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Volumn 26, Issue 4, 2006, Pages 291-305

Regulation of regulatory T cells: Role of dendritic cells and toll-like receptors

Author keywords

IL 6 receptor; T cell suppression; TLR ligands

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 33747034337     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (91)

References (118)
  • 1
    • 0023858264 scopus 로고
    • Do suppressor cells exist?
    • Möller G. Do suppressor cells exist? Scand J Immunol. 1988;27:247-50.
    • (1988) Scand J Immunol , vol.27 , pp. 247-250
    • Möller, G.1
  • 2
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Ithoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155:1151-64.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Ithoh, M.4    Toda, M.5
  • 3
    • 33748862913 scopus 로고
    • Pernis B, Vogel HJ, editors. New York: Academic Press
    • Pernis B, Vogel HJ, editors. Regulatory T lymphocytes. New York: Academic Press; 1980.
    • (1980) Regulatory T Lymphocytes
  • 4
    • 2442484053 scopus 로고    scopus 로고
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004; 22:531-62.
    • (2004) Annu Rev Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 9
    • 16844369607 scopus 로고    scopus 로고
    • Natural regulatory T cells in infectious disease
    • Belkaid Y, Rouse BT. Natural regulatory T cells in infectious disease. Nat Immunol. 2005;6:353-60.
    • (2005) Nat Immunol , vol.6 , pp. 353-360
    • Belkaid, Y.1    Rouse, B.T.2
  • 10
    • 16844365788 scopus 로고    scopus 로고
    • + regulatory T cells in immunological tolerance to self and non-self
    • + regulatory T cells in immunological tolerance to self and non-self. Nat Immunol. 2005;6:345-52.
    • (2005) Nat Immunol , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 14
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol. 2004;5:987-95.
    • (2004) Nat Immunol , vol.5 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 16
    • 16844378209 scopus 로고    scopus 로고
    • Natural regulatory T cells and selftolerance
    • Schwartz RH. Natural regulatory T cells and selftolerance. Nat Immunol. 2005;6:327-30.
    • (2005) Nat Immunol , vol.6 , pp. 327-330
    • Schwartz, R.H.1
  • 17
    • 0037364976 scopus 로고    scopus 로고
    • Regulatory T cells in transplantation tolerance
    • Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol. 2003;3:199-210.
    • (2003) Nat Rev Immunol , vol.3 , pp. 199-210
    • Wood, K.J.1    Sakaguchi, S.2
  • 18
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells
    • Weiner HL. Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells. Immunol Rev. 2001;182:207-14.
    • (2001) Immunol Rev , vol.182 , pp. 207-214
    • Weiner, H.L.1
  • 19
    • 0346996879 scopus 로고    scopus 로고
    • The regulatory T cell family: Distinct subsets and their interrelations
    • Jonuleit H, Schmitt E. The regulatory T cell family: distinct subsets and their interrelations. J Immunol. 2003;171:6323-7.
    • (2003) J Immunol , vol.171 , pp. 6323-6327
    • Jonuleit, H.1    Schmitt, E.2
  • 20
    • 32944473707 scopus 로고    scopus 로고
    • Induced peripheral regulatory T cells: The family grows larger
    • Höglund P. Induced peripheral regulatory T cells: the family grows larger. Eur J Immunol. 2006;36:264-6.
    • (2006) Eur J Immunol , vol.36 , pp. 264-266
    • Höglund, P.1
  • 21
    • 0021997185 scopus 로고
    • Organ-specific autoimmune diseases induced in mice by elimination of T cell subsets. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease
    • Sakaguchi S, Fukuma K, Kuribayashi K, Masuda T. Organ-specific autoimmune diseases induced in mice by elimination of T cell subsets. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J Exp Med. 1985;161:72-87.
    • (1985) J Exp Med , vol.161 , pp. 72-87
    • Sakaguchi, S.1    Fukuma, K.2    Kuribayashi, K.3    Masuda, T.4
  • 24
    • 0036568942 scopus 로고    scopus 로고
    • + regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression
    • + regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J Immunol. 2002;168:4399-405.
    • (2002) J Immunol , vol.168 , pp. 4399-4405
    • Kawahata, K.1    Misaki, Y.2    Yamauchi, M.3    Tsunekawa, S.4    Setoguchi, K.5    Miyazaki, J.6    Yamamoto, K.7
  • 29
    • 16844363097 scopus 로고    scopus 로고
    • A well adapted regulatory contrivance: Regulatory T cell development and the forkhead family transcription factor Foxp3
    • Fontenot JD, Rudensky AY. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol. 2005;6:331-7.
    • (2005) Nat Immunol , vol.6 , pp. 331-337
    • Fontenot, J.D.1    Rudensky, A.Y.2
  • 35
    • 4544241811 scopus 로고    scopus 로고
    • Tolerance, not immunity, crucially depends on IL-2
    • Malek TR, Bayer AL. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol. 2004;4:665-74.
    • (2004) Nat Rev Immunol , vol.4 , pp. 665-674
    • Malek, T.R.1    Bayer, A.L.2
  • 41
    • 17444414236 scopus 로고    scopus 로고
    • GITR: A multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily
    • Nocentini G, Riccardi C. GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily. Eur J Immunol. 2005;35:1016-22.
    • (2005) Eur J Immunol , vol.35 , pp. 1016-1022
    • Nocentini, G.1    Riccardi, C.2
  • 47
    • 0036200757 scopus 로고    scopus 로고
    • CD28 function: A balance of costimulatory and regulatory signals
    • Bour-Jourdan H, Bluestone JA. CD28 function: a balance of costimulatory and regulatory signals. J Clin Immunol. 2002;22:1-7.
    • (2002) J Clin Immunol , vol.22 , pp. 1-7
    • Bour-Jourdan, H.1    Bluestone, J.A.2
  • 53
    • 1342345915 scopus 로고    scopus 로고
    • CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells
    • Zheng Y, Manzotti CN, Liu M, Burke F, Mead KI, Sansom DM. CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells. J Immunol. 2004;172:2778-84.
    • (2004) J Immunol , vol.172 , pp. 2778-2784
    • Zheng, Y.1    Manzotti, C.N.2    Liu, M.3    Burke, F.4    Mead, K.I.5    Sansom, D.M.6
  • 54
    • 11144246359 scopus 로고    scopus 로고
    • Expanding role of T-cell costimulators in regulatory T-cell function: Recent advances in accessory molecules expressed on both regulatory and nonregulatory T cells
    • Ndhlovo LC, Takeda I, Sugamuru K, Ishii N. Expanding role of T-cell costimulators in regulatory T-cell function: recent advances in accessory molecules expressed on both regulatory and nonregulatory T cells. Crit Rev Immunol. 2004;24:251-66.
    • (2004) Crit Rev Immunol , vol.24 , pp. 251-266
    • Ndhlovo, L.C.1    Takeda, I.2    Sugamuru, K.3    Ishii, N.4
  • 58
    • 30444458396 scopus 로고    scopus 로고
    • Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44
    • Firan M, Dhillon S, Estess P, Siegelman MH. Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44. Blood. 2006;107:619-27.
    • (2006) Blood , vol.107 , pp. 619-627
    • Firan, M.1    Dhillon, S.2    Estess, P.3    Siegelman, M.H.4
  • 60
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1057-61.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 62
    • 0035813231 scopus 로고    scopus 로고
    • Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
    • Schubert LA, Jeffery EJ, Zhang Y, Ramsdell F, Ziegler SF. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem. 2001;276:37672-9.
    • (2001) J Biol Chem , vol.276 , pp. 37672-37679
    • Schubert, L.A.1    Jeffery, E.J.2    Zhang, Y.3    Ramsdell, F.4    Ziegler, S.F.5
  • 63
    • 17044393922 scopus 로고    scopus 로고
    • Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells
    • Bettelli E, Dastrange M, Ouka M. Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A. 2005;102:5138-43.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 5138-5143
    • Bettelli, E.1    Dastrange, M.2    Ouka, M.3
  • 68
    • 16844362608 scopus 로고    scopus 로고
    • Mechanisms of suppression by suppressor T cells
    • von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol. 2005;6:338-44.
    • (2005) Nat Immunol , vol.6 , pp. 338-344
    • Von Boehmer, H.1
  • 70
    • 0035801335 scopus 로고    scopus 로고
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor-β
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor-β. J Exp Med. 2001;194:629-44.
    • (2001) J Exp Med , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 72
    • 33645506145 scopus 로고    scopus 로고
    • Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-β
    • Ostroukhova M, Qi Z, Oriss TB, Dixon-McCarthy B, Ray P, Ray A. Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-β. J Clin Invest. 2006;116:996-1004.
    • (2006) J Clin Invest , vol.116 , pp. 996-1004
    • Ostroukhova, M.1    Qi, Z.2    Oriss, T.B.3    Dixon-McCarthy, B.4    Ray, P.5    Ray, A.6
  • 74
    • 5644302161 scopus 로고    scopus 로고
    • Human T regulatory cells can use the perforin pathway to cause autologous target cell death
    • Grossman WJ, Verbsky JW, Barchet W, Colonna M, Atkinson JP, Ley TJ. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity. 2004;21:589-601.
    • (2004) Immunity , vol.21 , pp. 589-601
    • Grossman, W.J.1    Verbsky, J.W.2    Barchet, W.3    Colonna, M.4    Atkinson, J.P.5    Ley, T.J.6
  • 75
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med. 1998;188:287-96.
    • (1998) J Exp Med , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 76
    • 0041806547 scopus 로고    scopus 로고
    • In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro
    • Klein L, Khazaie K, von Boehmer H. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc Natl Acad Sci U S A. 2003;100:8886-91.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8886-8891
    • Klein, L.1    Khazaie, K.2    Von Boehmer, H.3
  • 79
    • 31144464767 scopus 로고    scopus 로고
    • Cutting edge: Deficiency in the E3 ubiquitin ligase cbl-b results in a multifunctional defect in T cell TGF-β sensitivity in vitro and in vivo
    • Wohlfert EA, Gorelik L, Mittler R, Flavell RA, Clark RB. Cutting edge: deficiency in the E3 ubiquitin ligase cbl-b results in a multifunctional defect in T cell TGF-β sensitivity in vitro and in vivo. J Immunol. 2006;176:1316-20.
    • (2006) J Immunol , vol.176 , pp. 1316-1320
    • Wohlfert, E.A.1    Gorelik, L.2    Mittler, R.3    Flavell, R.A.4    Clark, R.B.5
  • 84
    • 0037240852 scopus 로고    scopus 로고
    • Antigenspecific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10
    • Martin E, O'Sullivan B, Low P, Thomas R. Antigenspecific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10. Immunity. 2003;18:155-67.
    • (2003) Immunity , vol.18 , pp. 155-167
    • Martin, E.1    O'Sullivan, B.2    Low, P.3    Thomas, R.4
  • 85
    • 0037987977 scopus 로고    scopus 로고
    • Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo
    • Wakkach A, Fournier N, Brun V, Breittmayer JP, Cottrez F, Groux H. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity. 2003;18:605-17.
    • (2003) Immunity , vol.18 , pp. 605-617
    • Wakkach, A.1    Fournier, N.2    Brun, V.3    Breittmayer, J.P.4    Cottrez, F.5    Groux, H.6
  • 87
    • 29744454134 scopus 로고    scopus 로고
    • Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro
    • Rössner S, Voigtländer C, Wiethe C, Hänig J, Seifarth C, Lutz MB. Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro. Eur J Immunol. 2005;35:3533-44.
    • (2005) Eur J Immunol , vol.35 , pp. 3533-3544
    • Rössner, S.1    Voigtländer, C.2    Wiethe, C.3    Hänig, J.4    Seifarth, C.5    Lutz, M.B.6
  • 88
    • 31544446571 scopus 로고    scopus 로고
    • + immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
    • + immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res. 2006;66:1123-31.
    • (2006) Cancer Res , vol.66 , pp. 1123-1131
    • Huang, B.1    Pan, P.Y.2    Li, Q.3    Sato, A.I.4    Levy, D.E.5    Bromberg, J.6    Divino, C.M.7    Chen, S.H.8
  • 89
    • 32344435015 scopus 로고    scopus 로고
    • The immunoregulatory role of IDO-producing human dendritic cells revisited
    • Terness P, Chuang JJ, Opelz G. The immunoregulatory role of IDO-producing human dendritic cells revisited. Trends Immunol. 2006;27:68-73.
    • (2006) Trends Immunol , vol.27 , pp. 68-73
    • Terness, P.1    Chuang, J.J.2    Opelz, G.3
  • 91
    • 10844252294 scopus 로고    scopus 로고
    • + regulatory cell activation and function by dendritic cells
    • + regulatory cell activation and function by dendritic cells. Int Immunol. 2004;16:1769-80.
    • (2004) Int Immunol , vol.16 , pp. 1769-1780
    • Fehervari, Z.1    Sakaguchi, S.2
  • 94
    • 0037436119 scopus 로고    scopus 로고
    • + T cell-mediated suppression by dendritic cells
    • + T cell-mediated suppression by dendritic cells. Science. 2003;299:1033-6.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 95
    • 0027421831 scopus 로고
    • Interleukin-6 in biology and medicine
    • Akira S, Taga T, Kishimoto T. Interleukin-6 in biology and medicine. Adv Immunol. 1993;54:1-78.
    • (1993) Adv Immunol , vol.54 , pp. 1-78
    • Akira, S.1    Taga, T.2    Kishimoto, T.3
  • 98
    • 1642578987 scopus 로고    scopus 로고
    • IL-6 trans-signaling: The heat is on
    • Rose-John S, Neurath MF. IL-6 trans-signaling: the heat is on. Immunity. 2004;20:2-4.
    • (2004) Immunity , vol.20 , pp. 2-4
    • Rose-John, S.1    Neurath, M.F.2
  • 102
    • 10344233176 scopus 로고    scopus 로고
    • Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells
    • Kubo T, Hatton RD, Oliver J, Liu X, Elson CO, Weaver CT. Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells. J Immunol. 2004;173:7249-58.
    • (2004) J Immunol , vol.173 , pp. 7249-7258
    • Kubo, T.1    Hatton, R.D.2    Oliver, J.3    Liu, X.4    Elson, C.O.5    Weaver, C.T.6
  • 103
    • 2442655250 scopus 로고    scopus 로고
    • Persistent toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance
    • Yang Y, Huang CT, Huang X, Pardoll DM. Persistent toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat Immunol. 2004;5:508-15.
    • (2004) Nat Immunol , vol.5 , pp. 508-515
    • Yang, Y.1    Huang, C.T.2    Huang, X.3    Pardoll, D.M.4
  • 106
    • 0035339861 scopus 로고    scopus 로고
    • Endotoxin-induced maturation of MyD88-deficient dendritic cells
    • Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol. 2001;166:5688-94.
    • (2001) J Immunol , vol.166 , pp. 5688-5694
    • Kaisho, T.1    Takeuchi, O.2    Kawai, T.3    Hoshino, K.4    Akira, S.5
  • 107
    • 8444245925 scopus 로고    scopus 로고
    • Toll-dependent control mechanisms of CD4 T cell activation
    • Pasare C, Medhzitov R. Toll-dependent control mechanisms of CD4 T cell activation. Immunity. 2004;21:733-41.
    • (2004) Immunity , vol.21 , pp. 733-741
    • Pasare, C.1    Medhzitov, R.2
  • 109
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, Endres S, Hartmann G. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol. 2002;168:4531-7.
    • (2002) J Immunol , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 112
    • 31144458579 scopus 로고    scopus 로고
    • Direct costimulatory effect of TLR3 ligand poly(I:C) on human γδ T lymphocytes
    • Wesch D, Beetz S, Oberg HH, Marget M, Krengel K, Kabelitz D. Direct costimulatory effect of TLR3 ligand poly(I:C) on human γδ T lymphocytes. J Immunol. 2006;176:1348-54.
    • (2006) J Immunol , vol.176 , pp. 1348-1354
    • Wesch, D.1    Beetz, S.2    Oberg, H.H.3    Marget, M.4    Krengel, K.5    Kabelitz, D.6
  • 114
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    • Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med. 2003;197:403-11.
    • (2003) J Exp Med , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3    Zelenay, S.4    Haury, M.5    Demengeot, J.6


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