-
1
-
-
63649108380
-
The roles of TLRs, RLRs and NLRs in pathogen recognition
-
Kawai T, Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol 2009;21:317-337.
-
(2009)
Int Immunol
, vol.21
, pp. 317-337
-
-
Kawai, T.1
Akira, S.2
-
2
-
-
20344389060
-
Toll-like receptors: Linking innate and adaptive immunity
-
Pasare C, Medzhitov R. Toll-like receptors: Linking innate and adaptive immunity. Adv Exp Med Biol 2005;560:11-18.
-
(2005)
Adv Exp Med Biol
, vol.560
, pp. 11-18
-
-
Pasare, C.1
Medzhitov, R.2
-
3
-
-
3142779901
-
Therapeutics targeting the innate immune system
-
Ulevitch RJ. Therapeutics targeting the innate immune system. Nat Rev Immunol 2004;4:512-520.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 512-520
-
-
Ulevitch, R.J.1
-
4
-
-
33646478589
-
Therapeutic targeting of pattern-recognition receptors
-
Rezaei N. Therapeutic targeting of pattern-recognition receptors. Int Immunopharmacol 2006;6:863-869.
-
(2006)
Int Immunopharmacol
, vol.6
, pp. 863-869
-
-
Rezaei, N.1
-
5
-
-
34249677845
-
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
-
Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007;13:552-559.
-
(2007)
Nat Med
, vol.13
, pp. 552-559
-
-
Kanzler, H.1
Barrat, F.J.2
Hessel, E.M.3
Coffman, R.L.4
-
6
-
-
67649422321
-
Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer
-
O'Neill LA, Bryant CE, Doyle SL. Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev 2009;61:177-197.
-
(2009)
Pharmacol Rev
, vol.61
, pp. 177-197
-
-
O'Neill, L.A.1
Bryant, C.E.2
Doyle, S.L.3
-
7
-
-
17344370677
-
Evolution and integration of innate immune recognition systems: The Toll-like receptors
-
Takeda K. Evolution and integration of innate immune recognition systems: The Toll-like receptors. J Endotoxin Res 2005;11:51-55.
-
(2005)
J Endotoxin Res
, vol.11
, pp. 51-55
-
-
Takeda, K.1
-
8
-
-
3142724031
-
Toll-like receptor signalling
-
Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004;4:499-511.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
9
-
-
68749115366
-
Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins
-
Carpenter S, O'Neill LA. Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins. Biochem J 2009;422:1-10.
-
(2009)
Biochem J
, vol.422
, pp. 1-10
-
-
Carpenter, S.1
O'Neill, L.A.2
-
10
-
-
23044445303
-
Crystal structure of human toll-like receptor 3 (TLR3) ectodomain
-
Choe J, Kelker MS, Wilson IA. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science 2005;309:581-585.
-
(2005)
Science
, vol.309
, pp. 581-585
-
-
Choe, J.1
Kelker, M.S.2
Wilson, I.A.3
-
11
-
-
23344431978
-
The molecular structure of the Toll-like receptor 3 ligand-binding domain
-
Bell JK, Botos I, Hall PR, Askins J, Shiloach J, Segal DM, Davies DR. The molecular structure of the Toll-like receptor 3 ligand-binding domain. Proc Natl Acad Sci USA 2005;102:10976-10980.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 10976-10980
-
-
Bell, J.K.1
Botos, I.2
Hall, P.R.3
Askins, J.4
Shiloach, J.5
Segal, D.M.6
Davies, D.R.7
-
12
-
-
34548608447
-
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
-
Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 2007;130:1071-1082.
-
(2007)
Cell
, vol.130
, pp. 1071-1082
-
-
Jin, M.S.1
Kim, S.E.2
Heo, J.Y.3
Lee, M.E.4
Kim, H.M.5
Paik, S.G.6
Lee, H.7
Lee, J.O.8
-
13
-
-
71749118913
-
Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer
-
Kang JY, Nan X, Jin MS, Youn SJ, Ryu YH, Mah S, Han SH, Lee H, Paik SG, Lee JO. Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity 2009;31:873-884.
-
(2009)
Immunity
, vol.31
, pp. 873-884
-
-
Kang, J.Y.1
Nan, X.2
Jin, M.S.3
Youn, S.J.4
Ryu, Y.H.5
Mah, S.6
Han, S.H.7
Lee, H.8
Paik, S.G.9
Lee, J.O.10
-
14
-
-
34548222514
-
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran
-
Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, Lee JO. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 2007;130:906-917.
-
(2007)
Cell
, vol.130
, pp. 906-917
-
-
Kim, H.M.1
Park, B.S.2
Kim, J.I.3
Kim, S.E.4
Lee, J.5
Oh, S.C.6
Enkhbayar, P.7
Matsushima, N.8
Lee, H.9
Yoo, O.J.10
Lee, J.O.11
-
15
-
-
67349182481
-
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
-
Park BS, Song DH, Kim HM, Choi BS, Lee H, Lee JO. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 2009;458:1191-1195.
-
(2009)
Nature
, vol.458
, pp. 1191-1195
-
-
Park, B.S.1
Song, D.H.2
Kim, H.M.3
Choi, B.S.4
Lee, H.5
Lee, J.O.6
-
16
-
-
48749128643
-
Structures of the toll-like receptor family and its ligand complexes
-
Jin MS, Lee JO. Structures of the toll-like receptor family and its ligand complexes. Immunity 2008;29:182-191.
-
(2008)
Immunity
, vol.29
, pp. 182-191
-
-
Jin, M.S.1
Lee, J.O.2
-
17
-
-
33748871535
-
New insights into the regulation of TLR signaling
-
Miggin SM, O'Neill LA. New insights into the regulation of TLR signaling. J Leukoc Biol 2006;80:220-226.
-
(2006)
J Leukoc Biol
, vol.80
, pp. 220-226
-
-
Miggin, S.M.1
O'Neill, L.A.2
-
19
-
-
12444341944
-
Toll-like receptors in innate immunity
-
Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol 2005;17:1-14.
-
(2005)
Int Immunol
, vol.17
, pp. 1-14
-
-
Takeda, K.1
Akira, S.2
-
21
-
-
1842607467
-
Innate immunity and toll-like receptors: Clinical implications of basic science research
-
Abreu MT, Arditi M. Innate immunity and toll-like receptors: Clinical implications of basic science research. J Pediatr 2004;144:421-429.
-
(2004)
J Pediatr
, vol.144
, pp. 421-429
-
-
Abreu, M.T.1
Arditi, M.2
-
22
-
-
0034997845
-
Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
-
Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH. Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocr Rev 2001;22:153-183.
-
(2001)
Endocr Rev
, vol.22
, pp. 153-183
-
-
Pearson, G.1
Robinson, F.2
Beers Gibson, T.3
Xu, B.E.4
Karandikar, M.5
Berman, K.6
Cobb, M.H.7
-
23
-
-
0141923690
-
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling
-
Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K, Akira S. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J Immunol 2003;171:4304-4310.
-
(2003)
J Immunol
, vol.171
, pp. 4304-4310
-
-
Sato, S.1
Sugiyama, M.2
Yamamoto, M.3
Watanabe, Y.4
Kawai, T.5
Takeda, K.6
Akira, S.7
-
24
-
-
2442642691
-
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation
-
Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M, Tschopp J. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol 2004;5:503-507.
-
(2004)
Nat Immunol
, vol.5
, pp. 503-507
-
-
Meylan, E.1
Burns, K.2
Hofmann, K.3
Blancheteau, V.4
Martinon, F.5
Kelliher, M.6
Tschopp, J.7
-
25
-
-
0038393016
-
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
-
Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 2003;4:491-496.
-
(2003)
Nat Immunol
, vol.4
, pp. 491-496
-
-
Fitzgerald, K.A.1
McWhirter, S.M.2
Faia, K.L.3
Rowe, D.C.4
Latz, E.5
Golenbock, D.T.6
Coyle, A.J.7
Liao, S.M.8
Maniatis, T.9
-
26
-
-
18844457095
-
Mechanisms of type-I- and type-II-interferon-mediated signalling
-
Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol 2005;5:375-386.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 375-386
-
-
Platanias, L.C.1
-
27
-
-
0037205084
-
The global impact of vaccines containing aluminium adjuvants
-
Clements CJ, Griffiths E. The global impact of vaccines containing aluminium adjuvants. Vaccine 2002;20:S24-S33.
-
(2002)
Vaccine
, vol.20
-
-
Clements, C.J.1
Griffiths, E.2
-
29
-
-
56649108016
-
Engagement of TLR signaling as adjuvant: Towards smarter vaccine and beyond
-
Lahiri A, Das P, Chakravortty D. Engagement of TLR signaling as adjuvant: Towards smarter vaccine and beyond. Vaccine 2008;26:6777-6783.
-
(2008)
Vaccine
, vol.26
, pp. 6777-6783
-
-
Lahiri, A.1
Das, P.2
Chakravortty, D.3
-
30
-
-
0038282518
-
Toll-like receptors and T-helper-1/T-helper-2 responses
-
Dabbagh K, Lewis DB. Toll-like receptors and T-helper-1/T-helper-2 responses. Curr Opin Infect Dis 2003;16:199-204.
-
(2003)
Curr Opin Infect Dis
, vol.16
, pp. 199-204
-
-
Dabbagh, K.1
Lewis, D.B.2
-
31
-
-
0037654784
-
Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529
-
Evans JT, Cluff CW, Johnson DA, Lacy MJ, Persing DH, Baldridge JR. Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529. Expert Rev Vaccines 2003;2:219-229.
-
(2003)
Expert Rev Vaccines
, vol.2
, pp. 219-229
-
-
Evans, J.T.1
Cluff, C.W.2
Johnson, D.A.3
Lacy, M.J.4
Persing, D.H.5
Baldridge, J.R.6
-
32
-
-
34250854079
-
The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4
-
Mata-Haro V, Cekic C, Martin M, Chilton PM, Casella CR, Mitchell TC. The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science 2007;316:1628-1632.
-
(2007)
Science
, vol.316
, pp. 1628-1632
-
-
Mata-Haro, V.1
Cekic, C.2
Martin, M.3
Chilton, P.M.4
Casella, C.R.5
Mitchell, T.C.6
-
33
-
-
35349028297
-
GlaxoSmithKline Adjuvant Systems in vaccines: Concepts, achievements and perspectives
-
Garcon N, Chomez P, Van Mechelen M. GlaxoSmithKline Adjuvant Systems in vaccines: Concepts, achievements and perspectives. Expert Rev Vaccines 2007;6:723-739.
-
(2007)
Expert Rev Vaccines
, vol.6
, pp. 723-739
-
-
Garcon, N.1
Chomez, P.2
Van Mechelen, M.3
-
34
-
-
34247234090
-
New hepatitis B vaccine formulated with an improved adjuvant system
-
Kundi M. New hepatitis B vaccine formulated with an improved adjuvant system. Expert Rev Vaccines 2007;6:133-140.
-
(2007)
Expert Rev Vaccines
, vol.6
, pp. 133-140
-
-
Kundi, M.1
-
35
-
-
67651049056
-
Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): Final analysis of a double-blind, randomised study in young women
-
Paavonen J, Naud P, Salmeron J, Wheeler CM, Chow SN, Apter D, Kitchener H, Castellsague X, Teixeira JC, Skinner SR, Hedrick J, Jaisamrarn U, Limson G, Garland S, Szarewski A, Romanowski B, Aoki FY, Schwarz TF, Poppe WA, Bosch FX, Jenkins D, Hardt K, Zahaf T, Descamps D, Struyf F, Lehtinen M, Dubin G, Greenacre M. Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): Final analysis of a double-blind, randomised study in young women. Lancet 2009;374:301-314.
-
(2009)
Lancet
, vol.374
, pp. 301-314
-
-
Paavonen, J.1
Naud, P.2
Salmeron, J.3
Wheeler, C.M.4
Chow, S.N.5
Apter, D.6
Kitchener, H.7
Castellsague, X.8
Teixeira, J.C.9
Skinner, S.R.10
Hedrick, J.11
Jaisamrarn, U.12
Limson, G.13
Garland, S.14
Szarewski, A.15
Romanowski, B.16
Aoki, F.Y.17
Schwarz, T.F.18
Poppe, W.A.19
Bosch, F.X.20
Jenkins, D.21
Hardt, K.22
Zahaf, T.23
Descamps, D.24
Struyf, F.25
Lehtinen, M.26
Dubin, G.27
Greenacre, M.28
more..
-
36
-
-
0037153024
-
Glycoprotein-D-adjuvant vaccine to prevent genital herpes
-
Stanberry LR, Spruance SL, Cunningham AL, Bernstein DI, Mindel A, Sacks S, Tyring S, Aoki FY, Slaoui M, Denis M, Vandepapeliere P, Dubin G. Glycoprotein-D-adjuvant vaccine to prevent genital herpes. N Engl J Med 2002;347:1652-1661.
-
(2002)
N Engl J Med
, vol.347
, pp. 1652-1661
-
-
Stanberry, L.R.1
Spruance, S.L.2
Cunningham, A.L.3
Bernstein, D.I.4
Mindel, A.5
Sacks, S.6
Tyring, S.7
Aoki, F.Y.8
Slaoui, M.9
Denis, M.10
Vandepapeliere, P.11
Dubin, G.12
-
37
-
-
39149121505
-
Recombinant gp350 vaccine for infectious mononucleosis: A phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adults
-
Sokal EM, Hoppenbrouwers K, Vandermeulen C, Moutschen M, Leonard P, Moreels A, Haumont M, Bollen A, Smets F, Denis M. Recombinant gp350 vaccine for infectious mononucleosis: A phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adults. J Infect Dis 2007;196:1749-1753.
-
(2007)
J Infect Dis
, vol.196
, pp. 1749-1753
-
-
Sokal, E.M.1
Hoppenbrouwers, K.2
Vandermeulen, C.3
Moutschen, M.4
Leonard, P.5
Moreels, A.6
Haumont, M.7
Bollen, A.8
Smets, F.9
Denis, M.10
-
38
-
-
38949200368
-
Human papillomavirus types 16 and 18 vaccine (recombinant, AS04 adjuvanted, adsorbed) [Cervarix]
-
Keam SJ, Harper DM. Human papillomavirus types 16 and 18 vaccine (recombinant, AS04 adjuvanted, adsorbed) [Cervarix]. Drugs 2008;68:359-372.
-
(2008)
Drugs
, vol.68
, pp. 359-372
-
-
Keam, S.J.1
Harper, D.M.2
-
39
-
-
70349485373
-
Five-year safety and immunogenicity of GlaxoSmithKline's candidate malaria vaccine RTS,S/AS02 following administration to semi-immune adult men living in a malaria-endemic region of The Gambia
-
Bojang K, Milligan P, Pinder M, Doherty T, Leach A, Ofori-Anyinam O, Lievens M, Kester K, Schaecher K, Ballou WR, Cohen J. Five-year safety and immunogenicity of GlaxoSmithKline's candidate malaria vaccine RTS, S/AS02 following administration to semi-immune adult men living in a malaria-endemic region of The Gambia. Hum Vaccin 2009;5:242-247.
-
(2009)
Hum Vaccin
, vol.5
, pp. 242-247
-
-
Bojang, K.1
Milligan, P.2
Pinder, M.3
Doherty, T.4
Leach, A.5
Ofori-Anyinam, O.6
Lievens, M.7
Kester, K.8
Schaecher, K.9
Ballou, W.R.10
Cohen, J.11
-
40
-
-
10744225844
-
Cellular immunity induced by the recombinant Plasmodium falciparum malaria vaccine, RTS,S/AS02, in semi-immune adults in The Gambia
-
Pinder M, Reece WH, Plebanski M, Akinwunmi P, Flanagan KL, Lee EA, Doherty T, Milligan P, Jaye A, Tornieporth N, Ballou R, McAdam KP, Cohen J, Hill AV. Cellular immunity induced by the recombinant Plasmodium falciparum malaria vaccine, RTS, S/AS02, in semi-immune adults in The Gambia. Clin Exp Immunol 2004;135:286-293.
-
(2004)
Clin Exp Immunol
, vol.135
, pp. 286-293
-
-
Pinder, M.1
Reece, W.H.2
Plebanski, M.3
Akinwunmi, P.4
Flanagan, K.L.5
Lee, E.A.6
Doherty, T.7
Milligan, P.8
Jaye, A.9
Tornieporth, N.10
Ballou, R.11
McAdam, K.P.12
Cohen, J.13
Hill, A.V.14
-
41
-
-
35548999572
-
Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: A double blind randomised controlled phase I/IIb trial
-
Aponte JJ, Aide P, Renom M, Mandomando I, Bassat Q, Sacarlal J, Manaca MN, Lafuente S, Barbosa A, Leach A, Lievens M, Vekemans J, Sigauque B, Dubois MC, Demoitie MA, Sillman M, Savarese B, McNeil JG, Macete E, Ballou WR, Cohen J, Alonso PL. Safety of the RTS, S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: A double blind randomised controlled phase I/IIb trial. Lancet 2007;370:1543-1551.
-
(2007)
Lancet
, vol.370
, pp. 1543-1551
-
-
Aponte, J.J.1
Aide, P.2
Renom, M.3
Mandomando, I.4
Bassat, Q.5
Sacarlal, J.6
Manaca, M.N.7
Lafuente, S.8
Barbosa, A.9
Leach, A.10
Lievens, M.11
Vekemans, J.12
Sigauque, B.13
Dubois, M.C.14
Demoitie, M.A.15
Sillman, M.16
Savarese, B.17
McNeil, J.G.18
Macete, E.19
Ballou, W.R.20
Cohen, J.21
Alonso, P.L.22
more..
-
42
-
-
5644228594
-
Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: Randomised controlled trial
-
Alonso PL, Sacarlal J, Aponte JJ, Leach A, Macete E, Milman J, Mandomando I, Spiessens B, Guinovart C, Espasa M, Bassat Q, Aide P, Ofori-Anyinam O, Navia MM, Corachan S, Ceuppens M, Dubois MC, Demoitie MA, Dubovsky F, Menendez C, Tornieporth N, Ballou WR, Thompson R, Cohen J. Efficacy of the RTS, S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: Randomised controlled trial. Lancet 2004;364:1411-1420.
-
(2004)
Lancet
, vol.364
, pp. 1411-1420
-
-
Alonso, P.L.1
Sacarlal, J.2
Aponte, J.J.3
Leach, A.4
Macete, E.5
Milman, J.6
Mandomando, I.7
Spiessens, B.8
Guinovart, C.9
Espasa, M.10
Bassat, Q.11
Aide, P.12
Ofori-Anyinam, O.13
Navia, M.M.14
Corachan, S.15
Ceuppens, M.16
Dubois, M.C.17
Demoitie, M.A.18
Dubovsky, F.19
Menendez, C.20
Tornieporth, N.21
Ballou, W.R.22
Thompson, R.23
Cohen, J.24
more..
-
43
-
-
33749444615
-
Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A
-
Stewart VA, McGrath SM, Walsh DS, Davis S, Hess AS, Ware LA, Kester KE, Cummings JF, Burge JR, Voss G, Delchambre M, Garcon N, Tang DB, Cohen JD, Heppner DG Jr. Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS, S/AS02A. Vaccine 2006;24:6483-6492.
-
(2006)
Vaccine
, vol.24
, pp. 6483-6492
-
-
Stewart, V.A.1
McGrath, S.M.2
Walsh, D.S.3
Davis, S.4
Hess, A.S.5
Ware, L.A.6
Kester, K.E.7
Cummings, J.F.8
Burge, J.R.9
Voss, G.10
Delchambre, M.11
Garcon, N.12
Tang, D.B.13
Cohen, J.D.14
Heppner Jr, D.G.15
-
44
-
-
67650699591
-
Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: Safety, efficacy, and immunologic associates of protection
-
Kester KE, Cummings JF, Ofori-Anyinam O, Ockenhouse CF, Krzych U, Moris P, Schwenk R, Nielsen RA, Debebe Z, Pinelis E, Juompan L, Williams J, Dowler M, Stewart VA, Wirtz RA, Dubois MC, Lievens M, Cohen J, Ballou WR, Heppner DG Jr. Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS, S/AS01B and RTS, S/AS02A in malaria-naive adults: Safety, efficacy, and immunologic associates of protection. J Infect Dis 2009;200:337-346.
-
(2009)
J Infect Dis
, vol.200
, pp. 337-346
-
-
Kester, K.E.1
Cummings, J.F.2
Ofori-Anyinam, O.3
Ockenhouse, C.F.4
Krzych, U.5
Moris, P.6
Schwenk, R.7
Nielsen, R.A.8
Debebe, Z.9
Pinelis, E.10
Juompan, L.11
Williams, J.12
Dowler, M.13
Stewart, V.A.14
Wirtz, R.A.15
Dubois, M.C.16
Lievens, M.17
Cohen, J.18
Ballou, W.R.19
Heppner Jr, D.G.20
more..
-
45
-
-
34247259834
-
The year's new drugs and biologics-2006
-
Graul AI, Sorbera LA, Bozzo J, Serradell N, Revel L, Prous JR. The year's new drugs and biologics-2006. Drug News Perspect 2007;20:17-44.
-
(2007)
Drug News Perspect
, vol.20
, pp. 17-44
-
-
Graul, A.I.1
Sorbera, L.A.2
Bozzo, J.3
Serradell, N.4
Revel, L.5
Prous, J.R.6
-
46
-
-
3142690381
-
Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents
-
Baldridge JR, McGowan P, Evans JT, Cluff C, Mossman S, Johnson D, Persing D. Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents. Expert Opin Biol Ther 2004;4:1129-1138.
-
(2004)
Expert Opin Biol Ther
, vol.4
, pp. 1129-1138
-
-
Baldridge, J.R.1
McGowan, P.2
Evans, J.T.3
Cluff, C.4
Mossman, S.5
Johnson, D.6
Persing, D.7
-
48
-
-
20244369887
-
Synthetic toll-like receptor 4 agonists stimulate innate resistance to infectious challenge
-
Cluff CW, Baldridge JR, Stover AG, Evans JT, Johnson DA, Lacy MJ, Clawson VG, Yorgensen VM, Johnson CL, Livesay MT, Hershberg RM, Persing DH. Synthetic toll-like receptor 4 agonists stimulate innate resistance to infectious challenge. Infect Immun 2005;73:3044-3052.
-
(2005)
Infect Immun
, vol.73
, pp. 3044-3052
-
-
Cluff, C.W.1
Baldridge, J.R.2
Stover, A.G.3
Evans, J.T.4
Johnson, D.A.5
Lacy, M.J.6
Clawson, V.G.7
Yorgensen, V.M.8
Johnson, C.L.9
Livesay, M.T.10
Hershberg, R.M.11
Persing, D.H.12
-
49
-
-
12244272464
-
Immunostimulatory activity of aminoalkyl glucosaminide 4-phosphates (AGPs): Induction of protective innate immune responses by RC-524 and RC-529
-
Baldridge JR, Cluff CW, Evans JT, Lacy MJ, Stephens JR, Brookshire VG, Wang R, Ward JR, Yorgensen YM, Persing DH, Johnson DA. Immunostimulatory activity of aminoalkyl glucosaminide 4-phosphates (AGPs): Induction of protective innate immune responses by RC-524 and RC-529. J Endotoxin Res 2002;8:453-458.
-
(2002)
J Endotoxin Res
, vol.8
, pp. 453-458
-
-
Baldridge, J.R.1
Cluff, C.W.2
Evans, J.T.3
Lacy, M.J.4
Stephens, J.R.5
Brookshire, V.G.6
Wang, R.7
Ward, J.R.8
Yorgensen, Y.M.9
Persing, D.H.10
Johnson, D.A.11
-
50
-
-
0037435929
-
Novel synthetic LPS receptor agonists boost systemic and mucosal antibody responses in mice
-
Przetak M, Chow J, Cheng H, Rose J, Hawkins LD, Ishizaka ST. Novel synthetic LPS receptor agonists boost systemic and mucosal antibody responses in mice. Vaccine 2003;21:961-970.
-
(2003)
Vaccine
, vol.21
, pp. 961-970
-
-
Przetak, M.1
Chow, J.2
Cheng, H.3
Rose, J.4
Hawkins, L.D.5
Ishizaka, S.T.6
-
51
-
-
0036219195
-
CpG motifs in bacterial DNA and their immune effects
-
Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002;20:709-760.
-
(2002)
Annu Rev Immunol
, vol.20
, pp. 709-760
-
-
Krieg, A.M.1
-
52
-
-
0036570169
-
Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
-
Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, Endres S, Hartmann G. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002;168:4531-4537.
-
(2002)
J Immunol
, vol.168
, pp. 4531-4537
-
-
Hornung, V.1
Rothenfusser, S.2
Britsch, S.3
Krug, A.4
Jahrsdorfer, B.5
Giese, T.6
Endres, S.7
Hartmann, G.8
-
53
-
-
0041496974
-
CpG-A and B oligodeoxynucleotides enhance the efficacy of antibody therapy by activating different effector cell populations
-
van Ojik HH, Bevaart L, Dahle CE, Bakker A, Jansen MJ, van Vugt MJ, van de Winkel JG, Weiner GJ. CpG-A and B oligodeoxynucleotides enhance the efficacy of antibody therapy by activating different effector cell populations. Cancer Res 2003;63:5595-5600.
-
(2003)
Cancer Res
, vol.63
, pp. 5595-5600
-
-
van Ojik, H.H.1
Bevaart, L.2
Dahle, C.E.3
Bakker, A.4
Jansen, M.J.5
van Vugt, M.J.6
van de Winkel, J.G.7
Weiner, G.J.8
-
54
-
-
0030764558
-
Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
-
Roman M, Martin-Orozco E, Goodman JS, Nguyen MD, Sato Y, Ronaghy A, Kornbluth RS, Richman DD, Carson DA, Raz E. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med 1997;3:849-854.
-
(1997)
Nat Med
, vol.3
, pp. 849-854
-
-
Roman, M.1
Martin-Orozco, E.2
Goodman, J.S.3
Nguyen, M.D.4
Sato, Y.5
Ronaghy, A.6
Kornbluth, R.S.7
Richman, D.D.8
Carson, D.A.9
Raz, E.10
-
55
-
-
0034163408
-
CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses
-
Vabulas RM, Pircher H, Lipford GB, Hacker H, Wagner H. CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses. J Immunol 2000;164:2372-2378.
-
(2000)
J Immunol
, vol.164
, pp. 2372-2378
-
-
Vabulas, R.M.1
Pircher, H.2
Lipford, G.B.3
Hacker, H.4
Wagner, H.5
-
56
-
-
0028931102
-
CpG motifs in bacterial DNA trigger direct B-cell activation
-
Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Klinman DM. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995;374:546-549.
-
(1995)
Nature
, vol.374
, pp. 546-549
-
-
Krieg, A.M.1
Yi, A.K.2
Matson, S.3
Waldschmidt, T.J.4
Bishop, G.A.5
Teasdale, R.6
Koretzky, G.A.7
Klinman, D.M.8
-
57
-
-
0032526607
-
CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry
-
Yi AK, Chang M, Peckham DW, Krieg AM, Ashman RF. CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry. J Immunol 1998;160:5898-5906.
-
(1998)
J Immunol
, vol.160
, pp. 5898-5906
-
-
Yi, A.K.1
Chang, M.2
Peckham, D.W.3
Krieg, A.M.4
Ashman, R.F.5
-
58
-
-
1942470399
-
Characterization of effusion-infiltrating T cells: Benign versus malignant effusions
-
Atanackovic D, Block A, de Weerth A, Faltz C, Hossfeld DK, Hegewisch-Becker S. Characterization of effusion-infiltrating T cells: Benign versus malignant effusions. Clin Cancer Res 2004;10:2600-2608.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2600-2608
-
-
Atanackovic, D.1
Block, A.2
de Weerth, A.3
Faltz, C.4
Hossfeld, D.K.5
Hegewisch-Becker, S.6
-
59
-
-
11344257404
-
CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/II study
-
Cooper CL, Davis HL, Morris ML, Efler SM, Adhami MA, Krieg AM, Cameron DW, Heathcote J. CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase I/II study. J Clin Immunol 2004;24:693-701.
-
(2004)
J Clin Immunol
, vol.24
, pp. 693-701
-
-
Cooper, C.L.1
Davis, H.L.2
Morris, M.L.3
Efler, S.M.4
Adhami, M.A.5
Krieg, A.M.6
Cameron, D.W.7
Heathcote, J.8
-
60
-
-
20844436439
-
Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response
-
Siegrist CA, Pihlgren M, Tougne C, Efler SM, Morris ML, AlAdhami MJ, Cameron DW, Cooper CL, Heathcote J, Davis HL, Lambert PH. Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response. Vaccine 2004;23:615-622.
-
(2004)
Vaccine
, vol.23
, pp. 615-622
-
-
Siegrist, C.A.1
Pihlgren, M.2
Tougne, C.3
Efler, S.M.4
Morris, M.L.5
AlAdhami, M.J.6
Cameron, D.W.7
Cooper, C.L.8
Heathcote, J.9
Davis, H.L.10
Lambert, P.H.11
-
61
-
-
25844484501
-
CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults
-
Cooper CL, Davis HL, Angel JB, Morris ML, Elfer SM, Seguin I, Krieg AM, Cameron DW. CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults. AIDS 2005;19:1473-1479.
-
(2005)
AIDS
, vol.19
, pp. 1473-1479
-
-
Cooper, C.L.1
Davis, H.L.2
Angel, J.B.3
Morris, M.L.4
Elfer, S.M.5
Seguin, I.6
Krieg, A.M.7
Cameron, D.W.8
-
62
-
-
28344457315
-
Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults
-
Halperin SA, Dobson S, McNeil S, Langley JM, Smith B, McCall-Sani R, Levitt D, Nest GV, Gennevois D, Eiden JJ. Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults. Vaccine 2006;24:20-26.
-
(2006)
Vaccine
, vol.24
, pp. 20-26
-
-
Halperin, S.A.1
Dobson, S.2
McNeil, S.3
Langley, J.M.4
Smith, B.5
McCall-Sani, R.6
Levitt, D.7
Nest, G.V.8
Gennevois, D.9
Eiden, J.J.10
-
63
-
-
0037726807
-
A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant
-
Halperin SA, Van Nest G, Smith B, Abtahi S, Whiley H, Eiden JJ. A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant. Vaccine 2003;21:2461-2467.
-
(2003)
Vaccine
, vol.21
, pp. 2461-2467
-
-
Halperin, S.A.1
Van Nest, G.2
Smith, B.3
Abtahi, S.4
Whiley, H.5
Eiden, J.J.6
-
64
-
-
3843052308
-
Safety and immunogenicity of CPG 7909 injection as an adjuvant to Fluarix influenza vaccine
-
Cooper CL, Davis HL, Morris ML, Efler SM, Krieg AM, Li Y, Laframboise C, Al Adhami MJ, Khaliq Y, Seguin I, Cameron DW. Safety and immunogenicity of CPG 7909 injection as an adjuvant to Fluarix influenza vaccine. Vaccine 2004;22:3136-3143.
-
(2004)
Vaccine
, vol.22
, pp. 3136-3143
-
-
Cooper, C.L.1
Davis, H.L.2
Morris, M.L.3
Efler, S.M.4
Krieg, A.M.5
Li, Y.6
Laframboise, C.7
Al Adhami, M.J.8
Khaliq, Y.9
Seguin, I.10
Cameron, D.W.11
-
65
-
-
34248169629
-
Development of TLR9 agonists for cancer therapy
-
Krieg AM. Development of TLR9 agonists for cancer therapy. J Clin Invest 2007;117:1184-1194.
-
(2007)
J Clin Invest
, vol.117
, pp. 1184-1194
-
-
Krieg, A.M.1
-
66
-
-
14644390867
-
Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909
-
Speiser DE, Lienard D, Rufer N, Rubio-Godoy V, Rimoldi D, Lejeune F, Krieg AM, Cerottini JC, Romero P. Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909. J Clin Invest 2005;115:739-746.
-
(2005)
J Clin Invest
, vol.115
, pp. 739-746
-
-
Speiser, D.E.1
Lienard, D.2
Rufer, N.3
Rubio-Godoy, V.4
Rimoldi, D.5
Lejeune, F.6
Krieg, A.M.7
Cerottini, J.C.8
Romero, P.9
-
67
-
-
33746214819
-
New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site
-
Appay V, Jandus C, Voelter V, Reynard S, Coupland SE, Rimoldi D, Lienard D, Guillaume P, Krieg AM, Cerottini JC, Romero P, Leyvraz S, Rufer N, Speiser DE. New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site. J Immunol 2006;177:1670-1678.
-
(2006)
J Immunol
, vol.177
, pp. 1670-1678
-
-
Appay, V.1
Jandus, C.2
Voelter, V.3
Reynard, S.4
Coupland, S.E.5
Rimoldi, D.6
Lienard, D.7
Guillaume, P.8
Krieg, A.M.9
Cerottini, J.C.10
Romero, P.11
Leyvraz, S.12
Rufer, N.13
Speiser, D.E.14
-
68
-
-
0038683055
-
Phase I/II study with CpG 7909 as adjuvant to vaccination with MAGA-3 protein in patients with MAGE-3 positive tumors
-
van Ojik H, Kruit W, Portielje J, Brichard V, Verloes R, Delire M, Stoter G. Phase I/II study with CpG 7909 as adjuvant to vaccination with MAGA-3 protein in patients with MAGE-3 positive tumors. Ann Oncol 2002;13:157.
-
(2002)
Ann Oncol
, vol.13
, pp. 157
-
-
van Ojik, H.1
Kruit, W.2
Portielje, J.3
Brichard, V.4
Verloes, R.5
Delire, M.6
Stoter, G.7
-
69
-
-
41349102954
-
TLR3: Interferon induction by double-stranded RNA including poly(I:C)
-
Matsumoto M, Seya T. TLR3: Interferon induction by double-stranded RNA including poly(I:C). Adv Drug Deliv Rev 2008;60:805-812.
-
(2008)
Adv Drug Deliv Rev
, vol.60
, pp. 805-812
-
-
Matsumoto, M.1
Seya, T.2
-
70
-
-
0346098026
-
Polyriboinosinic polyribocytidylic acid [poly(I:C)]/TLR3 signaling allows class I processing of exogenous protein and induction of HIV-specific CD8+ cytotoxic T lymphocytes
-
Fujimoto C, Nakagawa Y, Ohara K, Takahashi H. Polyriboinosinic polyribocytidylic acid [poly(I:C)]/TLR3 signaling allows class I processing of exogenous protein and induction of HIV-specific CD8+ cytotoxic T lymphocytes. Int Immunol 2004;16:55-63.
-
(2004)
Int Immunol
, vol.16
, pp. 55-63
-
-
Fujimoto, C.1
Nakagawa, Y.2
Ohara, K.3
Takahashi, H.4
-
71
-
-
68649086251
-
Progress on the induction of neutralizing antibodies against HIV type 1 (HIV-1)
-
Vaine M, Lu S, Wang S. Progress on the induction of neutralizing antibodies against HIV type 1 (HIV-1). BioDrugs 2009;23:137-153.
-
(2009)
BioDrugs
, vol.23
, pp. 137-153
-
-
Vaine, M.1
Lu, S.2
Wang, S.3
-
72
-
-
33751071573
-
Combination DNA plus protein HIV vaccines
-
Lu S. Combination DNA plus protein HIV vaccines. Springer Semin Immunopathol 2006;28:255-265.
-
(2006)
Springer Semin Immunopathol
, vol.28
, pp. 255-265
-
-
Lu, S.1
-
73
-
-
2942519878
-
DNA vaccines against human immunodeficiency virus type 1
-
Estcourt MJ, McMichael AJ, Hanke T. DNA vaccines against human immunodeficiency virus type 1. Immunol Rev 2004;199:144-155.
-
(2004)
Immunol Rev
, vol.199
, pp. 144-155
-
-
Estcourt, M.J.1
McMichael, A.J.2
Hanke, T.3
-
74
-
-
0037122011
-
Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
-
Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med 2002;196:1627-1638.
-
(2002)
J Exp Med
, vol.196
, pp. 1627-1638
-
-
Bonifaz, L.1
Bonnyay, D.2
Mahnke, K.3
Rivera, M.4
Nussenzweig, M.C.5
Steinman, R.M.6
-
75
-
-
33645048192
-
Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine
-
Trumpfheller C, Finke JS, Lopez CB, Moran TM, Moltedo B, Soares H, Huang Y, Schlesinger SJ, Park CG, Nussenzweig MC, Granelli-Piperno A, Steinman RM. Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. J Exp Med 2006;203:607-617.
-
(2006)
J Exp Med
, vol.203
, pp. 607-617
-
-
Trumpfheller, C.1
Finke, J.S.2
Lopez, C.B.3
Moran, T.M.4
Moltedo, B.5
Soares, H.6
Huang, Y.7
Schlesinger, S.J.8
Park, C.G.9
Nussenzweig, M.C.10
Granelli-Piperno, A.11
Steinman, R.M.12
-
76
-
-
40649097299
-
The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine
-
Trumpfheller C, Caskey M, Nchinda G, Longhi MP, Mizenina O, Huang Y, Schlesinger SJ, Colonna M, Steinman RM. The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine. Proc Natl Acad Sci USA 2008;105:2574-2579.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2574-2579
-
-
Trumpfheller, C.1
Caskey, M.2
Nchinda, G.3
Longhi, M.P.4
Mizenina, O.5
Huang, Y.6
Schlesinger, S.J.7
Colonna, M.8
Steinman, R.M.9
-
77
-
-
0041427900
-
Prime-boost vaccination with HIV-1 Gag protein and cytosine phosphate guanosine oligodeoxynucleotide, followed by adenovirus, induces sustained and robust humoral and cellular immune responses
-
Tritel M, Stoddard AM, Flynn BJ, Darrah PA, Wu CY, Wille U, Shah JA, Huang Y, Xu L, Betts MR, Nabel GJ, Seder RA. Prime-boost vaccination with HIV-1 Gag protein and cytosine phosphate guanosine oligodeoxynucleotide, followed by adenovirus, induces sustained and robust humoral and cellular immune responses. J Immunol 2003;171:2538-2547.
-
(2003)
J Immunol
, vol.171
, pp. 2538-2547
-
-
Tritel, M.1
Stoddard, A.M.2
Flynn, B.J.3
Darrah, P.A.4
Wu, C.Y.5
Wille, U.6
Shah, J.A.7
Huang, Y.8
Xu, L.9
Betts, M.R.10
Nabel, G.J.11
Seder, R.A.12
-
78
-
-
69349101739
-
Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands
-
Grossmann C, Tenbusch M, Nchinda G, Temchura V, Nabi G, Stone GW, Kornbluth RS, Uberla K. Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands. BMC Immunol 2009;10:43.
-
(2009)
BMC Immunol
, vol.10
, pp. 43
-
-
Grossmann, C.1
Tenbusch, M.2
Nchinda, G.3
Temchura, V.4
Nabi, G.5
Stone, G.W.6
Kornbluth, R.S.7
Uberla, K.8
-
79
-
-
0035180620
-
T cell infiltration and MHC I and II expression in the presence of tumor antigens: An immunohistochemical study in patients with serous epithelial ovarian cancer
-
Nijman HW, van Diest PJ, Poort-Keesom RJ, von Mensdorff-Pouilly S, Verstraeten RA, Kummer A, Meijer CJ, Melief CJ, Hilgers J, Kenemans P. T cell infiltration and MHC I and II expression in the presence of tumor antigens: An immunohistochemical study in patients with serous epithelial ovarian cancer. Eur J Obstet Gynecol Reprod Biol 2001;94:114-120.
-
(2001)
Eur J Obstet Gynecol Reprod Biol
, vol.94
, pp. 114-120
-
-
Nijman, H.W.1
van Diest, P.J.2
Poort-Keesom, R.J.3
von Mensdorff-Pouilly, S.4
Verstraeten, R.A.5
Kummer, A.6
Meijer, C.J.7
Melief, C.J.8
Hilgers, J.9
Kenemans, P.10
-
80
-
-
0029842830
-
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
-
Gabrilovich DI, Chen HL, Girgis KR, Cunningham HT, Meny GM, Nadaf S, Kavanaugh D, Carbone DP. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med 1996;2:1096-1103.
-
(1996)
Nat Med
, vol.2
, pp. 1096-1103
-
-
Gabrilovich, D.I.1
Chen, H.L.2
Girgis, K.R.3
Cunningham, H.T.4
Meny, G.M.5
Nadaf, S.6
Kavanaugh, D.7
Carbone, D.P.8
-
81
-
-
11144357779
-
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
-
Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S, Bhattacharya R, Gabrilovich D, Heller R, Coppola D, Dalton W, Jove R, Pardoll D, Yu H. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med 2004;10:48-54.
-
(2004)
Nat Med
, vol.10
, pp. 48-54
-
-
Wang, T.1
Niu, G.2
Kortylewski, M.3
Burdelya, L.4
Shain, K.5
Zhang, S.6
Bhattacharya, R.7
Gabrilovich, D.8
Heller, R.9
Coppola, D.10
Dalton, W.11
Jove, R.12
Pardoll, D.13
Yu, H.14
-
82
-
-
33847387125
-
Cellular and molecular mechanisms of tumor-induced T-cell tolerance
-
Horna P, Sotomayor EM. Cellular and molecular mechanisms of tumor-induced T-cell tolerance. Curr Cancer Drug Targets 2007;7:41-53.
-
(2007)
Curr Cancer Drug Targets
, vol.7
, pp. 41-53
-
-
Horna, P.1
Sotomayor, E.M.2
-
83
-
-
33745074981
-
Signals required for programming effector and memory development by CD8+ T cells
-
Mescher MF, Curtsinger JM, Agarwal P, Casey KA, Gerner M, Hammerbeck CD, Popescu F, Xiao Z. Signals required for programming effector and memory development by CD8+ T cells. Immunol Rev 2006;211:81-92.
-
(2006)
Immunol Rev
, vol.211
, pp. 81-92
-
-
Mescher, M.F.1
Curtsinger, J.M.2
Agarwal, P.3
Casey, K.A.4
Gerner, M.5
Hammerbeck, C.D.6
Popescu, F.7
Xiao, Z.8
-
84
-
-
0033168630
-
Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cells
-
Verdijk RM, Mutis T, Esendam B, Kamp J, Melief CJ, Brand A, Goulmy E. Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cells. J Immunol 1999;163:57-61.
-
(1999)
J Immunol
, vol.163
, pp. 57-61
-
-
Verdijk, R.M.1
Mutis, T.2
Esendam, B.3
Kamp, J.4
Melief, C.J.5
Brand, A.6
Goulmy, E.7
-
85
-
-
0017108014
-
A phase I-II trial of multiple-dose polyriboinosic-polyribocytidylic acid in patieonts with leukemia or solid tumors
-
Robinson RA, DeVita VT, Levy HB, Baron S, Hubbard SP, Levine AS. A phase I-II trial of multiple-dose polyriboinosic-polyribocytidylic acid in patieonts with leukemia or solid tumors. J Natl Cancer Inst 1976;57:599-602.
-
(1976)
J Natl Cancer Inst
, vol.57
, pp. 599-602
-
-
Robinson, R.A.1
DeVita, V.T.2
Levy, H.B.3
Baron, S.4
Hubbard, S.P.5
Levine, A.S.6
-
86
-
-
0028009931
-
A controlled clinical trial with a specifically configured RNA drug, poly(I).poly(C12U), in chronic fatigue syndrome
-
Strayer DR, Carter WA, Brodsky I, Cheney P, Peterson D, Salvato P, Thompson C, Loveless M, Shapiro DE, Elsasser W, Gillespie DH. A controlled clinical trial with a specifically configured RNA drug, poly(I).poly(C12U), in chronic fatigue syndrome. Clin Infect Dis 1994;18:S88-S95.
-
(1994)
Clin Infect Dis
, vol.18
-
-
Strayer, D.R.1
Carter, W.A.2
Brodsky, I.3
Cheney, P.4
Peterson, D.5
Salvato, P.6
Thompson, C.7
Loveless, M.8
Shapiro, D.E.9
Elsasser, W.10
Gillespie, D.H.11
-
87
-
-
9444284910
-
Results of a double-blind placebo-controlled study of the double-stranded RNA drug polyI:polyC12U in the treatment of HIV infection
-
Thompson KA, Strayer DR, Salvato PD, Thompson CE, Klimas N, Molavi A, Hamill AK, Zheng Z, Ventura D, Carter WA. Results of a double-blind placebo-controlled study of the double-stranded RNA drug polyI:polyC12U in the treatment of HIV infection. Eur J Clin Microbiol Infect Dis 1996;15:580-587.
-
(1996)
Eur J Clin Microbiol Infect Dis
, vol.15
, pp. 580-587
-
-
Thompson, K.A.1
Strayer, D.R.2
Salvato, P.D.3
Thompson, C.E.4
Klimas, N.5
Molavi, A.6
Hamill, A.K.7
Zheng, Z.8
Ventura, D.9
Carter, W.A.10
-
88
-
-
14844303287
-
The rationale for combined chemo/immunotherapy using a Toll-like receptor 3 (TLR3) agonist and tumour-derived exosomes in advanced ovarian cancer
-
Adams M, Navabi H, Croston D, Coleman S, Tabi Z, Clayton A, Jasani B, Mason MD. The rationale for combined chemo/immunotherapy using a Toll-like receptor 3 (TLR3) agonist and tumour-derived exosomes in advanced ovarian cancer. Vaccine 2005;23:2374-2378.
-
(2005)
Vaccine
, vol.23
, pp. 2374-2378
-
-
Adams, M.1
Navabi, H.2
Croston, D.3
Coleman, S.4
Tabi, Z.5
Clayton, A.6
Jasani, B.7
Mason, M.D.8
-
89
-
-
67349117313
-
Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer
-
Jasani B, Navabi H, Adams M. Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer. Vaccine 2009;27:3401-3404.
-
(2009)
Vaccine
, vol.27
, pp. 3401-3404
-
-
Jasani, B.1
Navabi, H.2
Adams, M.3
-
90
-
-
10744220836
-
Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naive Tc1 lymphocytes leading to tumor rejection
-
Chaput N, Schartz NE, Andre F, Taieb J, Novault S, Bonnaventure P, Aubert N, Bernard J, Lemonnier F, Merad M, Adema G, Adams M, Ferrantini M, Carpentier AF, Escudier B, Tursz T, Angevin E, Zitvogel L. Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naive Tc1 lymphocytes leading to tumor rejection. J Immunol 2004;172:2137-2146.
-
(2004)
J Immunol
, vol.172
, pp. 2137-2146
-
-
Chaput, N.1
Schartz, N.E.2
Andre, F.3
Taieb, J.4
Novault, S.5
Bonnaventure, P.6
Aubert, N.7
Bernard, J.8
Lemonnier, F.9
Merad, M.10
Adema, G.11
Adams, M.12
Ferrantini, M.13
Carpentier, A.F.14
Escudier, B.15
Tursz, T.16
Angevin, E.17
Zitvogel, L.18
-
91
-
-
77953124392
-
Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine
-
Skountzou I, Martin MD, Wang B, Ye L, Koutsonanos D, Weldon W, Jacob J, Compans RW. Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine. Vaccine 2010;28:4103-4112.
-
(2010)
Vaccine
, vol.28
, pp. 4103-4112
-
-
Skountzou, I.1
Martin, M.D.2
Wang, B.3
Ye, L.4
Koutsonanos, D.5
Weldon, W.6
Jacob, J.7
Compans, R.W.8
-
92
-
-
33845224163
-
Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity
-
Huleatt JW, Jacobs AR, Tang J, Desai P, Kopp EB, Huang Y, Song L, Nakaar V, Powell TJ. Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity. Vaccine 2007;25:763-775.
-
(2007)
Vaccine
, vol.25
, pp. 763-775
-
-
Huleatt, J.W.1
Jacobs, A.R.2
Tang, J.3
Desai, P.4
Kopp, E.B.5
Huang, Y.6
Song, L.7
Nakaar, V.8
Powell, T.J.9
-
93
-
-
48249121152
-
Efficacious recombinant influenza vaccines produced by high yield bacterial expression: A solution to global pandemic and seasonal needs
-
Song L, Nakaar V, Kavita U, Price A, Huleatt J, Tang J, Jacobs A, Liu G, Huang Y, Desai P, Maksymiuk G, Takahashi V, Umlauf S, Reiserova L, Bell R, Li H, Zhang Y, McDonald WF, Powell TJ, Tussey L. Efficacious recombinant influenza vaccines produced by high yield bacterial expression: A solution to global pandemic and seasonal needs. PLoS One 2008;3:e2257.
-
(2008)
PLoS One
, vol.3
-
-
Song, L.1
Nakaar, V.2
Kavita, U.3
Price, A.4
Huleatt, J.5
Tang, J.6
Jacobs, A.7
Liu, G.8
Huang, Y.9
Desai, P.10
Maksymiuk, G.11
Takahashi, V.12
Umlauf, S.13
Reiserova, L.14
Bell, R.15
Li, H.16
Zhang, Y.17
McDonald, W.F.18
Powell, T.J.19
Tussey, L.20
more..
-
94
-
-
84857682910
-
-
Escalating dose-ranging study to evaluate the safety and immunogenicity of the VAX125 (STF2.HA1(SI)), a recombinant hemagglutinin influenza vaccine, in healthy young adults. The twelfth annual conference on vaccine research, National Foundation for Infectious Diseases.
-
Treanor JJ, Taylor DN, Song L, Fitzgerald T, Shaw A, Tussey L. Escalating dose-ranging study to evaluate the safety and immunogenicity of the VAX125 (STF2.HA1(SI)), a recombinant hemagglutinin influenza vaccine, in healthy young adults. The twelfth annual conference on vaccine research, National Foundation for Infectious Diseases. 2009. 130p.
-
(2009)
, pp. 130
-
-
Treanor, J.J.1
Taylor, D.N.2
Song, L.3
Fitzgerald, T.4
Shaw, A.5
Tussey, L.6
-
95
-
-
37449031125
-
Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin
-
Huleatt JW, Nakaar V, Desai P, Huang Y, Hewitt D, Jacobs A, Tang J, McDonald W, Song L, Evans RK, Umlauf S, Tussey L, Powell TJ. Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin. Vaccine 2008;26:201-214.
-
(2008)
Vaccine
, vol.26
, pp. 201-214
-
-
Huleatt, J.W.1
Nakaar, V.2
Desai, P.3
Huang, Y.4
Hewitt, D.5
Jacobs, A.6
Tang, J.7
McDonald, W.8
Song, L.9
Evans, R.K.10
Umlauf, S.11
Tussey, L.12
Powell, T.J.13
-
96
-
-
31844436647
-
Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis
-
Honko AN, Sriranganathan N, Lees CJ, Mizel SB. Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis. Infect Immun 2006;74:1113-1120.
-
(2006)
Infect Immun
, vol.74
, pp. 1113-1120
-
-
Honko, A.N.1
Sriranganathan, N.2
Lees, C.J.3
Mizel, S.B.4
-
97
-
-
58149392737
-
Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates
-
Mizel SB, Graff AH, Sriranganathan N, Ervin S, Lees CJ, Lively MO, Hantgan RR, Thomas MJ, Wood J, Bell B. Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates. Clin Vaccine Immunol 2009;16:21-28.
-
(2009)
Clin Vaccine Immunol
, vol.16
, pp. 21-28
-
-
Mizel, S.B.1
Graff, A.H.2
Sriranganathan, N.3
Ervin, S.4
Lees, C.J.5
Lively, M.O.6
Hantgan, R.R.7
Thomas, M.J.8
Wood, J.9
Bell, B.10
-
98
-
-
55049115986
-
New malaria vaccine candidates based on the Plasmodium vivax Merozoite Surface Protein-1 and the TLR-5 agonist Salmonella Typhimurium FliC flagellin
-
Bargieri DY, Rosa DS, Braga CJ, Carvalho BO, Costa FT, Espindola NM, Vaz AJ, Soares IS, Ferreira LC, Rodrigues MM. New malaria vaccine candidates based on the Plasmodium vivax Merozoite Surface Protein-1 and the TLR-5 agonist Salmonella Typhimurium FliC flagellin. Vaccine 2008;26:6132-6142.
-
(2008)
Vaccine
, vol.26
, pp. 6132-6142
-
-
Bargieri, D.Y.1
Rosa, D.S.2
Braga, C.J.3
Carvalho, B.O.4
Costa, F.T.5
Espindola, N.M.6
Vaz, A.J.7
Soares, I.S.8
Ferreira, L.C.9
Rodrigues, M.M.10
-
99
-
-
55249083982
-
Phase 1 evaluation of intralesionally injected TLR9-agonist PF-3512676 in patients with basal cell carcinoma or metastatic melanoma
-
Hofmann MA, Kors C, Audring H, Walden P, Sterry W, Trefzer U. Phase 1 evaluation of intralesionally injected TLR9-agonist PF-3512676 in patients with basal cell carcinoma or metastatic melanoma. J Immunother 2008;31:520-527.
-
(2008)
J Immunother
, vol.31
, pp. 520-527
-
-
Hofmann, M.A.1
Kors, C.2
Audring, H.3
Walden, P.4
Sterry, W.5
Trefzer, U.6
-
100
-
-
34247389227
-
Phase II trial of a toll-like receptor 9-activating oligonucleotide in patients with metastatic melanoma
-
Pashenkov M, Goess G, Wagner C, Hormann M, Jandl T, Moser A, Britten CM, Smolle J, Koller S, Mauch C, Tantcheva-Poor I, Grabbe S, Loquai C, Esser S, Franckson T, Schneeberger A, Haarmann C, Krieg AM, Stingl G, Wagner SN. Phase II trial of a toll-like receptor 9-activating oligonucleotide in patients with metastatic melanoma. J Clin Oncol 2006;24:5716-5724.
-
(2006)
J Clin Oncol
, vol.24
, pp. 5716-5724
-
-
Pashenkov, M.1
Goess, G.2
Wagner, C.3
Hormann, M.4
Jandl, T.5
Moser, A.6
Britten, C.M.7
Smolle, J.8
Koller, S.9
Mauch, C.10
Tantcheva-Poor, I.11
Grabbe, S.12
Loquai, C.13
Esser, S.14
Franckson, T.15
Schneeberger, A.16
Haarmann, C.17
Krieg, A.M.18
Stingl, G.19
Wagner, S.N.20
more..
-
101
-
-
27844589626
-
Phase Ib trial of a targeted TLR9 CpG immunomodulator (CPG 7909) in advanced renal cell carcinoma (RCC)
-
J Clin Oncol, American Society of Clinical Oncology Annual Meeting
-
Thompson JA, Kuxel T, Bukowski F, Schmalbach T. Phase Ib trial of a targeted TLR9 CpG immunomodulator (CPG 7909) in advanced renal cell carcinoma (RCC). J Clin Oncol, American Society of Clinical Oncology Annual Meeting. 2004. 4644p.
-
(2004)
, pp. 4644
-
-
Thompson, J.A.1
Kuxel, T.2
Bukowski, F.3
Schmalbach, T.4
-
102
-
-
84857678957
-
Cutaneous T-cell lymphoma (CTCL) responses to a TLR9 agonist CpG immunomodulator (CPG 7909), a phase I study
-
J Clin Oncol, American Society of Clinical Oncology Annual Meeting
-
Kim Y, Girardi M, McAuley S, Schmalbach T. Cutaneous T-cell lymphoma (CTCL) responses to a TLR9 agonist CpG immunomodulator (CPG 7909), a phase I study. J Clin Oncol, American Society of Clinical Oncology Annual Meeting. 2004. 6600p.
-
(2004)
, pp. 6600
-
-
Kim, Y.1
Girardi, M.2
McAuley, S.3
Schmalbach, T.4
-
103
-
-
50549084485
-
Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer
-
Manegold C, Gravenor D, Woytowitz D, Mezger J, Hirsh V, Albert G, Al-Adhami M, Readett D, Krieg AM, Leichman CG. Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer. J Clin Oncol 2008;26:3979-3986.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3979-3986
-
-
Manegold, C.1
Gravenor, D.2
Woytowitz, D.3
Mezger, J.4
Hirsh, V.5
Albert, G.6
Al-Adhami, M.7
Readett, D.8
Krieg, A.M.9
Leichman, C.G.10
-
104
-
-
0036456708
-
Imiquimod and the imidazoquinolones: Mechanism of action and therapeutic potential
-
Stanley MA. Imiquimod and the imidazoquinolones: Mechanism of action and therapeutic potential. Clin Exp Dermatol 2002;27:571-577.
-
(2002)
Clin Exp Dermatol
, vol.27
, pp. 571-577
-
-
Stanley, M.A.1
-
105
-
-
17444378895
-
Treatment of lentigo maligna (melanoma in situ) with the immune response modifier imiquimod
-
Wolf IH, Cerroni L, Kodama K, Kerl H. Treatment of lentigo maligna (melanoma in situ) with the immune response modifier imiquimod. Arch Dermatol 2005;141:510-514.
-
(2005)
Arch Dermatol
, vol.141
, pp. 510-514
-
-
Wolf, I.H.1
Cerroni, L.2
Kodama, K.3
Kerl, H.4
-
106
-
-
0037342360
-
Topical imiquimod in the treatment of metastatic melanoma to skin
-
Wolf IH, Smolle J, Binder B, Cerroni L, Richtig E, Kerl H. Topical imiquimod in the treatment of metastatic melanoma to skin. Arch Dermatol 2003;139:273-276.
-
(2003)
Arch Dermatol
, vol.139
, pp. 273-276
-
-
Wolf, I.H.1
Smolle, J.2
Binder, B.3
Cerroni, L.4
Richtig, E.5
Kerl, H.6
-
107
-
-
58749111641
-
Imiquimod: A review of basal cell carcinoma treatments
-
Karve SJ, Feldman SR, Yentzer BA, Pearce DJ, Balkrishnan R. Imiquimod: A review of basal cell carcinoma treatments. J Drugs Dermatol 2008;7:1044-1051.
-
(2008)
J Drugs Dermatol
, vol.7
, pp. 1044-1051
-
-
Karve, S.J.1
Feldman, S.R.2
Yentzer, B.A.3
Pearce, D.J.4
Balkrishnan, R.5
-
108
-
-
2342450044
-
Imiquimod 5% cream for the treatment of actinic keratosis: Results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials
-
Lebwohl M, Dinehart S, Whiting D, Lee PK, Tawfik N, Jorizzo J, Lee JH, Fox TL. Imiquimod 5% cream for the treatment of actinic keratosis: Results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J Am Acad Dermatol 2004;50:714-721.
-
(2004)
J Am Acad Dermatol
, vol.50
, pp. 714-721
-
-
Lebwohl, M.1
Dinehart, S.2
Whiting, D.3
Lee, P.K.4
Tawfik, N.5
Jorizzo, J.6
Lee, J.H.7
Fox, T.L.8
-
109
-
-
0035102498
-
Imiquimod 5% cream in the treatment of Bowen's disease
-
Mackenzie-Wood A, Kossard S, de Launey J, Wilkinson B, Owens ML. Imiquimod 5% cream in the treatment of Bowen's disease. J Am Acad Dermatol 2001;44:462-470.
-
(2001)
J Am Acad Dermatol
, vol.44
, pp. 462-470
-
-
Mackenzie-Wood, A.1
Kossard, S.2
de Launey, J.3
Wilkinson, B.4
Owens, M.L.5
-
110
-
-
34147144925
-
Topical imiquimod therapy for basal and squamous cell carcinomas: A clinical experience
-
Tillman DK Jr, Carroll MT. Topical imiquimod therapy for basal and squamous cell carcinomas: A clinical experience. Cutis 2007;79:241-248.
-
(2007)
Cutis
, vol.79
, pp. 241-248
-
-
Tillman Jr, D.K.1
Carroll, M.T.2
-
111
-
-
41449089985
-
Complete resolution of Paget disease of the vulva with imiquimod cream
-
Hatch KD, Davis JR. Complete resolution of Paget disease of the vulva with imiquimod cream. J Low Genit Tract Dis 2008;12:90-94.
-
(2008)
J Low Genit Tract Dis
, vol.12
, pp. 90-94
-
-
Hatch, K.D.1
Davis, J.R.2
-
112
-
-
84857659971
-
Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod-proposal of a therapeutic schedule
-
J Eur Acad Dermatol Venereol
-
Sendagorta E, Herranz P, Feito M, Ramirez P, Floristan U, Feltes R, Benito D, Casado M. Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod-proposal of a therapeutic schedule. J Eur Acad Dermatol Venereol 2009.
-
(2009)
-
-
Sendagorta, E.1
Herranz, P.2
Feito, M.3
Ramirez, P.4
Floristan, U.5
Feltes, R.6
Benito, D.7
Casado, M.8
-
113
-
-
25844505692
-
Current and potential uses of imiquimod
-
Chang YC, Madkan V, Cook-Norris R, Sra K, Tyring S. Current and potential uses of imiquimod. South Med J 2005;98:914-920.
-
(2005)
South Med J
, vol.98
, pp. 914-920
-
-
Chang, Y.C.1
Madkan, V.2
Cook-Norris, R.3
Sra, K.4
Tyring, S.5
-
115
-
-
4844224383
-
Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells
-
Tallant T, Deb A, Kar N, Lupica J, de Veer MJ, DiDonato JA. Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells. BMC Microbiol 2004;4:33.
-
(2004)
BMC Microbiol
, vol.4
, pp. 33
-
-
Tallant, T.1
Deb, A.2
Kar, N.3
Lupica, J.4
de Veer, M.J.5
DiDonato, J.A.6
-
116
-
-
33644797847
-
Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways
-
Zeng H, Wu H, Sloane V, Jones R, Yu Y, Lin P, Gewirtz AT, Neish AS. Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. Am J Physiol Gastrointest Liver Physiol 2006;290:G96-G108.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Zeng, H.1
Wu, H.2
Sloane, V.3
Jones, R.4
Yu, Y.5
Lin, P.6
Gewirtz, A.T.7
Neish, A.S.8
-
117
-
-
42049095095
-
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
-
Burdelya LG, Krivokrysenko VI, Tallant TC, Strom E, Gleiberman AS, Gupta D, Kurnasov OV, Fort FL, Osterman AL, Didonato JA, Feinstein E, Gudkov AV. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 2008;320:226-230.
-
(2008)
Science
, vol.320
, pp. 226-230
-
-
Burdelya, L.G.1
Krivokrysenko, V.I.2
Tallant, T.C.3
Strom, E.4
Gleiberman, A.S.5
Gupta, D.6
Kurnasov, O.V.7
Fort, F.L.8
Osterman, A.L.9
Didonato, J.A.10
Feinstein, E.11
Gudkov, A.V.12
-
118
-
-
33645755382
-
TLR3 can directly trigger apoptosis in human cancer cells
-
Salaun B, Coste I, Rissoan MC, Lebecque SJ, Renno T. TLR3 can directly trigger apoptosis in human cancer cells. J Immunol 2006;176:4894-4901.
-
(2006)
J Immunol
, vol.176
, pp. 4894-4901
-
-
Salaun, B.1
Coste, I.2
Rissoan, M.C.3
Lebecque, S.J.4
Renno, T.5
-
119
-
-
35348813788
-
Identification of Toll-like receptor 3 as a potential therapeutic target in clear cell renal cell carcinoma
-
Morikawa T, Sugiyama A, Kume H, Ota S, Kashima T, Tomita K, Kitamura T, Kodama T, Fukayama M, Aburatani H. Identification of Toll-like receptor 3 as a potential therapeutic target in clear cell renal cell carcinoma. Clin Cancer Res 2007;13:5703-5709.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5703-5709
-
-
Morikawa, T.1
Sugiyama, A.2
Kume, H.3
Ota, S.4
Kashima, T.5
Tomita, K.6
Kitamura, T.7
Kodama, T.8
Fukayama, M.9
Aburatani, H.10
-
120
-
-
33845874634
-
Pollinex Quattro: A novel and well-tolerated, ultra short-course allergy vaccine
-
Patel P, Salapatek AM. Pollinex Quattro: A novel and well-tolerated, ultra short-course allergy vaccine. Expert Rev Vaccines 2006;5:617-629.
-
(2006)
Expert Rev Vaccines
, vol.5
, pp. 617-629
-
-
Patel, P.1
Salapatek, A.M.2
-
121
-
-
3042718066
-
Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA
-
Simons FE, Shikishima Y, Van Nest G, Eiden JJ, HayGlass KT. Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA. J Allergy Clin Immunol 2004;113:1144-1151.
-
(2004)
J Allergy Clin Immunol
, vol.113
, pp. 1144-1151
-
-
Simons, F.E.1
Shikishima, Y.2
Van Nest, G.3
Eiden, J.J.4
HayGlass, K.T.5
-
122
-
-
33745471091
-
Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses
-
Gauvreau GM, Hessel EM, Boulet LP, Coffman RL, O'Byrne PM. Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses. Am J Respir Crit Care Med 2006;174:15-20.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 15-20
-
-
Gauvreau, G.M.1
Hessel, E.M.2
Boulet, L.P.3
Coffman, R.L.4
O'Byrne, P.M.5
-
123
-
-
9644258923
-
Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys
-
Fanucchi MV, Schelegle ES, Baker GL, Evans MJ, McDonald RJ, Gershwin LJ, Raz E, Hyde DM, Plopper CG, Miller LA. Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys. Am J Respir Crit Care Med 2004;170:1153-1157.
-
(2004)
Am J Respir Crit Care Med
, vol.170
, pp. 1153-1157
-
-
Fanucchi, M.V.1
Schelegle, E.S.2
Baker, G.L.3
Evans, M.J.4
McDonald, R.J.5
Gershwin, L.J.6
Raz, E.7
Hyde, D.M.8
Plopper, C.G.9
Miller, L.A.10
-
124
-
-
0034767753
-
Antiviral actions of interferons
-
table of contents.
-
Samuel CE. Antiviral actions of interferons. Clin Microbiol Rev 2001;14:778-809, table of contents.
-
(2001)
Clin Microbiol Rev
, vol.14
, pp. 778-809
-
-
Samuel, C.E.1
-
125
-
-
0041662272
-
Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence
-
Takaoka A, Hayakawa S, Yanai H, Stoiber D, Negishi H, Kikuchi H, Sasaki S, Imai K, Shibue T, Honda K, Taniguchi T. Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature 2003;424:516-523.
-
(2003)
Nature
, vol.424
, pp. 516-523
-
-
Takaoka, A.1
Hayakawa, S.2
Yanai, H.3
Stoiber, D.4
Negishi, H.5
Kikuchi, H.6
Sasaki, S.7
Imai, K.8
Shibue, T.9
Honda, K.10
Taniguchi, T.11
-
126
-
-
0038651180
-
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7
-
Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA, Raz E, Cottam HB. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7. Proc Natl Acad Sci USA 2003;100:6646-6651.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 6646-6651
-
-
Lee, J.1
Chuang, T.H.2
Redecke, V.3
She, L.4
Pitha, P.M.5
Carson, D.A.6
Raz, E.7
Cottam, H.B.8
-
127
-
-
24144448068
-
Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection
-
Horsmans Y, Berg T, Desager JP, Mueller T, Schott E, Fletcher SP, Steffy KR, Bauman LA, Kerr BM, Averett DR. Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. Hepatology 2005;42:724-731.
-
(2005)
Hepatology
, vol.42
, pp. 724-731
-
-
Horsmans, Y.1
Berg, T.2
Desager, J.P.3
Mueller, T.4
Schott, E.5
Fletcher, S.P.6
Steffy, K.R.7
Bauman, L.A.8
Kerr, B.M.9
Averett, D.R.10
-
128
-
-
33747622584
-
Masked oral prodrugs of toll-like receptor 7 agonists: A new approach for the treatment of infectious disease
-
Fletcher S, Steffy K, Averett D. Masked oral prodrugs of toll-like receptor 7 agonists: A new approach for the treatment of infectious disease. Curr Opin Investig Drugs 2006;7:702-708.
-
(2006)
Curr Opin Investig Drugs
, vol.7
, pp. 702-708
-
-
Fletcher, S.1
Steffy, K.2
Averett, D.3
-
129
-
-
34347399259
-
Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies
-
Pockros PJ, Guyader D, Patton H, Tong MJ, Wright T, McHutchison JG, Meng TC. Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies. J Hepatol 2007;47:174-182.
-
(2007)
J Hepatol
, vol.47
, pp. 174-182
-
-
Pockros, P.J.1
Guyader, D.2
Patton, H.3
Tong, M.J.4
Wright, T.5
McHutchison, J.G.6
Meng, T.C.7
-
130
-
-
63749130351
-
A class C CpG toll-like receptor 9 agonist successfully induces robust interferon-alpha production by plasmacytoid dendritic cells from patients chronically infected with hepatitis C
-
Libri NA, Barker SJ, Rosenberg WM, Semper AE. A class C CpG toll-like receptor 9 agonist successfully induces robust interferon-alpha production by plasmacytoid dendritic cells from patients chronically infected with hepatitis C. J Viral Hepat 2009;16:315-324.
-
(2009)
J Viral Hepat
, vol.16
, pp. 315-324
-
-
Libri, N.A.1
Barker, S.J.2
Rosenberg, W.M.3
Semper, A.E.4
-
131
-
-
0036048526
-
Topical 5% imiquimod long-term treatment of cutaneous warts resistant to standard therapy modalities
-
Grussendorf-Conen EI, Jacobs S, Rubben A, Dethlefsen U. Topical 5% imiquimod long-term treatment of cutaneous warts resistant to standard therapy modalities. Dermatology 2002;205:139-145.
-
(2002)
Dermatology
, vol.205
, pp. 139-145
-
-
Grussendorf-Conen, E.I.1
Jacobs, S.2
Rubben, A.3
Dethlefsen, U.4
-
132
-
-
0033747683
-
Self-administered topical 5% imiquimod for the treatment of common warts and molluscum contagiosum
-
Hengge UR, Esser S, Schultewolter T, Behrendt C, Meyer T, Stockfleth E, Goos M. Self-administered topical 5% imiquimod for the treatment of common warts and molluscum contagiosum. Br J Dermatol 2000;143:1026-1031.
-
(2000)
Br J Dermatol
, vol.143
, pp. 1026-1031
-
-
Hengge, U.R.1
Esser, S.2
Schultewolter, T.3
Behrendt, C.4
Meyer, T.5
Stockfleth, E.6
Goos, M.7
-
133
-
-
0344873639
-
An open label evaluation of the efficacy of imiquimod 5% cream in the treatment of recalcitrant subungual and periungual cutaneous warts
-
Micali G, Dall'Oglio F, Nasca MR. An open label evaluation of the efficacy of imiquimod 5% cream in the treatment of recalcitrant subungual and periungual cutaneous warts. J Dermatolog Treat 2003;14:233-236.
-
(2003)
J Dermatolog Treat
, vol.14
, pp. 233-236
-
-
Micali, G.1
Dall'Oglio, F.2
Nasca, M.R.3
-
134
-
-
0036280054
-
Efficacy of imiquimod 5% cream in the treatment of recalcitrant warts in children
-
Grussendorf-Conen EI, Jacobs S. Efficacy of imiquimod 5% cream in the treatment of recalcitrant warts in children. Pediatr Dermatol 2002;19:263-266.
-
(2002)
Pediatr Dermatol
, vol.19
, pp. 263-266
-
-
Grussendorf-Conen, E.I.1
Jacobs, S.2
-
135
-
-
19344376816
-
Effectiveness of imiquimod cream 5% for treating childhood molluscum contagiosum in a double-blind, randomized pilot trial
-
Theos AU, Cummins R, Silverberg NB, Paller AS. Effectiveness of imiquimod cream 5% for treating childhood molluscum contagiosum in a double-blind, randomized pilot trial. Cutis 2004;74:134-138, 141-142.
-
(2004)
Cutis
, vol.74
, pp. 134-138
-
-
Theos, A.U.1
Cummins, R.2
Silverberg, N.B.3
Paller, A.S.4
-
136
-
-
0347320539
-
Experience in treating molluscum contagiosum in children with imiquimod 5% cream
-
Bayerl C, Feller G, Goerdt S. Experience in treating molluscum contagiosum in children with imiquimod 5% cream. Br J Dermatol 2003;149:25-29.
-
(2003)
Br J Dermatol
, vol.149
, pp. 25-29
-
-
Bayerl, C.1
Feller, G.2
Goerdt, S.3
-
137
-
-
18244373947
-
Randomized, double-blind clinical trial of topical imiquimod 5% with parenteral meglumine antimoniate in the treatment of cutaneous leishmaniasis in Peru
-
Miranda-Verastegui C, Llanos-Cuentas A, Arevalo I, Ward BJ, Matlashewski G. Randomized, double-blind clinical trial of topical imiquimod 5% with parenteral meglumine antimoniate in the treatment of cutaneous leishmaniasis in Peru. Clin Infect Dis 2005;40:1395-1403.
-
(2005)
Clin Infect Dis
, vol.40
, pp. 1395-1403
-
-
Miranda-Verastegui, C.1
Llanos-Cuentas, A.2
Arevalo, I.3
Ward, B.J.4
Matlashewski, G.5
-
138
-
-
34249890840
-
Role of imiquimod and parenteral meglumine antimoniate in the initial treatment of cutaneous leishmaniasis
-
Arevalo I, Tulliano G, Quispe A, Spaeth G, Matlashewski G, Llanos-Cuentas A, Pollack H. Role of imiquimod and parenteral meglumine antimoniate in the initial treatment of cutaneous leishmaniasis. Clin Infect Dis 2007;44:1549-1554.
-
(2007)
Clin Infect Dis
, vol.44
, pp. 1549-1554
-
-
Arevalo, I.1
Tulliano, G.2
Quispe, A.3
Spaeth, G.4
Matlashewski, G.5
Llanos-Cuentas, A.6
Pollack, H.7
-
139
-
-
38649143209
-
Effect of resiquimod 0.01% gel on lesion healing and viral shedding when applied to genital herpes lesions
-
Fife KH, Meng TC, Ferris DG, Liu P. Effect of resiquimod 0.01% gel on lesion healing and viral shedding when applied to genital herpes lesions. Antimicrob Agents Chemother 2008;52:477-482.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 477-482
-
-
Fife, K.H.1
Meng, T.C.2
Ferris, D.G.3
Liu, P.4
-
140
-
-
34247467903
-
Topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: A randomized, controlled trial
-
Mark KE, Corey L, Meng TC, Magaret AS, Huang ML, Selke S, Slade HB, Tyring SK, Warren T, Sacks SL, Leone P, Bergland VA, Wald A. Topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: A randomized, controlled trial. J Infect Dis 2007;195:1324-1331.
-
(2007)
J Infect Dis
, vol.195
, pp. 1324-1331
-
-
Mark, K.E.1
Corey, L.2
Meng, T.C.3
Magaret, A.S.4
Huang, M.L.5
Selke, S.6
Slade, H.B.7
Tyring, S.K.8
Warren, T.9
Sacks, S.L.10
Leone, P.11
Bergland, V.A.12
Wald, A.13
-
141
-
-
37349041656
-
The role of toll-like receptor ligands/agonists in protection against genital HSV-2 infection
-
Gill N, Davies EJ, Ashkar AA. The role of toll-like receptor ligands/agonists in protection against genital HSV-2 infection. Am J Reprod Immunol 2008;59:35-43.
-
(2008)
Am J Reprod Immunol
, vol.59
, pp. 35-43
-
-
Gill, N.1
Davies, E.J.2
Ashkar, A.A.3
-
142
-
-
0036827534
-
Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection
-
Pyles RB, Higgins D, Chalk C, Zalar A, Eiden J, Brown C, Van Nest G, Stanberry LR. Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection. J Virol 2002;76:11387-11396.
-
(2002)
J Virol
, vol.76
, pp. 11387-11396
-
-
Pyles, R.B.1
Higgins, D.2
Chalk, C.3
Zalar, A.4
Eiden, J.5
Brown, C.6
Van Nest, G.7
Stanberry, L.R.8
-
143
-
-
33749497006
-
Quantification of poly(I:C)-mediated protection against genital herpes simplex virus type 2 infection
-
Herbst-Kralovetz MM, Pyles RB. Quantification of poly(I:C)-mediated protection against genital herpes simplex virus type 2 infection. J Virol 2006;80:9988-9997.
-
(2006)
J Virol
, vol.80
, pp. 9988-9997
-
-
Herbst-Kralovetz, M.M.1
Pyles, R.B.2
-
145
-
-
41349107635
-
Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection
-
Lester RT, Yao XD, Ball TB, McKinnon LR, Kaul R, Wachihi C, Jaoko W, Plummer FA, Rosenthal KL. Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection. AIDS 2008;22:685-694.
-
(2008)
AIDS
, vol.22
, pp. 685-694
-
-
Lester, R.T.1
Yao, X.D.2
Ball, T.B.3
McKinnon, L.R.4
Kaul, R.5
Wachihi, C.6
Jaoko, W.7
Plummer, F.A.8
Rosenthal, K.L.9
-
146
-
-
65549155443
-
Expression levels of TLRs involved in viral recognition in PBMCs from HIV-1-infected patients failing antiretroviral therapy
-
Scagnolari C, Selvaggi C, Chiavuzzo L, Carbone T, Zaffiri L, d'Ettorre G, Girardi E, Turriziani O, Vullo V, Antonelli G. Expression levels of TLRs involved in viral recognition in PBMCs from HIV-1-infected patients failing antiretroviral therapy. Intervirology 2009;52:107-114.
-
(2009)
Intervirology
, vol.52
, pp. 107-114
-
-
Scagnolari, C.1
Selvaggi, C.2
Chiavuzzo, L.3
Carbone, T.4
Zaffiri, L.5
d'Ettorre, G.6
Girardi, E.7
Turriziani, O.8
Vullo, V.9
Antonelli, G.10
-
147
-
-
0026601777
-
The effect of combinations of ampligen and zidovudine or dideoxyinosine against human immunodeficiency viruses in vitro
-
O'Marro SD, Armstrong JA, Asuncion C, Gueverra L, Ho M. The effect of combinations of ampligen and zidovudine or dideoxyinosine against human immunodeficiency viruses in vitro. Antiviral Res 1992;17:169-177.
-
(1992)
Antiviral Res
, vol.17
, pp. 169-177
-
-
O'Marro, S.D.1
Armstrong, J.A.2
Asuncion, C.3
Gueverra, L.4
Ho, M.5
-
148
-
-
0028024371
-
Synergistic inhibition of AZT-resistant HIV by AZT combined with poly(I):poly(C12U), without synergistic toxicity to bone marrow progenitor cell elements
-
Gillespie D, Hubbell HR, Carter WA, Midgette P, Elsasser W, Mullaney R, Strayer DR. Synergistic inhibition of AZT-resistant HIV by AZT combined with poly(I):poly(C12U), without synergistic toxicity to bone marrow progenitor cell elements. In Vivo 1994;8:375-381.
-
(1994)
In Vivo
, vol.8
, pp. 375-381
-
-
Gillespie, D.1
Hubbell, H.R.2
Carter, W.A.3
Midgette, P.4
Elsasser, W.5
Mullaney, R.6
Strayer, D.R.7
-
149
-
-
0026356275
-
Mismatched double-stranded RNA, Ampligen (poly(I): Poly(C12U), demonstrates antiviral and immunostimulatory activities in HIV disease
-
Carter WA, Ventura D, Shapiro DE, Strayer DR, Gillespie DH, Hubbell HR. Mismatched double-stranded RNA, Ampligen (poly(I): Poly(C12U), demonstrates antiviral and immunostimulatory activities in HIV disease. Int J Immunopharmacol 1991;13:69-76.
-
(1991)
Int J Immunopharmacol
, vol.13
, pp. 69-76
-
-
Carter, W.A.1
Ventura, D.2
Shapiro, D.E.3
Strayer, D.R.4
Gillespie, D.H.5
Hubbell, H.R.6
-
150
-
-
0023186579
-
Clinical, immunological, and virological effects of ampligen, a mismatched double-stranded RNA, in patients with AIDS or AIDS-related complex
-
Carter WA, Brodsky I, Pellegrino MG, Henriques HF, Parenti DM, Schulof RS, Robinson WE, Volsky DJ, Paxtone H, Karikó K, Suhadolnik RJ, Strayer DR, Lewin M, Einck L, Simon GL, Scheib RG, Montefiori DC, Mitchell WM, Paul D, Meyer WA, Reichenbach N, Gillespie DH. Clinical, immunological, and virological effects of ampligen, a mismatched double-stranded RNA, in patients with AIDS or AIDS-related complex. Lancet 1987;1:1286-1292.
-
(1987)
Lancet
, vol.1
, pp. 1286-1292
-
-
Carter, W.A.1
Brodsky, I.2
Pellegrino, M.G.3
Henriques, H.F.4
Parenti, D.M.5
Schulof, R.S.6
Robinson, W.E.7
Volsky, D.J.8
Paxtone, H.9
Karikó, K.10
Suhadolnik, R.J.11
Strayer, D.R.12
Lewin, M.13
Einck, L.14
Simon, G.L.15
Scheib, R.G.16
Montefiori, D.C.17
Mitchell, W.M.18
Paul, D.19
Meyer, W.A.20
Reichenbach, N.21
Gillespie, D.H.22
more..
-
152
-
-
3142713223
-
Inhibition of endotoxin response by synthetic TLR4 antagonists
-
Hawkins LD, Christ WJ, Rossignol DP. Inhibition of endotoxin response by synthetic TLR4 antagonists. Curr Top Med Chem 2004;4:1147-1171.
-
(2004)
Curr Top Med Chem
, vol.4
, pp. 1147-1171
-
-
Hawkins, L.D.1
Christ, W.J.2
Rossignol, D.P.3
-
153
-
-
0033532629
-
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
-
Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 1999;189:1777-1782.
-
(1999)
J Exp Med
, vol.189
, pp. 1777-1782
-
-
Shimazu, R.1
Akashi, S.2
Ogata, H.3
Nagai, Y.4
Fukudome, K.5
Miyake, K.6
Kimoto, M.7
-
154
-
-
0025166114
-
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
-
Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990;249:1431-1433.
-
(1990)
Science
, vol.249
, pp. 1431-1433
-
-
Wright, S.D.1
Ramos, R.A.2
Tobias, P.S.3
Ulevitch, R.J.4
Mathison, J.C.5
-
155
-
-
60549101332
-
Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4
-
Roger T, Froidevaux C, Le Roy D, Reymond MK, Chanson AL, Mauri D, Burns K, Riederer BM, Akira S, Calandra T. Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. Proc Natl Acad Sci USA 2009;106:2348-2352.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 2348-2352
-
-
Roger, T.1
Froidevaux, C.2
Le Roy, D.3
Reymond, M.K.4
Chanson, A.L.5
Mauri, D.6
Burns, K.7
Riederer, B.M.8
Akira, S.9
Calandra, T.10
-
156
-
-
38449100254
-
TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock
-
Daubeuf B, Mathison J, Spiller S, Hugues S, Herren S, Ferlin W, Kosco-Vilbois M, Wagner H, Kirschning CJ, Ulevitch R, Elson G. TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock. J Immunol 2007;179:6107-6114.
-
(2007)
J Immunol
, vol.179
, pp. 6107-6114
-
-
Daubeuf, B.1
Mathison, J.2
Spiller, S.3
Hugues, S.4
Herren, S.5
Ferlin, W.6
Kosco-Vilbois, M.7
Wagner, H.8
Kirschning, C.J.9
Ulevitch, R.10
Elson, G.11
-
157
-
-
70350540674
-
Toll-like receptor 4 decoy, TOY, attenuates gram-negative bacterial sepsis
-
Jung K, Lee JE, Kim HZ, Kim HM, Park BS, Hwang SI, Lee JO, Kim SC, Koh GY. Toll-like receptor 4 decoy, TOY, attenuates gram-negative bacterial sepsis. PLoS One 2009;4:e7403.
-
(2009)
PLoS One
, vol.4
-
-
Jung, K.1
Lee, J.E.2
Kim, H.Z.3
Kim, H.M.4
Park, B.S.5
Hwang, S.I.6
Lee, J.O.7
Kim, S.C.8
Koh, G.Y.9
-
158
-
-
9144271703
-
Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling
-
Hyakushima N, Mitsuzawa H, Nishitani C, Sano H, Kuronuma K, Konishi M, Himi T, Miyake K, Kuroki Y. Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling. J Immunol 2004;173:6949-6954.
-
(2004)
J Immunol
, vol.173
, pp. 6949-6954
-
-
Hyakushima, N.1
Mitsuzawa, H.2
Nishitani, C.3
Sano, H.4
Kuronuma, K.5
Konishi, M.6
Himi, T.7
Miyake, K.8
Kuroki, Y.9
-
159
-
-
33751584426
-
Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice
-
Mitsuzawa H, Nishitani C, Hyakushima N, Shimizu T, Sano H, Matsushima N, Fukase K, Kuroki Y. Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice. J Immunol 2006;177:8133-8139.
-
(2006)
J Immunol
, vol.177
, pp. 8133-8139
-
-
Mitsuzawa, H.1
Nishitani, C.2
Hyakushima, N.3
Shimizu, T.4
Sano, H.5
Matsushima, N.6
Fukase, K.7
Kuroki, Y.8
-
160
-
-
41349102757
-
Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria
-
Tissieres P, Dunn-Siegrist I, Schappi M, Elson G, Comte R, Nobre V, Pugin J. Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria. Blood 2008;111:2122-2131.
-
(2008)
Blood
, vol.111
, pp. 2122-2131
-
-
Tissieres, P.1
Dunn-Siegrist, I.2
Schappi, M.3
Elson, G.4
Comte, R.5
Nobre, V.6
Pugin, J.7
-
161
-
-
47149099757
-
Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling
-
Jain V, Halle A, Halmen KA, Lien E, Charrel-Dennis M, Ram S, Golenbock DT, Visintin A. Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling. Blood 2008;111:4637-4645.
-
(2008)
Blood
, vol.111
, pp. 4637-4645
-
-
Jain, V.1
Halle, A.2
Halmen, K.A.3
Lien, E.4
Charrel-Dennis, M.5
Ram, S.6
Golenbock, D.T.7
Visintin, A.8
-
162
-
-
46749136744
-
Discovery and development of toll-like receptor 4 (TLR4) antagonists: A new paradigm for treating sepsis and other diseases
-
Leon CG, Tory R, Jia J, Sivak O, Wasan KM. Discovery and development of toll-like receptor 4 (TLR4) antagonists: A new paradigm for treating sepsis and other diseases. Pharm Res 2008;25:1751-1761.
-
(2008)
Pharm Res
, vol.25
, pp. 1751-1761
-
-
Leon, C.G.1
Tory, R.2
Jia, J.3
Sivak, O.4
Wasan, K.M.5
-
163
-
-
0037372661
-
Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist
-
Mullarkey M, Rose JR, Bristol J, Kawata T, Kimura A, Kobayashi S, Przetak M, Chow J, Gusovsky F, Christ WJ, Rossignol DP. Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist. J Pharmacol Exp Ther 2003;304:1093-1102.
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 1093-1102
-
-
Mullarkey, M.1
Rose, J.R.2
Bristol, J.3
Kawata, T.4
Kimura, A.5
Kobayashi, S.6
Przetak, M.7
Chow, J.8
Gusovsky, F.9
Christ, W.J.10
Rossignol, D.P.11
-
164
-
-
48549083746
-
Structures of TLR-ligand complexes
-
Jin MS, Lee JO. Structures of TLR-ligand complexes. Curr Opin Immunol 2008;20:414-419.
-
(2008)
Curr Opin Immunol
, vol.20
, pp. 414-419
-
-
Jin, M.S.1
Lee, J.O.2
-
165
-
-
74049125175
-
Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis
-
Tidswell M, Tillis W, Larosa SP, Lynn M, Wittek AE, Kao R, Wheeler J, Gogate J, Opal SM. Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis. Crit Care Med 2010;38:72-83.
-
(2010)
Crit Care Med
, vol.38
, pp. 72-83
-
-
Tidswell, M.1
Tillis, W.2
Larosa, S.P.3
Lynn, M.4
Wittek, A.E.5
Kao, R.6
Wheeler, J.7
Gogate, J.8
Opal, S.M.9
-
166
-
-
41149131096
-
TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain
-
Kawamoto T, Ii M, Kitazaki T, Iizawa Y, Kimura H. TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain. Eur J Pharmacol 2008;584:40-48.
-
(2008)
Eur J Pharmacol
, vol.584
, pp. 40-48
-
-
Kawamoto, T.1
Ii, M.2
Kitazaki, T.3
Iizawa, Y.4
Kimura, H.5
-
167
-
-
28544447821
-
Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: Synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate
-
Yamada M, Ichikawa T, Ii M, Sunamoto M, Itoh K, Tamura N, Kitazaki T. Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: Synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate. J Med Chem 2005;48:7457-7467.
-
(2005)
J Med Chem
, vol.48
, pp. 7457-7467
-
-
Yamada, M.1
Ichikawa, T.2
Ii, M.3
Sunamoto, M.4
Itoh, K.5
Tamura, N.6
Kitazaki, T.7
-
168
-
-
34548496023
-
Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model
-
Sha T, Sunamoto M, Kitazaki T, Sato J, Ii M, Iizawa Y. Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model. Eur J Pharmacol 2007;571:231-239.
-
(2007)
Eur J Pharmacol
, vol.571
, pp. 231-239
-
-
Sha, T.1
Sunamoto, M.2
Kitazaki, T.3
Sato, J.4
Ii, M.5
Iizawa, Y.6
-
169
-
-
0034597766
-
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
-
Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 2000;408:111-115.
-
(2000)
Nature
, vol.408
, pp. 111-115
-
-
Xu, Y.1
Tao, X.2
Shen, B.3
Horng, T.4
Medzhitov, R.5
Manley, J.L.6
Tong, L.7
-
170
-
-
33847369756
-
Cutting Edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs
-
Toshchakov VY, Fenton MJ, Vogel SN. Cutting Edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs. J Immunol 2007;178:2655-2660.
-
(2007)
J Immunol
, vol.178
, pp. 2655-2660
-
-
Toshchakov, V.Y.1
Fenton, M.J.2
Vogel, S.N.3
-
171
-
-
21244503817
-
Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction
-
Toshchakov VU, Basu S, Fenton MJ, Vogel SN. Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction. J Immunol 2005;175:494-500.
-
(2005)
J Immunol
, vol.175
, pp. 494-500
-
-
Toshchakov, V.U.1
Basu, S.2
Fenton, M.J.3
Vogel, S.N.4
-
173
-
-
67649884545
-
Lipopolysaccharide-induced inflammatory cytokine production by Schwann's cells dependent upon TLR4 expression
-
Hao HN, Peduzzi-Nelson JD, VandeVord PJ, Barami K, DeSilva SP, Pelinkovic D, Morawa LG. Lipopolysaccharide-induced inflammatory cytokine production by Schwann's cells dependent upon TLR4 expression. J Neuroimmunol 2009;212:26-34.
-
(2009)
J Neuroimmunol
, vol.212
, pp. 26-34
-
-
Hao, H.N.1
Peduzzi-Nelson, J.D.2
VandeVord, P.J.3
Barami, K.4
DeSilva, S.P.5
Pelinkovic, D.6
Morawa, L.G.7
-
174
-
-
9644289387
-
Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?
-
Andreakos E, Foxwell B, Feldmann M. Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation? Immunol Rev 2004;202:250-265.
-
(2004)
Immunol Rev
, vol.202
, pp. 250-265
-
-
Andreakos, E.1
Foxwell, B.2
Feldmann, M.3
-
175
-
-
39549103221
-
The roles of pathogen-associated molecular patterns in atherosclerosis
-
Erridge C. The roles of pathogen-associated molecular patterns in atherosclerosis. Trends Cardiovasc Med 2008;18:52-56.
-
(2008)
Trends Cardiovasc Med
, vol.18
, pp. 52-56
-
-
Erridge, C.1
-
176
-
-
58149288126
-
Toll-like receptors: New therapeutic targets for the treatment of atherosclerosis, acute coronary syndromes, and myocardial failure
-
Erickson B, Sperber K, Frishman WH. Toll-like receptors: New therapeutic targets for the treatment of atherosclerosis, acute coronary syndromes, and myocardial failure. Cardiol Rev 2008;16:273-279.
-
(2008)
Cardiol Rev
, vol.16
, pp. 273-279
-
-
Erickson, B.1
Sperber, K.2
Frishman, W.H.3
-
177
-
-
67749102142
-
Toll-like receptors in ischemia-reperfusion injury
-
Arumugam TV, Okun E, Tang SC, Thundyil J, Taylor SM, Woodruff TM. Toll-like receptors in ischemia-reperfusion injury. Shock 2009;32:4-16.
-
(2009)
Shock
, vol.32
, pp. 4-16
-
-
Arumugam, T.V.1
Okun, E.2
Tang, S.C.3
Thundyil, J.4
Taylor, S.M.5
Woodruff, T.M.6
-
178
-
-
47149105036
-
Toll-like receptors and adaptor molecules in liver disease: Update
-
Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: Update. Hepatology 2008;48:322-335.
-
(2008)
Hepatology
, vol.48
, pp. 322-335
-
-
Seki, E.1
Brenner, D.A.2
-
180
-
-
51249111466
-
The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease
-
Himmel ME, Hardenberg G, Piccirillo CA, Steiner TS, Levings MK. The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease. Immunology 2008;125:145-153.
-
(2008)
Immunology
, vol.125
, pp. 145-153
-
-
Himmel, M.E.1
Hardenberg, G.2
Piccirillo, C.A.3
Steiner, T.S.4
Levings, M.K.5
-
182
-
-
23844464444
-
Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
-
Kariko K, Buckstein M, Ni H, Weissman D. Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity 2005;23:165-175.
-
(2005)
Immunity
, vol.23
, pp. 165-175
-
-
Kariko, K.1
Buckstein, M.2
Ni, H.3
Weissman, D.4
-
183
-
-
37649018614
-
Toll-like receptors and autoimmunity
-
Hurst J, von Landenberg P. Toll-like receptors and autoimmunity. Autoimmun Rev 2008;7:204-208.
-
(2008)
Autoimmun Rev
, vol.7
, pp. 204-208
-
-
Hurst, J.1
von Landenberg, P.2
-
184
-
-
35748964708
-
Toll-like receptors 7, 8, and 9: Linking innate immunity to autoimmunity
-
Krieg AM, Vollmer J. Toll-like receptors 7, 8, and 9: Linking innate immunity to autoimmunity. Immunol Rev 2007;220:251-269.
-
(2007)
Immunol Rev
, vol.220
, pp. 251-269
-
-
Krieg, A.M.1
Vollmer, J.2
-
185
-
-
70349481019
-
Modulation of regulatory T cells in health and disease: Role of toll-like receptors
-
Nyirenda MH, O'Brien K, Sanvito L, Constantinescu CS, Gran B. Modulation of regulatory T cells in health and disease: Role of toll-like receptors. Inflamm Allergy Drug Targets 2009;8:124-129.
-
(2009)
Inflamm Allergy Drug Targets
, vol.8
, pp. 124-129
-
-
Nyirenda, M.H.1
O'Brien, K.2
Sanvito, L.3
Constantinescu, C.S.4
Gran, B.5
-
186
-
-
33747034337
-
Regulation of regulatory T cells: Role of dendritic cells and toll-like receptors
-
Kabelitz D, Wesch D, Oberg HH. Regulation of regulatory T cells: Role of dendritic cells and toll-like receptors. Crit Rev Immunol 2006;26:291-306.
-
(2006)
Crit Rev Immunol
, vol.26
, pp. 291-306
-
-
Kabelitz, D.1
Wesch, D.2
Oberg, H.H.3
-
187
-
-
33749331301
-
Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus
-
Feng X, Wu H, Grossman JM, Hanvivadhanakul P, FitzGerald JD, Park GS, Dong X, Chen W, Kim MH, Weng HH, Furst DE, Gorn A, McMahon M, Taylor M, Brahn E, Hahn BH, Tsao BP. Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Arthritis Rheum 2006;54:2951-2962.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 2951-2962
-
-
Feng, X.1
Wu, H.2
Grossman, J.M.3
Hanvivadhanakul, P.4
FitzGerald, J.D.5
Park, G.S.6
Dong, X.7
Chen, W.8
Kim, M.H.9
Weng, H.H.10
Furst, D.E.11
Gorn, A.12
McMahon, M.13
Taylor, M.14
Brahn, E.15
Hahn, B.H.16
Tsao, B.P.17
-
188
-
-
27944464836
-
Type I interferon correlates with serological and clinical manifestations of SLE
-
Dall'era MC, Cardarelli PM, Preston BT, Witte A, Davis JC Jr. Type I interferon correlates with serological and clinical manifestations of SLE. Ann Rheum Dis 2005;64:1692-1697.
-
(2005)
Ann Rheum Dis
, vol.64
, pp. 1692-1697
-
-
Dall'era, M.C.1
Cardarelli, P.M.2
Preston, B.T.3
Witte, A.4
Davis Jr, J.C.5
-
189
-
-
0034533825
-
Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies
-
Bengtsson AA, Sturfelt G, Truedsson L, Blomberg J, Alm G, Vallin H, Ronnblom L. Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies. Lupus 2000;9:664-671.
-
(2000)
Lupus
, vol.9
, pp. 664-671
-
-
Bengtsson, A.A.1
Sturfelt, G.2
Truedsson, L.3
Blomberg, J.4
Alm, G.5
Vallin, H.6
Ronnblom, L.7
-
190
-
-
26844467349
-
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
-
Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 2005;202:1131-1139.
-
(2005)
J Exp Med
, vol.202
, pp. 1131-1139
-
-
Barrat, F.J.1
Meeker, T.2
Gregorio, J.3
Chan, J.H.4
Uematsu, S.5
Akira, S.6
Chang, B.7
Duramad, O.8
Coffman, R.L.9
-
191
-
-
50549086761
-
Yaa autoimmune phenotypes are conferred by overexpression of TLR7
-
Fairhurst AM, Hwang SH, Wang A, Tian XH, Boudreaux C, Zhou XJ, Casco J, Li QZ, Connolly JE, Wakeland EK. Yaa autoimmune phenotypes are conferred by overexpression of TLR7. Eur J Immunol 2008;38:1971-1978.
-
(2008)
Eur J Immunol
, vol.38
, pp. 1971-1978
-
-
Fairhurst, A.M.1
Hwang, S.H.2
Wang, A.3
Tian, X.H.4
Boudreaux, C.5
Zhou, X.J.6
Casco, J.7
Li, Q.Z.8
Connolly, J.E.9
Wakeland, E.K.10
-
192
-
-
33745617886
-
A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
-
Subramanian S, Tus K, Li QZ, Wang A, Tian XH, Zhou J, Liang C, Bartov G, McDaniel LD, Zhou XJ, Schultz RA, Wakeland EK. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci USA 2006;103:9970-9975.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9970-9975
-
-
Subramanian, S.1
Tus, K.2
Li, Q.Z.3
Wang, A.4
Tian, X.H.5
Zhou, J.6
Liang, C.7
Bartov, G.8
McDaniel, L.D.9
Zhou, X.J.10
Schultz, R.A.11
Wakeland, E.K.12
-
193
-
-
36048962438
-
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
-
Deane JA, Pisitkun P, Barrett RS, Feigenbaum L, Town T, Ward JM, Flavell RA, Bolland S. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 2007;27:801-810.
-
(2007)
Immunity
, vol.27
, pp. 801-810
-
-
Deane, J.A.1
Pisitkun, P.2
Barrett, R.S.3
Feigenbaum, L.4
Town, T.5
Ward, J.M.6
Flavell, R.A.7
Bolland, S.8
-
194
-
-
33745679123
-
Targeting signal transduction as a strategy to treat inflammatory diseases
-
O'Neill LA. Targeting signal transduction as a strategy to treat inflammatory diseases. Nat Rev Drug Discov 2006;5:549-563.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 549-563
-
-
O'Neill, L.A.1
-
195
-
-
0036644042
-
Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
-
Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin RL, Akira S. Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol 2002;169:10-14.
-
(2002)
J Immunol
, vol.169
, pp. 10-14
-
-
Takeuchi, O.1
Sato, S.2
Horiuchi, T.3
Hoshino, K.4
Takeda, K.5
Dong, Z.6
Modlin, R.L.7
Akira, S.8
-
196
-
-
0034671803
-
Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses
-
Wyllie DH, Kiss-Toth E, Visintin A, Smith SC, Boussouf S, Segal DM, Duff GW, Dower SK. Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses. J Immunol 2000;165:7125-7132.
-
(2000)
J Immunol
, vol.165
, pp. 7125-7132
-
-
Wyllie, D.H.1
Kiss-Toth, E.2
Visintin, A.3
Smith, S.C.4
Boussouf, S.5
Segal, D.M.6
Duff, G.W.7
Dower, S.K.8
-
197
-
-
0038781697
-
Regulation of dendritic cell function through Toll-like receptors
-
Kaisho T, Akira S. Regulation of dendritic cell function through Toll-like receptors. Curr Mol Med 2003;3:373-385.
-
(2003)
Curr Mol Med
, vol.3
, pp. 373-385
-
-
Kaisho, T.1
Akira, S.2
-
198
-
-
0033618630
-
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
-
Aliprantis AO, Yang RB, Mark MR, Suggett S, Devaux B, Radolf JD, Klimpel GR, Godowski P, Zychlinsky A. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 1999;285:736-739.
-
(1999)
Science
, vol.285
, pp. 736-739
-
-
Aliprantis, A.O.1
Yang, R.B.2
Mark, M.R.3
Suggett, S.4
Devaux, B.5
Radolf, J.D.6
Klimpel, G.R.7
Godowski, P.8
Zychlinsky, A.9
-
199
-
-
0033580949
-
Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
-
Schwandner R, Dziarski R, Wesche H, Rothe M, Kirschning CJ. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 1999;274:17406-17409.
-
(1999)
J Biol Chem
, vol.274
, pp. 17406-17409
-
-
Schwandner, R.1
Dziarski, R.2
Wesche, H.3
Rothe, M.4
Kirschning, C.J.5
-
200
-
-
0035165287
-
Cutting edge: Functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
-
Hajjar AM, O'Mahony DS, Ozinsky A, Underhill DM, Aderem A, Klebanoff SJ, Wilson CB. Cutting edge: Functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin. J Immunol 2001;166:15-19.
-
(2001)
J Immunol
, vol.166
, pp. 15-19
-
-
Hajjar, A.M.1
O'Mahony, D.S.2
Ozinsky, A.3
Underhill, D.M.4
Aderem, A.5
Klebanoff, S.J.6
Wilson, C.B.7
-
201
-
-
0034651729
-
Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide
-
Flo TH, Halaas O, Lien E, Ryan L, Teti G, Golenbock DT, Sundan A, Espevik T. Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. J Immunol 2000;164:2064-2069.
-
(2000)
J Immunol
, vol.164
, pp. 2064-2069
-
-
Flo, T.H.1
Halaas, O.2
Lien, E.3
Ryan, L.4
Teti, G.5
Golenbock, D.T.6
Sundan, A.7
Espevik, T.8
-
202
-
-
0037083638
-
Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent
-
Massari P, Henneke P, Ho Y, Latz E, Golenbock DT, Wetzler LM. Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J Immunol 2002;168:1533-1537.
-
(2002)
J Immunol
, vol.168
, pp. 1533-1537
-
-
Massari, P.1
Henneke, P.2
Ho, Y.3
Latz, E.4
Golenbock, D.T.5
Wetzler, L.M.6
-
203
-
-
5944225473
-
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
-
Werts C, Tapping RI, Mathison JC, Chuang TH, Kravchenko V, Saint Girons I, Haake DA, Godowski PJ, Hayashi F, Ozinsky A, Underhill DM, Kirschning CJ, Wagner H, Aderem A, Tobias PS, Ulevitch RJ. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat Immunol 2001;2:346-352.
-
(2001)
Nat Immunol
, vol.2
, pp. 346-352
-
-
Werts, C.1
Tapping, R.I.2
Mathison, J.C.3
Chuang, T.H.4
Kravchenko, V.5
Saint Girons, I.6
Haake, D.A.7
Godowski, P.J.8
Hayashi, F.9
Ozinsky, A.10
Underhill, D.M.11
Kirschning, C.J.12
Wagner, H.13
Aderem, A.14
Tobias, P.S.15
Ulevitch, R.J.16
-
204
-
-
0035115080
-
Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages
-
Hirschfeld M, Weis JJ, Toshchakov V, Salkowski CA, Cody MJ, Ward DC, Qureshi N, Michalek SM, Vogel SN. Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 2001;69:1477-1482.
-
(2001)
Infect Immun
, vol.69
, pp. 1477-1482
-
-
Hirschfeld, M.1
Weis, J.J.2
Toshchakov, V.3
Salkowski, C.A.4
Cody, M.J.5
Ward, D.C.6
Qureshi, N.7
Michalek, S.M.8
Vogel, S.N.9
-
205
-
-
5944236044
-
OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway
-
Jeannin P, Renno T, Goetsch L, Miconnet I, Aubry JP, Delneste Y, Herbault N, Baussant T, Magistrelli G, Soulas C, Romero P, Cerottini JC, Bonnefoy JY. OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway. Nat Immunol 2000;1:502-509.
-
(2000)
Nat Immunol
, vol.1
, pp. 502-509
-
-
Jeannin, P.1
Renno, T.2
Goetsch, L.3
Miconnet, I.4
Aubry, J.P.5
Delneste, Y.6
Herbault, N.7
Baussant, T.8
Magistrelli, G.9
Soulas, C.10
Romero, P.11
Cerottini, J.C.12
Bonnefoy, J.Y.13
-
206
-
-
0001701294
-
Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation
-
Opitz B, Schroder NW, Spreitzer I, Michelsen KS, Kirschning CJ, Hallatschek W, Zahringer U, Hartung T, Gobel UB, Schumann RR. Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation. J Biol Chem 2001;276:22041-22047.
-
(2001)
J Biol Chem
, vol.276
, pp. 22041-22047
-
-
Opitz, B.1
Schroder, N.W.2
Spreitzer, I.3
Michelsen, K.S.4
Kirschning, C.J.5
Hallatschek, W.6
Zahringer, U.7
Hartung, T.8
Gobel, U.B.9
Schumann, R.R.10
-
207
-
-
0033215123
-
Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis
-
Means TK, Wang S, Lien E, Yoshimura A, Golenbock DT, Fenton MJ. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol 1999;163:3920-3927.
-
(1999)
J Immunol
, vol.163
, pp. 3920-3927
-
-
Means, T.K.1
Wang, S.2
Lien, E.3
Yoshimura, A.4
Golenbock, D.T.5
Fenton, M.J.6
-
208
-
-
0036340341
-
Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling
-
Bieback K, Lien E, Klagge IM, Avota E, Schneider-Schaulies J, Duprex WP, Wagner H, Kirschning CJ, Ter Meulen V, Schneider-Schaulies S. Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling. J Virol 2002;76:8729-8736.
-
(2002)
J Virol
, vol.76
, pp. 8729-8736
-
-
Bieback, K.1
Lien, E.2
Klagge, I.M.3
Avota, E.4
Schneider-Schaulies, J.5
Duprex, W.P.6
Wagner, H.7
Kirschning, C.J.8
Ter Meulen, V.9
Schneider-Schaulies, S.10
-
209
-
-
25444448498
-
Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus
-
Aravalli RN, Hu S, Rowen TN, Palmquist JM, Lokensgard JR. Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus. J Immunol 2005;175:4189-4193.
-
(2005)
J Immunol
, vol.175
, pp. 4189-4193
-
-
Aravalli, R.N.1
Hu, S.2
Rowen, T.N.3
Palmquist, J.M.4
Lokensgard, J.R.5
-
210
-
-
0345505220
-
Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2
-
Compton T, Kurt-Jones EA, Boehme KW, Belko J, Latz E, Golenbock DT, Finberg RW. Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol 2003;77:4588-4596.
-
(2003)
J Virol
, vol.77
, pp. 4588-4596
-
-
Compton, T.1
Kurt-Jones, E.A.2
Boehme, K.W.3
Belko, J.4
Latz, E.5
Golenbock, D.T.6
Finberg, R.W.7
-
211
-
-
0033592748
-
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
-
Underhill DM, Ozinsky A, Hajjar AM, Stevens A, Wilson CB, Bassetti M, Aderem A. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 1999;401:811-815.
-
(1999)
Nature
, vol.401
, pp. 811-815
-
-
Underhill, D.M.1
Ozinsky, A.2
Hajjar, A.M.3
Stevens, A.4
Wilson, C.B.5
Bassetti, M.6
Aderem, A.7
-
212
-
-
66949176665
-
Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2
-
Li M, Chen Q, Shen Y, Liu W. Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2. Exp Dermatol 2009;18:603-610.
-
(2009)
Exp Dermatol
, vol.18
, pp. 603-610
-
-
Li, M.1
Chen, Q.2
Shen, Y.3
Liu, W.4
-
213
-
-
0036587576
-
Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages
-
Coelho PS, Klein A, Talvani A, Coutinho SF, Takeuchi O, Akira S, Silva JS, Canizzaro H, Gazzinelli RT, Teixeira MM. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages. J Leukoc Biol 2002;71:837-844.
-
(2002)
J Leukoc Biol
, vol.71
, pp. 837-844
-
-
Coelho, P.S.1
Klein, A.2
Talvani, A.3
Coutinho, S.F.4
Takeuchi, O.5
Akira, S.6
Silva, J.S.7
Canizzaro, H.8
Gazzinelli, R.T.9
Teixeira, M.M.10
-
214
-
-
0035903158
-
Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells
-
Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, Hacker H, Wagner H. Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem 2001;276:31332-31339.
-
(2001)
J Biol Chem
, vol.276
, pp. 31332-31339
-
-
Vabulas, R.M.1
Ahmad-Nejad, P.2
da Costa, C.3
Miethke, T.4
Kirschning, C.J.5
Hacker, H.6
Wagner, H.7
-
215
-
-
0037177833
-
HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway
-
Vabulas RM, Ahmad-Nejad P, Ghose S, Kirschning CJ, Issels RD, Wagner H. HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem 2002;277:15107-15112.
-
(2002)
J Biol Chem
, vol.277
, pp. 15107-15112
-
-
Vabulas, R.M.1
Ahmad-Nejad, P.2
Ghose, S.3
Kirschning, C.J.4
Issels, R.D.5
Wagner, H.6
-
216
-
-
0037036369
-
The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway
-
Vabulas RM, Braedel S, Hilf N, Singh-Jasuja H, Herter S, Ahmad-Nejad P, Kirschning CJ, Da Costa C, Rammensee HG, Wagner H, Schild H. The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. J Biol Chem 2002;277:20847-20853.
-
(2002)
J Biol Chem
, vol.277
, pp. 20847-20853
-
-
Vabulas, R.M.1
Braedel, S.2
Hilf, N.3
Singh-Jasuja, H.4
Herter, S.5
Ahmad-Nejad, P.6
Kirschning, C.J.7
Da Costa, C.8
Rammensee, H.G.9
Wagner, H.10
Schild, H.11
-
217
-
-
30744462300
-
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
-
Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 2005;11:1173-1179.
-
(2005)
Nat Med
, vol.11
, pp. 1173-1179
-
-
Jiang, D.1
Liang, J.2
Fan, J.3
Yu, S.4
Chen, S.5
Luo, Y.6
Prestwich, G.D.7
Mascarenhas, M.M.8
Garg, H.G.9
Quinn, D.A.10
Homer, R.J.11
Goldstein, D.R.12
Bucala, R.13
Lee, P.J.14
Medzhitov, R.15
Noble, P.W.16
-
218
-
-
1542380035
-
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
-
Park JS, Svetkauskaite D, He Q, Kim JY, Strassheim D, Ishizaka A, Abraham E. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 2004;279:7370-7377.
-
(2004)
J Biol Chem
, vol.279
, pp. 7370-7377
-
-
Park, J.S.1
Svetkauskaite, D.2
He, Q.3
Kim, J.Y.4
Strassheim, D.5
Ishizaka, A.6
Abraham, E.7
-
219
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
-
Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001;413:732-738.
-
(2001)
Nature
, vol.413
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
220
-
-
1842477469
-
mRNA is an endogenous ligand for Toll-like receptor 3
-
Kariko K, Ni H, Capodici J, Lamphier M, Weissman D. mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 2004;279:12542-12550.
-
(2004)
J Biol Chem
, vol.279
, pp. 12542-12550
-
-
Kariko, K.1
Ni, H.2
Capodici, J.3
Lamphier, M.4
Weissman, D.5
-
221
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
-
Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 1998;282:2085-2088.
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
He, X.2
Smirnova, I.3
Liu, M.Y.4
Van Huffel, C.5
Du, X.6
Birdwell, D.7
Alejos, E.8
Silva, M.9
Galanos, C.10
Freudenberg, M.11
Ricciardi-Castagnoli, P.12
Layton, B.13
Beutler, B.14
-
222
-
-
0036467447
-
Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway
-
Bulut Y, Faure E, Thomas L, Karahashi H, Michelsen KS, Equils O, Morrison SG, Morrison RP, Arditi M. Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J Immunol 2002;168:1435-1440.
-
(2002)
J Immunol
, vol.168
, pp. 1435-1440
-
-
Bulut, Y.1
Faure, E.2
Thomas, L.3
Karahashi, H.4
Michelsen, K.S.5
Equils, O.6
Morrison, S.G.7
Morrison, R.P.8
Arditi, M.9
-
223
-
-
0037133308
-
Murine retroviruses activate B cells via interaction with toll-like receptor 4
-
Rassa JC, Meyers JL, Zhang Y, Kudaravalli R, Ross SR. Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc Natl Acad Sci USA 2002;99:2281-2286.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 2281-2286
-
-
Rassa, J.C.1
Meyers, J.L.2
Zhang, Y.3
Kudaravalli, R.4
Ross, S.R.5
-
224
-
-
53749095874
-
Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction
-
Shingai M, Azuma M, Ebihara T, Sasai M, Funami K, Ayata M, Ogura H, Tsutsumi H, Matsumoto M, Seya T. Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction. Int Immunol 2008;20:1169-1180.
-
(2008)
Int Immunol
, vol.20
, pp. 1169-1180
-
-
Shingai, M.1
Azuma, M.2
Ebihara, T.3
Sasai, M.4
Funami, K.5
Ayata, M.6
Ogura, H.7
Tsutsumi, H.8
Matsumoto, M.9
Seya, T.10
-
225
-
-
5944261457
-
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
-
Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, Finberg RW. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 2000;1:398-401.
-
(2000)
Nat Immunol
, vol.1
, pp. 398-401
-
-
Kurt-Jones, E.A.1
Popova, L.2
Kwinn, L.3
Haynes, L.M.4
Jones, L.P.5
Tripp, R.A.6
Walsh, E.E.7
Freeman, M.W.8
Golenbock, D.T.9
Anderson, L.J.10
Finberg, R.W.11
-
226
-
-
6344241296
-
Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T
-
Oliveira AC, Peixoto JR, de Arruda LB, Campos MA, Gazzinelli RT, Golenbock DT, Akira S, Previato JO, Mendonca-Previato L, Nobrega A, Bellio M. Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi. J Immunol 2004;173:5688-5696.
-
(2004)
cruzi. J Immunol
, vol.173
, pp. 5688-5696
-
-
Oliveira, A.C.1
Peixoto, J.R.2
de Arruda, L.B.3
Campos, M.A.4
Gazzinelli, R.T.5
Golenbock, D.T.6
Akira, S.7
Previato, J.O.8
Mendonca-Previato, L.9
Nobrega, A.10
Bellio, M.11
-
227
-
-
0034723186
-
Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol
-
Kawasaki K, Akashi S, Shimazu R, Yoshida T, Miyake K, Nishijima M. Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J Biol Chem 2000;275:2251-2254.
-
(2000)
J Biol Chem
, vol.275
, pp. 2251-2254
-
-
Kawasaki, K.1
Akashi, S.2
Shimazu, R.3
Yoshida, T.4
Miyake, K.5
Nishijima, M.6
-
228
-
-
0035971217
-
The extra domain A of fibronectin activates Toll-like receptor 4
-
Okamura Y, Watari M, Jerud ES, Young DW, Ishizaka ST, Rose J, Chow JC, Strauss 3rd JF. The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 2001;276:10229-10233.
-
(2001)
J Biol Chem
, vol.276
, pp. 10229-10233
-
-
Okamura, Y.1
Watari, M.2
Jerud, E.S.3
Young, D.W.4
Ishizaka, S.T.5
Rose, J.6
Chow, J.C.7
Strauss 3rd, J.F.8
-
229
-
-
0037033364
-
Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
-
Termeer C, Benedix F, Sleeman J, Fieber C, Voith U, Ahrens T, Miyake K, Freudenberg M, Galanos C, Simon JC. Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med 2002;195:99-111.
-
(2002)
J Exp Med
, vol.195
, pp. 99-111
-
-
Termeer, C.1
Benedix, F.2
Sleeman, J.3
Fieber, C.4
Voith, U.5
Ahrens, T.6
Miyake, K.7
Freudenberg, M.8
Galanos, C.9
Simon, J.C.10
-
230
-
-
0037094084
-
Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4
-
Johnson GB, Brunn GJ, Kodaira Y, Platt JL. Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J Immunol 2002;168:5233-5239.
-
(2002)
J Immunol
, vol.168
, pp. 5233-5239
-
-
Johnson, G.B.1
Brunn, G.J.2
Kodaira, Y.3
Platt, J.L.4
-
231
-
-
0035451118
-
Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
-
Smiley ST, King JA, Hancock WW. Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 2001;167:2887-2894.
-
(2001)
J Immunol
, vol.167
, pp. 2887-2894
-
-
Smiley, S.T.1
King, J.A.2
Hancock, W.W.3
-
232
-
-
0037097672
-
Cutting edge: The immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4
-
Guillot L, Balloy V, McCormack FX, Golenbock DT, Chignard M, Si-Tahar M. Cutting edge: The immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J Immunol 2002;168:5989-5992.
-
(2002)
J Immunol
, vol.168
, pp. 5989-5992
-
-
Guillot, L.1
Balloy, V.2
McCormack, F.X.3
Golenbock, D.T.4
Chignard, M.5
Si-Tahar, M.6
-
233
-
-
0036829687
-
Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2
-
Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, Chertov O, Shirakawa AK, Farber JM, Segal DM, Oppenheim JJ, Kwak LW. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 2002;298:1025-1029.
-
(2002)
Science
, vol.298
, pp. 1025-1029
-
-
Biragyn, A.1
Ruffini, P.A.2
Leifer, C.A.3
Klyushnenkova, E.4
Shakhov, A.5
Chertov, O.6
Shirakawa, A.K.7
Farber, J.M.8
Segal, D.M.9
Oppenheim, J.J.10
Kwak, L.W.11
-
234
-
-
0342712508
-
E5531, a synthetic non-toxic lipid A derivative blocks the immunobiological activities of lipopolysaccharide
-
Kawata T, Bristol JR, Rossignol DP, Rose JR, Kobayashi S, Yokohama H, Ishibashi A, Christ WJ, Katayama K, Yamatsu I, Kishi Y. E5531, a synthetic non-toxic lipid A derivative blocks the immunobiological activities of lipopolysaccharide. Br J Pharmacol 1999;127:853-862.
-
(1999)
Br J Pharmacol
, vol.127
, pp. 853-862
-
-
Kawata, T.1
Bristol, J.R.2
Rossignol, D.P.3
Rose, J.R.4
Kobayashi, S.5
Yokohama, H.6
Ishibashi, A.7
Christ, W.J.8
Katayama, K.9
Yamatsu, I.10
Kishi, Y.11
-
235
-
-
0035953543
-
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
-
Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001;410:1099-1103.
-
(2001)
Nature
, vol.410
, pp. 1099-1103
-
-
Hayashi, F.1
Smith, K.D.2
Ozinsky, A.3
Hawn, T.R.4
Yi, E.C.5
Goodlett, D.R.6
Eng, J.K.7
Akira, S.8
Underhill, D.M.9
Aderem, A.10
-
236
-
-
0034922923
-
Discrimination of bacterial lipoproteins by Toll-like receptor 6
-
Takeuchi O, Kawai T, Muhlradt PF, Morr M, Radolf JD, Zychlinsky A, Takeda K, Akira S. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol 2001;13:933-940.
-
(2001)
Int Immunol
, vol.13
, pp. 933-940
-
-
Takeuchi, O.1
Kawai, T.2
Muhlradt, P.F.3
Morr, M.4
Radolf, J.D.5
Zychlinsky, A.6
Takeda, K.7
Akira, S.8
-
237
-
-
0035892912
-
Novel engagement of CD14 and multiple toll-like receptors by group B streptococci
-
Henneke P, Takeuchi O, van Strijp JA, Guttormsen HK, Smith JA, Schromm AB, Espevik TA, Akira S, Nizet V, Kasper DL, Golenbock DT. Novel engagement of CD14 and multiple toll-like receptors by group B streptococci. J Immunol 2001;167:7069-7076.
-
(2001)
J Immunol
, vol.167
, pp. 7069-7076
-
-
Henneke, P.1
Takeuchi, O.2
van Strijp, J.A.3
Guttormsen, H.K.4
Smith, J.A.5
Schromm, A.B.6
Espevik, T.A.7
Akira, S.8
Nizet, V.9
Kasper, D.L.10
Golenbock, D.T.11
-
238
-
-
0034610291
-
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
-
Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, Schroeder L, Aderem A. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA 2000;97:13766-13771.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 13766-13771
-
-
Ozinsky, A.1
Underhill, D.M.2
Fontenot, J.D.3
Hajjar, A.M.4
Smith, K.D.5
Wilson, C.B.6
Schroeder, L.7
Aderem, A.8
-
239
-
-
1542317550
-
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
-
Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004;303:1529-1531.
-
(2004)
Science
, vol.303
, pp. 1529-1531
-
-
Diebold, S.S.1
Kaisho, T.2
Hemmi, H.3
Akira, S.4
Reis e Sousa, C.5
-
240
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
-
Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004;303:1526-1529.
-
(2004)
Science
, vol.303
, pp. 1526-1529
-
-
Heil, F.1
Hemmi, H.2
Hochrein, H.3
Ampenberger, F.4
Kirschning, C.5
Akira, S.6
Lipford, G.7
Wagner, H.8
Bauer, S.9
-
241
-
-
28544449709
-
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
-
Vollmer J, Tluk S, Schmitz C, Hamm S, Jurk M, Forsbach A, Akira S, Kelly KM, Reeves WH, Bauer S, Krieg AM. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med 2005;202:1575-1585.
-
(2005)
J Exp Med
, vol.202
, pp. 1575-1585
-
-
Vollmer, J.1
Tluk, S.2
Schmitz, C.3
Hamm, S.4
Jurk, M.5
Forsbach, A.6
Akira, S.7
Kelly, K.M.8
Reeves, W.H.9
Bauer, S.10
Krieg, A.M.11
-
242
-
-
0036008014
-
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
-
Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 2002;3:196-200.
-
(2002)
Nat Immunol
, vol.3
, pp. 196-200
-
-
Hemmi, H.1
Kaisho, T.2
Takeuchi, O.3
Sato, S.4
Sanjo, H.5
Hoshino, K.6
Horiuchi, T.7
Tomizawa, H.8
Takeda, K.9
Akira, S.10
-
243
-
-
0036088492
-
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
-
Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H, Lipford G, Bauer S. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol 2002;3:499.
-
(2002)
Nat Immunol
, vol.3
, pp. 499
-
-
Jurk, M.1
Heil, F.2
Vollmer, J.3
Schetter, C.4
Krieg, A.M.5
Wagner, H.6
Lipford, G.7
Bauer, S.8
-
244
-
-
0029035289
-
Structural studies on bioactive compounds. Part 26. Hydrogen bonding in the crystal structure of the N-methylformamide solvate of the immunomodulatory agent 2-amino-5-bromo-6-phenylpyrimidin-4-one (bropirimine): Implications for the design of novel anti-tumour strategies
-
Stevens MF, Schwalbe CH, Patel N, Gate EN, Bryant PK. Structural studies on bioactive compounds. Part 26. Hydrogen bonding in the crystal structure of the N-methylformamide solvate of the immunomodulatory agent 2-amino-5-bromo-6-phenylpyrimidin-4-one (bropirimine): Implications for the design of novel anti-tumour strategies. Anticancer Drug Des 1995;10:203-213.
-
(1995)
Anticancer Drug Des
, vol.10
, pp. 203-213
-
-
Stevens, M.F.1
Schwalbe, C.H.2
Patel, N.3
Gate, E.N.4
Bryant, P.K.5
-
245
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. A Toll-like receptor recognizes bacterial DNA. Nature 2000;408:740-745.
-
(2000)
Nature
, vol.408
, pp. 740-745
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Kaisho, T.4
Sato, S.5
Sanjo, H.6
Matsumoto, M.7
Hoshino, K.8
Wagner, H.9
Takeda, K.10
Akira, S.11
-
246
-
-
19944430901
-
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
-
Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med 2005;201:19-25.
-
(2005)
J Exp Med
, vol.201
, pp. 19-25
-
-
Coban, C.1
Ishii, K.J.2
Kawai, T.3
Hemmi, H.4
Sato, S.5
Uematsu, S.6
Yamamoto, M.7
Takeuchi, O.8
Itagaki, S.9
Kumar, N.10
Horii, T.11
Akira, S.12
-
247
-
-
0037061453
-
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
-
Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 2002;416:603-607.
-
(2002)
Nature
, vol.416
, pp. 603-607
-
-
Leadbetter, E.A.1
Rifkin, I.R.2
Hohlbaum, A.M.3
Beaudette, B.C.4
Shlomchik, M.J.5
Marshak-Rothstein, A.6
-
248
-
-
20644433342
-
TLR11 activation of dendritic cells by a protozoan profilin-like protein
-
Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, Hieny S, Sutterwala FS, Flavell RA, Ghosh S, Sher A. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 2005;308:1626-1629.
-
(2005)
Science
, vol.308
, pp. 1626-1629
-
-
Yarovinsky, F.1
Zhang, D.2
Andersen, J.F.3
Bannenberg, G.L.4
Serhan, C.N.5
Hayden, M.S.6
Hieny, S.7
Sutterwala, F.S.8
Flavell, R.A.9
Ghosh, S.10
Sher, A.11
|