349028297 scopus 로고    scopus 로고
    • GlaxoSmithKline Adjuvant Systems in vaccines: Concepts, achievements and perspectives
    • Garcon N, Chomez P, Van Mechelen M. GlaxoSmithKline Adjuvant Systems in vaccines: Concepts, achievements and perspectives. Expert Rev Vaccines 2007;6:723-739.
    • (2007) Expert Rev Vaccines , vol.6 , pp. 723-739
    • Garcon, N.1    Chomez, P.2    Van Mechelen, M.3
  • 34
    • 34247234090 scopus 로고    scopus 로고
    • New hepatitis B vaccine formulated with an improved adjuvant system
    • Kundi M. New hepatitis B vaccine formulated with an improved adjuvant system. Expert Rev Vaccines 2007;6:133-140.
    • (2007) Expert Rev Vaccines , vol.6 , pp. 133-140
    • Kundi, M.1
  • 37
    • 39149121505 scopus 로고    scopus 로고
    • Recombinant gp350 vaccine for infectious mononucleosis: A phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adults
    • Sokal EM, Hoppenbrouwers K, Vandermeulen C, Moutschen M, Leonard P, Moreels A, Haumont M, Bollen A, Smets F, Denis M. Recombinant gp350 vaccine for infectious mononucleosis: A phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adults. J Infect Dis 2007;196:1749-1753.
    • (2007) J Infect Dis , vol.196 , pp. 1749-1753
    • Sokal, E.M.1    Hoppenbrouwers, K.2    Vandermeulen, C.3    Moutschen, M.4    Leonard, P.5    Moreels, A.6    Haumont, M.7    Bollen, A.8    Smets, F.9    Denis, M.10
  • 38
    • 38949200368 scopus 로고    scopus 로고
    • Human papillomavirus types 16 and 18 vaccine (recombinant, AS04 adjuvanted, adsorbed) [Cervarix]
    • Keam SJ, Harper DM. Human papillomavirus types 16 and 18 vaccine (recombinant, AS04 adjuvanted, adsorbed) [Cervarix]. Drugs 2008;68:359-372.
    • (2008) Drugs , vol.68 , pp. 359-372
    • Keam, S.J.1    Harper, D.M.2
  • 39
    • 70349485373 scopus 로고    scopus 로고
    • Five-year safety and immunogenicity of GlaxoSmithKline's candidate malaria vaccine RTS,S/AS02 following administration to semi-immune adult men living in a malaria-endemic region of The Gambia
    • Bojang K, Milligan P, Pinder M, Doherty T, Leach A, Ofori-Anyinam O, Lievens M, Kester K, Schaecher K, Ballou WR, Cohen J. Five-year safety and immunogenicity of GlaxoSmithKline's candidate malaria vaccine RTS, S/AS02 following administration to semi-immune adult men living in a malaria-endemic region of The Gambia. Hum Vaccin 2009;5:242-247.
    • (2009) Hum Vaccin , vol.5 , pp. 242-247
    • Bojang, K.1    Milligan, P.2    Pinder, M.3    Doherty, T.4    Leach, A.5    Ofori-Anyinam, O.6    Lievens, M.7    Kester, K.8    Schaecher, K.9    Ballou, W.R.10    Cohen, J.11
  • 50
    • 0037435929 scopus 로고    scopus 로고
    • Novel synthetic LPS receptor agonists boost systemic and mucosal antibody responses in mice
    • Przetak M, Chow J, Cheng H, Rose J, Hawkins LD, Ishizaka ST. Novel synthetic LPS receptor agonists boost systemic and mucosal antibody responses in mice. Vaccine 2003;21:961-970.
    • (2003) Vaccine , vol.21 , pp. 961-970
    • Przetak, M.1    Chow, J.2    Cheng, H.3    Rose, J.4    Hawkins, L.D.5    Ishizaka, S.T.6
  • 51
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002;20:709-760.
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 52
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, Endres S, Hartmann G. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002;168:4531-4537.
    • (2002) J Immunol , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 55
    • 0034163408 scopus 로고    scopus 로고
    • CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses
    • Vabulas RM, Pircher H, Lipford GB, Hacker H, Wagner H. CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses. J Immunol 2000;164:2372-2378.
    • (2000) J Immunol , vol.164 , pp. 2372-2378
    • Vabulas, R.M.1    Pircher, H.2    Lipford, G.B.3    Hacker, H.4    Wagner, H.5
  • 57
    • 0032526607 scopus 로고    scopus 로고
    • CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry
    • Yi AK, Chang M, Peckham DW, Krieg AM, Ashman RF. CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry. J Immunol 1998;160:5898-5906.
    • (1998) J Immunol , vol.160 , pp. 5898-5906
    • Yi, A.K.1    Chang, M.2    Peckham, D.W.3    Krieg, A.M.4    Ashman, R.F.5
  • 59
    • 11344257404 scopus 로고    scopus 로고
    • CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/II study
    • Cooper CL, Davis HL, Morris ML, Efler SM, Adhami MA, Krieg AM, Cameron DW, Heathcote J. CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/II study. J Clin Immunol 2004;24:693-701.
    • (2004) J Clin Immunol , vol.24 , pp. 693-701
    • Cooper, C.L.1    Davis, H.L.2    Morris, M.L.3    Efler, S.M.4    Adhami, M.A.5    Krieg, A.M.6    Cameron, D.W.7    Heathcote, J.8
  • 61
    • 25844484501 scopus 로고    scopus 로고
    • CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults
    • Cooper CL, Davis HL, Angel JB, Morris ML, Elfer SM, Seguin I, Krieg AM, Cameron DW. CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults. AIDS 2005;19:1473-1479.
    • (2005) AIDS , vol.19 , pp. 1473-1479
    • Cooper, C.L.1    Davis, H.L.2    Angel, J.B.3    Morris, M.L.4    Elfer, S.M.5    Seguin, I.6    Krieg, A.M.7    Cameron, D.W.8
  • 62
    • 28344457315 scopus 로고    scopus 로고
    • Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults
    • Halperin SA, Dobson S, McNeil S, Langley JM, Smith B, McCall-Sani R, Levitt D, Nest GV, Gennevois D, Eiden JJ. Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults. Vaccine 2006;24:20-26.
    • (2006) Vaccine , vol.24 , pp. 20-26
    • Halperin, S.A.1    Dobson, S.2    McNeil, S.3    Langley, J.M.4    Smith, B.5    McCall-Sani, R.6    Levitt, D.7    Nest, G.V.8    Gennevois, D.9    Eiden, J.J.10
  • 63
    • 0037726807 scopus 로고    scopus 로고
    • A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant
    • Halperin SA, Van Nest G, Smith B, Abtahi S, Whiley H, Eiden JJ. A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant. Vaccine 2003;21:2461-2467.
    • (2003) Vaccine , vol.21 , pp. 2461-2467
    • Halperin, S.A.1    Van Nest, G.2    Smith, B.3    Abtahi, S.4    Whiley, H.5    Eiden, J.J.6
  • 65
    • 34248169629 scopus 로고    scopus 로고
    • Development of TLR9 agonists for cancer therapy
    • Krieg AM. Development of TLR9 agonists for cancer therapy. J Clin Invest 2007;117:1184-1194.
    • (2007) J Clin Invest , vol.117 , pp. 1184-1194
    • Krieg, A.M.1
  • 68
    • 0038683055 scopus 로고    scopus 로고
    • Phase I/II study with CpG 7909 as adjuvant to vaccination with MAGA-3 protein in patients with MAGE-3 positive tumors
    • van Ojik H, Kruit W, Portielje J, Brichard V, Verloes R, Delire M, Stoter G. Phase I/II study with CpG 7909 as adjuvant to vaccination with MAGA-3 protein in patients with MAGE-3 positive tumors. Ann Oncol 2002;13:157.
    • (2002) Ann Oncol , vol.13 , pp. 157
    • van Ojik, H.1    Kruit, W.2    Portielje, J.3    Brichard, V.4    Verloes, R.5    Delire, M.6    Stoter, G.7
  • 69
    • 41349102954 scopus 로고    scopus 로고
    • TLR3: Interferon induction by double-stranded RNA including poly(I:C)
    • Matsumoto M, Seya T. TLR3: Interferon induction by double-stranded RNA including poly(I:C). Adv Drug Deliv Rev 2008;60:805-812.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 805-812
    • Matsumoto, M.1    Seya, T.2
  • 70
    • 0346098026 scopus 로고    scopus 로고
    • Polyriboinosinic polyribocytidylic acid [poly(I:C)]/TLR3 signaling allows class I processing of exogenous protein and induction of HIV-specific CD8+ cytotoxic T lymphocytes
    • Fujimoto C, Nakagawa Y, Ohara K, Takahashi H. Polyriboinosinic polyribocytidylic acid [poly(I:C)]/TLR3 signaling allows class I processing of exogenous protein and induction of HIV-specific CD8+ cytotoxic T lymphocytes. Int Immunol 2004;16:55-63.
    • (2004) Int Immunol , vol.16 , pp. 55-63
    • Fujimoto, C.1    Nakagawa, Y.2    Ohara, K.3    Takahashi, H.4
  • 71
    • 68649086251 scopus 로고    scopus 로고
    • Progress on the induction of neutralizing antibodies against HIV type 1 (HIV-1)
    • Vaine M, Lu S, Wang S. Progress on the induction of neutralizing antibodies against HIV type 1 (HIV-1). BioDrugs 2009;23:137-153.
    • (2009) BioDrugs , vol.23 , pp. 137-153
    • Vaine, M.1    Lu, S.2    Wang, S.3
  • 72
    • 33751071573 scopus 로고    scopus 로고
    • Combination DNA plus protein HIV vaccines
    • Lu S. Combination DNA plus protein HIV vaccines. Springer Semin Immunopathol 2006;28:255-265.
    • (2006) Springer Semin Immunopathol , vol.28 , pp. 255-265
    • Lu, S.1
  • 73
    • 2942519878 scopus 로고    scopus 로고
    • DNA vaccines against human immunodeficiency virus type 1
    • Estcourt MJ, McMichael AJ, Hanke T. DNA vaccines against human immunodeficiency virus type 1. Immunol Rev 2004;199:144-155.
    • (2004) Immunol Rev , vol.199 , pp. 144-155
    • Estcourt, M.J.1    McMichael, A.J.2    Hanke, T.3
  • 74
    • 0037122011 scopus 로고    scopus 로고
    • Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    • Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med 2002;196:1627-1638.
    • (2002) J Exp Med , vol.196 , pp. 1627-1638
    • Bonifaz, L.1    Bonnyay, D.2    Mahnke, K.3    Rivera, M.4    Nussenzweig, M.C.5    Steinman, R.M.6
  • 77
    • 0041427900 scopus 로고    scopus 로고
    • Prime-boost vaccination with HIV-1 Gag protein and cytosine phosphate guanosine oligodeoxynucleotide, followed by adenovirus, induces sustained and robust humoral and cellular immune responses
    • Tritel M, Stoddard AM, Flynn BJ, Darrah PA, Wu CY, Wille U, Shah JA, Huang Y, Xu L, Betts MR, Nabel GJ, Seder RA. Prime-boost vaccination with HIV-1 Gag protein and cytosine phosphate guanosine oligodeoxynucleotide, followed by adenovirus, induces sustained and robust humoral and cellular immune responses. J Immunol 2003;171:2538-2547.
    • (2003) J Immunol , vol.171 , pp. 2538-2547
    • Tritel, M.1    Stoddard, A.M.2    Flynn, B.J.3    Darrah, P.A.4    Wu, C.Y.5    Wille, U.6    Shah, J.A.7    Huang, Y.8    Xu, L.9    Betts, M.R.10    Nabel, G.J.11    Seder, R.A.12
  • 78
    • 69349101739 scopus 로고    scopus 로고
    • Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands
    • Grossmann C, Tenbusch M, Nchinda G, Temchura V, Nabi G, Stone GW, Kornbluth RS, Uberla K. Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands. BMC Immunol 2009;10:43.
    • (2009) BMC Immunol , vol.10 , pp. 43
    • Grossmann, C.1    Tenbusch, M.2    Nchinda, G.3    Temchura, V.4    Nabi, G.5    Stone, G.W.6    Kornbluth, R.S.7    Uberla, K.8
  • 82
    • 33847387125 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of tumor-induced T-cell tolerance
    • Horna P, Sotomayor EM. Cellular and molecular mechanisms of tumor-induced T-cell tolerance. Curr Cancer Drug Targets 2007;7:41-53.
    • (2007) Curr Cancer Drug Targets , vol.7 , pp. 41-53
    • Horna, P.1    Sotomayor, E.M.2
  • 84
    • 0033168630 scopus 로고    scopus 로고
    • Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cells
    • Verdijk RM, Mutis T, Esendam B, Kamp J, Melief CJ, Brand A, Goulmy E. Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cells. J Immunol 1999;163:57-61.
    • (1999) J Immunol , vol.163 , pp. 57-61
    • Verdijk, R.M.1    Mutis, T.2    Esendam, B.3    Kamp, J.4    Melief, C.J.5    Brand, A.6    Goulmy, E.7
  • 85
    • 0017108014 scopus 로고
    • A phase I-II trial of multiple-dose polyriboinosic-polyribocytidylic acid in patieonts with leukemia or solid tumors
    • Robinson RA, DeVita VT, Levy HB, Baron S, Hubbard SP, Levine AS. A phase I-II trial of multiple-dose polyriboinosic-polyribocytidylic acid in patieonts with leukemia or solid tumors. J Natl Cancer Inst 1976;57:599-602.
    • (1976) J Natl Cancer Inst , vol.57 , pp. 599-602
    • Robinson, R.A.1    DeVita, V.T.2    Levy, H.B.3    Baron, S.4    Hubbard, S.P.5    Levine, A.S.6
  • 88
    • 14844303287 scopus 로고    scopus 로고
    • The rationale for combined chemo/immunotherapy using a Toll-like receptor 3 (TLR3) agonist and tumour-derived exosomes in advanced ovarian cancer
    • Adams M, Navabi H, Croston D, Coleman S, Tabi Z, Clayton A, Jasani B, Mason MD. The rationale for combined chemo/immunotherapy using a Toll-like receptor 3 (TLR3) agonist and tumour-derived exosomes in advanced ovarian cancer. Vaccine 2005;23:2374-2378.
    • (2005) Vaccine , vol.23 , pp. 2374-2378
    • Adams, M.1    Navabi, H.2    Croston, D.3    Coleman, S.4    Tabi, Z.5    Clayton, A.6    Jasani, B.7    Mason, M.D.8
  • 89
    • 67349117313 scopus 로고    scopus 로고
    • Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer
    • Jasani B, Navabi H, Adams M. Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer. Vaccine 2009;27:3401-3404.
    • (2009) Vaccine , vol.27 , pp. 3401-3404
    • Jasani, B.1    Navabi, H.2    Adams, M.3
  • 91
    • 77953124392 scopus 로고    scopus 로고
    • Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine
    • Skountzou I, Martin MD, Wang B, Ye L, Koutsonanos D, Weldon W, Jacob J, Compans RW. Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine. Vaccine 2010;28:4103-4112.
    • (2010) Vaccine , vol.28 , pp. 4103-4112
    • Skountzou, I.1    Martin, M.D.2    Wang, B.3    Ye, L.4    Koutsonanos, D.5    Weldon, W.6    Jacob, J.7    Compans, R.W.8
  • 92
    • 33845224163 scopus 로고    scopus 로고
    • Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity
    • Huleatt JW, Jacobs AR, Tang J, Desai P, Kopp EB, Huang Y, Song L, Nakaar V, Powell TJ. Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity. Vaccine 2007;25:763-775.
    • (2007) Vaccine , vol.25 , pp. 763-775
    • Huleatt, J.W.1    Jacobs, A.R.2    Tang, J.3    Desai, P.4    Kopp, E.B.5    Huang, Y.6    Song, L.7    Nakaar, V.8    Powell, T.J.9
  • 94
    • 84857682910 scopus 로고    scopus 로고
    • Escalating dose-ranging study to evaluate the safety and immunogenicity of the VAX125 (STF2.HA1(SI)), a recombinant hemagglutinin influenza vaccine, in healthy young adults. The twelfth annual conference on vaccine research, National Foundation for Infectious Diseases.
    • Treanor JJ, Taylor DN, Song L, Fitzgerald T, Shaw A, Tussey L. Escalating dose-ranging study to evaluate the safety and immunogenicity of the VAX125 (STF2.HA1(SI)), a recombinant hemagglutinin influenza vaccine, in healthy young adults. The twelfth annual conference on vaccine research, National Foundation for Infectious Diseases. 2009. 130p.
    • (2009) , pp. 130
    • Treanor, J.J.1    Taylor, D.N.2    Song, L.3    Fitzgerald, T.4    Shaw, A.5    Tussey, L.6
  • 96
    • 31844436647 scopus 로고    scopus 로고
    • Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis
    • Honko AN, Sriranganathan N, Lees CJ, Mizel SB. Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis. Infect Immun 2006;74:1113-1120.
    • (2006) Infect Immun , vol.74 , pp. 1113-1120
    • Honko, A.N.1    Sriranganathan, N.2    Lees, C.J.3    Mizel, S.B.4
  • 99
    • 55249083982 scopus 로고    scopus 로고
    • Phase 1 evaluation of intralesionally injected TLR9-agonist PF-3512676 in patients with basal cell carcinoma or metastatic melanoma
    • Hofmann MA, Kors C, Audring H, Walden P, Sterry W, Trefzer U. Phase 1 evaluation of intralesionally injected TLR9-agonist PF-3512676 in patients with basal cell carcinoma or metastatic melanoma. J Immunother 2008;31:520-527.
    • (2008) J Immunother , vol.31 , pp. 520-527
    • Hofmann, M.A.1    Kors, C.2    Audring, H.3    Walden, P.4    Sterry, W.5    Trefzer, U.6
  • 101
    • 27844589626 scopus 로고    scopus 로고
    • Phase Ib trial of a targeted TLR9 CpG immunomodulator (CPG 7909) in advanced renal cell carcinoma (RCC)
    • J Clin Oncol, American Society of Clinical Oncology Annual Meeting
    • Thompson JA, Kuxel T, Bukowski F, Schmalbach T. Phase Ib trial of a targeted TLR9 CpG immunomodulator (CPG 7909) in advanced renal cell carcinoma (RCC). J Clin Oncol, American Society of Clinical Oncology Annual Meeting. 2004. 4644p.
    • (2004) , pp. 4644
    • Thompson, J.A.1    Kuxel, T.2    Bukowski, F.3    Schmalbach, T.4
  • 102
    • 84857678957 scopus 로고    scopus 로고
    • Cutaneous T-cell lymphoma (CTCL) responses to a TLR9 agonist CpG immunomodulator (CPG 7909), a phase I study
    • J Clin Oncol, American Society of Clinical Oncology Annual Meeting
    • Kim Y, Girardi M, McAuley S, Schmalbach T. Cutaneous T-cell lymphoma (CTCL) responses to a TLR9 agonist CpG immunomodulator (CPG 7909), a phase I study. J Clin Oncol, American Society of Clinical Oncology Annual Meeting. 2004. 6600p.
    • (2004) , pp. 6600
    • Kim, Y.1    Girardi, M.2    McAuley, S.3    Schmalbach, T.4
  • 103
    • 50549084485 scopus 로고    scopus 로고
    • Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer
    • Manegold C, Gravenor D, Woytowitz D, Mezger J, Hirsh V, Albert G, Al-Adhami M, Readett D, Krieg AM, Leichman CG. Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer. J Clin Oncol 2008;26:3979-3986.
    • (2008) J Clin Oncol , vol.26 , pp. 3979-3986
    • Manegold, C.1    Gravenor, D.2    Woytowitz, D.3    Mezger, J.4    Hirsh, V.5    Albert, G.6    Al-Adhami, M.7    Readett, D.8    Krieg, A.M.9    Leichman, C.G.10
  • 104
    • 0036456708 scopus 로고    scopus 로고
    • Imiquimod and the imidazoquinolones: Mechanism of action and therapeutic potential
    • Stanley MA. Imiquimod and the imidazoquinolones: Mechanism of action and therapeutic potential. Clin Exp Dermatol 2002;27:571-577.
    • (2002) Clin Exp Dermatol , vol.27 , pp. 571-577
    • Stanley, M.A.1
  • 105
    • 17444378895 scopus 로고    scopus 로고
    • Treatment of lentigo maligna (melanoma in situ) with the immune response modifier imiquimod
    • Wolf IH, Cerroni L, Kodama K, Kerl H. Treatment of lentigo maligna (melanoma in situ) with the immune response modifier imiquimod. Arch Dermatol 2005;141:510-514.
    • (2005) Arch Dermatol , vol.141 , pp. 510-514
    • Wolf, I.H.1    Cerroni, L.2    Kodama, K.3    Kerl, H.4
  • 108
    • 2342450044 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of actinic keratosis: Results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials
    • Lebwohl M, Dinehart S, Whiting D, Lee PK, Tawfik N, Jorizzo J, Lee JH, Fox TL. Imiquimod 5% cream for the treatment of actinic keratosis: Results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J Am Acad Dermatol 2004;50:714-721.
    • (2004) J Am Acad Dermatol , vol.50 , pp. 714-721
    • Lebwohl, M.1    Dinehart, S.2    Whiting, D.3    Lee, P.K.4    Tawfik, N.5    Jorizzo, J.6    Lee, J.H.7    Fox, T.L.8
  • 110
    • 34147144925 scopus 로고    scopus 로고
    • Topical imiquimod therapy for basal and squamous cell carcinomas: A clinical experience
    • Tillman DK Jr, Carroll MT. Topical imiquimod therapy for basal and squamous cell carcinomas: A clinical experience. Cutis 2007;79:241-248.
    • (2007) Cutis , vol.79 , pp. 241-248
    • Tillman Jr, D.K.1    Carroll, M.T.2
  • 111
    • 41449089985 scopus 로고    scopus 로고
    • Complete resolution of Paget disease of the vulva with imiquimod cream
    • Hatch KD, Davis JR. Complete resolution of Paget disease of the vulva with imiquimod cream. J Low Genit Tract Dis 2008;12:90-94.
    • (2008) J Low Genit Tract Dis , vol.12 , pp. 90-94
    • Hatch, K.D.1    Davis, J.R.2
  • 112
    • 84857659971 scopus 로고    scopus 로고
    • Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod-proposal of a therapeutic schedule
    • J Eur Acad Dermatol Venereol
    • Sendagorta E, Herranz P, Feito M, Ramirez P, Floristan U, Feltes R, Benito D, Casado M. Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod-proposal of a therapeutic schedule. J Eur Acad Dermatol Venereol 2009.
    • (2009)
    • Sendagorta, E.1    Herranz, P.2    Feito, M.3    Ramirez, P.4    Floristan, U.5    Feltes, R.6    Benito, D.7    Casado, M.8
  • 115
    • 4844224383 scopus 로고    scopus 로고
    • Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells
    • Tallant T, Deb A, Kar N, Lupica J, de Veer MJ, DiDonato JA. Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells. BMC Microbiol 2004;4:33.
    • (2004) BMC Microbiol , vol.4 , pp. 33
    • Tallant, T.1    Deb, A.2    Kar, N.3    Lupica, J.4    de Veer, M.J.5    DiDonato, J.A.6
  • 120
    • 33845874634 scopus 로고    scopus 로고
    • Pollinex Quattro: A novel and well-tolerated, ultra short-course allergy vaccine
    • Patel P, Salapatek AM. Pollinex Quattro: A novel and well-tolerated, ultra short-course allergy vaccine. Expert Rev Vaccines 2006;5:617-629.
    • (2006) Expert Rev Vaccines , vol.5 , pp. 617-629
    • Patel, P.1    Salapatek, A.M.2
  • 121
    • 3042718066 scopus 로고    scopus 로고
    • Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA
    • Simons FE, Shikishima Y, Van Nest G, Eiden JJ, HayGlass KT. Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA. J Allergy Clin Immunol 2004;113:1144-1151.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 1144-1151
    • Simons, F.E.1    Shikishima, Y.2    Van Nest, G.3    Eiden, J.J.4    HayGlass, K.T.5
  • 124
    • 0034767753 scopus 로고    scopus 로고
    • Antiviral actions of interferons
    • table of contents.
    • Samuel CE. Antiviral actions of interferons. Clin Microbiol Rev 2001;14:778-809, table of contents.
    • (2001) Clin Microbiol Rev , vol.14 , pp. 778-809
    • Samuel, C.E.1
  • 126
    • 0038651180 scopus 로고    scopus 로고
    • Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7
    • Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA, Raz E, Cottam HB. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7. Proc Natl Acad Sci USA 2003;100:6646-6651.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6646-6651
    • Lee, J.1    Chuang, T.H.2    Redecke, V.3    She, L.4    Pitha, P.M.5    Carson, D.A.6    Raz, E.7    Cottam, H.B.8
  • 128
    • 33747622584 scopus 로고    scopus 로고
    • Masked oral prodrugs of toll-like receptor 7 agonists: A new approach for the treatment of infectious disease
    • Fletcher S, Steffy K, Averett D. Masked oral prodrugs of toll-like receptor 7 agonists: A new approach for the treatment of infectious disease. Curr Opin Investig Drugs 2006;7:702-708.
    • (2006) Curr Opin Investig Drugs , vol.7 , pp. 702-708
    • Fletcher, S.1    Steffy, K.2    Averett, D.3
  • 129
    • 34347399259 scopus 로고    scopus 로고
    • Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies
    • Pockros PJ, Guyader D, Patton H, Tong MJ, Wright T, McHutchison JG, Meng TC. Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies. J Hepatol 2007;47:174-182.
    • (2007) J Hepatol , vol.47 , pp. 174-182
    • Pockros, P.J.1    Guyader, D.2    Patton, H.3    Tong, M.J.4    Wright, T.5    McHutchison, J.G.6    Meng, T.C.7
  • 130
    • 63749130351 scopus 로고    scopus 로고
    • A class C CpG toll-like receptor 9 agonist successfully induces robust interferon-alpha production by plasmacytoid dendritic cells from patients chronically infected with hepatitis C
    • Libri NA, Barker SJ, Rosenberg WM, Semper AE. A class C CpG toll-like receptor 9 agonist successfully induces robust interferon-alpha production by plasmacytoid dendritic cells from patients chronically infected with hepatitis C. J Viral Hepat 2009;16:315-324.
    • (2009) J Viral Hepat , vol.16 , pp. 315-324
    • Libri, N.A.1    Barker, S.J.2    Rosenberg, W.M.3    Semper, A.E.4
  • 131
    • 0036048526 scopus 로고    scopus 로고
    • Topical 5% imiquimod long-term treatment of cutaneous warts resistant to standard therapy modalities
    • Grussendorf-Conen EI, Jacobs S, Rubben A, Dethlefsen U. Topical 5% imiquimod long-term treatment of cutaneous warts resistant to standard therapy modalities. Dermatology 2002;205:139-145.
    • (2002) Dermatology , vol.205 , pp. 139-145
    • Grussendorf-Conen, E.I.1    Jacobs, S.2    Rubben, A.3    Dethlefsen, U.4
  • 133
    • 0344873639 scopus 로고    scopus 로고
    • An open label evaluation of the efficacy of imiquimod 5% cream in the treatment of recalcitrant subungual and periungual cutaneous warts
    • Micali G, Dall'Oglio F, Nasca MR. An open label evaluation of the efficacy of imiquimod 5% cream in the treatment of recalcitrant subungual and periungual cutaneous warts. J Dermatolog Treat 2003;14:233-236.
    • (2003) J Dermatolog Treat , vol.14 , pp. 233-236
    • Micali, G.1    Dall'Oglio, F.2    Nasca, M.R.3
  • 134
    • 0036280054 scopus 로고    scopus 로고
    • Efficacy of imiquimod 5% cream in the treatment of recalcitrant warts in children
    • Grussendorf-Conen EI, Jacobs S. Efficacy of imiquimod 5% cream in the treatment of recalcitrant warts in children. Pediatr Dermatol 2002;19:263-266.
    • (2002) Pediatr Dermatol , vol.19 , pp. 263-266
    • Grussendorf-Conen, E.I.1    Jacobs, S.2
  • 135
    • 19344376816 scopus 로고    scopus 로고
    • Effectiveness of imiquimod cream 5% for treating childhood molluscum contagiosum in a double-blind, randomized pilot trial
    • Theos AU, Cummins R, Silverberg NB, Paller AS. Effectiveness of imiquimod cream 5% for treating childhood molluscum contagiosum in a double-blind, randomized pilot trial. Cutis 2004;74:134-138, 141-142.
    • (2004) Cutis , vol.74 , pp. 134-138
    • Theos, A.U.1    Cummins, R.2    Silverberg, N.B.3    Paller, A.S.4
  • 136
    • 0347320539 scopus 로고    scopus 로고
    • Experience in treating molluscum contagiosum in children with imiquimod 5% cream
    • Bayerl C, Feller G, Goerdt S. Experience in treating molluscum contagiosum in children with imiquimod 5% cream. Br J Dermatol 2003;149:25-29.
    • (2003) Br J Dermatol , vol.149 , pp. 25-29
    • Bayerl, C.1    Feller, G.2    Goerdt, S.3
  • 137
    • 18244373947 scopus 로고    scopus 로고
    • Randomized, double-blind clinical trial of topical imiquimod 5% with parenteral meglumine antimoniate in the treatment of cutaneous leishmaniasis in Peru
    • Miranda-Verastegui C, Llanos-Cuentas A, Arevalo I, Ward BJ, Matlashewski G. Randomized, double-blind clinical trial of topical imiquimod 5% with parenteral meglumine antimoniate in the treatment of cutaneous leishmaniasis in Peru. Clin Infect Dis 2005;40:1395-1403.
    • (2005) Clin Infect Dis , vol.40 , pp. 1395-1403
    • Miranda-Verastegui, C.1    Llanos-Cuentas, A.2    Arevalo, I.3    Ward, B.J.4    Matlashewski, G.5
  • 139
    • 38649143209 scopus 로고    scopus 로고
    • Effect of resiquimod 0.01% gel on lesion healing and viral shedding when applied to genital herpes lesions
    • Fife KH, Meng TC, Ferris DG, Liu P. Effect of resiquimod 0.01% gel on lesion healing and viral shedding when applied to genital herpes lesions. Antimicrob Agents Chemother 2008;52:477-482.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 477-482
    • Fife, K.H.1    Meng, T.C.2    Ferris, D.G.3    Liu, P.4
  • 141
    • 37349041656 scopus 로고    scopus 로고
    • The role of toll-like receptor ligands/agonists in protection against genital HSV-2 infection
    • Gill N, Davies EJ, Ashkar AA. The role of toll-like receptor ligands/agonists in protection against genital HSV-2 infection. Am J Reprod Immunol 2008;59:35-43.
    • (2008) Am J Reprod Immunol , vol.59 , pp. 35-43
    • Gill, N.1    Davies, E.J.2    Ashkar, A.A.3
  • 142
    • 0036827534 scopus 로고    scopus 로고
    • Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection
    • Pyles RB, Higgins D, Chalk C, Zalar A, Eiden J, Brown C, Van Nest G, Stanberry LR. Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection. J Virol 2002;76:11387-11396.
    • (2002) J Virol , vol.76 , pp. 11387-11396
    • Pyles, R.B.1    Higgins, D.2    Chalk, C.3    Zalar, A.4    Eiden, J.5    Brown, C.6    Van Nest, G.7    Stanberry, L.R.8
  • 143
    • 33749497006 scopus 로고    scopus 로고
    • Quantification of poly(I:C)-mediated protection against genital herpes simplex virus type 2 infection
    • Herbst-Kralovetz MM, Pyles RB. Quantification of poly(I:C)-mediated protection against genital herpes simplex virus type 2 infection. J Virol 2006;80:9988-9997.
    • (2006) J Virol , vol.80 , pp. 9988-9997
    • Herbst-Kralovetz, M.M.1    Pyles, R.B.2
  • 147
    • 0026601777 scopus 로고
    • The effect of combinations of ampligen and zidovudine or dideoxyinosine against human immunodeficiency viruses in vitro
    • O'Marro SD, Armstrong JA, Asuncion C, Gueverra L, Ho M. The effect of combinations of ampligen and zidovudine or dideoxyinosine against human immunodeficiency viruses in vitro. Antiviral Res 1992;17:169-177.
    • (1992) Antiviral Res , vol.17 , pp. 169-177
    • O'Marro, S.D.1    Armstrong, J.A.2    Asuncion, C.3    Gueverra, L.4    Ho, M.5
  • 148
    • 0028024371 scopus 로고
    • Synergistic inhibition of AZT-resistant HIV by AZT combined with poly(I):poly(C12U), without synergistic toxicity to bone marrow progenitor cell elements
    • Gillespie D, Hubbell HR, Carter WA, Midgette P, Elsasser W, Mullaney R, Strayer DR. Synergistic inhibition of AZT-resistant HIV by AZT combined with poly(I):poly(C12U), without synergistic toxicity to bone marrow progenitor cell elements. In Vivo 1994;8:375-381.
    • (1994) In Vivo , vol.8 , pp. 375-381
    • Gillespie, D.1    Hubbell, H.R.2    Carter, W.A.3    Midgette, P.4    Elsasser, W.5    Mullaney, R.6    Strayer, D.R.7
  • 149
    • 0026356275 scopus 로고
    • Mismatched double-stranded RNA, Ampligen (poly(I): Poly(C12U), demonstrates antiviral and immunostimulatory activities in HIV disease
    • Carter WA, Ventura D, Shapiro DE, Strayer DR, Gillespie DH, Hubbell HR. Mismatched double-stranded RNA, Ampligen (poly(I): Poly(C12U), demonstrates antiviral and immunostimulatory activities in HIV disease. Int J Immunopharmacol 1991;13:69-76.
    • (1991) Int J Immunopharmacol , vol.13 , pp. 69-76
    • Carter, W.A.1    Ventura, D.2    Shapiro, D.E.3    Strayer, D.R.4    Gillespie, D.H.5    Hubbell, H.R.6
  • 152
    • 3142713223 scopus 로고    scopus 로고
    • Inhibition of endotoxin response by synthetic TLR4 antagonists
    • Hawkins LD, Christ WJ, Rossignol DP. Inhibition of endotoxin response by synthetic TLR4 antagonists. Curr Top Med Chem 2004;4:1147-1171.
    • (2004) Curr Top Med Chem , vol.4 , pp. 1147-1171
    • Hawkins, L.D.1    Christ, W.J.2    Rossignol, D.P.3
  • 153
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    • Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 1999;189:1777-1782.
    • (1999) J Exp Med , vol.189 , pp. 1777-1782
    • Shimazu, R.1    Akashi, S.2    Ogata, H.3    Nagai, Y.4    Fukudome, K.5    Miyake, K.6    Kimoto, M.7
  • 154
    • 0025166114 scopus 로고
    • CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990;249:1431-1433.
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 158
    • 9144271703 scopus 로고    scopus 로고
    • Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling
    • Hyakushima N, Mitsuzawa H, Nishitani C, Sano H, Kuronuma K, Konishi M, Himi T, Miyake K, Kuroki Y. Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling. J Immunol 2004;173:6949-6954.
    • (2004) J Immunol , vol.173 , pp. 6949-6954
    • Hyakushima, N.1    Mitsuzawa, H.2    Nishitani, C.3    Sano, H.4    Kuronuma, K.5    Konishi, M.6    Himi, T.7    Miyake, K.8    Kuroki, Y.9
  • 159
    • 33751584426 scopus 로고    scopus 로고
    • Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice
    • Mitsuzawa H, Nishitani C, Hyakushima N, Shimizu T, Sano H, Matsushima N, Fukase K, Kuroki Y. Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice. J Immunol 2006;177:8133-8139.
    • (2006) J Immunol , vol.177 , pp. 8133-8139
    • Mitsuzawa, H.1    Nishitani, C.2    Hyakushima, N.3    Shimizu, T.4    Sano, H.5    Matsushima, N.6    Fukase, K.7    Kuroki, Y.8
  • 161
    • 47149099757 scopus 로고    scopus 로고
    • Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling
    • Jain V, Halle A, Halmen KA, Lien E, Charrel-Dennis M, Ram S, Golenbock DT, Visintin A. Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling. Blood 2008;111:4637-4645.
    • (2008) Blood , vol.111 , pp. 4637-4645
    • Jain, V.1    Halle, A.2    Halmen, K.A.3    Lien, E.4    Charrel-Dennis, M.5    Ram, S.6    Golenbock, D.T.7    Visintin, A.8
  • 162
    • 46749136744 scopus 로고    scopus 로고
    • Discovery and development of toll-like receptor 4 (TLR4) antagonists: A new paradigm for treating sepsis and other diseases
    • Leon CG, Tory R, Jia J, Sivak O, Wasan KM. Discovery and development of toll-like receptor 4 (TLR4) antagonists: A new paradigm for treating sepsis and other diseases. Pharm Res 2008;25:1751-1761.
    • (2008) Pharm Res , vol.25 , pp. 1751-1761
    • Leon, C.G.1    Tory, R.2    Jia, J.3    Sivak, O.4    Wasan, K.M.5
  • 164
    • 48549083746 scopus 로고    scopus 로고
    • Structures of TLR-ligand complexes
    • Jin MS, Lee JO. Structures of TLR-ligand complexes. Curr Opin Immunol 2008;20:414-419.
    • (2008) Curr Opin Immunol , vol.20 , pp. 414-419
    • Jin, M.S.1    Lee, J.O.2
  • 166
    • 41149131096 scopus 로고    scopus 로고
    • TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain
    • Kawamoto T, Ii M, Kitazaki T, Iizawa Y, Kimura H. TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain. Eur J Pharmacol 2008;584:40-48.
    • (2008) Eur J Pharmacol , vol.584 , pp. 40-48
    • Kawamoto, T.1    Ii, M.2    Kitazaki, T.3    Iizawa, Y.4    Kimura, H.5
  • 167
    • 28544447821 scopus 로고    scopus 로고
    • Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: Synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate
    • Yamada M, Ichikawa T, Ii M, Sunamoto M, Itoh K, Tamura N, Kitazaki T. Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: Synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate. J Med Chem 2005;48:7457-7467.
    • (2005) J Med Chem , vol.48 , pp. 7457-7467
    • Yamada, M.1    Ichikawa, T.2    Ii, M.3    Sunamoto, M.4    Itoh, K.5    Tamura, N.6    Kitazaki, T.7
  • 168
    • 34548496023 scopus 로고    scopus 로고
    • Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model
    • Sha T, Sunamoto M, Kitazaki T, Sato J, Ii M, Iizawa Y. Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model. Eur J Pharmacol 2007;571:231-239.
    • (2007) Eur J Pharmacol , vol.571 , pp. 231-239
    • Sha, T.1    Sunamoto, M.2    Kitazaki, T.3    Sato, J.4    Ii, M.5    Iizawa, Y.6
  • 169
    • 0034597766 scopus 로고    scopus 로고
    • Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
    • Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 2000;408:111-115.
    • (2000) Nature , vol.408 , pp. 111-115
    • Xu, Y.1    Tao, X.2    Shen, B.3    Horng, T.4    Medzhitov, R.5    Manley, J.L.6    Tong, L.7
  • 170
    • 33847369756 scopus 로고    scopus 로고
    • Cutting Edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs
    • Toshchakov VY, Fenton MJ, Vogel SN. Cutting Edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs. J Immunol 2007;178:2655-2660.
    • (2007) J Immunol , vol.178 , pp. 2655-2660
    • Toshchakov, V.Y.1    Fenton, M.J.2    Vogel, S.N.3
  • 171
    • 21244503817 scopus 로고    scopus 로고
    • Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction
    • Toshchakov VU, Basu S, Fenton MJ, Vogel SN. Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction. J Immunol 2005;175:494-500.
    • (2005) J Immunol , vol.175 , pp. 494-500
    • Toshchakov, V.U.1    Basu, S.2    Fenton, M.J.3    Vogel, S.N.4
  • 174
    • 9644289387 scopus 로고    scopus 로고
    • Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?
    • Andreakos E, Foxwell B, Feldmann M. Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation? Immunol Rev 2004;202:250-265.
    • (2004) Immunol Rev , vol.202 , pp. 250-265
    • Andreakos, E.1    Foxwell, B.2    Feldmann, M.3
  • 175
    • 39549103221 scopus 로고    scopus 로고
    • The roles of pathogen-associated molecular patterns in atherosclerosis
    • Erridge C. The roles of pathogen-associated molecular patterns in atherosclerosis. Trends Cardiovasc Med 2008;18:52-56.
    • (2008) Trends Cardiovasc Med , vol.18 , pp. 52-56
    • Erridge, C.1
  • 176
    • 58149288126 scopus 로고    scopus 로고
    • Toll-like receptors: New therapeutic targets for the treatment of atherosclerosis, acute coronary syndromes, and myocardial failure
    • Erickson B, Sperber K, Frishman WH. Toll-like receptors: New therapeutic targets for the treatment of atherosclerosis, acute coronary syndromes, and myocardial failure. Cardiol Rev 2008;16:273-279.
    • (2008) Cardiol Rev , vol.16 , pp. 273-279
    • Erickson, B.1    Sperber, K.2    Frishman, W.H.3
  • 178
    • 47149105036 scopus 로고    scopus 로고
    • Toll-like receptors and adaptor molecules in liver disease: Update
    • Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: Update. Hepatology 2008;48:322-335.
    • (2008) Hepatology , vol.48 , pp. 322-335
    • Seki, E.1    Brenner, D.A.2
  • 179
    • 49649100702 scopus 로고    scopus 로고
    • Tracking the toll of kidney disease
    • Shirali AC, Goldstein DR. Tracking the toll of kidney disease. J Am Soc Nephrol 2008;19:1444-1450.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1444-1450
    • Shirali, A.C.1    Goldstein, D.R.2
  • 180
    • 51249111466 scopus 로고    scopus 로고
    • The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease
    • Himmel ME, Hardenberg G, Piccirillo CA, Steiner TS, Levings MK. The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease. Immunology 2008;125:145-153.
    • (2008) Immunology , vol.125 , pp. 145-153
    • Himmel, M.E.1    Hardenberg, G.2    Piccirillo, C.A.3    Steiner, T.S.4    Levings, M.K.5
  • 181
    • 56249101032 scopus 로고    scopus 로고
    • Toll-like receptor modulation: A novel therapeutic strategy in cardiovascular disease?
    • Katsargyris A, Klonaris C, Bastounis E, Theocharis S. Toll-like receptor modulation: A novel therapeutic strategy in cardiovascular disease? Expert Opin Ther Targets 2008;12:1329-1346.
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 1329-1346
    • Katsargyris, A.1    Klonaris, C.2    Bastounis, E.3    Theocharis, S.4
  • 182
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
    • Kariko K, Buckstein M, Ni H, Weissman D. Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity 2005;23:165-175.
    • (2005) Immunity , vol.23 , pp. 165-175
    • Kariko, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 183
    • 37649018614 scopus 로고    scopus 로고
    • Toll-like receptors and autoimmunity
    • Hurst J, von Landenberg P. Toll-like receptors and autoimmunity. Autoimmun Rev 2008;7:204-208.
    • (2008) Autoimmun Rev , vol.7 , pp. 204-208
    • Hurst, J.1    von Landenberg, P.2
  • 184
    • 35748964708 scopus 로고    scopus 로고
    • Toll-like receptors 7, 8, and 9: Linking innate immunity to autoimmunity
    • Krieg AM, Vollmer J. Toll-like receptors 7, 8, and 9: Linking innate immunity to autoimmunity. Immunol Rev 2007;220:251-269.
    • (2007) Immunol Rev , vol.220 , pp. 251-269
    • Krieg, A.M.1    Vollmer, J.2
  • 186
    • 33747034337 scopus 로고    scopus 로고
    • Regulation of regulatory T cells: Role of dendritic cells and toll-like receptors
    • Kabelitz D, Wesch D, Oberg HH. Regulation of regulatory T cells: Role of dendritic cells and toll-like receptors. Crit Rev Immunol 2006;26:291-306.
    • (2006) Crit Rev Immunol , vol.26 , pp. 291-306
    • Kabelitz, D.1    Wesch, D.2    Oberg, H.H.3
  • 189
    • 0034533825 scopus 로고    scopus 로고
    • Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies
    • Bengtsson AA, Sturfelt G, Truedsson L, Blomberg J, Alm G, Vallin H, Ronnblom L. Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies. Lupus 2000;9:664-671.
    • (2000) Lupus , vol.9 , pp. 664-671
    • Bengtsson, A.A.1    Sturfelt, G.2    Truedsson, L.3    Blomberg, J.4    Alm, G.5    Vallin, H.6    Ronnblom, L.7
  • 190
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 2005;202:1131-1139.
    • (2005) J Exp Med , vol.202 , pp. 1131-1139
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3    Chan, J.H.4    Uematsu, S.5    Akira, S.6    Chang, B.7    Duramad, O.8    Coffman, R.L.9
  • 194
    • 33745679123 scopus 로고    scopus 로고
    • Targeting signal transduction as a strategy to treat inflammatory diseases
    • O'Neill LA. Targeting signal transduction as a strategy to treat inflammatory diseases. Nat Rev Drug Discov 2006;5:549-563.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 549-563
    • O'Neill, L.A.1
  • 197
    • 0038781697 scopus 로고    scopus 로고
    • Regulation of dendritic cell function through Toll-like receptors
    • Kaisho T, Akira S. Regulation of dendritic cell function through Toll-like receptors. Curr Mol Med 2003;3:373-385.
    • (2003) Curr Mol Med , vol.3 , pp. 373-385
    • Kaisho, T.1    Akira, S.2
  • 199
    • 0033580949 scopus 로고    scopus 로고
    • Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
    • Schwandner R, Dziarski R, Wesche H, Rothe M, Kirschning CJ. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 1999;274:17406-17409.
    • (1999) J Biol Chem , vol.274 , pp. 17406-17409
    • Schwandner, R.1    Dziarski, R.2    Wesche, H.3    Rothe, M.4    Kirschning, C.J.5
  • 200
    • 0035165287 scopus 로고    scopus 로고
    • Cutting edge: Functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
    • Hajjar AM, O'Mahony DS, Ozinsky A, Underhill DM, Aderem A, Klebanoff SJ, Wilson CB. Cutting edge: Functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin. J Immunol 2001;166:15-19.
    • (2001) J Immunol , vol.166 , pp. 15-19
    • Hajjar, A.M.1    O'Mahony, D.S.2    Ozinsky, A.3    Underhill, D.M.4    Aderem, A.5    Klebanoff, S.J.6    Wilson, C.B.7
  • 201
    • 0034651729 scopus 로고    scopus 로고
    • Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide
    • Flo TH, Halaas O, Lien E, Ryan L, Teti G, Golenbock DT, Sundan A, Espevik T. Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. J Immunol 2000;164:2064-2069.
    • (2000) J Immunol , vol.164 , pp. 2064-2069
    • Flo, T.H.1    Halaas, O.2    Lien, E.3    Ryan, L.4    Teti, G.5    Golenbock, D.T.6    Sundan, A.7    Espevik, T.8
  • 202
    • 0037083638 scopus 로고    scopus 로고
    • Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent
    • Massari P, Henneke P, Ho Y, Latz E, Golenbock DT, Wetzler LM. Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J Immunol 2002;168:1533-1537.
    • (2002) J Immunol , vol.168 , pp. 1533-1537
    • Massari, P.1    Henneke, P.2    Ho, Y.3    Latz, E.4    Golenbock, D.T.5    Wetzler, L.M.6
  • 207
    • 0033215123 scopus 로고    scopus 로고
    • Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis
    • Means TK, Wang S, Lien E, Yoshimura A, Golenbock DT, Fenton MJ. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol 1999;163:3920-3927.
    • (1999) J Immunol , vol.163 , pp. 3920-3927
    • Means, T.K.1    Wang, S.2    Lien, E.3    Yoshimura, A.4    Golenbock, D.T.5    Fenton, M.J.6
  • 209
    • 25444448498 scopus 로고    scopus 로고
    • Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus
    • Aravalli RN, Hu S, Rowen TN, Palmquist JM, Lokensgard JR. Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus. J Immunol 2005;175:4189-4193.
    • (2005) J Immunol , vol.175 , pp. 4189-4193
    • Aravalli, R.N.1    Hu, S.2    Rowen, T.N.3    Palmquist, J.M.4    Lokensgard, J.R.5
  • 211
  • 212
    • 66949176665 scopus 로고    scopus 로고
    • Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2
    • Li M, Chen Q, Shen Y, Liu W. Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2. Exp Dermatol 2009;18:603-610.
    • (2009) Exp Dermatol , vol.18 , pp. 603-610
    • Li, M.1    Chen, Q.2    Shen, Y.3    Liu, W.4
  • 213
    • 0036587576 scopus 로고    scopus 로고
    • Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages
    • Coelho PS, Klein A, Talvani A, Coutinho SF, Takeuchi O, Akira S, Silva JS, Canizzaro H, Gazzinelli RT, Teixeira MM. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages. J Leukoc Biol 2002;71:837-844.
    • (2002) J Leukoc Biol , vol.71 , pp. 837-844
    • Coelho, P.S.1    Klein, A.2    Talvani, A.3    Coutinho, S.F.4    Takeuchi, O.5    Akira, S.6    Silva, J.S.7    Canizzaro, H.8    Gazzinelli, R.T.9    Teixeira, M.M.10
  • 214
    • 0035903158 scopus 로고    scopus 로고
    • Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells
    • Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, Hacker H, Wagner H. Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem 2001;276:31332-31339.
    • (2001) J Biol Chem , vol.276 , pp. 31332-31339
    • Vabulas, R.M.1    Ahmad-Nejad, P.2    da Costa, C.3    Miethke, T.4    Kirschning, C.J.5    Hacker, H.6    Wagner, H.7
  • 218
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park JS, Svetkauskaite D, He Q, Kim JY, Strassheim D, Ishizaka A, Abraham E. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 2004;279:7370-7377.
    • (2004) J Biol Chem , vol.279 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3    Kim, J.Y.4    Strassheim, D.5    Ishizaka, A.6    Abraham, E.7
  • 219
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001;413:732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 222
    • 0036467447 scopus 로고    scopus 로고
    • Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway
    • Bulut Y, Faure E, Thomas L, Karahashi H, Michelsen KS, Equils O, Morrison SG, Morrison RP, Arditi M. Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J Immunol 2002;168:1435-1440.
    • (2002) J Immunol , vol.168 , pp. 1435-1440
    • Bulut, Y.1    Faure, E.2    Thomas, L.3    Karahashi, H.4    Michelsen, K.S.5    Equils, O.6    Morrison, S.G.7    Morrison, R.P.8    Arditi, M.9
  • 227
    • 0034723186 scopus 로고    scopus 로고
    • Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol
    • Kawasaki K, Akashi S, Shimazu R, Yoshida T, Miyake K, Nishijima M. Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J Biol Chem 2000;275:2251-2254.
    • (2000) J Biol Chem , vol.275 , pp. 2251-2254
    • Kawasaki, K.1    Akashi, S.2    Shimazu, R.3    Yoshida, T.4    Miyake, K.5    Nishijima, M.6
  • 230
    • 0037094084 scopus 로고    scopus 로고
    • Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4
    • Johnson GB, Brunn GJ, Kodaira Y, Platt JL. Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J Immunol 2002;168:5233-5239.
    • (2002) J Immunol , vol.168 , pp. 5233-5239
    • Johnson, G.B.1    Brunn, G.J.2    Kodaira, Y.3    Platt, J.L.4
  • 231
    • 0035451118 scopus 로고    scopus 로고
    • Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    • Smiley ST, King JA, Hancock WW. Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 2001;167:2887-2894.
    • (2001) J Immunol , vol.167 , pp. 2887-2894
    • Smiley, S.T.1    King, J.A.2    Hancock, W.W.3
  • 232
    • 0037097672 scopus 로고    scopus 로고
    • Cutting edge: The immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4
    • Guillot L, Balloy V, McCormack FX, Golenbock DT, Chignard M, Si-Tahar M. Cutting edge: The immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J Immunol 2002;168:5989-5992.
    • (2002) J Immunol , vol.168 , pp. 5989-5992
    • Guillot, L.1    Balloy, V.2    McCormack, F.X.3    Golenbock, D.T.4    Chignard, M.5    Si-Tahar, M.6
  • 239
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004;303:1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis e Sousa, C.5
  • 244
    • 0029035289 scopus 로고
    • Structural studies on bioactive compounds. Part 26. Hydrogen bonding in the crystal structure of the N-methylformamide solvate of the immunomodulatory agent 2-amino-5-bromo-6-phenylpyrimidin-4-one (bropirimine): Implications for the design of novel anti-tumour strategies
    • Stevens MF, Schwalbe CH, Patel N, Gate EN, Bryant PK. Structural studies on bioactive compounds. Part 26. Hydrogen bonding in the crystal structure of the N-methylformamide solvate of the immunomodulatory agent 2-amino-5-bromo-6-phenylpyrimidin-4-one (bropirimine): Implications for the design of novel anti-tumour strategies. Anticancer Drug Des 1995;10:203-213.
    • (1995) Anticancer Drug Des , vol.10 , pp. 203-213
    • Stevens, M.F.1    Schwalbe, C.H.2    Patel, N.3    Gate, E.N.4    Bryant, P.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.