The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4

Science

Volumn 316, Issue 5831, 2007, Pages 1628-1632

  Mata Haro, Verónica ^a,b,c   Cekic, Caglar ^a,b   Martin, Michael ^a   Chilton, Paula M ^a   Casella, Carolyn R ^a   Mitchell, Thomas C ^a,b  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

^c CENTRO DE INVESTIGACIÓN EN ALIMENTACIÓN Y DESARROLLO   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BACTERIUM LIPOPOLYSACCHARIDE; IMMUNOLOGICAL ADJUVANT; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHORYL LIPID A; TOLL INTERLEUKIN 1 RECEPTOR DOMAIN CONTAINING ADAPTER INDUCING INTERFERON 1; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; VACCINE;

BIOASSAY; DRUG DEVELOPMENT; GENETIC DIFFERENTIATION; LIPID; POLYSACCHARIDE; PROTEIN; SIGNALING; TOXICITY; TOXIN; VACCINE;

ADOPTIVE TRANSFER; AGONIST; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADJUVANTS, IMMUNOLOGIC; ADOPTIVE TRANSFER; ANIMALS; CYTOKINES; IMMUNIZATION; LIPID A; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED C57BL; MONOCYTES; MYELOID DIFFERENTIATION FACTOR 88; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVALBUMIN; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 4;

BACTERIA (MICROORGANISMS); MUS;

EID: 34250854079     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1138963     Document Type: Article

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28. This work was supported by the U.S. Public Health Service (grants AI51377 and AI059023), the Commonwealth of Kentucky Research Challenge Trust and Lung Cancer Research Funds, and the Barnstable Brown Foundation.