Immunology: Diversity and function of adaptive immune receptors in a jawless vertebrate

Science

Volumn 310, Issue 5756, 2005, Pages 1970-1973

  Alder, Matthew N ^a   Rogozin, Igor B ^b   Iyer, Lakshminarayan M ^b   Glazko, Galina V ^c   Cooper, Max D ^a   Pancer, Zeev ^d  

^a and Clinical Center   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; COMPUTATIONAL METHODS; IMMUNOLOGY;

JAWED VERTEBRATES; LEUCINE-RICH REPEAT (LRR); VARIABLE LYMPHOCYTE RECEPTORS (VLR);

GENES;

IMMUNOGLOBULIN RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; LYMPHOCYTE RECEPTOR;

MEDICINE;

ANTHRAX; ANTIGEN RECOGNITION; ARTICLE; BACTERIAL SPORE; DNA FLANKING REGION; GENE CASSETTE; GENETIC VARIABILITY; IMMUNE RESPONSE; IMMUNOSTIMULATION; NONHUMAN; PRIORITY JOURNAL; ADAPTATION; ANIMAL; BACILLUS ANTHRACIS; BACILLUS SUBTILIS; GENE REARRANGEMENT; GENETIC SELECTION; GENETICS; IMMUNITY; IMMUNOLOGY; LAMPREY; MOLECULAR EVOLUTION; MOLECULAR GENETICS; PHYSIOLOGY;

AGNATHA; BACTERIA (MICROORGANISMS); GNATHOSTOMATA (VERTEBRATE); PETROMYZONTIDAE; VERTEBRATA;

ADAPTATION, BIOLOGICAL; ANIMALS; BACILLUS ANTHRACIS; BACILLUS SUBTILIS; EVOLUTION, MOLECULAR; GENE REARRANGEMENT; IMMUNITY; LAMPREYS; MOLECULAR SEQUENCE DATA; RECEPTORS, IMMUNOLOGIC; SELECTION (GENETICS); SPORES, BACTERIAL; VARIATION (GENETICS);

EID: 29344475707     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1119420     Document Type: Article

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25. We thank C. L. Turnbough and J. F. Kearney labs for advice and anthrax reagents; L. Gartland for the VLR-specific antibody, G. L. Gartland for help with the FACS; L. Aravind, M. F. Flajnik, A. N. Haines, and M. Criscitiello for critical comments. I.B.R. and L.M.I. were supported by the NLM/NIH/DHHS Intramural Research Program; M.D.C. is a HHMI Investigator; Z.P. was funded by NSF-MCB-0317460; contribution 05-122 from COMB. Reported sequences were deposited in GenBank: DQ150997to DQ151421.