Class switch recombination of the chicken IgH chain genes: Implications for the primordial switch region repeats

International Immunology

Volumn 12, Issue 7, 2000, Pages 959-968

  Kitao, Hiroyuki ^a   Arakawa, Hiroshi ^a,e   Kuma, Kei Ichi ^a   Yamagishi, Hideo ^a,b   Nakamura, Naoto ^c   Furusawa, Shuichi ^c   Matsuda, Haruo ^c   Yasuda, Masahiro ^d   Ekino, Shigeo ^d   Shimizu, Akira ^a  

^a KYOTO UNIVERSITY   (Japan)

^b HEALTH RESEARCH FOUNDATION   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

^d KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^e LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

Author keywords

Chicken switch region; Deletional recombination; Palindrome; Prevalent pentamer; Repetitive sequence

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

AMPHIBIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHICKEN; CONSENSUS SEQUENCE; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE LOCUS; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC RECOMBINATION; HYBRIDOMA; IMMUNIZATION; IMMUNOGLOBULIN GENE; INTRON; MAMMAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; REGULATOR GENE; SPLEEN CELL; TANDEM REPEAT; XENOPUS;

XENOPUS;

EID: 0033859765     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/12.7.959     Document Type: Article

References (60)

1. Somatic generation of antibody diversity
2. Immunoglobulin class switching
3. Immunoglobulin class switching: Molecular and cellular analysis
4. Antibody class switching
5. Organization of immunoglobulin heavy chain genes and allelic deletion model
6. Switch region of immunoglobulin Cμ gene is composed of simple tandem repetitive sequences
7. Repetitive sequence in class-switch recombination regions of immunoglobulin heavy chain genes
8. Nucleotide sequences of switch regions of immunoglobulin Cε and Cγ genes and their comparison
9. Organization of the constant-region gene family of the mouse immunoglobulin heavy chain
10. DNA sequences at immunoglobulin switch region recombination sites
11. Frequent but biased class switch recombination in the Sμ flanking regions
12. Looping out and deletion mechanism for the immunoglobulin heavy-chain class switch
13. Structure of a rearranged γ1 chain gene and its implication to immunoglobulin class-switch mechanism
14. Circular DNA is a product of the immunoglobulin class switch rearrangement
15. Circular DNA is excised by immunoglobulin class switch recombination
16. Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching
17. Phylogeny of immunoglobulin heavy chain isotypes: Structure of the constant region of Ambystoma mexicanum υ chain deduced from cDNA sequence
18. Membrane exon sequences of the three Xenopus Ig classes explain the evolutionary origin of mammalian isotypes
19. A third immunoglobulin class in amphibians
20. Ontogeny of the immune system in Xenopus II. Antibody repertoire differences between larvae and adults
21. Is Xenopus IgX an analog of IgA?
22. Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals
23. Somatic hyperconversion diversifies the single V(H) gene of the chicken with a high incidence in the D region
24. A hyperconversion mechanism generates the chicken light chain pre-immune repertoire
25. Immunoglobulin gene hyperconversion ongoing in chicken splenic germinal centers
26. Nucleotide sequence of the constant region of a chicken μ heavy chain immunoglobulin mRNA
27. Chicken immunoglobulin γ-heavy chains: Limited V(H) gene repertoire, combinatorial diversification by D gene segments and evolution of the heavy chain locus
28. Chicken IgA H chains. Implications concerning the evolution of H chain genes
29. The role of various compartments in the chicken spleen during are antigen-specific humoral response
30. Chicken immunoglobulin μ-chain gene: Germline organization and tandem repeats characteristic of class switch recombination
31. Creation of immunoglobulin diversity by intrachromosomal gene conversion
32. Evolution of somatic hypermutation and gene conversion in adaptive immunity
33. The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes
34. Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse
35. Production of sterile transcripts of Cγ genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells
36. Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene
37. Signal joint of immunoglobulin Vλ1-Jλ and novel joints of chimeric V pseudogenes on extrachromosomal circular DNA from chicken bursa
38. A chicken monoclonal antibody with specificity for the N-terminal of human prion protein
39. Two chicken B cell lines resistant to ouabain for the production of chicken monoclonal antibodies
40. Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus
41. Analysis of a hotspot for DNA insertion suggests a mechanism for Ig switch recombination
42. Immunoglobulin S(γ)3 DNA specific double stranded breaks are induced in mitogen activated B cells and are implicated in switch recombination
43. The 3' to 5' exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks
44. Sequences of human immunoglobulin switch regions: Implications for recombination and transcription
45. The complete murine immunoglobulin class switch region of the α heavy chain gene-hierarchic repetitive structure and recombination breakpoints
46. EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA
47. DNA-dependent protein kinase is activated by nicks and large single-stranded gaps
48. The SCID but not the RAG-2 gene product is required for S(μ)-S(ε) heavy chain class switching
49. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching
50. Ku80 is required for immunoglobulin isotype switching
51. Ku protein stimulates DNA end joining by mammalian DNA ligases: A direct role for Ku in repair of DNA double-strand breaks
52. The liaison of isotype class switch and mismatch repair: An illegitimate affair
53. Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation
54. Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes
55. Mutations, duplications, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch
56. Analysis of immunoglobulin Sγ3 recombination breakpoints by PCR: Implications for the mechanism of isotype switching
57. Sequence analysis of pig switch μ, Cμ, and Cμm
58. A novel chimeric Ig heavy chain from a teleost fish shares similarities to IgD
59. IgD class switching: Identification of a novel recombination site in neoplasmic and normal B cells