메뉴 건너뛰기




Volumn 4, Issue 7, 2004, Pages 512-520

Therapeutics targeting the innate immune system

Author keywords

[No Author keywords available]

Indexed keywords

MYELOID DIFFERENTIATION FACTOR 88; NOD PROTEIN; NUCLEOTIDE BINDING PROTEIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

EID: 3142779901     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1396     Document Type: Review
Times cited : (280)

References (98)
  • 1
    • 0346157331 scopus 로고    scopus 로고
    • TIR domain-containing adaptors define the specificity of TLR signaling
    • Yamamoto, M., Takeda, K. & Akira, S. TIR domain-containing adaptors define the specificity of TLR signaling. Mol. Immunol. 40, 861-868 (2004).
    • (2004) Mol. Immunol. , vol.40 , pp. 861-868
    • Yamamoto, M.1    Takeda, K.2    Akira, S.3
  • 2
    • 0346731246 scopus 로고    scopus 로고
    • How we detect microbes and respond to them: The Toll-like receptors and their transducers
    • Beutler, B., Hoebe, K., Du, X. & Ulevitch, R. J. How we detect microbes and respond to them: the Toll-like receptors and their transducers. J. Leukoc. Biol. 74, 479-485 (2003).
    • (2003) J. Leukoc. Biol. , vol.74 , pp. 479-485
    • Beutler, B.1    Hoebe, K.2    Du, X.3    Ulevitch, R.J.4
  • 3
    • 0041467711 scopus 로고    scopus 로고
    • Toll-like receptors: Networking for success
    • Underhill, D. M. Toll-like receptors: networking for success. Eur. J. Immunol. 88, 1767-1775 (2003).
    • (2003) Eur. J. Immunol. , vol.88 , pp. 1767-1775
    • Underhill, D.M.1
  • 4
    • 0038540887 scopus 로고    scopus 로고
    • The role of MyD88-like adapters in Toll-like receptor signal transduction
    • O'Neill, L. A. The role of MyD88-like adapters in Toll-like receptor signal transduction. Biochem. Soc. Trans. 31, 643-647 (2003).
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 643-647
    • O'Neill, L.A.1
  • 5
    • 0037465251 scopus 로고    scopus 로고
    • The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense
    • Dunne, A. & O'Neill, L. A. The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci. STKE [online] 2003, re3 (2003).
    • (2003) Sci. STKE [Online] , vol.2003
    • Dunne, A.1    O'Neill, L.A.2
  • 7
    • 0041827164 scopus 로고    scopus 로고
    • Nods, Nalps and Nalp: Intracellular regulators of bacterial-induced inflammation
    • Chamaillard, M., Girardin, S. E., Viala, J. & Philpott, D. J. Nods, Nalps and Nalp: intracellular regulators of bacterial-induced inflammation. Cell. Microbiol. 5, 581-592 (2003).
    • (2003) Cell. Microbiol. , vol.5 , pp. 581-592
    • Chamaillard, M.1    Girardin, S.E.2    Viala, J.3    Philpott, D.J.4
  • 8
    • 0038624558 scopus 로고    scopus 로고
    • NODs: Intracellular proteins involved in inflammation and apoptosis
    • Inohara, N. & Nunez, G. NODs: intracellular proteins involved in inflammation and apoptosis. Nature Rev. Immunol. 5, 371-382 (2003).
    • (2003) Nature Rev. Immunol. , vol.5 , pp. 371-382
    • Inohara, N.1    Nunez, G.2
  • 9
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira, S. & Takeda, K. Toll-like receptor signalling. Nature Rev. Immunol. 4, 499-511 (2004).
    • (2004) Nature Rev. Immunol. , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 10
    • 0142180157 scopus 로고    scopus 로고
    • Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2
    • Girardin, S. E. et al. Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J. Biol. Chem. 278, 41702-41708 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 41702-41708
    • Girardin, S.E.1
  • 11
    • 0038824980 scopus 로고    scopus 로고
    • An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid
    • Chamaillard, M. et al. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nature Immunol. 4, 702-707 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 702-707
    • Chamaillard, M.1
  • 12
    • 0038615855 scopus 로고    scopus 로고
    • Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan
    • Girardin, S. E. et al. Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan. Science 300, 1584-1587 (2003). Provides the first definition of the structural requirements of the NOD1 ligand.
    • (2003) Science , vol.300 , pp. 1584-1587
    • Girardin, S.E.1
  • 13
    • 0037226672 scopus 로고    scopus 로고
    • Mal and MyD88: Adapter proteins involved in signal transduction by Toll-like receptors
    • O'Neill, L. A. et al. Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors. J. Endotoxin Res. 9, 55-59 (2003).
    • (2003) J. Endotoxin Res. , vol.9 , pp. 55-59
    • O'Neill, L.A.1
  • 14
    • 0037064536 scopus 로고    scopus 로고
    • Summary and comparison of the signaling mechanisms of the Toll/Interleukin-1 receptor family
    • Martin, M. U. & Wesche, H. Summary and comparison of the signaling mechanisms of the Toll/Interleukin-1 receptor family. Biochim. Biophys. Acta 1592, 265-268 (2002).
    • (2002) Biochim. Biophys. Acta , vol.1592 , pp. 265-268
    • Martin, M.U.1    Wesche, H.2
  • 15
    • 0037505362 scopus 로고    scopus 로고
    • The Toll-IL-1 receptor adaptor family grows to five members
    • O'Neill, L. A., Fitzgerard, K. A. & Bowie, A. G. The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol. 24, 286-290 (2003).
    • (2003) Trends Immunol. , vol.24 , pp. 286-290
    • O'Neill, L.A.1    Fitzgerard, K.A.2    Bowie, A.G.3
  • 16
    • 0035895992 scopus 로고    scopus 로고
    • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB
    • Ogura, Y. et al. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J. Biol. Chem. 276, 4812-4818 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 4812-4818
    • Ogura, Y.1
  • 17
    • 0037075551 scopus 로고    scopus 로고
    • RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    • Kobayashi, K. et al. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416, 194-199 (2002). Provides important evidence implicating RICK in both TLR- and NOD-protein signalling pathways.
    • (2002) Nature , vol.416 , pp. 194-199
    • Kobayashi, K.1
  • 18
    • 0242581687 scopus 로고    scopus 로고
    • The immune response of Drosophila
    • Hoffmann, J. A. The immune response of Drosophila. Nature 426, 33-38 (2003).
    • (2003) Nature , vol.426 , pp. 33-38
    • Hoffmann, J.A.1
  • 19
    • 0345731463 scopus 로고    scopus 로고
    • Dual activation of the Drosophila Toll pathway by two pattern recognition receptors
    • Gobert, V. et al. Dual activation of the Drosophila Toll pathway by two pattern recognition receptors. Science 302, 2126-2130 (2003).
    • (2003) Science , vol.302 , pp. 2126-2130
    • Gobert, V.1
  • 20
    • 0037322295 scopus 로고    scopus 로고
    • Toll signaling: The TIReless quest for specificity
    • Imler, J. L. & Hoffmann, J. A. Toll signaling: the TIReless quest for specificity. Nature Immunol. 4, 105-106 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 105-106
    • Imler, J.L.1    Hoffmann, J.A.2
  • 21
    • 0037061450 scopus 로고    scopus 로고
    • The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
    • Gottar, M. et al. The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature 416, 640-644 (2002). Provides a new paradigm that describes different arms of the innate immune response in insects.
    • (2002) Nature , vol.416 , pp. 640-644
    • Gottar, M.1
  • 22
    • 1542377424 scopus 로고    scopus 로고
    • A Toll-like receptor that prevents infection by uropathogenic bacteria
    • Zhang, D. et al. A Toll-like receptor that prevents infection by uropathogenic bacteria. Science 303, 1522-1526 (2004).
    • (2004) Science , vol.303 , pp. 1522-1526
    • Zhang, D.1
  • 23
    • 2442565738 scopus 로고    scopus 로고
    • Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors
    • Nishiya, T. & DeFranco, A. L. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J. Biol. Chem. 279, 19008-19017 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 19008-19017
    • Nishiya, T.1    DeFranco, A.L.2
  • 24
    • 0742324858 scopus 로고    scopus 로고
    • Endotoxin recognition molecules, Toll-like receptor 4-MD-2
    • Miyake, K. Endotoxin recognition molecules, Toll-like receptor 4-MD-2. Semin. Immunol. 16, 11-16 (2004).
    • (2004) Semin. Immunol. , vol.16 , pp. 11-16
    • Miyake, K.1
  • 25
    • 0141890200 scopus 로고    scopus 로고
    • Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: Higher affinity than that with MD-2 or CD14
    • Akashi, S. et al. Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J. Exp. Med. 198, 1035-1042 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1035-1042
    • Akashi, S.1
  • 26
    • 0038664380 scopus 로고    scopus 로고
    • The role of Toll-like receptor 2 in microbial disease and immunity
    • Wetzler, L. M. The role of Toll-like receptor 2 in microbial disease and immunity. Vaccine 21, S55-S60 (2003).
    • (2003) Vaccine , vol.21
    • Wetzler, L.M.1
  • 27
    • 0036453356 scopus 로고    scopus 로고
    • TLR2: Cellular sensor for microbial and endogenous molecular patterns
    • Kirschning, C. J. & Schumann, R. R. TLR2: cellular sensor for microbial and endogenous molecular patterns. Curr. Top. Microbiol. Immunol. 270, 121-144 (2002).
    • (2002) Curr. Top. Microbiol. Immunol. , vol.270 , pp. 121-144
    • Kirschning, C.J.1    Schumann, R.R.2
  • 28
    • 0035165287 scopus 로고    scopus 로고
    • Cutting edge: Functional interactions between Toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
    • Hajjar, A. M. et al. Cutting edge: Functional interactions between Toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin. J. Immunol. 166, 15-19 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 15-19
    • Hajjar, A.M.1
  • 29
    • 0034610291 scopus 로고    scopus 로고
    • The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
    • Ozinsky, A. et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc. Natl Acad. Sci. USA 97, 13766-13771 (2000). Provides key data showing how TLRs comprise heteromeric subunits that determine ligand specificity.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13766-13771
    • Ozinsky, A.1
  • 30
    • 0037604765 scopus 로고    scopus 로고
    • Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes
    • Mizel, S. B., Honko, A. N., Moors, M. A., Smith, P. S. & West, A. P. Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes. J. Immunol. 170, 6217-6223 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 6217-6223
    • Mizel, S.B.1    Honko, A.N.2    Moors, M.A.3    Smith, P.S.4    West, A.P.5
  • 31
    • 0346965742 scopus 로고    scopus 로고
    • Plant immunity: The origami of receptor activation
    • Schulze-Lefert, P. Plant immunity: the origami of receptor activation. Curr. Biol. 14, R22-R24 (2004).
    • (2004) Curr. Biol. , vol.14
    • Schulze-Lefert, P.1
  • 32
    • 0347416705 scopus 로고    scopus 로고
    • Recognition and response in the plant immune system
    • Nimchuk, Z., Eulgem, T., Holt, B. F. & Dangl, J. L. Recognition and response in the plant immune system. Annu. Rev. Genet. 37, 579-609 (2003).
    • (2003) Annu. Rev. Genet. , vol.37 , pp. 579-609
    • Nimchuk, Z.1    Eulgem, T.2    Holt, B.F.3    Dangl, J.L.4
  • 33
    • 0142057020 scopus 로고    scopus 로고
    • Understanding the functions of plant disease resistance proteins
    • Martin, G. B., Bogdanove, A. J. & Sessa, G. Understanding the functions of plant disease resistance proteins. Annu. Rev. Plant Biol. 54, 23-61 (2003).
    • (2003) Annu. Rev. Plant Biol. , vol.54 , pp. 23-61
    • Martin, G.B.1    Bogdanove, A.J.2    Sessa, G.3
  • 34
    • 2542457495 scopus 로고    scopus 로고
    • Inflammatory caspases; linking an intracellular innate immune system to autoinflammatory diseases
    • Martinon, F. & Tschopp, J. Inflammatory caspases; linking an intracellular innate immune system to autoinflammatory diseases. Cell 117, 561-574 (2004).
    • (2004) Cell , vol.117 , pp. 561-574
    • Martinon, F.1    Tschopp, J.2
  • 35
    • 2342583513 scopus 로고    scopus 로고
    • Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition
    • Tanabe, T. et al. Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J. 23, 1587-1597 (2004).
    • (2004) EMBO J. , vol.23 , pp. 1587-1597
    • Tanabe, T.1
  • 36
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund, J., Sato, A., Akira, S., Medzhitov, R. & Iwasaki, A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198, 513-520 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 37
    • 0842328805 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 activates murine natural interferon producing cells through Toll-like receptor 9
    • Krug, A. et al. Herpes simplex virus type 1 activates murine natural interferon producing cells through Toll-like receptor 9. Blood 103, 1433-1437 (2004).
    • (2004) Blood , vol.103 , pp. 1433-1437
    • Krug, A.1
  • 38
    • 0038781697 scopus 로고    scopus 로고
    • Regulation of dendritic cell function through Toll-like receptors
    • Kaisho, T. & Akira, S. Regulation of dendritic cell function through Toll-like receptors. Curr. Mol. Med. 3, 373-385 (2003).
    • (2003) Curr. Mol. Med. , vol.3 , pp. 373-385
    • Kaisho, T.1    Akira, S.2
  • 39
    • 0042827302 scopus 로고    scopus 로고
    • T cell activation, from atopy to asthma: More a paradox than a paradigm
    • El Biaze, M. et al. T cell activation, from atopy to asthma: more a paradox than a paradigm. Allergy 58, 844-853 (2003).
    • (2003) Allergy , vol.58 , pp. 844-853
    • El Biaze, M.1
  • 40
    • 0142231999 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides: A novel therapeutic approach for atopic disorders
    • Hussain, I. & Kline, J. N. CpG oligodeoxynucleotides: a novel therapeutic approach for atopic disorders. Curr. Drug Targets Inflamm. Allergy 2, 199-205 (2003).
    • (2003) Curr. Drug Targets Inflamm. Allergy , vol.2 , pp. 199-205
    • Hussain, I.1    Kline, J.N.2
  • 42
    • 0033916260 scopus 로고    scopus 로고
    • Strategies for immunotherapy of cancer
    • Melief, C. J. Strategies for immunotherapy of cancer. Adv. Immunol. 75, 235-282 (2000).
    • (2000) Adv. Immunol. , vol.75 , pp. 235-282
    • Melief, C.J.1
  • 43
    • 0033946269 scopus 로고    scopus 로고
    • Exploiting the immune system: Toward new vaccines against intracellular bacteria
    • Hess, J., Schaible, U., Raupach, B. & Kaufmann, S. H. Exploiting the immune system: toward new vaccines against intracellular bacteria. Adv. Immunol. 75, 1-88 (2000).
    • (2000) Adv. Immunol. , vol.75 , pp. 1-88
    • Hess, J.1    Schaible, U.2    Raupach, B.3    Kaufmann, S.H.4
  • 44
    • 0037070113 scopus 로고    scopus 로고
    • Toll-like receptors as adjuvant receptors
    • Kaisho, T. & Akira, S. Toll-like receptors as adjuvant receptors. Biochim. Biophys. Acta 1589, 1-13 (2002).
    • (2002) Biochim. Biophys. Acta , vol.1589 , pp. 1-13
    • Kaisho, T.1    Akira, S.2
  • 45
    • 0042873015 scopus 로고    scopus 로고
    • Synthetic vaccines: The role of adjuvants in immune targeting
    • Jiang, Z. H. & Koganty, R. R. Synthetic vaccines: the role of adjuvants in immune targeting. Curr. Med. Chem. 10, 1423-1439 (2003).
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1423-1439
    • Jiang, Z.H.1    Koganty, R.R.2
  • 46
    • 0037654784 scopus 로고    scopus 로고
    • Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi. 529
    • Evans, J. T. et al. Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi. 529. Expert Rev. Vaccines 2, 219-229 (2003).
    • (2003) Expert Rev. Vaccines , vol.2 , pp. 219-229
    • Evans, J.T.1
  • 47
    • 0036789814 scopus 로고    scopus 로고
    • Taking Toll: Lipid A mimetics as adjuvants and immunomodulators
    • Persing, D. H. Taking Toll: lipid A mimetics as adjuvants and immunomodulators. Trends Microbiol. 10, S32-S37 (2002).
    • (2002) Trends Microbiol. , vol.10
    • Persing, D.H.1
  • 48
    • 2442499153 scopus 로고    scopus 로고
    • Structure-activity relationship of synthetic Toll-like receptor 4 agonists
    • Stover, A. G. et al. Structure-activity relationship of synthetic Toll-like receptor 4 agonists. J. Biol. Chem. 279, 4440-4449 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 4440-4449
    • Stover, A.G.1
  • 49
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8
    • Heil, F. et al. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303, 1526-1529 (2004). Identifies a naturally occurring ligand for TLR 7 and TLR 8.
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1
  • 50
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S. & Reis e Sousa, C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529-1531 (2004). Identifies a naturally occurring ligand for TLR7.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis E Sousa, C.5
  • 52
    • 0346059383 scopus 로고    scopus 로고
    • Topical immunomodulators for the treatment of external genital warts, cutaneous warts and molluscum contagiosum
    • Hengge, U. R. & Cusini, M. Topical immunomodulators for the treatment of external genital warts, cutaneous warts and molluscum contagiosum. Br. J. Dermatol. 149 (Suppl. 66), 15-19 (2003).
    • (2003) Br. J. Dermatol. , vol.149 , Issue.SUPPL. 66 , pp. 15-19
    • Hengge, U.R.1    Cusini, M.2
  • 53
    • 1242352914 scopus 로고    scopus 로고
    • Established and potential strategies against papillomavirus infections
    • Bernard, H. U. Established and potential strategies against papillomavirus infections. J. Antimicrob. Chemother. 53, 137-139 (2004).
    • (2004) J. Antimicrob. Chemother. , vol.53 , pp. 137-139
    • Bernard, H.U.1
  • 54
    • 0037460116 scopus 로고    scopus 로고
    • Recognition of pathogen-associated molecular patterns by TLR family
    • Akira, S. & Hemmi, H. Recognition of pathogen-associated molecular patterns by TLR family. Immunol. Lett. 85, 85-95 (2003).
    • (2003) Immunol. Lett. , vol.85 , pp. 85-95
    • Akira, S.1    Hemmi, H.2
  • 55
    • 0242391997 scopus 로고    scopus 로고
    • The Toll-like receptor 7 (TLRT)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily
    • Heil, F. et al. The Toll-like receptor 7 (TLRT)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur. J. Immunol. 33, 2987-2997 (2003).
    • (2003) Eur. J. Immunol. , vol.33 , pp. 2987-2997
    • Heil, F.1
  • 56
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi, H. et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nature Immunol. 3, 196-200 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 196-200
    • Hemmi, H.1
  • 57
    • 12244272464 scopus 로고    scopus 로고
    • Immunostimulatory activity of aminoalkyl glucosaminice 4-phosphates (AGPs): Induction of protective innate immune responses by RC-524 and RC-529
    • Baldridge, J. R. et al. Immunostimulatory activity of aminoalkyl glucosaminice 4-phosphates (AGPs): induction of protective innate immune responses by RC-524 and RC-529. J. Endotoxin Res. 8, 453-458 (2002).
    • (2002) J. Endotoxin Res. , vol.8 , pp. 453-458
    • Baldridge, J.R.1
  • 58
    • 5944261457 scopus 로고    scopus 로고
    • Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
    • Kurt-Jones, E. A. et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nature Immunol. 1, 398-401 (2000). Among the first reports to indicate a role for the innate immune system in antiviral responses.
    • (2000) Nature Immunol. , vol.1 , pp. 398-401
    • Kurt-Jones, E.A.1
  • 59
    • 18644376284 scopus 로고    scopus 로고
    • IRF3 mediates a TLR3/TLR4-specific antiviral gene program
    • Doyle, S. et al. IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity 17, 251-263 (2002).
    • (2002) Immunity , vol.17 , pp. 251-263
    • Doyle, S.1
  • 60
    • 2342441717 scopus 로고    scopus 로고
    • LPS dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins
    • Hoebe, K. & Beutler, B. LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins. J. Endotoxin Res. 10, 130-136 (2004).
    • (2004) J. Endotoxin Res. , vol.10 , pp. 130-136
    • Hoebe, K.1    Beutler, B.2
  • 61
    • 12144286763 scopus 로고    scopus 로고
    • Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
    • Tabeta, K. et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. USA 101, 3516-3521 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 3516-3521
    • Tabeta, K.1
  • 62
    • 0347146027 scopus 로고    scopus 로고
    • Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
    • Hoebe, K. et al. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nature Immunol. 4, 1223-1229 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 1223-1229
    • Hoebe, K.1
  • 63
    • 0242383213 scopus 로고    scopus 로고
    • Lps2 and signal transduction in sepsis: At the intersection of host responses to bacteria and viruses
    • Beutler, B. et al. Lps2 and signal transduction in sepsis: at the intersection of host responses to bacteria and viruses. Scand. J. Infect. Dis. 35, 563-567 (2003).
    • (2003) Scand. J. Infect. Dis. , vol.35 , pp. 563-567
    • Beutler, B.1
  • 64
    • 0141703238 scopus 로고    scopus 로고
    • Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection
    • Honda, K. et al. Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc. Natl Acad. Sci. USA 100, 10872-10877 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 10872-10877
    • Honda, K.1
  • 65
    • 1642422416 scopus 로고    scopus 로고
    • Toll-like receptor 3: A link between Toll-like receptor, interferon and viruses
    • Matsumoto, M., Funami, K., Oshiumi, H. & Seya, T. Toll-like receptor 3: a link between Toll-like receptor, interferon and viruses. Microbiol. Immunol. 48, 147-154 (2004).
    • (2004) Microbiol. Immunol. , vol.48 , pp. 147-154
    • Matsumoto, M.1    Funami, K.2    Oshiumi, H.3    Seya, T.4
  • 66
    • 0037443413 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells
    • Heit, A. et al. Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells. J. Immunol. 170, 2802-2805 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 2802-2805
    • Heit, A.1
  • 67
    • 1642566833 scopus 로고    scopus 로고
    • CpG-DNA aided cross-priming by cross-presenting B cells
    • Heit, A. et al. CpG-DNA aided cross-priming by cross-presenting B cells. J. Immunol. 172, 1501-1507 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 1501-1507
    • Heit, A.1
  • 68
    • 0036964533 scopus 로고    scopus 로고
    • Allergen-immunostimulatory oligodeoxynucleotide conjugate: A novel allergoid for immunotherapy
    • Speigelberg, H. L., Homer, A. A., Takabayashi, K. & Raz, E. Allergen-immunostimulatory oligodeoxynucleotide conjugate: a novel allergoid for immunotherapy. Curr. Opin. Allergy Clin. Immunol. 2, 547-551 (2002).
    • (2002) Curr. Opin. Allergy Clin. Immunol. , vol.2 , pp. 547-551
    • Speigelberg, H.L.1    Homer, A.A.2    Takabayashi, K.3    Raz, E.4
  • 69
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-κB system: A treasure trove for drug development
    • Karin, M., Yamamoto, Y. & Wang, Q. M. The IKK NF-κB system: a treasure trove for drug development. Nature Rev. Drug Discov. 3, 17-26 (2004).
    • (2004) Nature Rev. Drug Discov. , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 70
    • 3142781225 scopus 로고    scopus 로고
    • Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
    • Arkin, M. R. & Wells, J. A. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nature Rev. Drug Discov. 3, 301-317 (2004).
    • (2004) Nature Rev. Drug Discov. , vol.3 , pp. 301-317
    • Arkin, M.R.1    Wells, J.A.2
  • 71
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev, L. T. et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (2004).
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1
  • 72
    • 0037596457 scopus 로고    scopus 로고
    • A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses
    • Bartfai, T. et al. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc. Natl Acad. Sci. USA 100, 7971-7976 (2003). Provides the first evidence indicating that it is possible to target TIR-TIR domain interactions with a small molecule.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 7971-7976
    • Bartfai, T.1
  • 73
    • 0842343142 scopus 로고    scopus 로고
    • Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration
    • Heikenwalder, M. et al. Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nature Med. 10, 187-192 (2004).
    • (2004) Nature Med. , vol.10 , pp. 187-192
    • Heikenwalder, M.1
  • 74
    • 0042679529 scopus 로고    scopus 로고
    • Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
    • Hoebe, K. et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424, 743-748 (2003). This seminal paper describes the use of forward genetics to decipher TLR-signalling pathways and identifies Lps2 as a gene encoding TRIF.
    • (2003) Nature , vol.424 , pp. 743-748
    • Hoebe, K.1
  • 75
    • 0033166472 scopus 로고    scopus 로고
    • Unresponsiveness of MyD88-deficient mice to endotoxin
    • Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115-122 (1999).
    • (1999) Immunity , vol.11 , pp. 115-122
    • Kawai, T.1    Adachi, O.2    Ogawa, T.3    Takeda, K.4    Akira, S.5
  • 76
    • 0242624622 scopus 로고    scopus 로고
    • TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
    • Yamamoto, M. et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nature Immunol. 4, 1144-1150 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 1144-1150
    • Yamamoto, M.1
  • 77
    • 0141959224 scopus 로고    scopus 로고
    • LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the Toll adapters TRAM and TRIF
    • Fitzgerald, K. A. et al. LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the Toll adapters TRAM and TRIF. J. Exp. Med. 198, 1043-1055 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1043-1055
    • Fitzgerald, K.A.1
  • 78
    • 0242641243 scopus 로고    scopus 로고
    • Efficacy and tolerability of short-term specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A (MPL) for children and adolescents
    • Drachenberg, K. J., Heinzkill, M., Urban, E. & Woroniecke, S. R. Efficacy and tolerability of short-term specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A (MPL) for children and adolescents. Allergol. Immunopathol. (Madr.) 31, 270-277 (2003).
    • (2003) Allergol. Immunopathol. (Madr.) , vol.31 , pp. 270-277
    • Drachenberg, K.J.1    Heinzkill, M.2    Urban, E.3    Woroniecke, S.R.4
  • 79
    • 0043264799 scopus 로고    scopus 로고
    • Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: Reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies
    • Mothes, N. et al. Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin. Exp. Allergy 33, 1198-1208 (2003).
    • (2003) Clin. Exp. Allergy , vol.33 , pp. 1198-1208
    • Mothes, N.1
  • 80
    • 0141532308 scopus 로고    scopus 로고
    • Immunization with an adjuvant hepatitis B vaccine after liver transplantation for hepatitis B-related disease
    • Bienzle, U. et al. Immunization with an adjuvant hepatitis B vaccine after liver transplantation for hepatitis B-related disease. Hepatology 38, 811-819 (2003).
    • (2003) Hepatology , vol.38 , pp. 811-819
    • Bienzle, U.1
  • 81
    • 0036841435 scopus 로고    scopus 로고
    • Effect of monophosphoryl lipid A (MPL) on T-helper cells when administered as an adjuvant with pneumocococcal-CRM197 conjugate vaccine in healthy toddlers
    • Vernacchio, L. et al. Effect of monophosphoryl lipid A (MPL) on T-helper cells when administered as an adjuvant with pneumocococcal-CRM197 conjugate vaccine in healthy toddlers. Vaccine 20, 3658-3667 (2002).
    • (2002) Vaccine , vol.20 , pp. 3658-3667
    • Vernacchio, L.1
  • 82
    • 9144257824 scopus 로고    scopus 로고
    • Extended in vivo pharmacodynamic activity of E5564 in normal volunteers with experimental endotoxemia
    • Lynn, M. et al. Extended in vivo pharmacodynamic activity of E5564 in normal volunteers with experimental endotoxemia. J. Pharmacol. Exp. Ther. 308, 175-181 (2004).
    • (2004) J. Pharmacol. Exp. Ther. , vol.308 , pp. 175-181
    • Lynn, M.1
  • 83
    • 0037635980 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and pharmacodynamics of E5564, a lipid A antagonist, during an ascending single-dose clinical study
    • Wong, Y. N. et al. Safety, pharmacokinetics, and pharmacodynamics of E5564, a lipid A antagonist, during an ascending single-dose clinical study. J. Clin. Pharmacol. 43, 735-742 (2003).
    • (2003) J. Clin. Pharmacol. , vol.43 , pp. 735-742
    • Wong, Y.N.1
  • 84
    • 0242721762 scopus 로고    scopus 로고
    • Pharmacokinetics of E5564, a lipopolysaccharide antagonist, in patients with impaired hepatic function
    • Liang, E. et al. Pharmacokinetics of E5564, a lipopolysaccharide antagonist, in patients with impaired hepatic function. J. Clin. Pharmacol. 43, 1361-1369 (2003).
    • (2003) J. Clin. Pharmacol. , vol.43 , pp. 1361-1369
    • Liang, E.1
  • 85
    • 0034351121 scopus 로고    scopus 로고
    • Phase 1, randomized, double-blind trial of 7-allyl-8-oxoguanosine (loxoribine) in advanced cancer
    • Agarwala, S. S., Kirkwood, J. M. & Bryant, J. Phase 1, randomized, double-blind trial of 7-allyl-8-oxoguanosine (loxoribine) in advanced cancer. Cytokines Cell. Mol. Ther. 6, 171-176 (2000).
    • (2000) Cytokines Cell. Mol. Ther. , vol.6 , pp. 171-176
    • Agarwala, S.S.1    Kirkwood, J.M.2    Bryant, J.3
  • 86
    • 0344443213 scopus 로고    scopus 로고
    • Randomized, single-blind, placebo-controlled study of topical application of the immune response modulator resiquimod in healthy adults
    • Sauder, D. N., Smith, M. H., Senta-McMillian, T., Soria, I. & Meng T. C. Randomized, single-blind, placebo-controlled study of topical application of the immune response modulator resiquimod in healthy adults. Antimicrob. Agents Chemother. 47, 3846-3852 (2003).
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 3846-3852
    • Sauder, D.N.1    Smith, M.H.2    Senta-McMillian, T.3    Soria, I.4    Meng, T.C.5
  • 88
    • 2542529956 scopus 로고    scopus 로고
    • Imiquimod (Aldara) for actinic keratoses
    • Imiquimod (Aldara) for actinic keratoses. Med. Lett. Drugs Ther. 46, 42-44 (2004).
    • (2004) Med. Lett. Drugs Ther. , vol.46 , pp. 42-44
  • 89
    • 1642416709 scopus 로고    scopus 로고
    • Treatment of Bowen's disease with imiquimod 5% cream in transplant recipients
    • Prinz, B. M. et al. Treatment of Bowen's disease with imiquimod 5% cream in transplant recipients, Transplantation 77, 790-791 (2004).
    • (2004) Transplantation , vol.77 , pp. 790-791
    • Prinz, B.M.1
  • 90
    • 2542434082 scopus 로고    scopus 로고
    • Treatment of anal intraepithelial neoplasia in patients with acquired HIV with imiquimod 5% cream
    • Kreuter, A. et al. Treatment of anal intraepithelial neoplasia in patients with acquired HIV with imiquimod 5% cream. J. Am. Acad. Dermatol. 50, 980-981 (2004).
    • (2004) J. Am. Acad. Dermatol. , vol.50 , pp. 980-981
    • Kreuter, A.1
  • 91
    • 1942504386 scopus 로고    scopus 로고
    • Topical imiquimod treatment for nodular basal cell carcinomas: An open-label series
    • Huber, A. et al. Topical imiquimod treatment for nodular basal cell carcinomas: an open-label series. Dermatol. Surg. 30, 429-430 (2004).
    • (2004) Dermatol. Surg. , vol.30 , pp. 429-430
    • Huber, A.1
  • 92
    • 2142692247 scopus 로고    scopus 로고
    • Imiquimod and the treatment of cutaneous T-cell proliferative diseases: At the threshold
    • Herbert, W. C. Imiquimod and the treatment of cutaneous T-cell proliferative diseases: at the threshold. Skinmed. 2, 273-274 (2003).
    • (2003) Skinmed. , vol.2 , pp. 273-274
    • Herbert, W.C.1
  • 93
    • 0037829434 scopus 로고    scopus 로고
    • Heterogeneity in the human response to immunostimulatory CpG oligodeoxynucleotides
    • Leifer, C. A., Verthelyi, D. & Klinman, D. M. Heterogeneity in the human response to immunostimulatory CpG oligodeoxynucleotides. J. Immunother. 26, 313-319 (2003).
    • (2003) J. Immunother. , vol.26 , pp. 313-319
    • Leifer, C.A.1    Verthelyi, D.2    Klinman, D.M.3
  • 94
    • 1142273128 scopus 로고    scopus 로고
    • Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response
    • Tulic, M. K. Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response. J. Allergy Clin. Immunol. 113, 234-241 (2004).
    • (2004) J. Allergy Clin. Immunol. , vol.113 , pp. 234-241
    • Tulic, M.K.1
  • 96
    • 0036043857 scopus 로고    scopus 로고
    • Immunostimulatory DNA-Dynavax. AIC, Amb a 1 immunostimulatory conjugate, HBV-ISS, ISS 1018, ISS DNA, ISS DNA-dynavax, ISS1, ISS2
    • Immunostimulatory DNA-Dynavax. AIC, Amb a 1 immunostimulatory conjugate, HBV-ISS, ISS 1018, ISS DNA, ISS DNA-dynavax, ISS1, ISS2. Drugs R D 3, 193-196 (2002).
    • (2002) Drugs R D , vol.3 , pp. 193-196
  • 97
    • 0142185281 scopus 로고    scopus 로고
    • Technology evaluation: CpG-7909, Coley
    • Paul, S. Technology evaluation: CpG-7909, Coley. Curr. Opin. Mol. Ther. 5, 553-559 (2003).
    • (2003) Curr. Opin. Mol. Ther. , vol.5 , pp. 553-559
    • Paul, S.1
  • 98
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov, R., Preston-Hurlburt, P. & Janeway, C. A. Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394-397 (1997).
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.