Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA

Journal of Allergy and Clinical Immunology

Volumn 113, Issue 6, 2004, Pages 1144-1151

  Simons, F Estelle R ^a,b   Shikishima, Yasufumi ^a   Van Nest, Gary ^c   Eiden, Joseph J ^c   Hayglass, Kent T ^a,b,d  

^a UNIVERSITY OF MANITOBA   (Canada)

^b CANADIAN INSTITUTES OF HEALTH RESEARCH   (Canada)

^c Dynavax Technologies Corporation   (United States)

^d FRCPC   (Canada)

Author keywords

Ag; AIC; allergen vaccines; Allergen specific immunotherapy; Amb a 1; Amb a 1 immunostimulatory DNA sequence conjugate; Antigen; chemokines; cytokines; DNA vaccines; humans; immunostimulatory DNA sequences; ragweed allergy

Indexed keywords

ALPHA CHEMOKINE; AMB A 1 VACCINE; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 5; PHYTOHEMAGGLUTININ; PROTEIN DERIVATIVE; RAGWEED ANTIGEN; RECOMBINANT DNA; STREPTOKINASE DERIVATIVE; THYMUS AND ACTIVATION REGULATED CHEMOKINE; UNCLASSIFIED DRUG; VACCINE;

ADULT; ALLERGIC REACTION; ALLERGY; ARTICLE; CLINICAL TRIAL; CONJUGATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS LINKING; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DNA SEQUENCE; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREACTIVITY; IMMUNOSTIMULATION; INJECTION; INTERMETHOD COMPARISON; MALE; PHASE 1 CLINICAL TRIAL; PHENOMENOLOGY; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE ACTIVATION; TH2 CELL; TREATMENT OUTCOME;

ADJUVANTS, IMMUNOLOGIC; ADULT; ALLERGENS; AMBROSIA; DESENSITIZATION, IMMUNOLOGIC; FEMALE; HUMANS; HYPERSENSITIVITY; INJECTIONS; MALE; MIDDLE AGED; OLIGODEOXYRIBONUCLEOTIDES; PLANT PROTEINS; TH1 CELLS; TH2 CELLS;

EID: 3042718066     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2004.03.003     Document Type: Article

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