Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys

American Journal of Respiratory and Critical Care Medicine

Volumn 170, Issue 11, 2004, Pages 1153-1157

  Fanucchi, Michelle V ^a   Schelegle, Edward S ^b   Baker, Gregory L ^b   Evans, Michael J ^b   McDonald, Ruth J ^b   Gershwin, Laurel J ^b   Raz, Eyal ^b   Hyde, Dallas M ^b   Plopper, Charles G ^b   Miller, Lisa A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

Airway wall alterations; Allergic asthma; Immunostimulatory DNA sequence oligonucleotides; Nonhuman primate

Indexed keywords

OLIGONUCLEOTIDE;

ALLERGY; ANIMAL MODEL; ARTICLE; ASTHMA; BASEMENT MEMBRANE; CONTROLLED STUDY; CPG ISLAND; DNA SEQUENCE; EOSINOPHIL; IMMUNOSTIMULATION; MAST CELL; MONKEY; MUCOUS CELL; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN MOTIF;

ADMINISTRATION, INHALATION; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTHMA; BASE SEQUENCE; BRONCHI; BRONCHIAL HYPERREACTIVITY; CPG ISLANDS; MACACA MULATTA; MODELS, ANIMAL; OLIGONUCLEOTIDES;

EID: 9644258923     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200404-533OC     Document Type: Article

References (30)

1. Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002;20:197-216.
2. Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol 2001;1:135-145.
3. Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2001;2:947-950.
4. Beutler B, Poltorak A. Sepsis and evolution of the innate immune response. Crit Care Med 2001; 29(Suppl 7):S2-S6; discussion S6-S7.
5. Mutwiri G, Pontarollo R, Babiuk S, Griebel P, van Drunen Littel-van den Hurk S, Mena A, Tsang C, Alcon V, Nichani A, Ioannou X, et al. Biological activity of immunostimulatory CpG DNA motifs in domestic animals. Vet Immunol Immunopathol 2003;91:89-103.
6. Santeliz JV, Van Nest G, Traquina P, Larsen E, Wills-Karp M. Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J Allergy Clin Immunol 2002;109:455-462.
7. Kline JN, Kitagaki K, Businga TR, Jain VV. Treatment of established asthma in a murine model using CpG oligodeoxynucleotides. Am J Physiol Lung Cell Mol Physiol 2002;283:L170-L179.
8. Jain VV, Businga TR, Kitagaki K, George CL, O'Shaughnessy PT, Kline JN. Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure. Am J Physiol Lung Cell Mol Physiol 2003;285:L1137-L1146.
9. Jain VV, Kitagaki K, Businga T, Hussain I, George C, O'Shaughnessy P, Kline JN. CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma. J Allergy Clin Immunol 2002; 110:867-872.
10. Broide D, Schwarze J, Tighe H, Gifford T, Nguyen MD, Malek S, Van Uden J, Martin-Orozco E, Gelfand EW, Raz E. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J Immunol 1998;161:7054-7062.
11. Schelegle ES, Gershwin LJ, Miller LA, Fanucchi MV, Van Winkle LS, Gerriets JP, Walby WF, Omlor AM, Buckpitt AR, Tarkington BK. et al. Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae). Am J Pathol 2001;158:333-341.
12. Fanucchi M, Evans M, Baker G, Miller L, Hyde D, Schelegle E, Raz E, Plopper C. Airways remodeling in young adult rhesus monkeys is inhibited by immunostimulatory DNA sequences (ISS) [abstract]. Keystone Symposia: Regulation of Mucosal Inflammation/Hygiene, Allergy and Asthma. A108. 2003.
13. Fanucchi M, Evans M, Baker G, Miller L, Hyde D, Schelegle E, Raz E, Plopper C. Immunostimulatory DNA sequences (ISS) inhibition of airways remodeling in young adult rhesus monkeys [abstract]. Am J Respir Crit Care Med 2003;167:A7654.
14. Horner AA, Van Uden JH, Zubeldia JM, Broide D, Raz E. DNA-based immunotherapeutics for the treatment of allergic disease. Immunol Rev 2001;179:102-118.
15. Evans MJ, Van Winkle LS, Fanucchi MV, Baker GL, Murphy AE, Nishio SJ, Schelegle ES, Gershwin LJ, Sannes PL, Plopper CG. Fibroblast growth factor-2 in remodeling of the developing basement membrane zone in the trachea of infant rhesus monkeys sensitized and challenged with allergen. Lab Invest 2002;82:1747-1754.
16. Hyde DM, Magliano DJ, Plopper CG. Morphometric assessment of pulmonary toxicity in the rodent lung. Toxicol Pathol 1991;19:428-446.
17. Glantz SA. Primer of Biostatistics, 3rd ed. New York: McGraw-Hill, Inc; 1992.
18. Schelegle ES, Miller LA, Gershwin LJ, Fanucchi MV, Van Winkle LS, Gerriets JE, Walby WF, Mitchell V, Tarkington BK, Wong VJ, et al. Repeated episodes of ozone inhalation amplifies the effects of allergen sensitization and inhalation on airway immune and structural development in Rhesus monkeys. Toxicol Appl Pharmacol 2003;191:74-85.
19. Jeffery PK. The development of large and small airways. Am J Respir Crit Care Med 1998;157:S174-S180.
20. Lieberman P, Calhoun W, Panettieri RA Jr, Peters S, Rennard S. 2003. Airway remodeling in asthma: do histogical changes and functional changes correlate? Medical Crossfire 2002;4(5):34-47.
21. Vignola AM, Mirabella F, Costanzo G, Di Giorgi R, Gjomarkaj M, Bellia V, Bonsignore G. Airway remodeling in asthma. Chest 2003;123 (Suppl 3):417S-422S.
22. Elias JA. Airway remodeling in asthma: unanswered questions. Am J Respir Crit Care Med 2000;161:S168-S171.
23. Busse W, Elias J, Sheppard D, Banks-Schlegel S. Airway remodeling and repair. Am J Respir Crit Care Med 1999;160:1035-1042.
24. Plopper CG, Hyde DM. Epithelial cells of bronchioles. In: Parent RA. editor. Comparative biology of the normal lung. Boca Raton, FL: CRC Press; 1992. pp. 85-92.
25. Tyler WS, Julian MD. Gross and subgross anatomy of the lungs, pleura, connective tissue septa, distal airways, and structural units. In: Parent RA, editor. Comparative biology of the normal lung. Boca Raton, FL: CRC Press; 1992. pp. 37-48.
26. McCamish LE. Architecture of the tracheobronchial tree. In: Parent RA, editor. Comparative biology of the normal lung. Boca Raton, FL: CRC Press; 1992. pp. 49-62.
27. Mariassy A. Epithelial cells of the trachea and bronchi. In: Parent RA, editor. Comparative biology of the normal lung. Boca Raton, FL: CRC Press; 1992. pp. 63-76.
28. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Rodriguez M, Lee SY, McElwain K, McElwain S, Raz E, et al. Immunostimulatory DNA inhibits TGF-β expression and airway remodeling. Am J Respir Cell Mol Biol 2004;30:651-661.
29. Ikeda RK, Nayar J, Cho JY, Miller M, Rodriguez M, Raz E, Broide DH. Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroids. Am J Respir Cell Mol Biol 2003;28:655-663.
30. St. George JA, Wang S. Secretory glycoconjugates of trachea and bronchi. In: Parent RA, editor. Comparative biology of the normal lung. Boca Raton, FL: CRC Press; 1992. pp. 77-83.