Somatic mutation in ectothermic vertebrates: Musings on selection and origins

Current Topics in Microbiology and Immunology

Volumn 229, Issue , 1997, Pages 199-216

  Du Pasquier, L ^a   Wilson, M ^b   Greenberg, A S ^c   Flajnik, M F ^c  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE CONVERSION; GENE REARRANGEMENT; GENETIC VARIABILITY; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVIEW; SHARK; SOMATIC MUTATION; VERTEBRATE; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY AFFINITY; ANTIBODY DIVERSITY; BASE SEQUENCE; GENES, IMMUNOGLOBULIN; GERMINAL CENTER; HUMANS; IMMUNE SYSTEM; MOLECULAR SEQUENCE DATA; MUTATION; VERTEBRATES;

CHONDRICHTHYES; VERTEBRATA;

EID: 0031458712     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (14)

1. Anderson M, Amemiya C, Luer C, Litman R, Rast J, Nimura Y, Litman G (1994) Complete genomic sequence and patterns of transcription of a member of an unusual family of closely related, chromosomally dispersed Ig gene clusters in Raja. Int Immunol 6:1661-1670
2. Anderson MK, Shamblott MJ, Litman RT, Litman GW (1995) Generation of immunoglobulin light chain gene diversity in Raja erinacea is not associated with somatic rearrangement, an exception to a central paradigm of B cell immunity. J Exp Med 182:109-119
3. Bachl J, Wabl M (1996) An immunoglobulin mutator that targets G.C base pairs. Proc Natl Acad Sci USA 93:851-855
4. Betz AG, Neuberger MS, Milstein C (1993) Discriminating intrinsic and anti-selected mutational hotspots in immunoglobulin V genes. Immunol Today 14:405-411
5. Brandt DC, Griessen M, Du Pasquier L, Jaton JC (1980) Antibody diversity in amphibians: evidence for inheritance of idiotypic specificities in isogeneic Xenopus. Eur J Immunol 10:731-736
6. Borgulya P, Kishi H, Uematsu Y, von Boehmer H. (1992) Exclusion and inclusion of a and b T cell receptor alleles. Cell 69:529-537
7. Chen C, Radic MZ, Erikson J, Camper SA, Litwin S, Hardy RR, Weigert M (1994) Deletion and editing of B cells that express antibodies to DNA. J Immunol 152:1970-1982
8. Clem LW, Leslie GA (1971) Production of 19S IgM antibodies with restricted heterogeneity from sharks. Proc Natl Acad Sci USA 68:139-143
9. H antibody fragment in complex with lysozyme. Nature Struct Biol 3:803-811
10. Du Pasquier L (1982) Antibody diversity in lower vertebrates - why is it so restricted? Nature 276:311-313
11. Du Pasquier L (1993) Phylogeny of B-cell development. Curr Opin Immunol 5:185-193
12. Du Pasquier L, Haimovich J (1976) The antibody response during amphibian ontogeny. Immunogenetics 3:381-391
13. Du Pasquier L, Robert J (1992) In vitro growth of thymic tumor cell lines from Xenopus. Dev Immunol 2:295-307
14. Gallinari P, Jiricny J (1996) A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase. Nature 383:735-738