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Volumn 35, Issue 9, 2011, Pages 991-1007

Activation-induced cytidine deaminase structure and functions: A species comparative view

Author keywords

Activation induced cytidine deaminase; AID; Class switch recombination; Evolution; Immunoglobulin; Review; Somatic hypermutation

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 1; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3; CYTIDINE DEAMINASE; HYDROLASE; PROTEIN MDM2; PROTEIN MSH2; PROTEIN P53; SINGLE STRANDED DNA; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR E2A; UNCLASSIFIED DRUG;

EID: 79959560118     PISSN: 0145305X     EISSN: 0145305X     Source Type: Journal    
DOI: 10.1016/j.dci.2011.02.005     Document Type: Review
Times cited : (35)

References (201)
  • 1
    • 0142123328 scopus 로고    scopus 로고
    • Melano-macrophage centres and their role in fish pathology
    • Agius C., Roberts R.J. Melano-macrophage centres and their role in fish pathology. J Fish Dis 2003, 26:499-509.
    • (2003) J Fish Dis , vol.26 , pp. 499-509
    • Agius, C.1    Roberts, R.J.2
  • 2
    • 29344475707 scopus 로고    scopus 로고
    • Diversity and function of adaptive immune receptors in a jawless vertebrate
    • Alder M.N., Rogozin I.B., Iyer L.M., Glazko G.V., Cooper M.D., Pancer Z. Diversity and function of adaptive immune receptors in a jawless vertebrate. Science 2005, 310:1970-1973.
    • (2005) Science , vol.310 , pp. 1970-1973
    • Alder, M.N.1    Rogozin, I.B.2    Iyer, L.M.3    Glazko, G.V.4    Cooper, M.D.5    Pancer, Z.6
  • 3
    • 0029001636 scopus 로고
    • Generation of immunoglobulin light chain gene diversity in Raja erinacea is not associated with somatic rearrangement, an exception to a central paradigm of B cell immunity
    • Anderson M.K., Shamblott M.J., Litman R.T., Litman G.W. Generation of immunoglobulin light chain gene diversity in Raja erinacea is not associated with somatic rearrangement, an exception to a central paradigm of B cell immunity. J Exp Med 1995, 182:109-119.
    • (1995) J Exp Med , vol.182 , pp. 109-119
    • Anderson, M.K.1    Shamblott, M.J.2    Litman, R.T.3    Litman, G.W.4
  • 4
    • 19344367559 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate
    • Arakawa H., Saribasak H., Buerstedde J.M. Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate. PLoS Biol 2004, 2:E179.
    • (2004) PLoS Biol , vol.2
    • Arakawa, H.1    Saribasak, H.2    Buerstedde, J.M.3
  • 5
    • 34547430421 scopus 로고    scopus 로고
    • Immunoglobulin gene conversion and hypermutation assay by FACs
    • Arakawa H. Immunoglobulin gene conversion and hypermutation assay by FACs. Subcell Biochem 2006, 40:351-352.
    • (2006) Subcell Biochem , vol.40 , pp. 351-352
    • Arakawa, H.1
  • 6
    • 0242476502 scopus 로고    scopus 로고
    • Genomic analysis of immunity in a Urochordate and the emergence of the vertebrate immune system: " waiting for Godot"
    • Azumi K., De Santis R., De Tomaso A., Rigoutsos I., Yoshizaki F., Pinto M.R., et al. Genomic analysis of immunity in a Urochordate and the emergence of the vertebrate immune system: " waiting for Godot" Immunogenetics 2003, 55:570-581.
    • (2003) Immunogenetics , vol.55 , pp. 570-581
    • Azumi, K.1    De Santis, R.2    De Tomaso, A.3    Rigoutsos, I.4    Yoshizaki, F.5    Pinto, M.R.6
  • 7
    • 33646269045 scopus 로고    scopus 로고
    • Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines
    • Babbage G., Ottensmeier C.H., Blaydes J., Stevenson F.K., Sahota S.S. Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines. Cancer Res 2006, 66:3996-4000.
    • (2006) Cancer Res , vol.66 , pp. 3996-4000
    • Babbage, G.1    Ottensmeier, C.H.2    Blaydes, J.3    Stevenson, F.K.4    Sahota, S.S.5
  • 8
    • 0032478269 scopus 로고    scopus 로고
    • The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer
    • Bachl J., Olsson C., Chitkara N., Wabl M. The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer. Proc Natl Acad Sci U S A 1998, 95:2396-2399.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 2396-2399
    • Bachl, J.1    Olsson, C.2    Chitkara, N.3    Wabl, M.4
  • 9
    • 1142299546 scopus 로고    scopus 로고
    • Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
    • Bardwell P.D., Woo C.J., Wei K., Li Z., Martin A., Sack S.Z., et al. Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice. Nat Immunol 2004, 5:224-229.
    • (2004) Nat Immunol , vol.5 , pp. 224-229
    • Bardwell, P.D.1    Woo, C.J.2    Wei, K.3    Li, Z.4    Martin, A.5    Sack, S.Z.6
  • 10
    • 0141992113 scopus 로고    scopus 로고
    • C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion
    • Barreto V., Reina-San-Martin B., Ramiro A.R., McBride K.M., Nussenzweig M.C. C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol Cell 2003, 12:501-508.
    • (2003) Mol Cell , vol.12 , pp. 501-508
    • Barreto, V.1    Reina-San-Martin, B.2    Ramiro, A.R.3    McBride, K.M.4    Nussenzweig, M.C.5
  • 12
    • 77950630042 scopus 로고    scopus 로고
    • Molecular characterization of Pleurodeles waltl activation-induced cytidine deaminase
    • Bascove M., Frippiat J.P. Molecular characterization of Pleurodeles waltl activation-induced cytidine deaminase. Mol Immunol 2010, 47:1640-1649.
    • (2010) Mol Immunol , vol.47 , pp. 1640-1649
    • Bascove, M.1    Frippiat, J.P.2
  • 13
    • 28544438261 scopus 로고    scopus 로고
    • The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation
    • Basu U., Chaudhuri J., Alpert C., Dutt S., Ranganath S., Li G., et al. The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature 2005, 438:508-511.
    • (2005) Nature , vol.438 , pp. 508-511
    • Basu, U.1    Chaudhuri, J.2    Alpert, C.3    Dutt, S.4    Ranganath, S.5    Li, G.6
  • 14
    • 53949103770 scopus 로고    scopus 로고
    • Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase
    • Basu U., Wang Y., Alt F.W. Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase. Mol Cell 2008, 32:285-291.
    • (2008) Mol Cell , vol.32 , pp. 285-291
    • Basu, U.1    Wang, Y.2    Alt, F.W.3
  • 15
    • 60049095330 scopus 로고    scopus 로고
    • Post-translational regulation of activation-induced cytidine deaminase
    • Basu U., Franklin A., Alt F.W. Post-translational regulation of activation-induced cytidine deaminase. Philos Trans R Soc Lond B Biol Sci 2009, 364:667-673.
    • (2009) Philos Trans R Soc Lond B Biol Sci , vol.364 , pp. 667-673
    • Basu, U.1    Franklin, A.2    Alt, F.W.3
  • 16
    • 67749104765 scopus 로고    scopus 로고
    • Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation
    • Basu U., Franklin A., Schwer B., Cheng H.L., Chaudhuri J., Alt F.W. Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation. Biochem Soc Trans 2009, 37:561-568.
    • (2009) Biochem Soc Trans , vol.37 , pp. 561-568
    • Basu, U.1    Franklin, A.2    Schwer, B.3    Cheng, H.L.4    Chaudhuri, J.5    Alt, F.W.6
  • 17
    • 0033936658 scopus 로고    scopus 로고
    • Transcriptional enhancers of immunoglobulin light chain genes in Atlantic cod (Gadus morhua)
    • Bengten E., Stromberg S., Daggfeldt A., Magor B.G., Pilstrom L. Transcriptional enhancers of immunoglobulin light chain genes in Atlantic cod (Gadus morhua). Immunogenetics 2000, 51:647-658.
    • (2000) Immunogenetics , vol.51 , pp. 647-658
    • Bengten, E.1    Stromberg, S.2    Daggfeldt, A.3    Magor, B.G.4    Pilstrom, L.5
  • 18
    • 0022386943 scopus 로고
    • Molecular events during maturation of the immune response to oxazolone
    • Berek C., Griffiths G.M., Milstein C. Molecular events during maturation of the immune response to oxazolone. Nature 1985, 316:412-418.
    • (1985) Nature , vol.316 , pp. 412-418
    • Berek, C.1    Griffiths, G.M.2    Milstein, C.3
  • 19
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region
    • Betz A.G., Milstein C., Gonzalez-Fernandez A., Pannell R., Larson T., Neuberger M.S. Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region. Cell 1994, 77:239-248.
    • (1994) Cell , vol.77 , pp. 239-248
    • Betz, A.G.1    Milstein, C.2    Gonzalez-Fernandez, A.3    Pannell, R.4    Larson, T.5    Neuberger, M.S.6
  • 20
    • 77649104794 scopus 로고    scopus 로고
    • Reprogramming towards pluripotency requires AID-dependent DNA demethylation
    • Bhutani N., Brady J.J., Damian M., Sacco A., Corbel S.Y., Blau H.M. Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 2009, 463:1042-1047.
    • (2009) Nature , vol.463 , pp. 1042-1047
    • Bhutani, N.1    Brady, J.J.2    Damian, M.3    Sacco, A.4    Corbel, S.Y.5    Blau, H.M.6
  • 21
    • 59249094658 scopus 로고    scopus 로고
    • A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation
    • Blagodatski A., Batrak V., Schmidl S., Schoetz U., Caldwell R.B., Arakawa H., et al. A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation. PLoS Genet 2009, 5:e1000332.
    • (2009) PLoS Genet , vol.5
    • Blagodatski, A.1    Batrak, V.2    Schmidl, S.3    Schoetz, U.4    Caldwell, R.B.5    Arakawa, H.6
  • 22
    • 0037388165 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
    • Bransteitter R., Pham P., Scharff M.D., Goodman M.F. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A 2003, 100:4102-4107.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4102-4107
    • Bransteitter, R.1    Pham, P.2    Scharff, M.D.3    Goodman, M.F.4
  • 23
    • 2942722486 scopus 로고    scopus 로고
    • Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks
    • Brar S.S., Watson M., Diaz M. Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks. J Biol Chem 2004, 279:26395-26401.
    • (2004) J Biol Chem , vol.279 , pp. 26395-26401
    • Brar, S.S.1    Watson, M.2    Diaz, M.3
  • 24
    • 0036027673 scopus 로고    scopus 로고
    • Antibody-antigen kinetics following immunization of rainbow trout (Oncorhynchus mykiss) with a T-cell dependent antigen
    • Cain K.D., Jones D.R., Raison R.L. Antibody-antigen kinetics following immunization of rainbow trout (Oncorhynchus mykiss) with a T-cell dependent antigen. Dev Comp Immunol 2002, 26:181-190.
    • (2002) Dev Comp Immunol , vol.26 , pp. 181-190
    • Cain, K.D.1    Jones, D.R.2    Raison, R.L.3
  • 26
    • 38449084983 scopus 로고    scopus 로고
    • Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation
    • Chatterji M., Unniraman S., McBride K.M., Schatz D.G. Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation. J Immunol 2007, 179:5274-5280.
    • (2007) J Immunol , vol.179 , pp. 5274-5280
    • Chatterji, M.1    Unniraman, S.2    McBride, K.M.3    Schatz, D.G.4
  • 27
    • 0037452080 scopus 로고    scopus 로고
    • Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    • Chaudhuri J., Tian M., Khuong C., Chua K., Pinaud E., Alt F.W. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 2003, 422:726-730.
    • (2003) Nature , vol.422 , pp. 726-730
    • Chaudhuri, J.1    Tian, M.2    Khuong, C.3    Chua, K.4    Pinaud, E.5    Alt, F.W.6
  • 28
    • 4344700569 scopus 로고    scopus 로고
    • Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
    • Chaudhuri J., Khuong C., Alt F.W. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature 2004, 430:992-998.
    • (2004) Nature , vol.430 , pp. 992-998
    • Chaudhuri, J.1    Khuong, C.2    Alt, F.W.3
  • 29
    • 66649097841 scopus 로고    scopus 로고
    • Characterization of arrangement and expression of the T cell receptor gamma locus in the sandbar shark
    • Chen H., Kshirsagar S., Jensen I., Lau K., Covarrubias R., Schluter S.F., et al. Characterization of arrangement and expression of the T cell receptor gamma locus in the sandbar shark. Proc Natl Acad Sci U S A 2009, 106:8591-8596.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 8591-8596
    • Chen, H.1    Kshirsagar, S.2    Jensen, I.3    Lau, K.4    Covarrubias, R.5    Schluter, S.F.6
  • 30
    • 62449135436 scopus 로고    scopus 로고
    • Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice
    • Cheng H.L., Vuong B.Q., Basu U., Franklin A., Schwer B., Astarita J., et al. Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A 2009, 106:2717-2722.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 2717-2722
    • Cheng, H.L.1    Vuong, B.Q.2    Basu, U.3    Franklin, A.4    Schwer, B.5    Astarita, J.6
  • 31
  • 32
    • 50349093233 scopus 로고    scopus 로고
    • The AID/APOBEC family of nucleic acid mutators
    • Conticello S.G. The AID/APOBEC family of nucleic acid mutators. Genome Biol 2008, 9:229.
    • (2008) Genome Biol , vol.9 , pp. 229
    • Conticello, S.G.1
  • 33
    • 49349112190 scopus 로고    scopus 로고
    • Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1
    • Conticello S.G., Ganesh K., Xue K., Lu M., Rada C., Neuberger M.S. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell 2008, 31:474-484.
    • (2008) Mol Cell , vol.31 , pp. 474-484
    • Conticello, S.G.1    Ganesh, K.2    Xue, K.3    Lu, M.4    Rada, C.5    Neuberger, M.S.6
  • 34
    • 15944388958 scopus 로고    scopus 로고
    • Fish as models for environmental genomics
    • Cossins A.R., Crawford D.L. Fish as models for environmental genomics. Nat Rev Genet 2005, 6:324-333.
    • (2005) Nat Rev Genet , vol.6 , pp. 324-333
    • Cossins, A.R.1    Crawford, D.L.2
  • 36
    • 14944348431 scopus 로고    scopus 로고
    • The immunoglobulin heavy-chain locus in zebrafish: identification and expression of a previously unknown isotype, immunoglobulin Z
    • Danilova N., Bussmann J., Jekosch K., Steiner L.A. The immunoglobulin heavy-chain locus in zebrafish: identification and expression of a previously unknown isotype, immunoglobulin Z. Nat Immunol 2005, 6:295-302.
    • (2005) Nat Immunol , vol.6 , pp. 295-302
    • Danilova, N.1    Bussmann, J.2    Jekosch, K.3    Steiner, L.A.4
  • 37
    • 79151477303 scopus 로고    scopus 로고
    • The zebrafish IgH locus contains multiple transcriptional regulatory regions
    • Danilova N., Saunders H.L., Ellestad K.K., Magor B.G. The zebrafish IgH locus contains multiple transcriptional regulatory regions. Dev Comp Immunol 2010, 35(3):352-359.
    • (2010) Dev Comp Immunol , vol.35 , Issue.3 , pp. 352-359
    • Danilova, N.1    Saunders, H.L.2    Ellestad, K.K.3    Magor, B.G.4
  • 38
  • 39
    • 1542329612 scopus 로고    scopus 로고
    • Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB
    • Dedeoglu F., Horwitz B., Chaudhuri J., Alt F.W., Geha R.S. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol 2004, 16:395-404.
    • (2004) Int Immunol , vol.16 , pp. 395-404
    • Dedeoglu, F.1    Horwitz, B.2    Chaudhuri, J.3    Alt, F.W.4    Geha, R.S.5
  • 40
    • 33846404877 scopus 로고    scopus 로고
    • DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
    • Delbos F., Aoufouchi S., Faili A., Weill J.C., Reynaud C.A. DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse. J Exp Med 2007, 204:17-23.
    • (2007) J Exp Med , vol.204 , pp. 17-23
    • Delbos, F.1    Aoufouchi, S.2    Faili, A.3    Weill, J.C.4    Reynaud, C.A.5
  • 42
    • 0031894290 scopus 로고    scopus 로고
    • Evolution of somatic hypermutation and gene conversion in adaptive immunity
    • Diaz M., Flajnik M.F. Evolution of somatic hypermutation and gene conversion in adaptive immunity. Immunol Rev 1998, 162:13-24.
    • (1998) Immunol Rev , vol.162 , pp. 13-24
    • Diaz, M.1    Flajnik, M.F.2
  • 43
    • 0032564347 scopus 로고    scopus 로고
    • Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers
    • Diaz M., Greenberg A.S., Flajnik M.F. Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers. Proc Natl Acad Sci U S A 1998, 95:14343-14348.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 14343-14348
    • Diaz, M.1    Greenberg, A.S.2    Flajnik, M.F.3
  • 44
    • 0032911308 scopus 로고    scopus 로고
    • Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation
    • Diaz M., Velez J., Singh M., Cerny J., Flajnik M.F. Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation. Int Immunol 1999, 11:825-833.
    • (1999) Int Immunol , vol.11 , pp. 825-833
    • Diaz, M.1    Velez, J.2    Singh, M.3    Cerny, J.4    Flajnik, M.F.5
  • 45
    • 0037561998 scopus 로고    scopus 로고
    • AID mediates hypermutation by deaminating single stranded DNA
    • Dickerson S.K., Market E., Besmer E., Papavasiliou F.N. AID mediates hypermutation by deaminating single stranded DNA. J Exp Med 2003, 197:1291-1296.
    • (2003) J Exp Med , vol.197 , pp. 1291-1296
    • Dickerson, S.K.1    Market, E.2    Besmer, E.3    Papavasiliou, F.N.4
  • 46
    • 62449089909 scopus 로고    scopus 로고
    • The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
    • Doi T., Kato L., Ito S., Shinkura R., Wei M., Nagaoka H., et al. The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination. Proc Natl Acad Sci U S A 2009, 106:2758-2763.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 2758-2763
    • Doi, T.1    Kato, L.2    Ito, S.3    Shinkura, R.4    Wei, M.5    Nagaoka, H.6
  • 47
    • 0042195979 scopus 로고    scopus 로고
    • Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display
    • Dooley H., Flajnik M.F., Porter A.J. Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display. Mol Immunol 2003, 40:25-33.
    • (2003) Mol Immunol , vol.40 , pp. 25-33
    • Dooley, H.1    Flajnik, M.F.2    Porter, A.J.3
  • 48
    • 15844403109 scopus 로고    scopus 로고
    • Shark immunity bites back: affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum
    • Dooley H., Flajnik M.F. Shark immunity bites back: affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum. Eur J Immunol 2005, 35:936-945.
    • (2005) Eur J Immunol , vol.35 , pp. 936-945
    • Dooley, H.1    Flajnik, M.F.2
  • 49
    • 26044449608 scopus 로고    scopus 로고
    • Antibody repertoire development in cartilaginous fish
    • Dooley H., Flajnik M.F. Antibody repertoire development in cartilaginous fish. Dev Comp Immunol 2006, 30:43-56.
    • (2006) Dev Comp Immunol , vol.30 , pp. 43-56
    • Dooley, H.1    Flajnik, M.F.2
  • 50
    • 32444436434 scopus 로고    scopus 로고
    • First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate
    • Dooley H., Stanfield R.L., Brady R.A., Flajnik M.F. First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate. Proc Natl Acad Sci U S A 2006, 103:1846-1851.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1846-1851
    • Dooley, H.1    Stanfield, R.L.2    Brady, R.A.3    Flajnik, M.F.4
  • 51
    • 43049173617 scopus 로고    scopus 로고
    • MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation
    • Dorsett Y., McBride K.M., Jankovic M., Gazumyan A., Thai T.H., Robbiani D.F., et al. MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity 2008, 28:630-638.
    • (2008) Immunity , vol.28 , pp. 630-638
    • Dorsett, Y.1    McBride, K.M.2    Jankovic, M.3    Gazumyan, A.4    Thai, T.H.5    Robbiani, D.F.6
  • 53
    • 33750975915 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase: structure-function relationship as based on the study of mutants
    • Durandy A., Peron S., Taubenheim N., Fischer A. Activation-induced cytidine deaminase: structure-function relationship as based on the study of mutants. Hum Mutat 2006, 27:1185-1191.
    • (2006) Hum Mutat , vol.27 , pp. 1185-1191
    • Durandy, A.1    Peron, S.2    Taubenheim, N.3    Fischer, A.4
  • 54
    • 17844405098 scopus 로고    scopus 로고
    • Evolution of transcriptional enhancers in the immunoglobulin heavy-chain gene: functional characteristics of the zebrafish Emu3' enhancer
    • Ellestad K.K., Magor B.G. Evolution of transcriptional enhancers in the immunoglobulin heavy-chain gene: functional characteristics of the zebrafish Emu3' enhancer. Immunogenetics 2005, 57:129-139.
    • (2005) Immunogenetics , vol.57 , pp. 129-139
    • Ellestad, K.K.1    Magor, B.G.2
  • 55
    • 51249087746 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers
    • 898 e881-883
    • Endo Y., Marusawa H., Kou T., Nakase H., Fujii S., Fujimori T., et al. Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers. Gastroenterology 2008, 135:889-898. 898 e881-883.
    • (2008) Gastroenterology , vol.135 , pp. 889-898
    • Endo, Y.1    Marusawa, H.2    Kou, T.3    Nakase, H.4    Fujii, S.5    Fujimori, T.6
  • 56
    • 77951875791 scopus 로고    scopus 로고
    • Lack of Apobec2-related proteins causes a dystrophic muscle phenotype in zebrafish embryos
    • Etard, C., Roostalu, U., Strähle, U., 2010. Lack of Apobec2-related proteins causes a dystrophic muscle phenotype in zebrafish embryos. J Cell Biol 189, 527-539.
    • (2010) J Cell Biol , vol.189 , pp. 527-539
    • Etard, C.1    Roostalu, U.2    Strähle, U.3
  • 57
    • 41149099048 scopus 로고    scopus 로고
    • DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination
    • Franco S., Murphy M.M., Li G., Borjeson T., Boboila C., Alt F.W. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med 2008, 205:557-564.
    • (2008) J Exp Med , vol.205 , pp. 557-564
    • Franco, S.1    Murphy, M.M.2    Li, G.3    Borjeson, T.4    Boboila, C.5    Alt, F.W.6
  • 58
    • 33646370740 scopus 로고    scopus 로고
    • A/T-targeted somatic hypermutation: critique of the mainstream model
    • Franklin A., Blanden R.V. A/T-targeted somatic hypermutation: critique of the mainstream model. Trends Biochem Sci 2006, 31:252-258.
    • (2006) Trends Biochem Sci , vol.31 , pp. 252-258
    • Franklin, A.1    Blanden, R.V.2
  • 59
    • 0242695060 scopus 로고    scopus 로고
    • The balance between Pax5 and Id2 activities is the key to AID gene expression
    • Gonda H., Sugai M., Nambu Y., Katakai T., Agata Y., Mori K.J., et al. The balance between Pax5 and Id2 activities is the key to AID gene expression. J Exp Med 2003, 198:1427-1437.
    • (2003) J Exp Med , vol.198 , pp. 1427-1437
    • Gonda, H.1    Sugai, M.2    Nambu, Y.3    Katakai, T.4    Agata, Y.5    Mori, K.J.6
  • 60
    • 33744967284 scopus 로고    scopus 로고
    • A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus
    • Gourzi P., Leonova T., Papavasiliou F.N. A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus. Immunity 2006, 24:779-786.
    • (2006) Immunity , vol.24 , pp. 779-786
    • Gourzi, P.1    Leonova, T.2    Papavasiliou, F.N.3
  • 61
    • 0028962371 scopus 로고
    • A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks
    • Greenberg A.S., Avila D., Hughes M., Hughes A., McKinney E.C., Flajnik M.F. A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks. Nature 1995, 374:168-173.
    • (1995) Nature , vol.374 , pp. 168-173
    • Greenberg, A.S.1    Avila, D.2    Hughes, M.3    Hughes, A.4    McKinney, E.C.5    Flajnik, M.F.6
  • 62
    • 0021711720 scopus 로고
    • Somatic mutation and the maturation of immune response to 2-phenyl oxazolone
    • Griffiths G.M., Berek C., Kaartinen M., Milstein C. Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature 1984, 312:271-275.
    • (1984) Nature , vol.312 , pp. 271-275
    • Griffiths, G.M.1    Berek, C.2    Kaartinen, M.3    Milstein, C.4
  • 64
    • 67349128569 scopus 로고    scopus 로고
    • Dual nature of the adaptive immune system in lampreys
    • Guo P., Hirano M., Herrin B.R., Li J., Yu C., Sadlonova A., et al. Dual nature of the adaptive immune system in lampreys. Nature 2009, 459:796-801.
    • (2009) Nature , vol.459 , pp. 796-801
    • Guo, P.1    Hirano, M.2    Herrin, B.R.3    Li, J.4    Yu, C.5    Sadlonova, A.6
  • 65
    • 34447617375 scopus 로고    scopus 로고
    • Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors
    • Han J.H., Akira S., Calame K., Beutler B., Selsing E., Imanishi-Kari T. Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors. Immunity 2007, 27:64-75.
    • (2007) Immunity , vol.27 , pp. 64-75
    • Han, J.H.1    Akira, S.2    Calame, K.3    Beutler, B.4    Selsing, E.5    Imanishi-Kari, T.6
  • 66
    • 77956417669 scopus 로고    scopus 로고
    • Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination
    • Han L., Masani S., Yu K. Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination. J Immunol 2010, 185:1379-1381.
    • (2010) J Immunol , vol.185 , pp. 1379-1381
    • Han, L.1    Masani, S.2    Yu, K.3
  • 67
    • 18744371880 scopus 로고    scopus 로고
    • Discovery of a unique Ig heavy-chain isotype (IgT) in rainbow trout: implications for a distinctive B cell developmental pathway in teleost fish
    • Hansen J.D., Landis E.D., Phillips R.B. Discovery of a unique Ig heavy-chain isotype (IgT) in rainbow trout: implications for a distinctive B cell developmental pathway in teleost fish. Proc Natl Acad Sci U S A 2005, 102:6919-6924.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 6919-6924
    • Hansen, J.D.1    Landis, E.D.2    Phillips, R.B.3
  • 68
    • 77955921194 scopus 로고    scopus 로고
    • Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination
    • Hasham M.G., Donghia N.M., Coffey E., Maynard J., Snow K.J., Ames J., et al. Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination. Nat Immunol 2010, 11(9):820-826.
    • (2010) Nat Immunol , vol.11 , Issue.9 , pp. 820-826
    • Hasham, M.G.1    Donghia, N.M.2    Coffey, E.3    Maynard, J.4    Snow, K.J.5    Ames, J.6
  • 70
    • 6344275305 scopus 로고    scopus 로고
    • Evolution of transcriptional control of the IgH locus: characterization, expression, and function of TF12/HEB homologs of the catfish
    • Hikima J., Cioffi C.C., Middleton D.L., Wilson M.R., Miller N.W., Clem L.W., et al. Evolution of transcriptional control of the IgH locus: characterization, expression, and function of TF12/HEB homologs of the catfish. J Immunol 2004, 173:5476-5484.
    • (2004) J Immunol , vol.173 , pp. 5476-5484
    • Hikima, J.1    Cioffi, C.C.2    Middleton, D.L.3    Wilson, M.R.4    Miller, N.W.5    Clem, L.W.6
  • 71
    • 20144373911 scopus 로고    scopus 로고
    • Regulation of immunoglobulin gene transcription in a teleost fish: identification, expression and functional properties of E2A in the channel catfish
    • Hikima J., Middleton D.L., Wilson M.R., Miller N.W., Clem L.W., Warr G.W. Regulation of immunoglobulin gene transcription in a teleost fish: identification, expression and functional properties of E2A in the channel catfish. Immunogenetics 2005, 57:273-282.
    • (2005) Immunogenetics , vol.57 , pp. 273-282
    • Hikima, J.1    Middleton, D.L.2    Wilson, M.R.3    Miller, N.W.4    Clem, L.W.5    Warr, G.W.6
  • 73
    • 0027198363 scopus 로고
    • Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity
    • Hinds-Frey K.R., Nishikata H., Litman R.T., Litman G.W. Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity. J Exp Med 1993, 178:815-824.
    • (1993) J Exp Med , vol.178 , pp. 815-824
    • Hinds-Frey, K.R.1    Nishikata, H.2    Litman, R.T.3    Litman, G.W.4
  • 74
    • 55549098517 scopus 로고    scopus 로고
    • Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications
    • Holden L.G., Prochnow C., Chang Y.P., Bransteitter R., Chelico L., Sen U., et al. Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Nature 2008, 456:121-124.
    • (2008) Nature , vol.456 , pp. 121-124
    • Holden, L.G.1    Prochnow, C.2    Chang, Y.P.3    Bransteitter, R.4    Chelico, L.5    Sen, U.6
  • 76
  • 77
    • 1242341972 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
    • Ito S., Nagaoka H., Shinkura R., Begum N., Muramatsu M., Nakata M., et al. Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1. Proc Natl Acad Sci U S A 2004, 101:1975-1980.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 1975-1980
    • Ito, S.1    Nagaoka, H.2    Shinkura, R.3    Begum, N.4    Muramatsu, M.5    Nakata, M.6
  • 78
    • 33344468484 scopus 로고    scopus 로고
    • Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice
    • Jansen J.G., Langerak P., Tsaalbi-Shtylik A., van den Berk P., Jacobs H., de Wind N. Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice. J Exp Med 2006, 203:319-323.
    • (2006) J Exp Med , vol.203 , pp. 319-323
    • Jansen, J.G.1    Langerak, P.2    Tsaalbi-Shtylik, A.3    van den Berk, P.4    Jacobs, H.5    de Wind, N.6
  • 79
    • 41149132841 scopus 로고    scopus 로고
    • Fixing DNA breaks during class switch recombination
    • Jolly C.J., Cook A.J., Manis J.P. Fixing DNA breaks during class switch recombination. J Exp Med 2008, 205:509-513.
    • (2008) J Exp Med , vol.205 , pp. 509-513
    • Jolly, C.J.1    Cook, A.J.2    Manis, J.P.3
  • 80
    • 0036027536 scopus 로고    scopus 로고
    • Affinity maturation in trout: clonal dominance of high affinity antibodies late in the immune response
    • Kaattari S.L., Zhang H.L., Khor I.W., Kaattari I.M., Shapiro D.A. Affinity maturation in trout: clonal dominance of high affinity antibodies late in the immune response. Dev Comp Immunol 2002, 26:191-200.
    • (2002) Dev Comp Immunol , vol.26 , pp. 191-200
    • Kaattari, S.L.1    Zhang, H.L.2    Khor, I.W.3    Kaattari, I.M.4    Shapiro, D.A.5
  • 81
    • 42449100278 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase expression in gastric cancer
    • Kim C.J., Song J.H., Cho Y.G., Cao Z., Kim S.Y., Nam S.W., et al. Activation-induced cytidine deaminase expression in gastric cancer. Tumour Biol 2007, 28:333-339.
    • (2007) Tumour Biol , vol.28 , pp. 333-339
    • Kim, C.J.1    Song, J.H.2    Cho, Y.G.3    Cao, Z.4    Kim, S.Y.5    Nam, S.W.6
  • 82
    • 0033859765 scopus 로고    scopus 로고
    • Class switch recombination of the chicken IgH chain genes: implications for the primordial switch region repeats
    • Kitao H., Arakawa H., Kuma K., Yamagishi H., Nakamura N., Furusawa S., et al. Class switch recombination of the chicken IgH chain genes: implications for the primordial switch region repeats. Int Immunol 2000, 12:959-968.
    • (2000) Int Immunol , vol.12 , pp. 959-968
    • Kitao, H.1    Arakawa, H.2    Kuma, K.3    Yamagishi, H.4    Nakamura, N.5    Furusawa, S.6
  • 83
    • 69249137076 scopus 로고    scopus 로고
    • A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase
    • Kohli R.M., Abrams S.R., Gajula K.S., Maul R.W., Gearhart P.J., Stivers J.T. A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase. J Biol Chem 2009, 284:22898-22904.
    • (2009) J Biol Chem , vol.284 , pp. 22898-22904
    • Kohli, R.M.1    Abrams, S.R.2    Gajula, K.S.3    Maul, R.W.4    Gearhart, P.J.5    Stivers, J.T.6
  • 84
    • 42149132725 scopus 로고    scopus 로고
    • Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus
    • Kothapalli N., Norton D.D., Fugmann S.D. Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus. J Immunol 2008, 180:2019-2023.
    • (2008) J Immunol , vol.180 , pp. 2019-2023
    • Kothapalli, N.1    Norton, D.D.2    Fugmann, S.D.3
  • 85
    • 33845703967 scopus 로고    scopus 로고
    • Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis
    • Kou T., Marusawa H., Kinoshita K., Endo Y., Okazaki I.M., Ueda Y., et al. Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis. Int J Cancer 2007, 120:469-476.
    • (2007) Int J Cancer , vol.120 , pp. 469-476
    • Kou, T.1    Marusawa, H.2    Kinoshita, K.3    Endo, Y.4    Okazaki, I.M.5    Ueda, Y.6
  • 86
    • 34547797940 scopus 로고    scopus 로고
    • A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification
    • Langerak P., Nygren A.O., Krijger P.H., van den Berk P.C., Jacobs H. A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification. J Exp Med 2007, 204:1989-1998.
    • (2007) J Exp Med , vol.204 , pp. 1989-1998
    • Langerak, P.1    Nygren, A.O.2    Krijger, P.H.3    van den Berk, P.C.4    Jacobs, H.5
  • 88
    • 0028085932 scopus 로고
    • Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene
    • Lau P.P., Zhu H.J., Baldini A., Charnsangavej C., Chan L. Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene. Proc Natl Acad Sci U S A 1994, 91:8522-8526.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8522-8526
    • Lau, P.P.1    Zhu, H.J.2    Baldini, A.3    Charnsangavej, C.4    Chan, L.5
  • 89
    • 0000590741 scopus 로고
    • Genes and antibodies
    • Lederberg J. Genes and antibodies. Science 1959, 129:1649-1653.
    • (1959) Science , vol.129 , pp. 1649-1653
    • Lederberg, J.1
  • 91
    • 0036224829 scopus 로고    scopus 로고
    • Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions
    • Lee S.S., Tranchina D., Ohta Y., Flajnik M.F., Hsu E. Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions. Immunity 2002, 16:571-582.
    • (2002) Immunity , vol.16 , pp. 571-582
    • Lee, S.S.1    Tranchina, D.2    Ohta, Y.3    Flajnik, M.F.4    Hsu, E.5
  • 92
    • 33646015672 scopus 로고    scopus 로고
    • The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus
    • Li Z., Zhao C., Iglesias-Ussel M.D., Polonskaya Z., Zhuang M., Yang G., et al. The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus. Immunity 2006, 24:393-403.
    • (2006) Immunity , vol.24 , pp. 393-403
    • Li, Z.1    Zhao, C.2    Iglesias-Ussel, M.D.3    Polonskaya, Z.4    Zhuang, M.5    Yang, G.6
  • 93
    • 39149099085 scopus 로고    scopus 로고
    • Two levels of protection for the B cell genome during somatic hypermutation
    • Liu M., Duke J.L., Richter D.J., Vinuesa C.G., Goodnow C.C., Kleinstein S.H., et al. Two levels of protection for the B cell genome during somatic hypermutation. Nature 2008, 451:841-845.
    • (2008) Nature , vol.451 , pp. 841-845
    • Liu, M.1    Duke, J.L.2    Richter, D.J.3    Vinuesa, C.G.4    Goodnow, C.C.5    Kleinstein, S.H.6
  • 94
    • 36048978959 scopus 로고    scopus 로고
    • Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination
    • Longerich S., Meira L., Shah D., Samson L.D., Storb U. Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination. DNA Repair (Amst) 2007, 6:1764-1773.
    • (2007) DNA Repair (Amst) , vol.6 , pp. 1764-1773
    • Longerich, S.1    Meira, L.2    Shah, D.3    Samson, L.D.4    Storb, U.5
  • 96
    • 30344472683 scopus 로고    scopus 로고
    • MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells
    • MacDuff D.A., Neuberger M.S., Harris R.S. MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells. Mol Immunol 2006, 43:1099-1108.
    • (2006) Mol Immunol , vol.43 , pp. 1099-1108
    • MacDuff, D.A.1    Neuberger, M.S.2    Harris, R.S.3
  • 97
    • 64549103299 scopus 로고    scopus 로고
    • AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity
    • MacDuff D.A., Demorest Z.L., Harris R.S. AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity. Nucleic Acids Res 2009, 37:1854-1867.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1854-1867
    • MacDuff, D.A.1    Demorest, Z.L.2    Harris, R.S.3
  • 98
    • 0030753254 scopus 로고    scopus 로고
    • Functional motifs in the IgH enhancer of the channel catfish
    • Magor B.G., Ross D.A., Middleton D.L., Warr G.W. Functional motifs in the IgH enhancer of the channel catfish. Immunogenetics 1997, 46:192-198.
    • (1997) Immunogenetics , vol.46 , pp. 192-198
    • Magor, B.G.1    Ross, D.A.2    Middleton, D.L.3    Warr, G.W.4
  • 99
    • 0033051152 scopus 로고    scopus 로고
    • Transcriptional enhancers and the evolution of the IgH locus
    • Magor B.G., Ross D.A., Pilstrom L., Warr G.W. Transcriptional enhancers and the evolution of the IgH locus. Immunol Today 1999, 20:13-17.
    • (1999) Immunol Today , vol.20 , pp. 13-17
    • Magor, B.G.1    Ross, D.A.2    Pilstrom, L.3    Warr, G.W.4
  • 100
    • 0028625614 scopus 로고
    • CDNA sequence and organization of the immunoglobulin light chain gene of the duck, Anas platyrhynchos
    • Magor K.E., Higgins D.A., Middleton D.L., Warr G.W. cDNA sequence and organization of the immunoglobulin light chain gene of the duck, Anas platyrhynchos. Dev Comp Immunol 1994, 18:523-531.
    • (1994) Dev Comp Immunol , vol.18 , pp. 523-531
    • Magor, K.E.1    Higgins, D.A.2    Middleton, D.L.3    Warr, G.W.4
  • 101
    • 29144433461 scopus 로고    scopus 로고
    • Somatic hypermutation and junctional diversification at Ig heavy chain loci in the nurse shark
    • Malecek K., Brandman J., Brodsky J.E., Ohta Y., Flajnik M.F., Hsu E. Somatic hypermutation and junctional diversification at Ig heavy chain loci in the nurse shark. J Immunol 2005, 175:8105-8115.
    • (2005) J Immunol , vol.175 , pp. 8105-8115
    • Malecek, K.1    Brandman, J.2    Brodsky, J.E.3    Ohta, Y.4    Flajnik, M.F.5    Hsu, E.6
  • 102
    • 78650944304 scopus 로고    scopus 로고
    • Targets of somatic hypermutation within immunoglobulin light chain genes in zebrafish
    • Marianes A.E., Zimmerman A.M. Targets of somatic hypermutation within immunoglobulin light chain genes in zebrafish. Immunology 2010, 132(2):240-255.
    • (2010) Immunology , vol.132 , Issue.2 , pp. 240-255
    • Marianes, A.E.1    Zimmerman, A.M.2
  • 103
    • 38449122068 scopus 로고    scopus 로고
    • Localization and differential expression of activation-induced cytidine deaminase in the amphibian Xenopus upon antigen stimulation and during early development
    • Marr S., Morales H., Bottaro A., Cooper M., Flajnik M., Robert J. Localization and differential expression of activation-induced cytidine deaminase in the amphibian Xenopus upon antigen stimulation and during early development. J Immunol 2007, 179:6783-6789.
    • (2007) J Immunol , vol.179 , pp. 6783-6789
    • Marr, S.1    Morales, H.2    Bottaro, A.3    Cooper, M.4    Flajnik, M.5    Robert, J.6
  • 104
    • 3142663166 scopus 로고    scopus 로고
    • A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination
    • Martomo S.A., Yang W.W., Gearhart P.J. A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination. J Exp Med 2004, 200:61-68.
    • (2004) J Exp Med , vol.200 , pp. 61-68
    • Martomo, S.A.1    Yang, W.W.2    Gearhart, P.J.3
  • 105
    • 20844452399 scopus 로고    scopus 로고
    • Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification
    • Martomo S.A., Yang W.W., Wersto R.P., Ohkumo T., Kondo Y., Yokoi M., et al. Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification. Proc Natl Acad Sci U S A 2005, 102:8656-8661.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 8656-8661
    • Martomo, S.A.1    Yang, W.W.2    Wersto, R.P.3    Ohkumo, T.4    Kondo, Y.5    Yokoi, M.6
  • 107
    • 34147180434 scopus 로고    scopus 로고
    • Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
    • Matsumoto Y., Marusawa H., Kinoshita K., Endo Y., Kou T., Morisawa T., et al. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med 2007, 13:470-476.
    • (2007) Nat Med , vol.13 , pp. 470-476
    • Matsumoto, Y.1    Marusawa, H.2    Kinoshita, K.3    Endo, Y.4    Kou, T.5    Morisawa, T.6
  • 108
    • 20444427642 scopus 로고    scopus 로고
    • DNA polymerase eta contributes to strand bias of mutations of A versus T in immunoglobulin genes
    • Mayorov V.I., Rogozin I.B., Adkison L.R., Gearhart P.J. DNA polymerase eta contributes to strand bias of mutations of A versus T in immunoglobulin genes. J Immunol 2005, 174:7781-7786.
    • (2005) J Immunol , vol.174 , pp. 7781-7786
    • Mayorov, V.I.1    Rogozin, I.B.2    Adkison, L.R.3    Gearhart, P.J.4
  • 109
    • 2442474264 scopus 로고    scopus 로고
    • Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase
    • McBride K.M., Barreto V., Ramiro A.R., Stavropoulos P., Nussenzweig M.C. Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. J Exp Med 2004, 199:1235-1244.
    • (2004) J Exp Med , vol.199 , pp. 1235-1244
    • McBride, K.M.1    Barreto, V.2    Ramiro, A.R.3    Stavropoulos, P.4    Nussenzweig, M.C.5
  • 112
    • 0036169650 scopus 로고    scopus 로고
    • Effects of sequence and structure on the hypermutability of immunoglobulin genes
    • Michael N., Martin T.E., Nicolae D., Kim N., Padjen K., Zhan P., et al. Effects of sequence and structure on the hypermutability of immunoglobulin genes. Immunity 2002, 16:123-134.
    • (2002) Immunity , vol.16 , pp. 123-134
    • Michael, N.1    Martin, T.E.2    Nicolae, D.3    Kim, N.4    Padjen, K.5    Zhan, P.6
  • 113
    • 0041931059 scopus 로고    scopus 로고
    • The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription
    • Michael N., Shen H.M., Longerich S., Kim N., Longacre A., Storb U. The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. Immunity 2003, 19:235-242.
    • (2003) Immunity , vol.19 , pp. 235-242
    • Michael, N.1    Shen, H.M.2    Longerich, S.3    Kim, N.4    Longacre, A.5    Storb, U.6
  • 114
    • 10644282845 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming
    • Morgan H.D., Dean W., Coker H.A., Reik W., Petersen-Mahrt S.K. Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. J Biol Chem 2004, 279:52353-52360.
    • (2004) J Biol Chem , vol.279 , pp. 52353-52360
    • Morgan, H.D.1    Dean, W.2    Coker, H.A.3    Reik, W.4    Petersen-Mahrt, S.K.5
  • 115
    • 0033603340 scopus 로고    scopus 로고
    • Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
    • Muramatsu M., Sankaranand V.S., Anant S., Sugai M., Kinoshita K., Davidson N.O., et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem 1999, 274:18470-18476.
    • (1999) J Biol Chem , vol.274 , pp. 18470-18476
    • Muramatsu, M.1    Sankaranand, V.S.2    Anant, S.3    Sugai, M.4    Kinoshita, K.5    Davidson, N.O.6
  • 116
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000, 102:553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 117
    • 1842298136 scopus 로고    scopus 로고
    • Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals
    • Mussmann R., Courtet M., Schwager J., Du Pasquier L. Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals. Eur J Immunol 1997, 27:2610-2619.
    • (1997) Eur J Immunol , vol.27 , pp. 2610-2619
    • Mussmann, R.1    Courtet, M.2    Schwager, J.3    Du Pasquier, L.4
  • 118
    • 0034662773 scopus 로고    scopus 로고
    • Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene
    • Muto T., Muramatsu M., Taniwaki M., Kinoshita K., Honjo T. Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene. Genomics 2000, 68:85-88.
    • (2000) Genomics , vol.68 , pp. 85-88
    • Muto, T.1    Muramatsu, M.2    Taniwaki, M.3    Kinoshita, K.4    Honjo, T.5
  • 120
    • 33846481302 scopus 로고    scopus 로고
    • Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice
    • Nagawa F., Kishishita N., Shimizu K., Hirose S., Miyoshi M., Nezu J., et al. Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice. Nat Immunol 2007, 8:206-213.
    • (2007) Nat Immunol , vol.8 , pp. 206-213
    • Nagawa, F.1    Kishishita, N.2    Shimizu, K.3    Hirose, S.4    Miyoshi, M.5    Nezu, J.6
  • 122
    • 39749182247 scopus 로고    scopus 로고
    • Antibody diversification by somatic mutation: from Burnet onwards
    • Neuberger M.S. Antibody diversification by somatic mutation: from Burnet onwards. Immunol Cell Biol 2008, 86:124-132.
    • (2008) Immunol Cell Biol , vol.86 , pp. 124-132
    • Neuberger, M.S.1
  • 123
    • 3142616423 scopus 로고    scopus 로고
    • Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey
    • Pancer Z., Amemiya C.T., Ehrhardt G.R., Ceitlin J., Gartland G.L., Cooper M.D. Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey. Nature 2004, 430:174-180.
    • (2004) Nature , vol.430 , pp. 174-180
    • Pancer, Z.1    Amemiya, C.T.2    Ehrhardt, G.R.3    Ceitlin, J.4    Gartland, G.L.5    Cooper, M.D.6
  • 125
    • 0036234455 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity
    • Papavasiliou F.N., Schatz D.G. Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity. Cell 2002, 109(Suppl):S35-44.
    • (2002) Cell , vol.109 , Issue.SUPPL
    • Papavasiliou, F.N.1    Schatz, D.G.2
  • 126
    • 67349090990 scopus 로고    scopus 로고
    • HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation
    • Park S.R., Zan H., Pal Z., Zhang J., Al-Qahtani A., Pone E.J., et al. HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Nat Immunol 2009, 10:540-550.
    • (2009) Nat Immunol , vol.10 , pp. 540-550
    • Park, S.R.1    Zan, H.2    Pal, Z.3    Zhang, J.4    Al-Qahtani, A.5    Pone, E.J.6
  • 127
    • 31044435055 scopus 로고    scopus 로고
    • PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells
    • Pasqualucci L., Kitaura Y., Gu H., Dalla-Favera R. PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. Proc Natl Acad Sci U S A 2006, 103:395-400.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 395-400
    • Pasqualucci, L.1    Kitaura, Y.2    Gu, H.3    Dalla-Favera, R.4
  • 129
    • 67849106509 scopus 로고    scopus 로고
    • Alternative induction of meiotic recombination from single-base lesions of DNA deaminases
    • Pauklin S., Burkert J.S., Martin J., Osman F., Weller S., Boulton S.J., et al. Alternative induction of meiotic recombination from single-base lesions of DNA deaminases. Genetics 2009, 182:41-54.
    • (2009) Genetics , vol.182 , pp. 41-54
    • Pauklin, S.1    Burkert, J.S.2    Martin, J.3    Osman, F.4    Weller, S.5    Boulton, S.J.6
  • 130
    • 70249142555 scopus 로고    scopus 로고
    • Progesterone inhibits activation-induced deaminase by binding to the promoter
    • Pauklin S., Petersen-Mahrt S.K. Progesterone inhibits activation-induced deaminase by binding to the promoter. J Immunol 2009, 183:1238-1244.
    • (2009) J Immunol , vol.183 , pp. 1238-1244
    • Pauklin, S.1    Petersen-Mahrt, S.K.2
  • 132
    • 0037162552 scopus 로고    scopus 로고
    • Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene
    • Pavlov Y.I., Rogozin I.B., Galkin A.P., Aksenova A.Y., Hanaoka F., Rada C., et al. Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene. Proc Natl Acad Sci U S A 2002, 99:9954-9959.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 9954-9959
    • Pavlov, Y.I.1    Rogozin, I.B.2    Galkin, A.P.3    Aksenova, A.Y.4    Hanaoka, F.5    Rada, C.6
  • 133
    • 77957239251 scopus 로고    scopus 로고
    • Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5
    • Pavri R., Gazumyan A., Jankovic M., Di Virgilio M., Klein I., Ansarah-Sobrinho C., et al. Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5. Cell 2010, 143:122-133.
    • (2010) Cell , vol.143 , pp. 122-133
    • Pavri, R.1    Gazumyan, A.2    Jankovic, M.3    Di Virgilio, M.4    Klein, I.5    Ansarah-Sobrinho, C.6
  • 134
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
    • Petersen-Mahrt S.K., Harris R.S., Neuberger M.S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 2002, 418:99-103.
    • (2002) Nature , vol.418 , pp. 99-103
    • Petersen-Mahrt, S.K.1    Harris, R.S.2    Neuberger, M.S.3
  • 135
    • 0037926476 scopus 로고    scopus 로고
    • Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
    • Pham P., Bransteitter R., Petruska J., Goodman M.F. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 2003, 424:103-107.
    • (2003) Nature , vol.424 , pp. 103-107
    • Pham, P.1    Bransteitter, R.2    Petruska, J.3    Goodman, M.F.4
  • 136
    • 47749085064 scopus 로고    scopus 로고
    • Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase
    • Pham P., Smolka M.B., Calabrese P., Landolph A., Zhang K., Zhou H., et al. Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase. J Biol Chem 2008, 283:17428-17439.
    • (2008) J Biol Chem , vol.283 , pp. 17428-17439
    • Pham, P.1    Smolka, M.B.2    Calabrese, P.3    Landolph, A.4    Zhang, K.5    Zhou, H.6
  • 137
    • 0032101611 scopus 로고    scopus 로고
    • Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
    • Phung Q.H., Winter D.B., Cranston A., Tarone R.E., Bohr V.A., Fishel R., et al. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J Exp Med 1998, 187:1745-1751.
    • (1998) J Exp Med , vol.187 , pp. 1745-1751
    • Phung, Q.H.1    Winter, D.B.2    Cranston, A.3    Tarone, R.E.4    Bohr, V.A.5    Fishel, R.6
  • 138
    • 0033558532 scopus 로고    scopus 로고
    • Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein
    • Phung Q.H., Winter D.B., Alrefai R., Gearhart P.J. Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein. J Immunol 1999, 162:3121-3124.
    • (1999) J Immunol , vol.162 , pp. 3121-3124
    • Phung, Q.H.1    Winter, D.B.2    Alrefai, R.3    Gearhart, P.J.4
  • 139
    • 77249148019 scopus 로고    scopus 로고
    • Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency
    • Popp C., Dean W., Feng S., Cokus S.J., Andrews S., Pellegrini M., et al. Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature 2010, 463:1101-1105.
    • (2010) Nature , vol.463 , pp. 1101-1105
    • Popp, C.1    Dean, W.2    Feng, S.3    Cokus, S.J.4    Andrews, S.5    Pellegrini, M.6
  • 140
    • 33846555779 scopus 로고    scopus 로고
    • The APOBEC-2 crystal structure and functional implications for the deaminase AID
    • Prochnow C., Bransteitter R., Klein M.G., Goodman M.F., Chen X.S. The APOBEC-2 crystal structure and functional implications for the deaminase AID. Nature 2007, 445:447-451.
    • (2007) Nature , vol.445 , pp. 447-451
    • Prochnow, C.1    Bransteitter, R.2    Klein, M.G.3    Goodman, M.F.4    Chen, X.S.5
  • 141
    • 0032127804 scopus 로고    scopus 로고
    • Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
    • Rada C., Ehrenstein M.R., Neuberger M.S., Milstein C. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 1998, 9:135-141.
    • (1998) Immunity , vol.9 , pp. 135-141
    • Rada, C.1    Ehrenstein, M.R.2    Neuberger, M.S.3    Milstein, C.4
  • 142
    • 0037076208 scopus 로고    scopus 로고
    • AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization
    • Rada C., Jarvis J.M., Milstein C. AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization. Proc Natl Acad Sci U S A 2002, 99:7003-7008.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 7003-7008
    • Rada, C.1    Jarvis, J.M.2    Milstein, C.3
  • 143
    • 6344256944 scopus 로고    scopus 로고
    • Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
    • Rada C., Di Noia J.M., Neuberger M.S. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol Cell 2004, 16:163-171.
    • (2004) Mol Cell , vol.16 , pp. 163-171
    • Rada, C.1    Di Noia, J.M.2    Neuberger, M.S.3
  • 144
    • 57649196594 scopus 로고    scopus 로고
    • DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45
    • Rai K., Huggins I.J., James S.R., Karpf A.R., Jones D.A., Cairns B.R. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell 2008, 135:1201-1212.
    • (2008) Cell , vol.135 , pp. 1201-1212
    • Rai, K.1    Huggins, I.J.2    James, S.R.3    Karpf, A.R.4    Jones, D.A.5    Cairns, B.R.6
  • 145
    • 0038293484 scopus 로고    scopus 로고
    • Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
    • Ramiro A.R., Stavropoulos P., Jankovic M., Nussenzweig M.C. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat Immunol 2003, 4:452-456.
    • (2003) Nat Immunol , vol.4 , pp. 452-456
    • Ramiro, A.R.1    Stavropoulos, P.2    Jankovic, M.3    Nussenzweig, M.C.4
  • 147
    • 55849092898 scopus 로고    scopus 로고
    • Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression
    • Roa S., Avdievich E., Peled J.U., Maccarthy T., Werling U., Kuang F.L., et al. Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. Proc Natl Acad Sci U S A 2008, 105:16248-16253.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 16248-16253
    • Roa, S.1    Avdievich, E.2    Peled, J.U.3    Maccarthy, T.4    Werling, U.5    Kuang, F.L.6
  • 148
    • 77956218910 scopus 로고    scopus 로고
    • MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites
    • Roa S., Li Z., Peled J.U., Zhao C., Edelmann W., Scharff M.D. MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites. PLoS One 2010, 5:e11182.
    • (2010) PLoS One , vol.5
    • Roa, S.1    Li, Z.2    Peled, J.U.3    Zhao, C.4    Edelmann, W.5    Scharff, M.D.6
  • 149
    • 1542619234 scopus 로고    scopus 로고
    • Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process
    • Rogozin I.B., Diaz M. Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process. J Immunol 2004, 172:3382-3384.
    • (2004) J Immunol , vol.172 , pp. 3382-3384
    • Rogozin, I.B.1    Diaz, M.2
  • 150
    • 34249065874 scopus 로고    scopus 로고
    • Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase
    • Rogozin I.B., Iyer L.M., Liang L., Glazko G.V., Liston V.G., Pavlov Y.I., et al. Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase. Nat Immunol 2007, 8:647-656.
    • (2007) Nat Immunol , vol.8 , pp. 647-656
    • Rogozin, I.B.1    Iyer, L.M.2    Liang, L.3    Glazko, G.V.4    Liston, V.G.5    Pavlov, Y.I.6
  • 151
    • 0032435650 scopus 로고    scopus 로고
    • TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
    • Sale J.E., Neuberger M.S. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity 1998, 9:859-869.
    • (1998) Immunity , vol.9 , pp. 859-869
    • Sale, J.E.1    Neuberger, M.S.2
  • 153
    • 1642334586 scopus 로고    scopus 로고
    • Cloning and expression of the AID gene in the channel catfish
    • Saunders H.L., Magor B.G. Cloning and expression of the AID gene in the channel catfish. Dev Comp Immunol 2004, 28:657-663.
    • (2004) Dev Comp Immunol , vol.28 , pp. 657-663
    • Saunders, H.L.1    Magor, B.G.2
  • 154
  • 155
    • 27944452203 scopus 로고    scopus 로고
    • Discovery of a new class of immunoglobulin heavy chain from fugu
    • Savan R., Aman A., Sato K., Yamaguchi R., Sakai M. Discovery of a new class of immunoglobulin heavy chain from fugu. Eur J Immunol 2005, 35:3320-3331.
    • (2005) Eur J Immunol , vol.35 , pp. 3320-3331
    • Savan, R.1    Aman, A.2    Sato, K.3    Yamaguchi, R.4    Sakai, M.5
  • 156
    • 0038515309 scopus 로고    scopus 로고
    • E-proteins directly regulate expression of activation-induced deaminase in mature B cells
    • Sayegh C.E., Quong M.W., Agata Y., Murre C. E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nat Immunol 2003, 4:586-593.
    • (2003) Nat Immunol , vol.4 , pp. 586-593
    • Sayegh, C.E.1    Quong, M.W.2    Agata, Y.3    Murre, C.4
  • 158
    • 33747876747 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) is expressed in normal spermatogenesis but only infrequently in testicular germ cell tumours
    • Schreck S., Buettner M., Kremmer E., Bogdan M., Herbst H., Niedobitek G. Activation-induced cytidine deaminase (AID) is expressed in normal spermatogenesis but only infrequently in testicular germ cell tumours. J Pathol 2006, 210:26-31.
    • (2006) J Pathol , vol.210 , pp. 26-31
    • Schreck, S.1    Buettner, M.2    Kremmer, E.3    Bogdan, M.4    Herbst, H.5    Niedobitek, G.6
  • 159
    • 0030070295 scopus 로고    scopus 로고
    • Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis
    • Schroder A.E., Greiner A., Seyfert C., Berek C. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci U S A 1996, 93:221-225.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 221-225
    • Schroder, A.E.1    Greiner, A.2    Seyfert, C.3    Berek, C.4
  • 160
    • 57749181557 scopus 로고    scopus 로고
    • Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo
    • Sernandez I.V., de Yebenes V.G., Dorsett Y., Ramiro A.R. Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo. PLoS One 2008, 3:e3927.
    • (2008) PLoS One , vol.3
    • Sernandez, I.V.1    de Yebenes, V.G.2    Dorsett, Y.3    Ramiro, A.R.4
  • 161
    • 78650303776 scopus 로고    scopus 로고
    • Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo
    • Sharbeen G., Cook A.J., Lau K.K., Raftery J., Yee C.W., Jolly C.J. Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo. Nucleic Acids Res 2010, 38(22):8120-8130.
    • (2010) Nucleic Acids Res , vol.38 , Issue.22 , pp. 8120-8130
    • Sharbeen, G.1    Cook, A.J.2    Lau, K.K.3    Raftery, J.4    Yee, C.W.5    Jolly, C.J.6
  • 162
    • 3242795967 scopus 로고    scopus 로고
    • Separate domains of AID are required for somatic hypermutation and class-switch recombination
    • Shinkura R., Ito S., Begum N.A., Nagaoka H., Muramatsu M., Kinoshita K., et al. Separate domains of AID are required for somatic hypermutation and class-switch recombination. Nat Immunol 2004, 5:707-712.
    • (2004) Nat Immunol , vol.5 , pp. 707-712
    • Shinkura, R.1    Ito, S.2    Begum, N.A.3    Nagaoka, H.4    Muramatsu, M.5    Kinoshita, K.6
  • 163
    • 0037901850 scopus 로고    scopus 로고
    • Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations
    • Sohail A., Klapacz J., Samaranayake M., Ullah A., Bhagwat A.S. Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. Nucleic Acids Res 2003, 31:2990-2994.
    • (2003) Nucleic Acids Res , vol.31 , pp. 2990-2994
    • Sohail, A.1    Klapacz, J.2    Samaranayake, M.3    Ullah, A.4    Bhagwat, A.S.5
  • 164
    • 4544250973 scopus 로고    scopus 로고
    • Crystal structure of a shark single-domain antibody V region in complex with lysozyme
    • Stanfield R.L., Dooley H., Flajnik M.F., Wilson I.A. Crystal structure of a shark single-domain antibody V region in complex with lysozyme. Science 2004, 305:1770-1773.
    • (2004) Science , vol.305 , pp. 1770-1773
    • Stanfield, R.L.1    Dooley, H.2    Flajnik, M.F.3    Wilson, I.A.4
  • 165
    • 33847103076 scopus 로고    scopus 로고
    • Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
    • Stanfield R.L., Dooley H., Verdino P., Flajnik M.F., Wilson I.A. Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding. J Mol Biol 2007, 367:358-372.
    • (2007) J Mol Biol , vol.367 , pp. 358-372
    • Stanfield, R.L.1    Dooley, H.2    Verdino, P.3    Flajnik, M.F.4    Wilson, I.A.5
  • 166
    • 7444271524 scopus 로고    scopus 로고
    • Evolution of isotype switching
    • Stavnezer J., Amemiya C.T. Evolution of isotype switching. Semin Immunol 2004, 16:257-275.
    • (2004) Semin Immunol , vol.16 , pp. 257-275
    • Stavnezer, J.1    Amemiya, C.T.2
  • 167
    • 42649123314 scopus 로고    scopus 로고
    • Mechanism and regulation of class switch recombination
    • Stavnezer J., Guikema J.E., Schrader C.E. Mechanism and regulation of class switch recombination. Annu Rev Immunol 2008, 26:261-292.
    • (2008) Annu Rev Immunol , vol.26 , pp. 261-292
    • Stavnezer, J.1    Guikema, J.E.2    Schrader, C.E.3
  • 168
    • 0023267995 scopus 로고
    • Hypothesis: somatic hypermutation by gene conversion via the error prone DNA-RNA-DNA information loop
    • Steele E.J., Pollard J.W. Hypothesis: somatic hypermutation by gene conversion via the error prone DNA-RNA-DNA information loop. Mol Immunol 1987, 24:667-673.
    • (1987) Mol Immunol , vol.24 , pp. 667-673
    • Steele, E.J.1    Pollard, J.W.2
  • 169
    • 57849133053 scopus 로고    scopus 로고
    • Mechanism of somatic hypermutation: critical analysis of strand biased mutation signatures at A:T and G:C base pairs
    • Steele E.J. Mechanism of somatic hypermutation: critical analysis of strand biased mutation signatures at A:T and G:C base pairs. Mol Immunol 2009, 46:305-320.
    • (2009) Mol Immunol , vol.46 , pp. 305-320
    • Steele, E.J.1
  • 170
    • 0041381361 scopus 로고    scopus 로고
    • AID mutant analyses indicate requirement for class-switch-specific cofactors
    • Ta V.T., Nagaoka H., Catalan N., Durandy A., Fischer A., Imai K., et al. AID mutant analyses indicate requirement for class-switch-specific cofactors. Nat Immunol 2003, 4:843-848.
    • (2003) Nat Immunol , vol.4 , pp. 843-848
    • Ta, V.T.1    Nagaoka, H.2    Catalan, N.3    Durandy, A.4    Fischer, A.5    Imai, K.6
  • 171
  • 172
    • 0035067615 scopus 로고    scopus 로고
    • Palindromic but not G-rich sequences are targets of class switch recombination
    • Tashiro J., Kinoshita K., Honjo T. Palindromic but not G-rich sequences are targets of class switch recombination. Int Immunol 2001, 13:495-505.
    • (2001) Int Immunol , vol.13 , pp. 495-505
    • Tashiro, J.1    Kinoshita, K.2    Honjo, T.3
  • 173
    • 43049178852 scopus 로고    scopus 로고
    • MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase
    • Teng G., Hakimpour P., Landgraf P., Rice A., Tuschl T., Casellas R., et al. MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity 2008, 28:621-629.
    • (2008) Immunity , vol.28 , pp. 621-629
    • Teng, G.1    Hakimpour, P.2    Landgraf, P.3    Rice, A.4    Tuschl, T.5    Casellas, R.6
  • 174
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa S. Somatic generation of antibody diversity. Nature 1983, 302:575-581.
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 175
    • 75649096381 scopus 로고    scopus 로고
    • B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers
    • Tran T.H., Nakata M., Suzuki K., Begum N.A., Shinkura R., Fagarasan S., et al. B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers. Nat Immunol 2009, 11:148-154.
    • (2009) Nat Immunol , vol.11 , pp. 148-154
    • Tran, T.H.1    Nakata, M.2    Suzuki, K.3    Begum, N.A.4    Shinkura, R.5    Fagarasan, S.6
  • 176
    • 33947216515 scopus 로고    scopus 로고
    • T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells
    • Ueda Y., Liao D., Yang K., Patel A., Kelsoe G. T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells. J Immunol 2007, 178:3593-3601.
    • (2007) J Immunol , vol.178 , pp. 3593-3601
    • Ueda, Y.1    Liao, D.2    Yang, K.3    Patel, A.4    Kelsoe, G.5
  • 177
    • 34548526067 scopus 로고    scopus 로고
    • Strand-biased spreading of mutations during somatic hypermutation
    • Unniraman S., Schatz D.G. Strand-biased spreading of mutations during somatic hypermutation. Science 2007, 317:1227-1230.
    • (2007) Science , vol.317 , pp. 1227-1230
    • Unniraman, S.1    Schatz, D.G.2
  • 179
    • 37049002638 scopus 로고    scopus 로고
    • MicroRNA-155 regulates the generation of immunoglobulin class-switched plasma cells
    • Vigorito E., Perks K.L., Abreu-Goodger C., Bunting S., Xiang Z., Kohlhaas S., et al. microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity 2007, 27:847-859.
    • (2007) Immunity , vol.27 , pp. 847-859
    • Vigorito, E.1    Perks, K.L.2    Abreu-Goodger, C.3    Bunting, S.4    Xiang, Z.5    Kohlhaas, S.6
  • 180
    • 78651227102 scopus 로고    scopus 로고
    • APOBEC2, a selective inhibitor of TGFβ signaling, regulates left-right axis specification during early embryogenesis
    • Vonica A., Rosa A., Arduini B., Brivanlou A.H. APOBEC2, a selective inhibitor of TGFβ signaling, regulates left-right axis specification during early embryogenesis. Dev Biol 2011, 350(1):13-23.
    • (2011) Dev Biol , vol.350 , Issue.1 , pp. 13-23
    • Vonica, A.1    Rosa, A.2    Arduini, B.3    Brivanlou, A.H.4
  • 181
    • 62849104777 scopus 로고    scopus 로고
    • Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination
    • Vuong B.Q., Lee M., Kabir S., Irimia C., Macchiarulo S., McKnight G.S., et al. Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination. Nat Immunol 2009, 10:420-426.
    • (2009) Nat Immunol , vol.10 , pp. 420-426
    • Vuong, B.Q.1    Lee, M.2    Kabir, S.3    Irimia, C.4    Macchiarulo, S.5    McKnight, G.S.6
  • 182
    • 30344463017 scopus 로고    scopus 로고
    • Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID
    • Wakae K., Magor B.G., Saunders H., Nagaoka H., Kawamura A., Kinoshita K., et al. Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID. Int Immunol 2006, 18:41-47.
    • (2006) Int Immunol , vol.18 , pp. 41-47
    • Wakae, K.1    Magor, B.G.2    Saunders, H.3    Nagaoka, H.4    Kawamura, A.5    Kinoshita, K.6
  • 183
    • 67650330317 scopus 로고    scopus 로고
    • AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity
    • Wang M., Yang Z., Rada C., Neuberger M.S. AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity. Nat Struct Mol Biol 2009, 16:769-776.
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 769-776
    • Wang, M.1    Yang, Z.2    Rada, C.3    Neuberger, M.S.4
  • 184
    • 41149153412 scopus 로고    scopus 로고
    • DNA polymerases in adaptive immunity
    • Weill J.C., Reynaud C.A. DNA polymerases in adaptive immunity. Nat Rev Immunol 2008, 8:302-312.
    • (2008) Nat Rev Immunol , vol.8 , pp. 302-312
    • Weill, J.C.1    Reynaud, C.A.2
  • 185
    • 0032555715 scopus 로고    scopus 로고
    • Somatic hypermutation, transcription, and DNA mismatch repair
    • Wiesendanger M., Scharff M.D., Edelmann W. Somatic hypermutation, transcription, and DNA mismatch repair. Cell 1998, 94(4):415-418.
    • (1998) Cell , vol.94 , Issue.4 , pp. 415-418
    • Wiesendanger, M.1    Scharff, M.D.2    Edelmann, W.3
  • 186
    • 0034742679 scopus 로고    scopus 로고
    • Unraveling the mysteries of gammadelta T cell recognition
    • Wilson I.A., Stanfield R.L. Unraveling the mysteries of gammadelta T cell recognition. Nat Immunol 2001, 2:579-581.
    • (2001) Nat Immunol , vol.2 , pp. 579-581
    • Wilson, I.A.1    Stanfield, R.L.2
  • 187
    • 0026470596 scopus 로고
    • What limits affinity maturation of antibodies in Xenopus - the rate of somatic mutation or the ability to select mutants?
    • Wilson M.R., Hsu E., Marcuz A., Courtet M., Du Pasquier L., Steinberg C. What limits affinity maturation of antibodies in Xenopus - the rate of somatic mutation or the ability to select mutants?. EMBO J 1992, 11:4337-4347.
    • (1992) EMBO J , vol.11 , pp. 4337-4347
    • Wilson, M.R.1    Hsu, E.2    Marcuz, A.3    Courtet, M.4    Du Pasquier, L.5    Steinberg, C.6
  • 188
    • 11844264903 scopus 로고    scopus 로고
    • The double-edged sword of activation-induced cytidine deaminase
    • Wu X., Geraldes P., Platt J.L., Cascalho M. The double-edged sword of activation-induced cytidine deaminase. J Immunol 2005, 174:934-941.
    • (2005) J Immunol , vol.174 , pp. 934-941
    • Wu, X.1    Geraldes, P.2    Platt, J.L.3    Cascalho, M.4
  • 189
    • 58149384574 scopus 로고    scopus 로고
    • Alternative splicing regulates activation-induced cytidine deaminase (AID): implications for suppression of AID mutagenic activity in normal and malignant B cells
    • Wu X., Darce J.R., Chang S.K., Nowakowski G.S., Jelinek D.F. Alternative splicing regulates activation-induced cytidine deaminase (AID): implications for suppression of AID mutagenic activity in normal and malignant B cells. Blood 2008, 112:4675-4682.
    • (2008) Blood , vol.112 , pp. 4675-4682
    • Wu, X.1    Darce, J.R.2    Chang, S.K.3    Nowakowski, G.S.4    Jelinek, D.F.5
  • 190
    • 33846900907 scopus 로고    scopus 로고
    • Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias
    • Xiao Z., Ray M., Jiang C., Clark A.B., Rogozin I.B., Diaz M. Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias. Mol Immunol 2007, 44:2659-2666.
    • (2007) Mol Immunol , vol.44 , pp. 2659-2666
    • Xiao, Z.1    Ray, M.2    Jiang, C.3    Clark, A.B.4    Rogozin, I.B.5    Diaz, M.6
  • 191
    • 77956345401 scopus 로고    scopus 로고
    • 14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination
    • Xu Z., Fulop Z., Wu G., Pone E.J., Zhang J., Mai T., et al. 14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination. Nat Struct Mol Biol 2010, 17:1124-1135.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 1124-1135
    • Xu, Z.1    Fulop, Z.2    Wu, G.3    Pone, E.J.4    Zhang, J.5    Mai, T.6
  • 192
    • 28944438062 scopus 로고    scopus 로고
    • Identification of a ubiquitously active promoter of the murine activation-induced cytidine deaminase (AICDA) gene
    • Yadav A., Olaru A., Saltis M., Setren A., Cerny J., Livak F. Identification of a ubiquitously active promoter of the murine activation-induced cytidine deaminase (AICDA) gene. Mol Immunol 2006, 43:529-541.
    • (2006) Mol Immunol , vol.43 , pp. 529-541
    • Yadav, A.1    Olaru, A.2    Saltis, M.3    Setren, A.4    Cerny, J.5    Livak, F.6
  • 193
    • 31144478883 scopus 로고    scopus 로고
    • The nucleotide targets of somatic mutation and the role of selection in immunoglobulin heavy chains of a teleost fish
    • Yang F., Waldbieser G.C., Lobb C.J. The nucleotide targets of somatic mutation and the role of selection in immunoglobulin heavy chains of a teleost fish. J Immunol 2006, 176:1655-1667.
    • (2006) J Immunol , vol.176 , pp. 1655-1667
    • Yang, F.1    Waldbieser, G.C.2    Lobb, C.J.3
  • 194
    • 33845901812 scopus 로고    scopus 로고
    • Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences
    • Yang S.Y., Fugmann S.D., Schatz D.G. Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences. J Exp Med 2006, 203:2919-2928.
    • (2006) J Exp Med , vol.203 , pp. 2919-2928
    • Yang, S.Y.1    Fugmann, S.D.2    Schatz, D.G.3
  • 195
    • 0035879114 scopus 로고    scopus 로고
    • Intracellular trafficking determinants in APOBEC-1, the catalytic subunit for cytidine to uridine editing of apolipoprotein B mRNA
    • Yang Y., Sowden M.P., Smith H.C. Intracellular trafficking determinants in APOBEC-1, the catalytic subunit for cytidine to uridine editing of apolipoprotein B mRNA. Exp Cell Res 2001, 267:153-164.
    • (2001) Exp Cell Res , vol.267 , pp. 153-164
    • Yang, Y.1    Sowden, M.P.2    Smith, H.C.3
  • 196
    • 0037076967 scopus 로고    scopus 로고
    • AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts
    • Yoshikawa K., Okazaki I.M., Eto T., Kinoshita K., Muramatsu M., Nagaoka H., et al. AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science 2002, 296:2033-2036.
    • (2002) Science , vol.296 , pp. 2033-2036
    • Yoshikawa, K.1    Okazaki, I.M.2    Eto, T.3    Kinoshita, K.4    Muramatsu, M.5    Nagaoka, H.6
  • 197
    • 13444255004 scopus 로고    scopus 로고
    • An evolutionarily conserved target motif for immunoglobulin class-switch recombination
    • Zarrin A.A., Alt F.W., Chaudhuri J., Stokes N., Kaushal D., Du Pasquier L., et al. An evolutionarily conserved target motif for immunoglobulin class-switch recombination. Nat Immunol 2004, 5:1275-1281.
    • (2004) Nat Immunol , vol.5 , pp. 1275-1281
    • Zarrin, A.A.1    Alt, F.W.2    Chaudhuri, J.3    Stokes, N.4    Kaushal, D.5    Du Pasquier, L.6
  • 198
    • 0035377269 scopus 로고    scopus 로고
    • DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
    • Zeng X., Winter D.B., Kasmer C., Kraemer K.H., Lehmann A.R., Gearhart P.J. DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nat Immunol 2001, 2:537-541.
    • (2001) Nat Immunol , vol.2 , pp. 537-541
    • Zeng, X.1    Winter, D.B.2    Kasmer, C.3    Kraemer, K.H.4    Lehmann, A.R.5    Gearhart, P.J.6
  • 199
    • 3042802389 scopus 로고    scopus 로고
    • Diversification of Ig superfamily genes in an invertebrate
    • Zhang S.M., Adema C.M., Kepler T.B., Loker E.S. Diversification of Ig superfamily genes in an invertebrate. Science 2004, 305:251-254.
    • (2004) Science , vol.305 , pp. 251-254
    • Zhang, S.M.1    Adema, C.M.2    Kepler, T.B.3    Loker, E.S.4
  • 200
    • 4344654828 scopus 로고    scopus 로고
    • Identification of the activation-induced cytidine deaminase gene from zebrafish: an evolutionary analysis
    • Zhao Y., Pan-Hammarstrom Q., Zhao Z., Hammarstrom L. Identification of the activation-induced cytidine deaminase gene from zebrafish: an evolutionary analysis. Dev Comp Immunol 2005, 29:61-71.
    • (2005) Dev Comp Immunol , vol.29 , pp. 61-71
    • Zhao, Y.1    Pan-Hammarstrom, Q.2    Zhao, Z.3    Hammarstrom, L.4
  • 201
    • 78149476860 scopus 로고    scopus 로고
    • Error-prone DNA repair activity during somatic hypermutation in shark B lymphocytes
    • Zhu C., Hsu E. Error-prone DNA repair activity during somatic hypermutation in shark B lymphocytes. J Immunol 2010, 185:5336-5347.
    • (2010) J Immunol , vol.185 , pp. 5336-5347
    • Zhu, C.1    Hsu, E.2


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