E5531, a synthetic non-toxic lipid A derivative blocks the immunobiological activities of lipopolysaccharide

British Journal of Pharmacology

Volumn 127, Issue 4, 1999, Pages 853-862

  Kawata, Tsutomu ^b   Bristol, John R ^a   Rossignol, Daniel P ^a   Rose, Jeffrey R ^a   Kobayashi, Seiichi ^b   Yokohama, Hiromitsu ^b   Ishibashi, Akira ^b   Christ, William J ^a   Katayama, Koichi ^b   Yamatsu, Isao ^b   Kishi, Yoshito ^a  

^a EISAI RESEARCH INSTITUTE   (United States)

^b EISAI CO LTD   (Japan)

Author keywords

E5531; Endotoxin; Lipid A; Lipopolysaccharide; Lipoteichoic acid; Sepsis; TNF

Indexed keywords

ANTIBODY; CD14 ANTIGEN; CONCANAVALIN A; E 5531; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTOXIN; GAMMA INTERFERON; LIPID A; LIPID A DERIVATIVE; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; MY 4; NITRIC OXIDE; PHORBOL 13 ACETATE 12 MYRISTATE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFICACY; DRUG SPECIFICITY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOBIOLOGY; ISOTOPE LABELING; MALE; MEDIATOR RELEASE; MITOGENESIS; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK; THYMOCYTE;

E-SELECTIN; HUMANS; INTERFERON TYPE II; LIPID A; LIPOPOLYSACCHARIDES; MONOCYTES; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; NITRIC OXIDE; SUPEROXIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0342712508     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702596     Document Type: Article

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