Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency

Nature

Volumn 463, Issue 7284, 2010, Pages 1101-1105

  Popp, Christian ^a   Dean, Wendy ^a   Feng, Suhua ^b   Cokus, Shawn J ^b   Andrews, Simon ^c   Pellegrini, Matteo ^b   Jacobsen, Steven E ^b   Reik, Wolf ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

COLIFORM BACTERIUM; DNA; EMBRYO; ENZYME ACTIVITY; GENETIC ANALYSIS; GENOME; GERM CELL; METHYLATION; RODENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; EXON; FEMALE; GENE; GENE LOCUS; GENOME ANALYSIS; GERM LINE; INTRON; MALE; MOUSE; NONHUMAN; NP95 GENE; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; SEX DIFFERENCE; TRANSPOSON; UHRF1 GENE;

ANIMALS; CYTIDINE DEAMINASE; DNA METHYLATION; DNA TRANSPOSABLE ELEMENTS; EMBRYO, MAMMALIAN; EPIGENESIS, GENETIC; EXONS; FEMALE; GENOME; GERM CELLS; INTRONS; MALE; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; OCTAMER TRANSCRIPTION FACTOR-3;

ESCHERICHIA COLI; MAMMALIA;

EID: 77249148019     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08829     Document Type: Article

References (30)

1. Reik, W., Dean, W. & Walter, J. Epigenetic reprogramming in mammalian development. Science 293, 1089-1093 (2001).
2. Sasaki, H. & Matsui, Y. Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nature Rev. Genet. 9, 129-140 (2008).
3. Oswald, J. et al. Active demethylation of the paternal genome in the mouse zygote. Curr. Biol. 10, 475-478 (2000).
4. Mayer, W., Niveleau, A., Walter, J., Fundele, R. & Haaf, T. Demethylation of the zygotic paternal genome. Nature 403, 501-502 (2000).
5. Dean, W. et al. Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos. Proc. Natl Acad. Sci. USA 98, 13734-13738 (2001).
6. Hajkova, P. et al. Epigenetic reprogramming in mouse primordial germ cells. Mech. Dev. 117, 15-23 (2002).
7. Lee, J. et al. Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells. Development 129, 1807-1817 (2002).
8. Yamazaki, Y. et al. Reprogramming of primordial germ cells begins before migration into the genital ridge, making these cells inadequate donors for reproductive cloning. Proc. Natl Acad. Sci. USA 100, 12207-12212 (2003).
9. Hajkova, P. et al. Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature 452, 877-881 (2008).
10. Morgan, H. D., Dean, W., Coker, H. A., Reik, W. & Petersen-Mahrt, S. K. Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. J. Biol. Chem. 279, 52353-52360 (2004).
11. Cokus, S. J. et al. Shotgun bisulfite sequencing of the Arabidopsis genome reveals DNA methylation patterning. Nature 452, 215-219 (2008).
12. Meissner, A. et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454, 766-770 (2008).
13. Lister, R. et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462, 315-322 (2009).
14. Gehring, M., Reik, W. & Henikoff, S. DNA demethylation by DNA repair. Trends Genet. 25, 82-90 (2009).
15. Gehring, M., Bubb, K. L. & Henikoff, S. Extensive demethylation of repetitive elements during seed development underlies gene imprinting. Science 324, 1447-1451 (2009).
16. Hsieh, T. F. et al. Genome-wide demethylation of Arabidopsis endosperm. Science 324, 1451-1454 (2009).
17. Rai, K. et al. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase and gadd45. Cell 135, 1201-1212 (2008).
18. Lane, N. et al. Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis 35, 88-93 (2003).
19. Zvetkova, I. et al. Global hypomethylation of the genome in XX embryonic stem cells. Nature Genet. 37, 1274-1279 (2005).
20. Seki, T. et al. Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice. Development 134, 2627-2638 (2007).
21. Muramatsu, M. et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potent RNA editing enzyme. Cell 102, 553-563 (2000).
22. Whitelaw, N. C. & Whitelaw, E. Transgenerational epigenetic inheritance in health and disease. Curr. Opin. Genet. Dev. 18, 273-279 (2008).
23. Slotkin, R. K. et al. Epigenetic reprogramming and small RNA silencing of transposable elements in pollen. Cell 136, 461-472 (2009).
24. Teixeira, F. K. et al. A role for RNAi in the selective correction of DNA methylation defects. Science 323, 1600-1604 (2009).
25. Bhutani, N. et al. Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature doi:10.1038/nature08752 (21 December 2009).
26. Robbiani, D. F. et al. Aid produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol. Cell 36, 631-641 (2009).
27. Neuberger, M. S., Harris, R. S., Di Noia, J. & Petersen-Mahrt, S. K. Immunity through DNA deamination. Trends Biochem. Sci. 28, 305-312 (2003).
28. Larijani, M. et al. Methylation protects cytidines from Aid-mediated deamination. Mol. Immunol. 42, 599-604 (2005).
29. Kriaucionis, S. & Heintz, N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324, 929-930 (2009).
30. Tahiliani, M. et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930-935 (2009).